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公开(公告)号：EP1756550A1
公开(公告)日：2007-02-28
申请号：EP05738667.4
申请日：2005-04-25
Applicant: Sensors for Medicine and Science, Inc.
Inventor： COLVIN, Arthur, Earl, Jr. , LESHO, Jeffery, C. , LORENZ, Carrie, R.
CPC classification number: G01N21/6428 , A61B5/14532 , A61B5/1455 , A61B5/14556 , A61B5/1459 , A61B2560/0209
Abstract: The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.
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92.发明公开PRINTED CIRCUIT DEVICE WITH INTEGRATED ANTENNA AND IMPLANTABLE SENSOR PROCESSING SYSTEM WITH INTEGRATED PRINTED CIRCUIT BOARD ANTENNA 有权具有集成的电路板天线IMPLATIERBAREM传感器处理系统
公开(公告)号：EP1618768A2
公开(公告)日：2006-01-25
申请号：EP04759498.1
申请日：2004-04-14
Applicant: Sensors for Medicine and Science, Inc.
Inventor： COLVIN, Jr., Arthur E. , GERIG, John, S. , ZERWEKH, Paul, S. , LESHO, Jeffery, C. , MCLEOD, Benjamin, M.
CPC classification number: A61B5/14556 , A61B5/0031 , A61B5/14532 , A61B5/1459 , A61B5/681 , G01N21/6428 , G01N21/645 , G01N2201/1244 , H05K1/0306 , H05K1/165 , H05K3/403 , H05K2201/086 , H05K2201/09972 , H05K2201/10106
Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.
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公开(公告)号：EP1386140A1
公开(公告)日：2004-02-04
申请号：EP02725876.3
申请日：2002-05-03
Applicant: Sensors for Medicine and Science, Inc.
Inventor： COLVIN, JR., Arthur, E. , LYNN, Robert, W.
CPC classification number: G01N21/77 , G01N21/6428 , G01N21/783 , G01N2021/6432 , G01N2021/7786 , G01N2021/7793 , G01N2021/7796 , Y10T436/144444
Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions. The indicator element used to measure the analyte in the external medium is preferably also covered, but in a manner that provides direct contact between the analyte and the indicator element.
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公开(公告)号：EP1956365B1
公开(公告)日：2013-01-23
申请号：EP08155730.8
申请日：1999-08-26
Applicant: Sensors for Medicine and Science, Inc.
Inventor： Colvin, Arthur E , Dale, Gregory A , Zerwekh, Paul Samuel , Lesho, Jeffrey C , Lynn, Robert W
IPC: G01N21/64 , G01N21/55 , G01N21/77 , A61B5/00 , A61B5/07 , A61B5/145 , A61B5/1459 , G01N33/543 , G01N21/00 , G01N33/53
CPC classification number: A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
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公开(公告)号：EP2337495A1
公开(公告)日：2011-06-29
申请号：EP09815325.7
申请日：2009-09-21
Applicant: Sensors For Medicine And Science, Inc.
Inventor： COLVIN, Arthur, E. , O'CONNOR, Casey, J. , FERRARO, Daniel, C.
IPC: A61B5/1455
CPC classification number: G01J3/02 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/4406 , G01N21/55 , G01N21/6428 , G01N21/645 , G01N21/77 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , G01N2201/022 , G01N2201/062
Abstract: The present invention provides systems and methods for measuring an analyte in a medium without exposing the medium to contamination. The systems and methods employ a novel combination of a small sensor device embedded in a Luer cap and capable of wirelessly transmitting data to a reading device.
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Patent Agency Ranking
公开(公告)号：EP2325622A1
公开(公告)日：2011-05-25
申请号：EP10180990.3
申请日：1999-08-26
Applicant: Sensors for Medicine and Science, Inc.
