公开(公告)号：PL1559431T3

公开(公告)日：2007-10-31

申请号：PL04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

公开(公告)号：DE60313982D1

公开(公告)日：2007-07-05

申请号：DE60313982

申请日：2003-07-01

Applicant: ORTHOLOGIC CORP

Inventor： CARNEY DARRELL H

IPC: C07K5/00 ,  A61K38/00 ,  A61K38/16 ,  C07K5/10 ,  C12N9/74

Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

公开(公告)号：AT357928T

公开(公告)日：2007-04-15

申请号：AT04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K38/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

公开(公告)号：AU2001276977B2

公开(公告)日：2005-05-19

申请号：AU2001276977

申请日：2001-07-18

Applicant: ORTHOLOGIC CORP

Inventor： SIMMONS DAVID J ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  REDIN WILLIAM R ,  YANG JINPING

IPC: A61L27/00 ,  A61K38/00 ,  A61K38/10 ,  A61K38/16 ,  A61K38/18 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61K47/04 ,  A61K47/34 ,  A61K47/42 ,  A61P19/00 ,  C12N9/74 ,  C12N9/76 ,  A61K038/00

公开(公告)号：HK1065719A1

公开(公告)日：2005-03-24

申请号：HK04108700

申请日：2004-11-05

Applicant: ORTHOLOGIC CORP

Inventor： CARNEY DARRELL H

IPC: A61K20060101 ,  A61K38/00 ,  A61K38/48 ,  A61P20060101 ,  A61P3/10 ,  A61P17/02

Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.

公开(公告)号：AU2001273561B2

公开(公告)日：2004-10-28

申请号：AU2001273561

申请日：2001-07-19

Applicant: ORTHOLOGIC CORP

Inventor： CROWTHER ROGER S ,  CARNEY DARRELL H ,  BERGMANN JOHN ,  STIERNBERG JANET

IPC: C12N9/74 ,  A61K35/32 ,  A61K38/00 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61K47/34 ,  A61L27/00 ,  A61L27/18 ,  A61L27/22 ,  A61L27/54 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P43/00 ,  C12N5/06

Abstract: Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.

公开(公告)号：HK1060302A1

公开(公告)日：2004-08-06

申请号：HK04103301

申请日：2004-05-10

Applicant: ORTHOLOGIC CORP

Inventor： CARNEY DARRELL H

IPC: A61K47/34 ,  A61F2/06 ,  A61F2/84 ,  A61K20100101 ,  A61K9/16 ,  A61K38/48 ,  A61L29/00 ,  A61L31/00 ,  A61L33/00 ,  A61M25/00 ,  A61P20100101 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C12N9/74

公开(公告)号：ES2210320T3

公开(公告)日：2004-07-01

申请号：ES95937426

申请日：1995-10-04

Applicant: ORTHOLOGIC CORP

Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALLESSANDRO E

IPC: A61B17/00 ,  A61F2/28 ,  A61N1/00 ,  A61H23/02 ,  A61N7/00

Abstract: A method of ultrasonic bone-therapy subjects a bone to an ultrasonic excitation pulse signal of finite duration, supplied to a transducer next to the bone, and involving a sinusoidal signal in the ultrasonic region to approximately 2 MHz peculiarly modulated by a sinusoidal signal with frequency between about 0 Hz and about 25 kHz; the excitation signal is repeated in the range of 1 to 5000 Hz. The exposure time for therapy is chosen to be in the range of 5 minutes to 1 hour, for 1 to 3 times a day, for a period of days as necessary for healing or for promoting bone growth and ingrowth. An apparatus for implementing the above method for ultrasonic bone therapy is disclosed comprising a transducer having a transmitting and a receiving element, a special waveform signal generator, and a computer for performing the necessary operations defining a preferred treatment regime.

公开(公告)号：AT255935T

公开(公告)日：2003-12-15

申请号：AT95937426

申请日：1995-10-04

Applicant: ORTHOLOGIC CORP

Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALLESSANDRO E

IPC: A61N1/00 ,  A61B17/00 ,  A61F2/28 ,  A61H23/02 ,  A61N7/00

Abstract: A method of ultrasonic bone-therapy subjects a bone to an ultrasonic excitation pulse signal of finite duration, supplied to a transducer next to the bone, and involving a sinusoidal signal in the ultrasonic region to approximately 2 MHz peculiarly modulated by a sinusoidal signal with frequency between about 0 Hz and about 25 kHz; the excitation signal is repeated in the range of 1 to 5000 Hz. The exposure time for therapy is chosen to be in the range of 5 minutes to 1 hour, for 1 to 3 times a day, for a period of days as necessary for healing or for promoting bone growth and ingrowth. An apparatus for implementing the above method for ultrasonic bone therapy is disclosed comprising a transducer having a transmitting and a receiving element, a special waveform signal generator, and a computer for performing the necessary operations defining a preferred treatment regime.

公开(公告)号：AT138587T

公开(公告)日：1996-06-15

申请号：AT91309538

申请日：1991-10-16

Applicant: ORTHOLOGIC CORP

Inventor： LAMOND DONALD R ,  HEINZELMAN BERT

IPC: A61N2/00 ,  A61B19/00 ,  A61G13/12 ,  A61N2/02

Abstract: A medical treatment device (20) is disclosed which includes a medical treatment element (36,38) and resilient securing members (32,34) which adjust or deform to conform to the particular dimensions of that part of the patient's anatomy which is to be treated. The resilient securing members (32, 34) move or deform outwardly away from the patient (22) as the device is applied to conform to the size of the patient and ensure that the patient is centered within the treatment device. The medical treatment elements (36,38) are thus accurately positioned with respect to the patient (22). This is particularly important in treatments involving the application of magnetic fields to the patient (22). In addition, the disclosed medical device (20) is relatively comfortable and can be worn by a patient (22) for a relatively long period of time. The invention also extends to the method of applying the medical treatment device (20) to the patient (22).