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公开(公告)号：KR1020080105591A
公开(公告)日：2008-12-04
申请号：KR1020070053362
申请日：2007-05-31
Applicant: (주)아모레퍼시픽
Abstract: A cosmetic composition is provided to prevent the damage of hair by reducing the loss of labile proteins inside hair. A cosmetic composition for preventing the damage of hair contains 0.01-10 wt% of a lime oil, a lemon oil, or their mixture. Preferably the lime oil is an oil extracted by distilling Citrus aurantifolia, and the lemon oil is an oil extracted by compressing the shell of Citrus limon.
Abstract translation: 提供化妆品组合物以通过减少毛发内不稳定蛋白质的损失来防止毛发的损伤。 用于防止头发损伤的化妆品组合物含有0.01-10重量％的石灰油，柠檬油或它们的混合物。 优选地，石灰油是通过蒸馏柑橘柠檬提取的油，柠檬油是通过压缩柑橘柠檬的壳提取的油。
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公开(公告)号：KR100864677B1
公开(公告)日：2008-10-23
申请号：KR1020070029255
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/10
Abstract: 본 발명은 항비만 효과를 나타내는 하기 화학식 1로 표시되는 3,5-디히드록시벤조산 유도체 화합물 및 이의 제조방법에 관한 것이다:
[화학식 1]
상기 식 중, R은 아다만틸, 시클로헥실 또는 헥실이다.
3,5-디히드록시벤조산 유도체, 항비만, 루시퍼라아제, IDH3α, CPT1, 혈당-
公开(公告)号：KR100851044B1
公开(公告)日：2008-08-12
申请号：KR1020070083905
申请日：2007-08-21
Applicant: (주)아모레퍼시픽
Abstract: 3,5-Dihydroxy benzamide derivatives are provided to whiten the skin due to a depigmenting activity and improve stability in aqueous solution and organic solvent in formulation by inhibiting structure change. A cosmetic composition for whitening the skin comprises 0.01-20 wt.% of 3,5-dihydroxy benzamide derivatives represented by a formula(1), wherein a hydroxyl group is located in the 2,3-, 2,4-, 2,5-, 3,4- or 3,5-site, and is used in forms of emulsion, cream, cosmetic lotion, essence, pack, gel, powder, makeup base, foundation, lotion, ointment, patch, beauty solution, cleansing foam, cleansing cream, cleansing water, body lotion, body cream, body oil, body essence, shampoo, rinse, body cleanser, soap, hair dye or spray.
Abstract translation: 提供3,5-二羟基苯甲酰胺衍生物，由于脱色活性而使皮肤变白，并通过抑制结构变化提高配方中水溶液和有机溶剂的稳定性。 用于使皮肤美白的化妆品组合物包含0.01-20重量％的由式（1）表示的3,5-二羟基苯甲酰胺衍生物，其中羟基位于2,3-，2,4-， 5-，3,4-或3,5-位，并以乳液，霜剂，化妆水，精华，包装，凝胶，粉末，化妆底，粉底，洗剂，软膏，贴片，美容液，清洁剂的形式使用 泡沫，清洁霜，清洁水，身体乳液，身体霜，身体油，身体精华，洗发水，漂洗，身体清洁剂，肥皂，染发剂或喷雾剂。
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公开(公告)号：KR100845511B1
公开(公告)日：2008-07-10
申请号：KR1020070029253
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/68 , A61K31/357
Abstract: A hydroxamic acid derivative is provided to induce the activity increase of each promoter of IDH3alpha and CPT1 involving with energy consumption metabolism, thereby being usefully used for preventing or treating diseases related to dyslipidemia such as obesity, hyperlipidemia and diabetes. A hydroxamic acid is represented by a formula(1), wherein R1 is CONH, NHCO, CONR4 or NR4CO(where R4 is H or C1-10 alkyl); R2 is -(CH2)n-(where n is 0 or 1); and R3 is H or C1-10 alkyl. A method for preparing the hydroxamic acid comprises the steps of: (a) reacting an anhydrous compound synthesized by reacting ethyl chloroformate with piperonic acid using pyridine or N-methyl morpholine as a solvent with methyl 4-amino benzoate or 4-amino phenyl acetic acid ethyl ester at a temperature of 10-20 deg.C using pyridine or N-methyl morpholine as a solvent to prepare a benzamide compound; (b) reacting the benzamide with an alkyl halide selected from the group consisting of bromomethane, bromoethane, bromopropane, bromo isopropane, bromo butane, and bromo tert-butane to substitute an amide bond of the benzamide with an alkyl group; (c) hydrolyzing methyl ester in the benzamide obtained from the step(a) or the benzamide compound obtained from the step(b) to prepare an acid and reacting the acid with ethyl chloroformate using pyridine or N-methyl morpholine as a solvent to covert the acid into an anhydrous compound; and (d) reacting the anhydrous compound with hydroxyl amine chloride or N-methyl hydroxyl amine chloride at a temperature of 0-10 deg.C using pyridine or N-methyl morpholine as a solvent to obtain the product of the formula(1). An agent for anti-obese, treating diabetes or hyperlipidemia comprises the hydroxamic acid.