Inventor： Colvin, Arthur E , Dale, Gregory A , Zerwekh, Paul Samuel , LESHO, Jeffrey C , LYNN, Robert W
CPC classification number: A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body (12) with a source of radiation embedded therein (18). A matrix layer is disposed on the surface of the sensor body which layer is permeable to an analyte and comprises fluroescent indicator molecules responsive to the concentration of the analyte. Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e,g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte.
Abstract translation: 一种用于使用指示器和参考通道来检测分析物的存在或量的基于光学的传感器（10）。 该传感器具有传感器本体（12），其中嵌有辐射源（18）。 矩阵层设置在传感器主体的表面上，该层对分析物是可渗透的，并且包括响应于分析物浓度的荧光指示剂分子。 源发射的辐射与靠近身体表面的指示膜（3）指示剂分子（16）相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）在传感器体内进入和反射。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。
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公开(公告)号：EP2313761A1
公开(公告)日：2011-04-27
申请号：EP09803413.5
申请日：2009-07-24
Applicant: Sensors For Medicine And Science, Inc.
Inventor： COLVIN, Arthur, E. , DEHENNIS, Andrew
CPC classification number: G01N21/6428 , G01N21/643 , G01N21/77 , G01N33/1806 , G01N2021/6432 , G01N2021/7786
Abstract: A method and sensor for measuring the concentration of an analyte about radiantly excitable indicator molecules. A stimulus waveform is used to drive a radiant source. The indicator molecules are exposed to the radiant source. A response waveform is generated to represent photoluminescent radiation emitted by the indicator molecules. A phase difference between the stimulus waveform and the response waveform is a function of the concentration of the analyte that enables determining the analyte concentration.
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公开(公告)号：EP2292626A1
公开(公告)日：2011-03-09
申请号：EP10183994.2
申请日：2001-08-03
Applicant: Sensors for Medicine and Science, Inc.
Inventor： Colvin, Arthur, E. Jr.
CPC classification number: G01N21/6428 , A61B5/14532 , A61B5/1459 , C07D257/02 , G01N31/22 , G01N33/542 , G01N33/66 , G01N33/84 , G01N2021/6432 , G01N2021/7786 , Y10T436/143333 , Y10T436/144444
Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.
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公开(公告)号：EP2135302A2
公开(公告)日：2009-12-23
申请号：EP08726516.1
申请日：2008-03-06
Applicant: Sensors For Medicine And Science, Inc.
Inventor： COLVIN, Jason, D. , COLVIN, Arthur, E. , DEHENNIS, Andrew , KRSMANOVIC, Jody, L.
CPC classification number: H01L33/483 , A61B5/14532 , A61B5/1459 , G01N21/6428 , G01N21/8507 , H01L25/167 , H01L31/0203 , H01L31/125 , H01L33/44 , H01L33/52 , H01L33/54 , H01L33/62 , H01L2224/48091 , H01L2224/48227 , H01L2224/48472 , H01L2924/01019 , H01L2924/01087 , H01L2924/09701 , H01L2924/3011 , H01L2924/3025 , H01L2933/0091 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
Abstract: A light emitting diode for harsh environments includes a substantially transparent substrate, a semiconductor layer deposited on a bottom surface of the substrate, several bonding pads, coupled to the semiconductor layer, formed on the bottom surface of the substrate, and a micro post, formed on each bonding pad, for electrically connecting the light emitting diode to a printed circuit board. An underfill layer may be provided between the bottom surface of the substrate and the top surface of the printed circuit board, to reduce water infiltration under the light emitting diode substrate. Additionally, a diffuser may be mounted to a top surface of the light emitting diode substrate to diffuse the light emitted through the top surface.
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公开(公告)号：EP1956365A3
公开(公告)日：2008-10-29
申请号：EP08155730.8
申请日：1999-08-26
Applicant: Sensors for Medicine and Science, Inc.
Inventor： Colvin, Arthur E , Dale, Gregory A , Zerwekh, Paul Samuel , Lesho, Jeffrey C , Lynn, Robert W
CPC classification number: A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
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