公开(公告)号：CZ20022097A3

公开(公告)日：2002-11-13

申请号：CZ20022097

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/404 ,  A61K31/135 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn - (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：BR0016431A

公开(公告)日：2002-10-01

申请号：BR0016431

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/16 ,  A61K31/452 ,  A61P11/14 ,  C07D211/60 ,  C07D295/02 ,  C07D295/15

Abstract: In one aspect, the present invention concerns the use of certain cyclic quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula (I) wherein n is an integer of from 0 to 4; R1 and E are independently selected from -CH2-R16 and a group represented by formula (II).

公开(公告)号：NO20022870A

公开(公告)日：2002-08-14

申请号：NO20022870

申请日：2002-06-14

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/16 ,  A61K31/452 ,  A61P11/14 ,  C07D211/60 ,  C07D295/02 ,  C07D295/15

CPC classification number: C07D295/15 ,  C07D211/60

公开(公告)号：NO20022869L

公开(公告)日：2002-08-14

申请号：NO20022869

申请日：2002-06-14

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/166 ,  A61K31/24 ,  A61K31/40 ,  A61K31/445 ,  A61P11/14 ,  C07C219/14 ,  C07C219/26 ,  C07C229/60 ,  C07C229/64 ,  C07C237/34 ,  C07D211/14 ,  C07D295/08 ,  C07D295/088 ,  C07D295/10 ,  C07D295/13 ,  C07D295/18 ,  C07D295/195

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of the following formula (I): Y-J-E An wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：NO20022868A

公开(公告)日：2002-08-14

申请号：NO20022868

申请日：2002-06-14

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/404 ,  A61K31/135 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14

CPC classification number: C07D209/08 ,  C07C217/18 ,  C07C217/30

公开(公告)号：NO20022868D0

公开(公告)日：2002-06-14

申请号：NO20022868

申请日：2002-06-14

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/135 ,  A61K31/404 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14 ,  C07C

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn - (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：AU7389601A

公开(公告)日：2001-09-12

申请号：AU7389601

申请日：2001-02-21

Applicant: UCB FARCHIM SA

Inventor： SURTEES JOHN ,  MARMON VIOLETA ,  DIFFERDING EDMOND DR ,  ZIMMERMANN VINCENT

IPC: C07D401/04 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/16 ,  A61P37/08 ,  C07B61/00 ,  C07C237/06 ,  C07C237/12 ,  C07D207/26 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D307/33 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D495/04

Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of general formula (B. geometrical isomers, enantiomers, diastereoisomers, mixtures of each of these and pharmaceutically acceptable salts thereof. whereinR 1 is methyl,R 2 and R 4 are hydrogen.R 3 is alkyl or haloalkenyl, andX is -COOH. -COOMe or -COOEt.

公开(公告)号：AU2334701A

公开(公告)日：2001-06-25

申请号：AU2334701

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/404 ,  A61K31/135 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn - (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：AU6387398A

公开(公告)日：1998-10-12

申请号：AU6387398

申请日：1998-03-13

Applicant: UCB FARCHIM SA

Inventor： FANARA DOMENICO ,  BERWAER MONIQUE ,  BOUQUELLE ANNE ,  DELEERS MICHEL

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/24

Abstract: The invention relates to pharmaceutical compositions which can be administrated orally, allowing the controlled release of at least one active substance comprising a) the said at least one active substance, b) between 5 and 60% by weight, relative to the total weight of the composition, of at least one excipient, selected from inert matrices, hydrophilic matrices, lipid matrices, mixtures of inert matrices and of lipid matrices, mixtures of hydrophilic matrices and of inert matrices, with the exception of mixtures comprising a polyacrylic acid and at least one hydrophilic matrix of the cellulose type; c) between 5 and 50% by weight, relative to the total weight of the composition, of at least one alkalinizing agent soluble in an aqueous phase under physiological pH conditions, selected from alkali or alkaline-earth metal hydroxidcs, carbonates, bicarbonates and phosphates, sodium borate as well as the basic salts of organic acids. It also relates to processes for the preparation of said compositions, multi-layered pharmaceutical compositions comprising at least one layer with this composition, as well as processes for the preparation of said multi-layered composition.

公开(公告)号：AU1774097A

公开(公告)日：1997-10-16

申请号：AU1774097

申请日：1997-04-04

Applicant: UCB FARCHIM SA

Inventor： VAN DE VENNE HERMAN ,  MARTIN JEAN-PIERRE

IPC: A61K31/495 ,  A61K31/135

Abstract: A pharmaceutical composition comprising a therapeutically effective amount of a mixture consisting essentially of(i) pseudoephedrine, an individual optical isomer or a pharmaceutically acceptable salt thereof, and(ii) at least one compound selected from 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid or amide derivatives, an individual optical isomer or a pharmaceutically acceptable salt thereof.