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    족제비싸리 추출물을 포함하는 조성물
    91.
    发明公开
    족제비싸리 추출물을 포함하는 조성물 无效
    含有AMORPHA FRUTICOSA的提取物的组合物

    公开(公告)号：KR1020140030721A

    公开(公告)日：2014-03-12

    申请号：KR1020120097228

    申请日：2012-09-03

    Applicant: 한국과학기술연구원

    Inventor： 김수남 ,  이우정 ,  함정엽 ,  권학철 ,  정봉철

    IPC: A61K36/48 ,  A61K31/351 ,  A61K31/35 ,  A61P3/04

    CPC classification number: A61K36/48 ,  A23L33/105 ,  A61K31/05 ,  A61K31/353

    Abstract: The present invention relates to a composition comprising an Amorpha fruticosa extract for PTP inhibition and PPAR activation. The composition of the present invention is capable of reducing blood glucose by increasing susceptibility to insulin as both of activation and expression of PTP1B are inhibited, and shows an outstanding activity for glucose uptake in muscle cells. [Reference numerals] (AA) Normal condition; (BB,FF,II,KK) Control group; (CC,GG) Example ; (DD,HH) Example ; (EE) Insulin resistance condition; (JJ,LL) Example

    Abstract translation: 本发明涉及一种组合物，其包含用于PTP抑制和PPAR活化的弗氏酵母提取物。 本发明的组合物能够通过增加对胰岛素的敏感性而降低血糖，因为PTP1B的活化和表达都被抑制，并且对于肌肉细胞中的葡萄糖摄取显示出突出的活性。 （附图标记）（AA）正常条件; （BB，FF，II，KK）对照组; （CC，GG）实施例<3-1>; （DD，HH）实施例<5>; （EE）胰岛素抵抗状况; （JJ，LL）实施例<6>

    진세노사이드 ２０(Ｓ)-알지3 또는 진세노사이드 ２０(Ｒ)-알지3의 함량비율이 증가된 가공 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물
    93.
    发明公开
    진세노사이드 ２０(Ｓ)-알지3 또는 진세노사이드 ２０(Ｒ)-알지3의 함량비율이 증가된 가공 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물 有权
    加工PANAX SPP 植物提取物，其具有增加的茚三酮20（S）-RG 3或茚三酮20（R）-RG 3的含量比例，其制备方法和包含其的组合物

    公开(公告)号：KR1020130093331A

    公开(公告)日：2013-08-22

    申请号：KR1020120014831

    申请日：2012-02-14

    Applicant: 한국과학기술연구원

    Inventor： 강기성 ,  함정엽 ,  김수남 ,  권학철 ,  정봉철 ,  이우정 ,  박순혜

    IPC: A61K36/258 ,  A61K31/704 ,  A61P35/00

    CPC classification number: A61K36/258 ,  A23L33/105 ,  A23L33/175 ,  A61K31/198 ,  A61K31/704 ,  A61K2236/333

    Abstract: PURPOSE: A processed ginseng extract is provided to contain a large amount of ginsenoside Rg3, Rg5, Rk1, and to selectively contain ginsenoside of 20 (S)-Rg3 or ginsenoside of 20 (R)-Rg3 depending on the desired effect. CONSTITUTION: A processed panax species plant extract is obtained by Maillard-browning a panax species plant extract with more than one amino acid selected from a group comprising arginine, alanine, and valine at 100-130 deg. C for 0.5-12 hours. The processed panax species plant extract is obtained by Maillard-browing the panax species plant extract with more than one amino acid selected from a group comprising leucine and glutamine at 100-130 deg. C for 0.5-12 hours. A pharmaceutical composition for anti-cancer, neuroprotection, inhibition of platelet aggregating, anti-oxidation, anti-inflammation, kidney protection, and anti-fatigue comprises the panax species plant extract.

    Abstract translation: 目的：提供加工的人参提取物以含有大量人参皂苷Rg3，Rg5，Rk1，并根据所需效果选择性地含有20（S）-Rg3或人参皂苷20（R）-Rg3的人参皂甙。 构成：在100-130度下，通过美拉德褐化具有多于一种氨基酸的选自精氨酸，丙氨酸和缬氨酸的氨基酸，获得经处理的藜属植物提取物。 C为0.5-12小时。 经加工的ax属植物提取物通过美拉德在100-130度下从含有亮氨酸和谷氨酰胺的组中选出的多于一种氨基酸的堇菜属植物提取物获得。 C为0.5-12小时。 用于抗癌，神经保护，抑制血小板聚集，抗氧化，抗炎，肾脏保护和抗疲劳的药物组合物包括豌豆种植物提取物。

    신규 박테리아 균주 에어로마이크로비움 할로신디아 ＫＭＥ―００１ 및 이의 용도
    94.
    发明授权
    신규 박테리아 균주 에어로마이크로비움 할로신디아 ＫＭＥ―００１ 및 이의 용도 有权
    一种新型细菌气溶性氧氟尿嘧啶KME-001及其用途

