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    SYSTEM AND METHOD FOR USING A DYNAMIC GAMMA KNIFE FOR RADIOSURGERY
    91.
    发明申请
    SYSTEM AND METHOD FOR USING A DYNAMIC GAMMA KNIFE FOR RADIOSURGERY 审中-公开
    用于放射治疗的动态伽玛刀的系统和方法

    公开(公告)号：WO2009137010A3

    公开(公告)日：2010-02-18

    申请号：PCT/US2009002733

    申请日：2009-05-04

    Applicant: STC UNM ,  LUAN SHUANG ,  SWANSON NATHAN ,  MA LIJUN

    Inventor： LUAN SHUANG ,  SWANSON NATHAN ,  MA LIJUN

    IPC: A61B19/00 ,  A61B6/00 ,  A61B18/00

    CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

    Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of "dose-painting" to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical "paintbrush", and treatment planning is reduced to finding the best route of this "paintbrush" to "paint" a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

    Abstract translation: 本发明是基于“剂量绘画”的概念，利用伽玛刀C和Perfexion单元上的机器人患者定位系统开发伽玛刀放射外科的动态方案的方法和系统。 由Gamma Knife单元创建的球形高剂量体积将被视为3D球形“画笔”，并且减少治疗计划以找到该“画笔”将“绘制”3D肿瘤体积的最佳路线。 在剂量绘画概念下，伽玛刀放射外科手术变得动态，患者在机器人定位系统下连续移动。

    THERAPEUTIC ULTRASOUND TRANSDUCER CHIP WITH INTEGRATED ULTRASOUND IMAGER AND METHODS OF MAKING AND USING THE SAME
    92.
    发明申请
    THERAPEUTIC ULTRASOUND TRANSDUCER CHIP WITH INTEGRATED ULTRASOUND IMAGER AND METHODS OF MAKING AND USING THE SAME 审中-公开
    具有集成超声波成像器的治疗超声波传感器芯片及其制造和使用方法

    公开(公告)号：WO2009111351A3

    公开(公告)日：2010-01-07

    申请号：PCT/US2009035601

    申请日：2009-02-27

    Applicant: STC UNM ,  CHEN JINGKUANG

    Inventor： CHEN JINGKUANG

    IPC: A61B8/00

    CPC classification number: B06B1/0292

    Abstract: A therapeutic ultrasound device may include a substrate, at least one high power capacitive micromachined ultrasonic transducer, and at least one imager transducer comprising a capacitive micromachined ultrasonic transducer. The at least one high power capacitive micromachined ultrasonic transducer and the imager transducer may be monolithically integrated on the substrate.

    Abstract translation: 治疗性超声装置可以包括衬底，至少一个高功率电容微加工超声换能器，以及包括电容微加工超声换能器的至少一个成像器换能器。 至少一个高功率电容微加工超声换能器和成像器换能器可以单片地集成在基底上。

    ULTRA-THIN MICROPOROUS/HYBRID MATERIALS
    94.
    发明申请
    ULTRA-THIN MICROPOROUS/HYBRID MATERIALS 审中-公开
    超薄微孔/混合材料

    公开(公告)号：WO2009102363A3

    公开(公告)日：2009-10-08

    申请号：PCT/US2008083688

    申请日：2008-11-14

    Applicant: STC UNM ,  JIANG YING-BING ,  CECCHI JOSEPH L ,  BRINKER CHARLES JEFFERY

    Inventor： JIANG YING-BING ,  CECCHI JOSEPH L ,  BRINKER CHARLES JEFFERY

    IPC: B01D69/10 ,  B01D71/00

    CPC classification number: B01D69/122 ,  B01D67/0002 ,  B01D67/0079 ,  B01D67/0083 ,  B01D67/009 ,  B01D69/148 ,  C23C16/401 ,  C23C16/45536 ,  C23C16/45555 ,  Y10T428/24521 ,  Y10T428/24545 ,  Y10T428/249953

    Abstract: Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes.

