公开(公告)号：WO2015038919A1

公开(公告)日：2015-03-19

申请号：PCT/US2014/055430

申请日：2014-09-12

Applicant: STC. UNM

Inventor： JIANG, Ying-bing ,  CECCHI, Joseph, L. ,  FU, Yaqin ,  BRINKER, C., Jeffrey

IPC: C23C16/455 ,  C23C16/52

CPC classification number: C23C16/45525 ,  C23C16/45534 ,  C23C16/46

Abstract: An atomic layer deposition method is disclosed for preparing polypeptides. The method comprises providing a solid-phase support comprising a reactive amine monolayer in an atomic layer deposition (ALD) chamber. The solid-phase support is contacted with a first protected amino acid substituted with a protecting group by atomic layer deposition, wherein the protecting group is bonded to a non-side chain amino group of the protected amino acid. A carboxylic acid group of the first protected amino acid is reacted with the reactive amine monolayer, thereby coupling the first protected amino acid to the solid- phase support to produce a coupled-product.

Abstract translation: 公开了用于制备多肽的原子层沉积方法。 该方法包括在原子层沉积（ALD）室中提供包含反应性胺单层的固相载体。 固相载体与通过原子层沉积被保护基团取代的第一个被保护的氨基酸接触，其中保护基团与受保护的氨基酸的非侧链氨基键合。 第一个被保护的氨基酸的羧酸基与反应性胺单层反应，从而将第一个被保护的氨基酸与固相载体结合，产生偶联产物。

公开(公告)号：WO2015042279A1

公开(公告)日：2015-03-26

申请号：PCT/US2014/056342

申请日：2014-09-18

Applicant: STC. UNM ,  SANDIA CORPORATION

Inventor： BRINKER, C., Jeffrey ,  LIN, Yu-shen

IPC: A61K9/127 ,  A61K31/7088 ,  A61K38/00 ,  B82Y5/00

CPC classification number: A61K9/1271 ,  A61K9/14 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/88

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, torroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia base- catalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Abstract translation: 一方面，本发明提供了在低表面活性剂条件下使用氨碱催化法制备的由椭球形介孔二氧化硅纳米粒子（MSNP）合成的新型单分散，胶体稳定的环状介孔二氧化硅纳米粒子（TMSNP）。 值得注意的是，TMSNPs可以与小分子活性剂，siRNA，mRNA，质粒和其他货物同时加载，并且可以用于诊断和/或治疗各种疾病，包括癌症，细菌感染 和/或病毒感染等。 还提供了相关的原细胞，药物组合物和治疗和诊断方法。

公开(公告)号：WO2017023407A2

公开(公告)日：2017-02-09

申请号：PCT/US2016/035289

申请日：2016-06-01

Applicant: STC. UNM ,  JOHNSON, Patrick ,  BRINKER, C., Jeffrey ,  CARNES, Eric ,  TIMMINS, Graham ,  MUTTIL, Pavan

Inventor： JOHNSON, Patrick ,  BRINKER, C., Jeffrey ,  CARNES, Eric ,  TIMMINS, Graham ,  MUTTIL, Pavan

CPC classification number: A61K9/0073 ,  A61K9/12 ,  A61K9/1271 ,  A61K9/1617 ,  A61K47/543 ,  C08L23/22

Abstract: This disclosure describes compositions, vaccine, and methods that involve a biocomposite material Generally, the biocomposite material includes a cell and a lipid-silica matrix at least partially encapsulating the cell. In some cases, the cell can be viable but not culturable (VBNC). In some cases, the lipid-silica matrix includes a dried sol and/or possesses ordered nanostructure.

Abstract translation: 本公开描述了涉及生物复合材料的组合物，疫苗和方法。通常，生物复合材料包括细胞和至少部分包封细胞的脂质 - 二氧化硅基质。 在某些情况下，细胞可以存活但不可培养（VBNC）。 在一些情况下，脂质 - 二氧化硅基质包括干燥的溶胶和/或具有有序的纳米结构。