Abstract translation: 提供异羟肟酸衍生物以诱导与能量代谢相关的IDH3α和CPT1的每种启动子的活性增加，从而有效地用于预防或治疗与脂肪血症如肥胖症，高脂血症和糖尿病有关的疾病。 异羟肟酸由式（1）表示，其中R1是CONH，NHCO，CONR4或NR4CO（其中R4是H或C1-10烷基）; R2是 - （CH2）n-（其中n是0或1）; 并且R 3是H或C 1-10烷基。 制备异羟肟酸的方法包括以下步骤：（a）使吡啶或N-甲基吗啉作为溶剂与4-氨基苯甲酸甲酯或4-氨基苯基乙酸反应，使氯甲酸乙酯与胡椒酸反应合成的无水化合物 乙酯，使用吡啶或N-甲基吗啉作为溶剂，在10-20℃的温度下制备苯甲酰胺化合物; （b）使苯甲酰胺与选自溴甲烷，溴乙烷，溴丙烷，溴异丙烷，溴丁烷和溴叔丁烷的烷基卤反应，以苯甲酰胺与烷基取代; （c）水解由步骤（a）获得的苯甲酰胺中的甲酯或由步骤（b）获得的苯甲酰胺化合物制备酸，并使用吡啶或N-甲基吗啉作为溶剂使酸与氯甲酸乙酯反应，从而使 将酸变成无水化合物; 和（d）使用吡啶或N-甲基吗啉作为溶剂，在0-10℃的温度下使无水化合物与羟胺或N-甲基羟胺氯化物反应，得到式（1）的产物。 用于抗肥胖，治疗糖尿病或高脂血症的药物包括异羟肟酸。
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公开(公告)号：KR100836035B1
公开(公告)日：2008-06-09
申请号：KR1020020008693
申请日：2002-02-19
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 포화 및 불포화 레시틴 함유 나노에멀젼 및 이를 함유하는 화장료 조성물에 관한 것으로, 더욱 구체적으로는 포화 및 불포화 레시틴의 함량비를 조절하여 혼합한 레시틴 혼합물을 계면활성제로 사용하여 제조함으로써 나노입자 내상에 하나 이상의 오일 또는 생리활성 유효성분을 함유하고 외상으로는 물을 함유하는 입자크기 10~500nm인 나노에멀전 및 이를 함유하는 화장료 조성물에 관한 것이다.
레시틴*포화 레시틴*불포화 레시틴*계면활성제*나노에멀젼*화장료-
Patent Agency Ranking
公开(公告)号：KR100829819B1
公开(公告)日：2008-05-16
申请号：KR1020070054863
申请日：2007-06-05
Abstract: A skin whitening cosmetic composition comprising a panduratin derivative or an extract of Kaempferia Pandurata is provided to be safely used to skin without side effects and show excellent pigmentation inhibitory effect by inhibiting melanogenesis, thereby improving liver spots or freckles and showing excellent skin whitening effect. A skin whitening cosmetic composition comprises 0.001-10 wt.% of at least one panduratin derivative selected from the group consisting of compounds represented by formulae(1) to (3), wherein the panduratin derivative is extracted from Kaempferia Pandurata. Further, the skin whitening cosmetic composition is cosmetic water, cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing form, cleansing water, pack, gel, powder, body lotion, body cream, body oil and body essence.