    Abstract translation: 提供超薄混合和/或微孔材料及其制造方法。 在一个实施方案中，可以形成示例性混合膜，其包括在图案化或非图案化的多孔载体上的连续表面活化和反应步骤。 表面活化可以使用远程等离子体暴露来局部激活多孔载体的外表面来进行。 有机/无机混合前体如有机金属硅烷前体可以在局部活化的外表面上缩合，由此可以在缩合的混合前体和反应物之间发生ALD反应。 各种实施方案还可以包括在膜形成期间ALD前体的间歇替代，以增强膜的混合分子网络。

    SYSTEM AND METHODS FOR MEASURING A SKIN PROTECTION FACTOR
    95.
    发明申请
    SYSTEM AND METHODS FOR MEASURING A SKIN PROTECTION FACTOR 审中-公开

    公开(公告)号：WO2008008383A3

    公开(公告)日：2008-10-30

    申请号：PCT/US2007015802

    申请日：2007-07-11

    Applicant: STC UNM ,  TIMMINS GRAHAM S

    Inventor： TIMMINS GRAHAM S

    IPC: A61K9/00 ,  A61B5/05 ,  C12M1/34 ,  C12Q1/02

    CPC classification number: A61K49/0008 ,  A61B5/0059 ,  A61B5/444 ,  A61B5/445 ,  G01R33/60

    Abstract: The present invention is a system and methods of establishing a Melanocyte Protection Factor (MPF), which indicates the level of protection against DNA damage to a target cell, such as the level of protection a particular sunscreen offers against UVA rays when compared to the unprotected case, i.e., no sunscreen. The present invention determines and records levels of stable melanin radicals (SMR) in a target cell. Light is applied to the target cell forming light-induced melanin radicals (LIR). The levels of SMR and intensity of LIR are measured to determine the amount of incident light reaching the target cell. Since LIR is proportional to the square root of light intensity reaching the target cell, the ratio of light reaching the target cell is defined as the MPF (I).

    MOLECULAR TECHNOLOGIES FOR IMPROVED RISK CLASSIFICATION AND THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADULTS
    96.
    发明申请
    MOLECULAR TECHNOLOGIES FOR IMPROVED RISK CLASSIFICATION AND THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADULTS 审中-公开
    用于改善儿童和成人急性淋巴细胞白血病风险分类与治疗的分子技术

    公开(公告)号：WO2006086043A3

    公开(公告)日：2007-02-01

    申请号：PCT/US2005042733

    申请日：2005-11-23

    Applicant: STC UNM ,  WILLIAM CHERYL L ,  BEDRICK EDWARD ,  KANG HUINING ,  HELMAN PAUL ,  VEROFF ROBERT

    Inventor： WILLIAM CHERYL L ,  BEDRICK EDWARD ,  KANG HUINING ,  HELMAN PAUL ,  VEROFF ROBERT

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: To improve risk classification and outcome prediction in ALL, gene expression profiles were obtained using oligonucleotide arrays in a retrospective case control study of 220 children with B precursor ALL. Using multiple statistical methods and computational tools, these comprehensive gene expression profiles were reduced to a 26 gene expression classifier that was highly predictive of overall outcome. Each of these 26 genes was shown to provide additional prognositc information relative to established prognositc variables. The 26 genes include signaling, adhesion and growth regulatory proteins (RHoGEF4, FYB, HNK-I sulfotransferase, SMADl, HABP4, PHYH, IFI44L, JAGl, EFN-B2, type 3 inositol-1,4,5 triphosphate receptor, MONDOA, DOKl, CDK8, CD44, CL5/RANTES, galectin SPARC) and novel genes not previously known to play a role in hematopoiesis or leukemogenesis (DREBIN, MIDKINE, and the hypothetical protein LJ20154 or OPALlwhich have been cloned and characterized).

    Abstract translation: 为了改善ALL的风险分类和结果预测，在回顾性病例对照研究中，使用寡核苷酸阵列获得了220名B前体ALL患儿的基因表达谱。 使用多种统计方法和计算工具，将这些综合基因表达谱简化为26个基因表达分类器，其高度预测总体结果。 显示这26个基因中的每一个相对于建立的预后变量提供额外的预后信息。 26个基因包括信号传导，粘附和生长调节蛋白（RHoGEF4，FYB，HNK-1磺基转移酶，SMAD1，HABP4，PHYH，IFI44L，JAG1，EFN-B2，3型肌醇-1,4,5三磷酸受体，MONDOA，DOK1 ，CDK8，CD44，CL5 / RANTES，半乳凝素SPARC）和以前未知在造血或白血病发生中起作用的新基因（DREBIN，MIDKINE，以及已克隆和表征的假定蛋白LJ20154或OPAL1）。

