公开(公告)号：HU0203918A2

公开(公告)日：2003-03-28

申请号：HU0203918

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： BEATCH GREGORY N ,  CHOI LEWIS SIU LEUNG ,  PAGE CLIVE P

IPC: A61K31/135 ,  A61K31/404 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn - (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：CZ20022096A3

公开(公告)日：2003-02-12

申请号：CZ20022096

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/166 ,  A61K31/24 ,  A61K31/40 ,  A61K31/445 ,  A61P11/14 ,  C07C219/14 ,  C07C219/26 ,  C07C229/60 ,  C07C229/64 ,  C07C237/34 ,  C07D211/14 ,  C07D295/08 ,  C07D295/088 ,  C07D295/10 ,  C07D295/13 ,  C07D295/18 ,  C07D295/195 ,  A61K31/14

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of the following formula (I): Y-J-E An wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：CZ20022095A3

公开(公告)日：2003-02-12

申请号：CZ20022095

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/16 ,  A61K31/452 ,  A61P11/14 ,  C07D211/60 ,  C07D295/02 ,  C07D295/15

Abstract: In one aspect, the present invention concerns the use of certain cyclic quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula (I) wherein n is an integer of from 0 to 4; R1 and E are independently selected from -CH2-R16 and a group represented by formula (II).

公开(公告)号：NO20022870L

公开(公告)日：2002-08-14

申请号：NO20022870

申请日：2002-06-14

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/16 ,  A61K31/452 ,  A61P11/14 ,  C07D211/60 ,  C07D295/02 ,  C07D295/15

Abstract: In one aspect, the present invention concerns the use of certain cyclic quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula (I) wherein n is an integer of from 0 to 4; R1 and E are independently selected from -CH2-R16 and a group represented by formula (II).

公开(公告)号：NO20022869D0

公开(公告)日：2002-06-14

申请号：NO20022869

申请日：2002-06-14

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/166 ,  A61K31/24 ,  A61K31/40 ,  A61K31/445 ,  A61P11/14 ,  C07C219/14 ,  C07C219/26 ,  C07C229/60 ,  C07C229/64 ,  C07C237/34 ,  C07D211/14 ,  C07D295/08 ,  C07D295/088 ,  C07D295/10 ,  C07D295/13 ,  C07D295/18 ,  C07D295/195 ,  C07D

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of the following formula (I): Y-J-E An wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：CA2393711A1

公开(公告)日：2001-06-21

申请号：CA2393711

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： BEATCH GREGORY N ,  PAGE CLIVE P ,  CHOI LEWIS SIU LEUNG

IPC: C07C229/60 ,  C07C229/64 ,  C07C237/34 ,  C07D295/088 ,  C07D295/13 ,  C07D295/195 ,  A61K31/16 ,  A61P11/14 ,  C07C219/14 ,  C07C219/26 ,  C07D295/08 ,  C07D295/10 ,  C07D295/18

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament f or use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of the following formula (I): Y.mdash. J.mdash. E An- wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：PL355944A1

公开(公告)日：2004-05-31

申请号：PL35594400

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： LEUNG CHOI LEWIS SIU ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/135 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  A61K31/404 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn - (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：EE200200315A

公开(公告)日：2003-08-15

申请号：EEP200200315

申请日：2000-12-15

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS SIU LEUNG ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/404 ,  A61K31/135 ,  A61K31/14 ,  A61P11/14 ,  C07C215/40 ,  C07C217/14 ,  C07C217/18 ,  C07C217/30 ,  C07D209/08 ,  C07D211/14

Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn - (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：BG106816A

公开(公告)日：2003-04-30

申请号：BG10681602

申请日：2002-06-12

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS S ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: A61K31/16 ,  A61K31/452 ,  A61P11/14 ,  C07D211/60 ,  C07D295/02 ,  C07D295/15

Abstract: In one aspect, the present invention concerns the use of certain cyclic quaternary ammonium compounds as active ingredients in the manufacture of medicaments for use in the treatment and/or of cough in warm-blooded animals, including humans, such as compounds of formula wherein n is an integer of from 0 to 4; R1 and E are independently selected from -CH2-R16 and a group represented by the formula 27 claims, 3 figures

公开(公告)号：BG106814A

公开(公告)日：2003-04-30

申请号：BG10681402

申请日：2002-06-12

Applicant: UCB FARCHIM SA

Inventor： CHOI LEWIS S ,  BEATCH GREGORY N ,  PAGE CLIVE P

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/166 ,  A61K31/24 ,  A61K31/40 ,  A61K31/445 ,  A61P11/14 ,  C07C219/14 ,  C07C219/26 ,  C07C229/60 ,  C07C229/64 ,  C07C237/34 ,  C07D211/14 ,  C07D295/08 ,  C07D295/088 ,  C07D295/10 ,  C07D295/13 ,  C07D295/18 ,  C07D295/195

Abstract: In one aspect the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of the following formula Y - J - E An- wherein J is independently selected from a group represented by one of formulae 74 claims, 3 figures