公开(公告)号：KR1020140095850A

公开(公告)日：2014-08-04

申请号：KR1020130008745

申请日：2013-01-25

Applicant: 삼성전자주식회사

Inventor： 이우용 ,  이영민 ,  박재찬 ,  박진환 ,  송여주

IPC: C12N15/63 ,  C12N15/74 ,  C12N15/70

CPC classification number: C12N15/77 ,  C12N15/70

Abstract: The present invention relates to a vector. More specifically, the vector is replicated by using a corynebacterium or colon bacterium and used in various cloning process. The vector according to an embodiment of the present invention can be used to observe the transcription induction activation process of promoters in the corynebacterium or produce a product of a target gene. The vector includes a nucleotide sequence of SEQ ID NO. 1 and a multiple cloning site (MCS) of SEQ ID NO. 2.

Abstract translation: 本发明涉及载体。 更具体地，通过使用棒状杆菌或结肠细菌复制载体并用于各种克隆过程。 根据本发明实施方案的载体可用于观察棒状杆菌中启动子的转录诱导活化过程或产生靶基因的产物。 载体包含SEQ ID NO：1的核苷酸序列。 1和SEQ ID NO：1的多克隆位点（MCS）。 2。

公开(公告)号：KR1020140094757A

公开(公告)日：2014-07-31

申请号：KR1020130007091

申请日：2013-01-22

Applicant: 삼성전자주식회사 ,  중앙대학교 산학협력단

Inventor： 김재영 ,  강진규 ,  강창덕 ,  김성수 ,  이주영 ,  강현아 ,  박재찬 ,  임휘섭 ,  추진호

IPC: C12N15/63 ,  C12N15/81 ,  C12Q1/68

CPC classification number: C12N15/81 ,  C12N15/905 ,  C12N15/63 ,  C12N15/66 ,  C12N15/902 ,  C12Q1/6865

Abstract: The present invention relates to: a promoter specific homologous part which is homologous with a part of the promoter of a target gene; a marker gene which is connected with the promoter specific homologous part in order to be able to operate; a cassette, for causing a defect of the target gene, which is connected to the downstream of the marker gene and includes a gene specific homologous part which is homologous with at least one target gene; and a gene manipulation method which uses the cassette. The efficient gene manipulation and selection of a cell are possible by using the cassette and the gene manipulation method using the cassette.

Abstract translation: 本发明涉及：与靶基因的一部分启动子同源的启动子特异性同源部分; 与启动子特异性同源部分连接以便能够操作的标记基因; 用于引起靶标基因的缺陷，其与所述标记基因的下游连接并且包括与至少一种靶基因同源的基因特异性同源部分; 以及使用该盒的基因操作方法。 通过使用盒子和使用盒子的基因操作方法，可以有效地进行细胞的基因操作和选择。

公开(公告)号：KR1020140043559A

公开(公告)日：2014-04-10

申请号：KR1020120105939

申请日：2012-09-24

Applicant: 삼성전자주식회사 ,  한국과학기술원

Inventor： 이규상 ,  김태용 ,  손승범 ,  구현민 ,  박재찬 ,  이상엽

IPC: C12N1/19 ,  C12N15/52 ,  C12N15/81 ,  C12P7/52

Abstract: An embodiment relates to a metabolic network model for analyzing metabolic characteristics of Kluyveromyces marxianus microorganisms for producing 3HP and to metabolic characteristic analysis of Kluyveromyces marxianus using the same. More specifically, the present invention relates to building metabolic network model of the Kluyveromyces marxianus using gene-protein-biochemistry reaction relationship, to analysis of metabolic characteristics of metabolic flux using the model, and to a method for predicting a novel metabolic path which enhances production capacity of the 3HP using simulation based on metabolic flux. The method of an embodiment can efficiently predict cell growth speed and production of microorganisms, save time and costs for optimizing the novel path, and provide variant microorganisms which can produce specific metabolites with high efficiency.

