公开(公告)号：WO2016187272A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/033029

申请日：2016-05-18

Applicant: STC. UNM ,  DURVASULA, Ravi ,  ARORA, Arinder, Kumar

Inventor： DURVASULA, Ravi ,  ARORA, Arinder, Kumar

IPC: C12N1/21 ,  C12N15/63 ,  C07K14/00 ,  C07K16/00 ,  A01K67/033 ,  A01N63/00

CPC classification number: A01N63/00 ,  C07K14/43572 ,  C07K14/4723

Abstract: This disclosure describes a genetically-modified microbe that is a symbiont of an animal that is a vector organism for a pathogenic microbe, a paratransgenic organism that includes the genetically-modified microbe, and methods involving use of the genetically-modified microbe and/or the paratransgenic organism. Generally, the genetically-modified microbe includes a heterologous polynucleotide that encodes a heterologous polypeptide that reduces transmission of the pathogenic microbe.

Abstract translation: 本公开描述了遗传修饰的微生物，其是作为致病微生物的载体生物的动物的共生体，包括遗传修饰的微生物的相变转基因生物体，以及涉及使用遗传修饰的微生物和/或 副交配生物 通常，遗传修饰的微生物包括编码异源多肽的异源多核苷酸，其减少病原微生物的传播。

公开(公告)号：WO2015116769A1

公开(公告)日：2015-08-06

申请号：PCT/US2015/013434

申请日：2015-01-29

Applicant: STC. UNM ,  RUBIN, Robert, L. ,  KONSTANTINOV, Konstantin, N. ,  WALL, David, A.

Inventor： RUBIN, Robert, L. ,  KONSTANTINOV, Konstantin, N. ,  WALL, David, A.

IPC: G01N27/327

CPC classification number: G01N27/3273 ,  G01N27/3276 ,  G01N33/5438

Abstract: This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.

Abstract translation: 本公开在一个方面描述了一种用于自身抗体的电化学定量的装置。 通常，该装置包括限定多个通道的壳体和至少两个反应区域。 第一反应区包括多孔膜和与第一通道流体连通的第一电极组件。 第一反应区还包括固定在多孔膜上的第一组多个自身抗原。 第一电极组件与电流读数器连通。 第二反应区包括多孔膜和与第二通道流体连通的第二电极组件。 第二反应区包括固定在多孔膜上的第二多个自身抗原。 第二电极组件与电流读数器连通。 最后，该装置包括与第一反应区和第二反应区流体连通的负压源。

公开(公告)号：WO2015038919A1

公开(公告)日：2015-03-19

申请号：PCT/US2014/055430

申请日：2014-09-12

Applicant: STC. UNM

Inventor： JIANG, Ying-bing ,  CECCHI, Joseph, L. ,  FU, Yaqin ,  BRINKER, C., Jeffrey

IPC: C23C16/455 ,  C23C16/52

CPC classification number: C23C16/45525 ,  C23C16/45534 ,  C23C16/46

Abstract: An atomic layer deposition method is disclosed for preparing polypeptides. The method comprises providing a solid-phase support comprising a reactive amine monolayer in an atomic layer deposition (ALD) chamber. The solid-phase support is contacted with a first protected amino acid substituted with a protecting group by atomic layer deposition, wherein the protecting group is bonded to a non-side chain amino group of the protected amino acid. A carboxylic acid group of the first protected amino acid is reacted with the reactive amine monolayer, thereby coupling the first protected amino acid to the solid- phase support to produce a coupled-product.