    公开(公告)号：KR101152622B1

    公开(公告)日：2012-06-05

    申请号：KR1020090006514

    申请日：2009-01-28

    Applicant: 한국과학기술연구원

    Inventor： 권학철 ,  김성훈 ,  양현옥

    IPC: C12N1/20 ,  C12P33/00 ,  C12Q1/04

    Abstract: 본발명은신규박테리아균주에어로마이크로비움할로신디아 KME-001(KME-001) 및이의용도에관한것으로, 더욱상세하게는멍게로부터분리한해양박테리아에어로마이크로비움할로신디아 KME-001의유전자형태및 생화학적성상을분석하여신규박테리아균주임이밝혀졌으며, 상기균주가담즙의주성분인콜린산유도체중 타우로콜린산(taurocholic acid)을생산하고, 양식멍게에게질병을유발하는원인미생물임이밝혀짐으로써신규균주 KME-001, 이의유전체및 성분은콜린산유도체의대량생산및 멍게질병예방및 치료에유용하게이용될수 있다.

    올레아노닉산을 함유하는 치매 예방 또는 치료용 조성물
    97.
    发明公开
    올레아노닉산을 함유하는 치매 예방 또는 치료용 조성물 无效
    包含用于预防和治疗痴呆症的油酸钠的组合物

    公开(公告)号：KR1020110045351A

    公开(公告)日：2011-05-04

    申请号：KR1020090101896

    申请日：2009-10-26

    Applicant: 한국과학기술연구원

    Inventor： 양현옥 ,  권학철 ,  정성권 ,  박진수 ,  양민철 ,  천윤선

    IPC: A61K31/56 ,  A61P25/28 ,  A61K36/84 ,  A23L1/30

    CPC classification number: A61K31/56 ,  A23L33/10 ,  A61K36/748 ,  A61K36/84

    Abstract: PURPOSE: A composition containingi oleanonic acid for preventing or treating dementia is provided to suppress beta-amyloid generation. CONSTITUTION: A composition for preventing or treating neurodegenerative diseases contains oleanonic acid of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A composition for preventing or treating neurodegenerative diseases contains Patrinia scabiosaefolia extract, dried material of the extract, or concentrate of the extract as an active ingredient. The Patrinia scabiosaefolia extract is isolated using water or alcohol of C1-C4.

    Abstract translation: 目的：提供含有用于预防或治疗痴呆症的油酸组合物的组合物以抑制β-淀粉样蛋白的产生。 构成：用于预防或治疗神经变性疾病的组合物含有化学式1的油酸或其药学上可接受的盐作为活性成分。 用于预防或治疗神经退行性疾病的组合物含有芍药提取物，提取物的干燥物质或提取物的浓缩物作为活性成分。 使用C1-C4的水或酒精分离芍药提取物。

    퍼록시솜 증식자 활성화 수용체 알파/감마 이중 효능제인스틸벤 유도체 및 그 제조방법
    99.
    发明授权
    퍼록시솜 증식자 활성화 수용체 알파/감마 이중 효능제인스틸벤 유도체 및 그 제조방법 有权
    苯丙氨酸衍生物作为PPAR ALPHA / GAMMA双倍激动剂及其制备方法

    公开(公告)号：KR100894832B1

    公开(公告)日：2009-04-24

    申请号：KR1020070107775

    申请日：2007-10-25

    Applicant: 한국과학기술연구원

    Inventor： 함정엽 ,  안홍열 ,  박영희 ,  김수남 ,  이우정 ,  양현옥 ,  권학철

    IPC: C07C39/17 ,  C07C39/18 ,  C07C39/205

    Abstract: A stilbene derivatives as PPAR(peroxisome proliferator activation acceptor) alpha/gamma dual agonists is provided for treatment and prevention of obesity, diabetes, skin aging, skin wrinkle and skin hydration. A stilbene derivatives represented by the formula 1 is obtained by reacting a compound represented by the formula 2 and a compound represented by the formula 3. In the formula 1, 2 and 3, R^1 indicates an isoflavonoid group represented by the formula 1-a; R^2 is hydrogen, methyl, ethyl, tert-butyl, benzyl, methoxymethyl, trimethylsilyl, tert-butyldiphenylsilyl, tert-butyldimethylsilyl or triisopropylsilyl; R^3 shows -F, -CF3, -CH3 or -OCH3; A represents cis-, trans- isomers; m is an integer of 0~2; n is an integer of 1~5; p is integer of 0~2; and X shows a halogen atom.

    Abstract translation: 提供作为PPAR（过氧化物酶体增殖物激活受体）α/γ双重激动剂的二苯乙烯衍生物用于治疗和预防肥胖症，糖尿病，皮肤老化，皮肤皱纹和皮肤水合。 由式1表示的芪衍生物通过使式2表示的化合物与由式3表示的化合物反应而获得。在式1,2和3中，R 1表示由式1表示的异黄酮基， 一个; R 2是氢，甲基，乙基，叔丁基，苄基，甲氧基甲基，三甲基甲硅烷基，叔丁基二苯基甲硅烷基，叔丁基二甲基甲硅烷基或三异丙基甲硅烷基; R 3表示-F，-CF 3，-CH 3或-OCH 3; A代表顺式，反式异构体; m为0〜2的整数; n为1〜5的整数; p为0〜2的整数; X表示卤素原子。

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