Abstract translation: 一个实施方案涉及用于分析用于产生3HP的马克斯克鲁维酵母微生物的代谢特征的代谢网络模型和使用其的马克斯克鲁维酵母的代谢特征分析。 更具体地说，本发明涉及使用基因 - 蛋白 - 生物化学反应关系构建马克斯克鲁维酵母的代谢网络模型，使用该模型分析代谢通量的代谢特征，以及用于预测增加生产的新型代谢途径的方法 使用基于代谢通量的模拟的3HP容量。 实施方案的方法可以有效地预测细胞生长速度和微生物的产生，从而节省了用于优化新途径的时间和成本，并提供可以高效生产特定代谢物的变体微生物。

公开(公告)号：KR1020140014648A

公开(公告)日：2014-02-06

申请号：KR1020120081199

申请日：2012-07-25

Applicant: 삼성전자주식회사

Inventor： 이우용 ,  구현민 ,  김성수 ,  김재영 ,  박재찬

IPC: C12N1/21 ,  C12N15/52 ,  C12P7/16

CPC classification number: C12P7/18 ,  C07K14/34 ,  C08G63/16 ,  C08G63/183 ,  C12N9/1029 ,  C12N9/90 ,  C12N15/77 ,  C12P7/62

Abstract: The present invention relates to a modified microorganism for the highly efficient production of 1,4-butanediol, and a production method of 1,4-butanediol using the modified microorganism. The modified microorganism has improved tolerance against 1,4-butanediol by the loss or destruction of a gene encoding more than one selected from the group consisting of a transcriptional regulatory factor NCgl2886, GCN5-related N-acetyl transferase NCgl2090, hypothetical protein NCgl0224, and sugar phosphate isomerase/epimerase NCgl2956; and enables users to produce 1,4-butanediol in high efficiency even under the presence of the high concentration of 1,4-butanediol.

Abstract translation: 本发明涉及用于高效制备1,4-丁二醇的改性微生物，以及使用该改性微生物的1,4-丁二醇的制备方法。 修饰的微生物通过丧失或破坏编码多于一种的基因的转录调节因子NCgl2886，GCN5相关N-乙酰转移酶NCgl2090，假定蛋白NCgl0224和 糖磷酸异构酶/差向异构酶NCgl2956; 并且使用户即使在高浓度的1,4-丁二醇的存在下也能够高效地生产1,4-丁二醇。

公开(公告)号：KR1020130089179A

公开(公告)日：2013-08-09

申请号：KR1020130001792

申请日：2013-01-07

Applicant: 삼성전자주식회사

Inventor： 박선민 ,  김현령 ,  박재찬 ,  채수영

IPC: A61K9/16 ,  A61K9/14 ,  B82Y5/00

Abstract: PURPOSE: A solid lipid nanoparticle is provided to offer an effective method for transferring an active ingredient to the target site of body. CONSTITUTION: A solid lipid nanoparticle comprises an elastin-like polypeptide in which the moiety having hydrophobic group is bound and lipid molecule. The moiety having hydrophobic group is the saturated or unsaturated hydrocarbon group, the saturated or unsaturated acyl group, the saturated or unsaturated amide group, or the saturated or unsaturated alkoxy group. The lipid molecule is neutral lipid molecule or amphiphilic lipid molecule. The elastic-like polypeptide includes more than one repeat unit selected from among VPGXG, PGXGV, GXGVP, XGVPG, GVPGX, and a group comprised of combination thoseof more than once. The V, P, G, and X is respectively means valine, proline, glycine, and an amino acid which is not proline. [Reference numerals] (AA) Coefficient

Abstract translation: 目的：提供固体脂质纳米颗粒，以提供将活性成分转移到身体目标部位的有效方法。 构成：固体脂质纳米颗粒包含其中具有疏水基团的部分结合的弹性蛋白样多肽和脂质分子。 具有疏水基团的部分是饱和或不饱和烃基，饱和或不饱和酰基，饱和或不饱和酰胺基或饱和或不饱和烷氧基。 脂质分子是中性脂质分子或两亲性脂质分子。 弹性状多肽包括多于一个选自VPGXG，PGXGV，GXGVP，XGVPG，GVPGX的重复单元，以及由多于一种的组合组成的组。 V，P，G和X分别表示缬氨酸，脯氨酸，甘氨酸和不是脯氨酸的氨基酸。 （标号）（AA）系数