Abstract translation: 提供一种皮肤美白化妆品组合物，其包含潘多汀衍生物或山茶皮提取物以安全地用于皮肤而没有副作用，并通过抑制黑素生成显示出优异的色素沉着抑制作用，从而改善肝斑或雀斑并显示出优异的皮肤美白效果。 皮肤美白化妆品组合物包含0.001-10重量％的至少一种选自由式（1）至（3）表示的化合物的潘多肽衍生物，其中所述潘多汀衍生物从山茶中提取。 此外，皮肤美白化妆品组合物是化妆水，奶油，按摩霜，精华，眼霜，眼睛精华，清洁霜，清洁剂，清洁水，包装，凝胶，粉末，身体乳液，身体霜，身体油和身体精华 。
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97.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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98.发明授权액정 배열 안정화 시스템(ＬＡＳＳ)을 이용한 유용성활성물질 안정화 열방성 액정 마이크로 캡슐의 제조방법및 이를 함유하는 화장료 조성물 有权用于通过液晶缔合稳定体系LASS和其制备方法稳定水不溶性活性成分的热致液晶微胶囊和含有微胶囊的化妆品组合物
公开(公告)号：KR100825834B1
公开(公告)日：2008-04-28
申请号：KR1020020010961
申请日：2002-02-28
Applicant: (주)아모레퍼시픽
IPC: B01J13/14
Abstract: 본 발명은 유용성 활성물질을 안정화한 액정 가교 고분자 마이크로캡슐과 그 제조방법 및 상기 액정 가교 고분자 마이크로캡슐을 함유하는 화장료 조성물에 관한 것이다. 이러한 액정 가교 고분자 마이크로캡슐은 가교될 수 있는 관능기를 가진 고분자를 중합하는 단계; 열방성 액정 고분자 캡슐을 제조하는 단계; 상기 캡슐에 유용성 활성물질을 포집하는 단계; 상기 유용성 활성물질이 포집된 액정고분자 캡슐을 가교하는 단계를 포함하는 방법에 의하여 제조될 수 있다. 이렇게 제조된 제조된 액정 가교 고분자 캡슐에서는, 유용성 활성물질이 고분자 입자 내에 존재하는 액정과 함께 혼합되어 있으며, 이로 인하여 활성물질을 입자 내부의 액정과 입자 외각의 고분자 가교망에 의해 외부자극으로부터 차단하는 이중안정화시스템으로 우수한 안정화효과를 보인다.
액정*가교 고분자*캡슐*유용성분 안정화-
公开(公告)号：KR1020080027526A
公开(公告)日：2008-03-28
申请号：KR1020060092676
申请日：2006-09-25
Applicant: (주)아모레퍼시픽
IPC: A61K31/506 , A61K31/19 , A61P17/14
CPC classification number: A61K8/4953 , A61K8/34 , A61K8/92 , A61Q7/00 , Y10S514/88 , Y10S514/969
Abstract: A composition comprising minoxidil, tretinoin(all-trans retinoic acid), a solvent and glycerine is provided to promote permeation of the minoxidil without stimulus of the tretinoin, thereby inducing hair growth and alleviating alopecia. An external composition for preventing hair loss and promoting hair growth comprises 0.5-7.5 weight/volume% of minoxidil as a hair growth ingredient, 0.007-0.015 weight/volume% of tretinoin, 72-83 weight/volume% of ethanol, and 15-20 weight/volume% of glycerine.
Abstract translation: 提供包含米诺地尔，维A酸（全反式视黄酸），溶剂和甘油的组合物，以促进米诺地尔的渗透，而不刺激维甲酸，从而诱导毛发生长和减轻脱发。 用于防止脱发和促进毛发生长的外用组合物包含0.5-7.5重量/体积％的作为毛发生长成分的米诺地尔，0.007-0.015重量/体积％的维甲酸，72-83重量/体积％的乙醇和15- 20重量/体积％的甘油。
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公开(公告)号：KR100803577B1
公开(公告)日：2008-02-15
申请号：KR1020050115649
申请日：2005-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/602 , A61K2800/522 , A61Q19/02 , A61Q19/08
Abstract: 본 발명은 이카린의 가수분해물을 함유하는 화장료용 조성물에 관한 것으로, 보다 구체적으로는 이카린의 가수분해물인 이카리틴, 이카리시드 I 및 이카리시드 II를 함유하는 화장료에 관한 것이고, 상기 이카린(icariin)의 가수분해물은 (a) 식물로부터 물 또는 유기용매를 이용하여 이카린을 함유하는 식물 추출물을 수득하는 단계; 및 (b) 상기 수득된 식물 추출물을 산, 염기, 효소 또는 상기 효소를 생산하는 미생물을 이용하여 가수분해하는 단계를 포함하는 방법에 의해 제조될 수 있다.
본 발명에 따른 화장료용 조성물은 항산화, 항노화, 미백 또는 주름 개선용으로 적용될 수 있다.
에피메디움, 이카리틴, 이카리시드 I, 이카리시드 II, 이카린, 항산화, 미백, 주름 개선, 항노화, 화장료
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