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    MAGNETIC FIELD SENSOR DEVICE FOR DIRECT MAGNETIC FIELD IMAGING AND METHOD OF FABRICATION THEREOF
    91.
    发明公开
    MAGNETIC FIELD SENSOR DEVICE FOR DIRECT MAGNETIC FIELD IMAGING AND METHOD OF FABRICATION THEREOF 有权
    马德里广播电视台DEREKTMAGNETFELDBILDGEBUNG UNDHERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP2165211A2

    公开(公告)日：2010-03-24

    申请号：EP08763633.8

    申请日：2008-06-26

    Applicant: Yeda Research And Development Company Limited

    Inventor： FINKLER, Amit ,  MARTIN, Jens ,  MYASOEDOV, Yuri ,  SEGEV, Yehonathan ,  YACOBY, Amir ,  ZELDOV, Eli

    IPC: G01R33/038

    CPC classification number: G01R33/0354 ,  G01Q60/56 ,  G01R33/0385

    Abstract: The present invention discloses a novel magnetic sensor device performing direct magnetic field imaging, comprising a probe having a conical tip portion which is configured as a sensor having two superconductors separated by a thin non-superconducting layer (such as a Josephson junction based sensor), where the non-superconducting layer is located at the apex portion of said conical tip, thereby defining electron tunneling region(s) at said apex portion. The technique of the present invention enables the sensor device to be very small and to be brought very close to the sample surface.

    Abstract translation: 本发明公开了一种执行直接磁场成像的新型磁传感器装置，包括具有锥形尖端部分的探针，该锥形尖端部分被配置为具有由薄非超导层（例如约瑟夫逊结基传感器）隔开的两个超导体的传感器， 其中所述非超导层位于所述锥形尖端的顶点处，从而在所述顶点处限定电子隧穿区域。 本发明的技术使得传感器装置非常小并且使其非常靠近样品表面。

    METHODS OF DETERMINING TOTAL PON1 LEVEL
    93.
    发明公开
    METHODS OF DETERMINING TOTAL PON1 LEVEL 审中-公开
    方法确定PON1总浓度

    公开(公告)号：EP2134858A1

    公开(公告)日：2009-12-23

    申请号：EP08719960.0

    申请日：2008-03-11

    Applicant: Yeda Research And Development Company Limited

    Inventor： GAYDUKOV, Leonid ,  KHERSONSKY, Olga ,  TAWFIK, Dan S.

    IPC: C12Q1/34 ,  C12Q1/42 ,  C12Q1/44

    CPC classification number: C12Q1/34 ,  C12Q1/42 ,  C12Q1/44

    Abstract: A method of determining an amount of total PON1 in a sample of a subject is disclosed. The method comprises: (a) contacting the sample with a compound being capable of generating at least one spectrophotometrically detectable moiety upon contact with PON1, under conditions wherein the generating is not dependent on a PON1 status; and (b) spectrophotometrically measuring a level of the moiety, thereby determining an amount of total PON1 in the sample. Kits for measuring total PON1 levels comprising the compounds are also disclosed.

    REDIRECTED, GENETICALLY-ENGINEERED T REGULATORY CELLS AND THEIR USE IN SUPPRESSION OF AUTOIMMUNE AND INFLAMMATORY DISEASE
    94.
    发明公开
    REDIRECTED, GENETICALLY-ENGINEERED T REGULATORY CELLS AND THEIR USE IN SUPPRESSION OF AUTOIMMUNE AND INFLAMMATORY DISEASE 有权
    VICE发起并遗传操作的调节性T细胞和它们在自身免疫和炎性疾病的减少

    公开(公告)号：EP2126054A2

    公开(公告)日：2009-12-02

    申请号：EP08728776.9

    申请日：2008-01-31

    Applicant: Yeda Research And Development Company Limited

    Inventor： ESHHAR, Zelig ,  ELINAV, Eran

    IPC: C12N5/08 ,  A61K39/00

    CPC classification number: C12N5/0636 ,  A61K39/0008 ,  A61K39/0011

    Abstract: A redirected Treg cell is endowed with specificity toward a selected target antigen or ligand. The cell contains a chimeric receptor polypeptide that is expressed in a single, continuous chain, with an extracellular recognition region displayed on the surface of the cell, a transmembrane region and an intracellular signaling region. The extracellular recognition region is specific for the selected target antigen or ligand. The intracellular signaling region includes a combination of T-cell signaling polypeptide moieties, which combination, upon binding of the extracellular recognition region to the selected target antigen or ligand, triggers activation of the redirected Treg cells to cause suppression of T-cell mediated immunity. Such redirected Treg cells may be used to suppress undesired activity of T effector cells thereby mediating an immune or inflammatory response. They are particularly useful in treating T effector cell-mediated diseases, such as inflammatory bowel disease, transplant rejection and GVH disease.

    Abstract translation: 甲重定向Treg细胞被赋予了朝向所选择的靶抗原或配体的特异性。 单元格中包含的嵌合受体多肽没有在显示单元，一个跨膜区的表面上和上的胞内信号区的胞外识别区域中的单个连续链中过表达，与。 胞外识别区域是特异于所选择的目标抗原或配体。 胞内信导区域包括T-细胞信号多肽部分的组合，其组合，在到所选择的靶抗原或配体的胞外识别区域的绑定，触发重定向Treg细胞的活化，以使T细胞介导的免疫抑制。 搜索重定向Treg细胞可用于抑制T效应细胞从而介导免疫或炎症应答不希望的活动。 它们可用于治疗T效应细胞介导的疾病，：如炎性肠病，移植排斥和GVH病特别有用。

    METHOD FOR OBTAINING SPATIAL IMAGES THROUGH MRI AND PROCESSING THE RESULTING SPATIAL IMAGES AND PRODUCT
    96.
    发明公开
    METHOD FOR OBTAINING SPATIAL IMAGES THROUGH MRI AND PROCESSING THE RESULTING SPATIAL IMAGES AND PRODUCT 审中-公开
    程序，用于获得MRI和空间图像的处理者获得了太空图片和产品

    公开(公告)号：EP2074555A2

    公开(公告)日：2009-07-01

    申请号：EP07844336.3

    申请日：2007-10-17

    Applicant: Yeda Research And Development Company Limited

    Inventor： DEGANI, Hadassa ,  EYAL, Erez

    IPC: G06K9/32

    CPC classification number: G01R33/56366 ,  G01R33/5601 ,  G01R33/5608 ,  G06T7/11 ,  G06T7/187 ,  G06T2207/10016 ,  G06T2207/10088

    Abstract: A method for recording a set of MRI images of a tissue pixel by pixel that evolve with time in a specific manner described by a function; processing the recorded MRI images by aggregating the pixels thereof according to a preselected aspect of time behavior; best fitting the aggregated pixels to a predetermined pixel function to obtain the parameters of the function; and presenting the parameters visually. A computer readable medium containing executable program instructions for carrying out the method.

    Abstract translation: 一种用于记录一组由pixelthat组织像素的MRI图像的方法与由一个函数来描述的特定方式时间演变; 通过聚集其gemäß到的时间行为的预选方面的像素处理所记录的MRI图像; 最佳拟合聚集像素的预定像素函数来获取函数的参数; 和可视地呈现的参数。 一种计算机可读介质包含用于执行所述方法的可执行程序指令。

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