    RhPV AS A MODEL FOR HPV-INDUCED CANCERS
    97.
    发明申请
    RhPV AS A MODEL FOR HPV-INDUCED CANCERS 审中-公开
    RhPV作为HPV诱导型癌的模型

    公开(公告)号：WO2005041880A3

    公开(公告)日：2005-07-28

    申请号：PCT/US2004035961

    申请日：2004-10-29

    Applicant: STC UNM ,  OZBUN MICHELLE A

    Inventor： OZBUN MICHELLE A

    IPC: A01K67/00 ,  A01K67/027 ,  A01K67/033 ,  A61K20060101 ,  C12N5/10 ,  C12N15/63 ,  C12N15/86 ,  C12P21/04 ,  C12Q1/70

    CPC classification number: A01K67/027 ,  A01K2227/106 ,  A01K2267/0331 ,  A01K2267/0337 ,  C12N2710/20011

    Abstract: Provided is an animal model system for the study of papillomaviruses, especially anogenital papillomaviruses, especially those causing anogenital and/or head and neck cancers. The Rhesus papillomavirus (especially RhPV1) is a useful model for human papillomaviruses which cause anogenital infections and cancers of the anogenital region and/or the head, neck and respiratory system.

    Abstract translation: 提供了一种用于研究乳头瘤病毒，特别是肛门生殖器乳头瘤病毒的动物模型系统，特别是引起肛门生殖和/或头颈部癌症的那些。 恒河猴乳头瘤病毒（特别是RhPV1）是人乳头状瘤病毒的有用模型，其导致肛门生殖器感染和肛门生殖区域和/或头颈部和呼吸系统的癌症。

    NANOWIRE BENDING FOR PLANAR DEVICE PROCESS ON (001) Si SUBSTRATES
    100.
    发明申请
    NANOWIRE BENDING FOR PLANAR DEVICE PROCESS ON (001) Si SUBSTRATES 审中-公开
    （001）Si衬底上平面器件工艺的纳米线弯曲

    公开(公告)号：WO2017023394A3

    公开(公告)日：2017-04-20

    申请号：PCT/US2016032501

    申请日：2016-05-13

    Applicant: STC UNM

    Inventor： LEE SEUNG-CHANG ,  BRUECK STEVEN R J

    IPC: H01L29/88 ,  B82Y40/00

    CPC classification number: H01L21/02603 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/02433 ,  H01L21/02532 ,  H01L21/02535 ,  H01L21/02546 ,  H01L21/02639 ,  H01L21/02645 ,  H01L21/02653 ,  H01L21/02664 ,  H01L21/823807 ,  H01L27/092 ,  H01L27/0922 ,  H01L29/0673

    Abstract: Provided is a method for growing a nanowire, including: providing a substrate with a base portion having a first surface and at least one support structure extending above or below the first surface; forming a dielectric coating on the at least one support structure; forming a photoresist coating over the substrate; forming a metal coating over at least a portion of the dielectric coating; removing a portion of the dielectric coating to expose a surface of the at least one support structure; removing a portion of the at least one support structure to form a nanowire growth surface; growing at least one nanowire on the nanowire growth surface of a corresponding one of the at least one support structure, wherein the nanowire comprises a root end attached to the growth surface and an opposing, free end extending from the root end; and elastically bending the at least one nanowire.

    Abstract translation: 提供一种生长纳米线的方法，包括：提供具有基部的基板，所述基部具有第一表面和在所述第一表面的上方或下方延伸的至少一个支撑结构; 在所述至少一个支撑结构上形成电介质涂层; 在衬底上形成光刻胶涂层; 在电介质涂层的至少一部分上形成金属涂层; 去除所述电介质涂层的一部分以暴露所述至少一个支撑结构的表面; 去除所述至少一个支撑结构的一部分以形成纳米线生长表面; 在所述至少一个支撑结构中的相应一个的所述纳米线生长表面上生长至少一个纳米线，其中所述纳米线包括附接到所述生长表面的根端和从所述根端延伸的相对的自由端; 并弹性弯曲所述至少一个纳米线。

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