Abstract translation: 公开了用于制备多肽的原子层沉积方法。 该方法包括在原子层沉积（ALD）室中提供包含反应性胺单层的固相载体。 固相载体与通过原子层沉积被保护基团取代的第一个被保护的氨基酸接触，其中保护基团与受保护的氨基酸的非侧链氨基键合。 第一个被保护的氨基酸的羧酸基与反应性胺单层反应，从而将第一个被保护的氨基酸与固相载体结合，产生偶联产物。

公开(公告)号：WO2014176405A1

公开(公告)日：2014-10-30

申请号：PCT/US2014/035260

申请日：2014-04-24

Applicant: STC. UNM

Inventor： LESEMAN, Zayd ,  ABBAS, Khawar ,  BUTNER, Joseph ,  ELAHI, Mirza ,  PINON, Denise

IPC: H01L21/66 ,  H01L21/3065

CPC classification number: H01L21/3065 ,  H01L21/30655 ,  H01L21/67069 ,  H01L21/67253 ,  H01L22/26

Abstract: A method for determining depletion of an etchant, an etch depth, and an etch rate during an etch of a material such as Si using an etchant such as xenon difluoride (XeF 2 )in a pulsed etching system in real time measuring pressure within a closed system during the etch. Coupling the pressure data with the knowledge of the chemical reactions allows for the determination of the etching parameters of interest. While the etch of Si using XeF 2 is used for demonstration, the method may be generalized to any closed volume system provided there is a net change in number of moles of gaseous species present in the system before and after the reaction.

Abstract translation: 在脉冲蚀刻系统中使用诸如氙二氟化物（XeF2）的蚀刻剂蚀刻诸如Si之类的材料的蚀刻深度和蚀刻速率的方法，用于实时测量封闭系统内的压力的方法 在蚀刻期间。 将压力数据与化学反应的知识结合允许确定感兴趣的蚀刻参数。 虽然使用XeF2对Si的蚀刻用于示范，但是如果在反应之前和之后系统中存在的气态物质的摩尔数存在净变化，则该方法可以推广到任何封闭体积系统。

公开(公告)号：WO2013012891A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/047133

申请日：2012-07-18

Applicant: STC. UNM ,  ZEINELDEN, Reema

Inventor： ZEINELDEN, Reema

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/22 ,  A61K47/48 ,  A61K47/30 ,  A61P35/00

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5153 ,  A61K31/704 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/911

Abstract: In one embodiment, the invention provides a new design of nanocarrier compositions that release their therapeutic load specifically at intraperitoneal cancers' site. These nanocarriers are administered intraperitoneally and comprise a plurality of porous nanoparticulates that (a) are loaded with one or more pharmaceutically-active agents alone or in combination with imaging agents thus providing a theranostic value and (b) that are encapsulated by and that support a lipid bilayer which is disrupted upon contact with a reactive oxygen species generated within the environment of the cancer. In other embodiments, the invention provides methods of treatment and pharmaceutical compositions comprising nanocarriers as described herein.

Abstract translation: 在一个实施方案中，本发明提供纳米载体组合物的新设计，其特别在腹膜内癌症部位释放其治疗负荷。 这些纳米载体被腹膜内施用并且包含多个多孔纳米颗粒，其（a）单独或与成像剂组合加载一种或多种药物活性剂，从而提供神经元值，和（b）被包囊并支持 脂质双层在与癌症环境中产生的活性氧物质接触时被破坏。 在其它实施方案中，本发明提供了治疗方法和包含如本文所述的纳米载体的药物组合物。

公开(公告)号：WO2011112531A2

公开(公告)日：2011-09-15

申请号：PCT/US2011/027465

申请日：2011-03-08

Applicant: STC. UNM ,  MAYNARD, Nicola, Jeanne ,  SMYTH, Hugh, D.C.

Inventor： MAYNARD, Nicola, Jeanne ,  SMYTH, Hugh, D.C.

IPC: A61M11/02 ,  A61M15/00 ,  A61J1/05

CPC classification number: A61M15/0086 ,  A61M11/003 ,  A61M15/00 ,  A61M15/0006 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/009 ,  A61M2016/0015 ,  A61M2202/064 ,  A61M2205/0272 ,  A61M2205/8287 ,  A61M2206/16

Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically- responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

Abstract translation: 干粉递送装置可以被配置为向使用者的气道提供微粉化的干粉颗粒。 该装置可以包括限定包含至少一个磁响应物体的腔室的圆柱形容器，在该腔室外部的电动机，该腔室外部的磁体并与该电动机可旋转地联接，以及流出部件，其将气流引导至使用者 。 磁性响应物体可以涂覆有微粉化的干粉末颗粒，并且电动机可操作以使磁体围绕轴线旋转。 磁体的旋转产生磁场，使得响应于磁场的磁响应物体移动并与容器的侧壁碰撞，以使干粉颗粒解聚并使空腔中的干粉雾化。