公开(公告)号：KR1020130089110A

公开(公告)日：2013-08-09

申请号：KR1020120010506

申请日：2012-02-01

Applicant: 삼성전자주식회사

Inventor： 김민상 ,  채수영 ,  박상준 ,  김현령 ,  박재찬

IPC: A61K9/127 ,  A61K47/48 ,  A61K47/42

CPC classification number: A61K9/127 ,  A61K31/704 ,  A61K47/42

Abstract: PURPOSE: A liposome containing elastin-like polypeptide and cancer cell targeting material is provided to offer an effective method for transferring an active ingredient to the target site of body. CONSTITUTION: A liposome comprises: a lipid bilayer; an elastin-like polypeptide in which the moiety having hydrophobic group is bound; and a lipid bilayer stabilizer. The moiety having hydrophobic group is filled in the lipid bilayer. A first lipid molecule combining with cancer cell targeting material is included in the lipid bilayer. [Reference numerals] (AA) DOX discharge (%); (BB) Temperature (°C)

Abstract translation: 目的：提供含有弹性蛋白样多肽和癌细胞靶向材料的脂质体，以提供将活性成分转移到身体目标部位的有效方法。 构成：脂质体包括：脂质双层; 其中具有疏水基团的部分结合的弹性蛋白样多肽; 和脂质双层稳定剂。 具有疏水基团的部分填充在脂质双层中。 结合癌细胞靶向材料的第一种脂质分子被包括在脂质双层中。 （标号）（AA）DOX放电（％）; （BB）温度（℃）

公开(公告)号：KR101213157B1

公开(公告)日：2012-12-17

申请号：KR1020060052054

申请日：2006-06-09

Applicant: 삼성전자주식회사

Inventor： 김홍식 ,  장우영 ,  박재찬 ,  박정제

IPC: A61B5/053

CPC classification number: A61B5/0531 ,  A61B5/442 ,  A61B2562/02

Abstract: 본발명에따른피부임피던스측정센서는, 사용자피부에접촉되는 R 전극(Reference Electrode)과 C 전극(Current Carrying Electrode); 및상기 R 전극및 상기 C 전극사이에흐르는전류의임피던스(Impedance)를측정하는 M 전극(Measuring Electrode)을포함하고, 상기 M 전극은상기 R 전극및 상기 C 전극에대해단차를갖는것을특징으로한다.

公开(公告)号：KR1020110085668A

公开(公告)日：2011-07-27

申请号：KR1020100005576

申请日：2010-01-21

Applicant: 삼성전자주식회사 ,  고려대학교 산학협력단

Inventor： 조화영 ,  구현민 ,  박재찬 ,  박성민 ,  김경헌 ,  최인걸

IPC: C07K14/195 ,  C07K14/32 ,  C12P19/04 ,  C12N9/14

CPC classification number: C12P7/10 ,  C07K14/195 ,  C07K14/32 ,  C07K14/37 ,  C12N9/2437 ,  C12N9/248 ,  C12P19/02 ,  C12P19/14 ,  Y02E50/16 ,  Y02E50/343

Abstract: PURPOSE: An isolated protein and a composition containing the same for enhancing polysaccharide hydrolase activity are provided to enhance hydrolysis ability and to reduce the use of hydrolase. CONSTITUTION: An isolated protein enhances polysaccharide hydrolase activity and has polysaccharide binding ability. The protein contains GH45(glycoside hydrolase 45) or pollen-allergen domain. The polysaccharide hydrolase is cellulase, hemicellulase, alpha-amylase, glycoamylase, pectinase, xylanase, or cellobiase. The GH45 domain or pollen allergen domain is isolated from expansin, expansin-like protein, or bacterial protein.

