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公开(公告)号：KR101306960B1
公开(公告)日：2013-09-09
申请号：KR1020130038667
申请日：2013-04-09
Applicant: 재단법인 제주테크노파크
Abstract: 본 발명의 홍해삼으로부터의 콜라겐의 분리 방법을 개시한다. 구체적으로 본 발명의 홍해삼으로부터의 콜라겐의 분리 방법은 (a) 비콜라겐성 단백질의 제거를 위하여 수세한 홍해삼에 염기성 용액을 처리하는 단계, (b) 염기성 용액 처리 후 원심분리하여 알칼리 처리 잔사를 수득하는 단계 및 (c) 수득한 알칼리 처리 잔사에 대하여 산성 용액을 처리하는 단계를 포함하여 구성된다.
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公开(公告)号：KR1020130073179A
公开(公告)日：2013-07-03
申请号：KR1020110140888
申请日：2011-12-23
Applicant: 재단법인 제주테크노파크
IPC: A61K36/18 , A61K36/185 , A61P29/00 , A61P17/00
Abstract: PURPOSE: An anti-inflammatory composition and a skin whitening composition using a kiwi fruit fermentation are provided to suppress NO, PGE2, and inflammatory cytokine generation, and melanogenesis. CONSTITUTION: An anti-inflammatory composition contains a kiwi fruit fermentation which is prepared by inoculating lactic acid bacteria and yeast to a crushed kiwi fruit and fermenting. Sugar is added to the crushed kiwi fruit as an energy source. The lactic acid bacteria and the yeast are Lactobacillus plantarum and Saccharomyces cerevisiae. The composition is a pharmaceutical composition, a food composition, or a cosmetic composition.
Abstract translation: 目的：提供使用猕猴桃发酵的抗炎组合物和皮肤美白组合物，以抑制NO，PGE2和炎性细胞因子的产生以及黑素生成。 构成：抗炎组合物含有猕猴桃发酵，其通过将乳酸菌和酵母接种到破碎的猕猴桃中并发酵而制备。 糖被添加到被碾碎的猕猴桃作为能源。 乳酸菌和酵母是植物乳杆菌（Lactobacillus plantarum）和酿酒酵母（Saccharomyces cerevisiae）。 组合物是药物组合物，食品组合物或化妆品组合物。
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公开(公告)号：KR1020130071666A
公开(公告)日：2013-07-01
申请号：KR1020110139005
申请日：2011-12-21
Applicant: 재단법인 제주테크노파크
IPC: A61K31/343 , A61K31/045 , A61P29/00
Abstract: PURPOSE: An anti-inflammatory composition using vladinol F isolated from F. erecta var. sieboldii is provided to suppress generation of NO, PGE2 (prostaglandin), and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6). CONSTITUTION: An anti-inflammatory composition contains vladinol F as an active ingredient. A method for isolating vladinol F from F. erecta var. sieboldii comprises the steps of: dipping F. erecta var. sieboldii leaves, stems, or a mixture thereof in a mixture solvent of ethanol and water and preparing a power extract; suspending the extract in distilled water, and sequentially fractioning to obtain a dichloromethane fraction; coating a celite surface with the fraction and performing column chromatography using hexane, dichloromethane, ethyl acetate, and methanol to obtain 4 purified materials; performing normal phase column chromatography of a second purified material using hexane:ethyl acetate:methanol (1:2:0.2, v/v) to obtain total 20 purified materials; performing normal phase silicagel column chromatography of 16th purified material among 20 purified materials using chloroform:methanol (10:1, v/v) and preparing total 18 purified materials; and collecting 9th purified material among 18 purified materials. [Reference numerals] (AA) MC fraction of a F. erecta var. sieboldii extract (11.2g); (BB) Column chromatography; (CC) Normal phase silica gel (5cm×60cm); (DD) Normal phase silica gel (2.0cm×50cm)
Abstract translation: 目的：使用从F. erecta var。分离的vladinol F的抗炎组合物。 提供sieboldii以抑制NO，PGE2（前列腺素）和炎性细胞因子（TNF-α，IL-1β和IL-6）的产生。 构成：抗炎组合物含有vladinol F作为活性成分。 一种从F. erecta var。中分离vladinol F的方法。 sieboldii包括以下步骤：浸渍F.frecta var。 sieboldii叶，茎或其在乙醇和水的混合溶剂中的混合物，并制备动力提取物; 将提取物悬浮在蒸馏水中，并依次分级得到二氯甲烷馏分; 用级分涂覆硅藻土表面，并使用己烷，二氯甲烷，乙酸乙酯和甲醇进行柱层析，得到4种纯化物; 使用己烷：乙酸乙酯：甲醇（1:2:0.2，v / v）进行第二纯化物质的正相柱色谱，得到总共20种纯化物质; 使用氯仿：甲醇（10:1，v / v）在20个纯化物中进行第16次纯化物质的正相硅胶柱色谱，并制备总共18种纯化物质; 并在18种纯化材料中收集第9种纯化材料。 （参考数字）（AA）MC分数F.frecta var。 sieboldii提取物（11.2g）; （BB）柱色谱; （CC）正相硅胶（5cm×60cm）; （DD）正相硅胶（2.0cm×50cm）
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公开(公告)号：KR101280431B1
公开(公告)日：2013-06-28
申请号：KR1020100095098
申请日：2010-09-30
Applicant: 재단법인 제주테크노파크
IPC: A61K35/616 , A61K9/14 , A61K9/19
Abstract: 본 발명은 홍해삼 추출물을 이용한 항알러지제 조성물 및 항균제 조성물을 개시한다. 홍해삼 추출물은 비만세포의 탈과립 억제 활성을 보였으며 또한 피부 상재균인 스타필로코커스 아우레우스 및 스타필로코커스 에피더미디스에 항균 활성을 보였다.