公开(公告)号：WO2011062973A2

公开(公告)日：2011-05-26

申请号：PCT/US2010/057009

申请日：2010-11-17

Applicant: STC. UNM ,  HEILEMAN, Gregory, L. ,  JAMKHEDKAR, Pramod, A. ,  LAMB, Christopher, C.

Inventor： HEILEMAN, Gregory, L. ,  JAMKHEDKAR, Pramod, A. ,  LAMB, Christopher, C.

IPC: G06F13/14 ,  G06F13/38

CPC classification number: G06F21/10 ,  G06F2221/0759

Abstract: Generic rights expression language allowing interoperability across different computing environments including resource usage of different applications. A formal framework for usage management provides scaffolding upon which interoperable usage management systems can be built. Certain features of the framework are standardized, such as the operational semantics, including areas free of standards that necessitate choice and innovation to achieve a balance of flexibility and usability for interoperability in usage management systems.

Abstract translation: 通用权限表达语言允许跨不同计算环境的互操作性，包括不同应用程序的资源使用。 使用管理的一个正式框架提供了可以构建可互操作的使用管理系统的脚手架。 框架的某些特征是标准化的，例如操作语义，包括无需标准的区域，需要选择和创新来实现灵活性和使用管理系统互操作性的平衡。

公开(公告)号：WO2011044580A2

公开(公告)日：2011-04-14

申请号：PCT/US2010/052332

申请日：2010-10-12

Applicant: STC. UNM ,  WHITTEN, David ,  ISTA, Linnea ,  CORBITT, Thomas ,  OGAWA, Motokatsu ,  SCHANZE, Kirk ,  LOPEZ, Gabriel ,  NAGARAJAN, Ramanathan

Inventor： WHITTEN, David ,  ISTA, Linnea ,  CORBITT, Thomas ,  OGAWA, Motokatsu ,  SCHANZE, Kirk ,  LOPEZ, Gabriel ,  NAGARAJAN, Ramanathan

IPC: D06M14/02 ,  D06M15/37 ,  D06M13/165 ,  D06M11/32 ,  D06M14/04

CPC classification number: A01N43/90 ,  D06M13/513 ,  D06M14/02 ,  D06M14/04 ,  D06M14/06 ,  D06M14/08 ,  D06M15/227 ,  D06M16/00 ,  D06M23/005 ,  D06M2400/01 ,  Y10T442/20 ,  Y10T442/2525 ,  A01N25/10 ,  A01N25/34

Abstract: The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.

Abstract translation: 本公开描述了软表面的制造和使用，例如承载表面接枝抗微生物聚合物的织物。

公开(公告)号：WO2011005380A3

公开(公告)日：2011-01-13

申请号：PCT/US2010/036686

申请日：2010-05-28

Applicant: STC. UNM ,  MIAO, Yubin ,  YANG, Jianquan

Inventor： MIAO, Yubin ,  YANG, Jianquan

IPC: A61K38/06 ,  A61K38/08 ,  A61K38/22 ,  A61P17/00 ,  A61P35/00

Abstract: The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

公开(公告)号：WO2009025820A2

公开(公告)日：2009-02-26

申请号：PCT/US2008/009909

申请日：2008-08-20

Applicant: STC. UNM ,  TIMMINS, Graham ,  MASTER, Sharon ,  DERETIC, Vojo, P.

Inventor： TIMMINS, Graham ,  MASTER, Sharon ,  DERETIC, Vojo, P.

IPC: A61K31/4409 ,  A61K31/44 ,  A61K9/16

CPC classification number: C07D213/81 ,  A61K9/0019 ,  A61K9/0073 ,  A61K31/44 ,  A61K31/4409 ,  C07D213/83 ,  C07D213/86

Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

Abstract translation: 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。