Abstract translation: 目的：提供分离的蛋白质和含有该蛋白质的组合物，以增强多糖水解酶活性，以提高水解能力并减少水解酶的使用。 构成：分离蛋白提高多糖水解酶活性，具有多糖结合能力。 该蛋白质含有GH45（糖苷水解酶45）或花粉 - 变应原结构域。 多糖水解酶是纤维素酶，半纤维素酶，α-淀粉酶，糖酵解酶，果胶酶，木聚糖酶或纤维二糖酶。 从扩展蛋白，扩展蛋白样蛋白或细菌蛋白分离GH45结构域或花粉过敏原结构域。

公开(公告)号：KR1020110067992A

公开(公告)日：2011-06-22

申请号：KR1020090124803

申请日：2009-12-15

Applicant: 삼성전자주식회사

Inventor： 김진우 ,  박재찬 ,  박성민 ,  박영경

IPC: C12P7/06 ,  C12P7/16

CPC classification number: C12P7/08 ,  B01J8/10 ,  C12M41/12 ,  C12M45/02 ,  C12M45/06 ,  D21C1/00 ,  D21C1/02 ,  D21C1/04 ,  D21C1/06 ,  D21C1/10 ,  D21C3/20 ,  Y02E50/16 ,  Y02E50/17 ,  Y02P20/136

Abstract: PURPOSE: A pretreatment method of a biomass using internal heat is provided to induce heating reaction and to enhance pretreatment efficiency. CONSTITUTION: A pretreatment method of a biomass using internal heat comprises a step of adding water-reactive anhydride to the biomass for internal heat reaction. The biomass is lignocellulose biomass or macroalgae biomass. The water-reactive anhydride is alkaline gas and acidic gas. The water-reactive anhydride is anhyudrous ammonia, hydrogen sulfide(H_2S), anhydrous hydrochloride(HCl), phosphorus pentoxide (P_2O_5), the carbon dioxide (CO_2), or mixture thereof.

Abstract translation: 目的：提供使用内部热量的生物质的预处理方法，以引起加热反应并提高预处理效率。 构成：使用内部热量的生物质的预处理方法包括向生物质中加入水反应性酸酐用于内部热反应的步骤。 生物质是木质纤维素生物量或大型藻类生物量。 水反应性酸酐是碱性气体和酸性气体。 水反应性酸酐是无水氨，硫化氢（H_2S），无水盐酸盐（HCl），五氧化二磷（P_2O_5），二氧化碳（CO_2）或其混合物。

公开(公告)号：KR1020100021162A

公开(公告)日：2010-02-24

申请号：KR1020080079921

申请日：2008-08-14

Applicant: 삼성전자주식회사

Inventor： 이헌주 ,  박재찬

IPC: G01N29/02 ,  G01N29/036 ,  G01N29/00

CPC classification number: G01N29/022 ,  B01L3/5027 ,  B01L2200/10 ,  B01L2300/0663

Abstract: PURPOSE: A wave sensor with a gas removing unit, and a method for detecting a target material in a liquid sample are provided to effectively detect a target material within a liquid sample. CONSTITUTION: A method for detecting a target material in a liquid sample is as follows: A wave signal is offered to a standard liquid sample which not comprises a target material. And the wave signal is measured from the standard liquid sample. The measured signal is a base value, and offered to a target liquid sample which comprises the target material. A wave signal is measured from the target liquid sample. The target material is detected from the measured wave signal.

Abstract translation: 目的：提供具有气体去除单元的波传感器和用于检测液体样品中的目标材料的方法，以有效地检测液体样品内的目标材料。 构成：用于检测液体样品中的目标材料的方法如下：将波信号提供给不包括目标材料的标准液体样品。 并且从标准液体样品测量波信号。 测量的信号是基值，并提供给包含目标材料的目标液体样品。 从目标液体样品测量波信号。 从测量的波信号中检测目标材料。