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Patent Agency Ranking
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公开(公告)号：KR1020120100859A
公开(公告)日：2012-09-12
申请号：KR1020120082039
申请日：2012-07-26
Applicant: 재단법인 제주테크노파크
CPC classification number: A61K36/60 , A23L33/105 , A23V2002/00 , A23V2200/324
Abstract: PURPOSE: An anti-inflammatory composition using Ficus erecta leaf extract is provided to suppress IL-1beta generation and iNOS and COX-2 expression. CONSTITUTION: An anti-inflammatory composition contains Ficus erecta leaf extract as an active ingredient. The extract is selected from: extract prepared with alcohol of 1-5 carbon atoms, acetone, hexane, ethyl acetate, dichloromethane, water or a mixture thereof; extract of a fraction solvent layer prepared by fractioning solid extract with water and hexane, water and dichloromethane, or water and ethyl acetate; and extract prepared by suspending the solid extract in the water and fractioning with hexane, dichloromethane, and ethyl acetate in order. The composition is a pharmaceutical composition and food composition.
Abstract translation: 目的：提供使用Ficus erecta叶提取物的抗炎组合物，以抑制IL-1beta的产生和iNOS和COX-2的表达。 构成：抗炎组合物含有榕叶提取物作为活性成分。 提取物选自：用1-5个碳原子的醇制备的提取物，丙酮，己烷，乙酸乙酯，二氯甲烷，水或其混合物; 通过用水和己烷，水和二氯甲烷或水和乙酸乙酯分离固体提取物制备的级分溶剂层的提取物; 和通过将固体提取物悬浮在水中制备的提取物，并依次用己烷，二氯甲烷和乙酸乙酯分馏。 组合物是药物组合物和食物组合物。
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公开(公告)号：KR1020100122376A
公开(公告)日：2010-11-22
申请号：KR1020090041384
申请日：2009-05-12
Applicant: 재단법인 제주테크노파크
IPC: A61K36/185 , A61K8/97 , A61P11/06 , A61Q19/00
Abstract: PURPOSE: A composition containing kiwi leaf extract for anti-inflammation is provided to apply to atopic dermatitis. CONSTITUTION: A composition for anti-inflammation contains kiwi leaf extract as an active ingredient. The extract is obtained using water, distilled water, ethanol or mixture solvent thereof. The composition is a pharmaceutical composition. The composition is also a cosmetic composition for relieving atopic dermatitis. A composition for relieving atopic dermatitis contains kiwi pulp extract as an active ingredient.
Abstract translation: 目的：提供含有抗炎的猕猴桃提取物的组合物适用于特应性皮炎。 构成：抗炎组合物含有猕猴桃提取物作为活性成分。 萃取液用水，蒸馏水，乙醇或其混合溶剂得到。 组合物是药物组合物。 该组合物也是用于缓解特应性皮炎的化妆品组合物。 用于缓解特应性皮炎的组合物含有猕猴桃提取物作为活性成分。
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公开(公告)号：KR1020090118154A
公开(公告)日：2009-11-18
申请号：KR1020080043774
申请日：2008-05-13
Applicant: 재단법인 제주테크노파크
IPC: A61K36/185 , A61P17/18 , A61P35/00
Abstract: PURPOSE: A composition containing Quercus acuta Thunb extract is provided to ensure the effect of DNA damage suppression and cancer cell proliferation suppression. CONSTITUTION: A method for producing fraction of Quercus acuta Thunb extract comprises: a step of preparing stems with leaves of Quercus acuta Thunb then pulverizing; a step of extracting the pulverized Quercus acuta Thunb powder with ethanol; a step of decompress-concentrating then suspending with distilled water; and a step of extracting with hexane, dichloromethane, ethylacetate, butanol, and water. A composition for antioxidation contains fraction of Quercus acuta Thunb extract.
Abstract translation: 目的：提供含有栎属藜提取物的组合物，以确保DNA损伤抑制和癌细胞增殖抑制的作用。 构成：生产栎属栎提取物的方法，包括：用槲皮栎树叶制备茎的步骤，然后粉碎; 用乙醇提取粉碎的栎树栎粉末的步骤; 减压浓缩步骤，然后用蒸馏水悬浮; 和用己烷，二氯甲烷，乙酸乙酯，丁醇和水萃取的步骤。 用于抗氧化的组合物含有栎属栎提取物的分数。
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