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公开(公告)号:CA1058626A
公开(公告)日:1979-07-17
申请号:CA256969
申请日:1976-07-14
Applicant: BASF AG
Inventor: PAUST JOACHIM , SCHNEIDER JOACHIM , JAEDICKE HAGEN
IPC: C07B61/00 , B01J21/00 , B01J23/00 , C07C20060101 , C07C49/21 , C07C49/653 , C07C67/00 , C07C67/30 , C07C69/52 , C07C401/00 , C07C403/00 , C07C403/24 , C07C175/00
Abstract: Process for the manufacture of canthaxanthin by oxidizing B-carotene, retro-dehydro-carotene or echinenone with a salt of chloric or bromic acid in the presence of a catalyst and of an inert diluent or solvent.
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公开(公告)号:AU7760675A
公开(公告)日:1976-07-29
申请号:AU7760675
申请日:1975-01-24
Applicant: BASF AG
Inventor: HOFFMANN WERNER , HIMMELE WALTER , PAUST JOACHIM , FRANUBERG KARL VON , SIEGEL HARDO , PFOHL SIGBERG
IPC: B01D9/02 , C07B31/00 , C07B57/00 , C07C51/00 , C07C59/105 , C07C67/00 , C07C209/00 , C07C209/26 , C07C211/19 , C07D307/33 , C07C87/06 , C07D5/06
Abstract: A process for resolving racemic alpha -hydroxy- beta , beta -dimethyl- gamma -butyrolactone, referred to as D,L-pantolactone, into its optical antipodes, based on the separation of diastereomeric salts of D,L-pantoic acid ( alpha , gamma -dihydroxy- beta , beta -dimethylbutyric acid), produced from D,L-pantolactone, by means of (-)-3-aminomethylpinane, (+)-3-aminomethylpinane or one of their acid addition salts, as a new resolving agent.
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公开(公告)号:AU7728975A
公开(公告)日:1976-07-15
申请号:AU7728975
申请日:1975-01-14
Applicant: BASF AG
Inventor: HOFFMANN WERNER , HIMMELE WALTER , PAUST JOACHIM , FRAUNBERG KARL VON , SIEGEL HARDO , PFOHL SIEGBERG
IPC: C07C31/137 , C07B61/00 , C07C27/00 , C07C29/14 , C07C29/141 , C07C41/00 , C07C43/303 , C07C45/00 , C07C45/50 , C07C47/347 , C07C47/45 , C07C51/00 , C07C61/13 , C07C67/00 , C07C69/753 , C07C209/00 , C07C209/26 , C07C209/28 , C07C209/52 , C07C209/88 , C07C211/03 , C07C211/17 , C07C211/19 , C07C211/27 , C07C211/38 , C07C211/44 , C07C213/08 , C07C231/00 , C07C231/02 , C07C233/55 , C07D295/02 , C07D295/03 , C07D295/22 , C07D29/10 , C07C31/02 , C07C43/30 , C07C103/19 , C07D27/04 , C07C87/36 , C07C87/50 , C07C87/08 , C07C87/28 , C07C61/10 , C07C69/74 , C07C47/30 , C07C49/43
Abstract: Pinanes substituted by a group X in the 3-position which group is formyl, or its alkyl-acetals or alkyl-hemiacetals, carboxylic acid, carboxylic acid chloride, carboxylic acid amide, hydroxymethyl or aminomethyl substituted in a specific manner at the nitrogen, the optical isomers of these compounds and a process for their manufacture by hydroformylation of alpha -pinene in the presence of rhodium catalysts, and conversion of the 3-formylpinane first produced into the above derivatives by conventional methods.
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公开(公告)号:ES2266299T3
公开(公告)日:2007-03-01
申请号:ES01990455
申请日:2001-11-29
Applicant: BASF AG
Inventor: KLATT MARTIN JOCHEN , NIEBEL MARKUS , PAUST JOACHIM
IPC: C07D339/04
Abstract: Procedimiento para la obtención del ácido R- o S- dihidrolipoico, que comprende (a) la reacción de o sus estereoisómeros, donde MS significan SO2-R¿ y R y R¿ significan, independientemente entre sí, alquilo con 1 a 6 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono, cicloalquilalquilo con 3 a 8 átomos de carbono, arilo o aralquilo, con sulfuro de sodio y azufre en metanol.
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公开(公告)号:ES2186065T3
公开(公告)日:2003-05-01
申请号:ES98114885
申请日:1998-08-07
Applicant: BASF AG
Inventor: WEGNER CHRISTOPH , PAUST JOACHIM , JOHN MICHAEL
IPC: C07C403/24 , C07C11/21 , C07F9/54
Abstract: New and known phosphonium salts are prepared by reacting an alcohol with a triarylphosphine and a sulfonic acid in a solvent. Preparation of phosphonium salts of formula (I) comprises reaction of 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol (II) with a triarylphosphine and a sulfonic acid of formula XH (III) in a solvent. X = Q-SO3 ; Q = CnH2n+1, Ar' or CF3; R = aryl; n = 1, 2, 3 or 4; Ar' = phenyl or toluyl Independent claims are included for: (1) compounds (I) when Q is other than Ar'; and (2) preparation of lycopine by reaction of a compound of formula (I) with 2,7-dimethyl-2,4,6- octatrienedial.
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公开(公告)号:CA2417842A1
公开(公告)日:2003-01-30
申请号:CA2417842
申请日:2001-07-24
Applicant: BASF AG
Inventor: PAUST JOACHIM , KLATT MARTIN JOCHEN , NIEBEL MARKUS
IPC: A61K31/20 , A61P3/10 , C07B53/00 , C07C303/38 , C07C309/66 , C07C319/08 , C07C319/18 , C07C319/28 , C07C321/04 , C07C323/52 , C07D339/04
Abstract: The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents SO2-R', and R and R' independently mean C1-C6-alkyl, C3-C8- cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulphide and sulphur in ethanol and reaction with a complex hydride, (c) extraction of a protic solution of R dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent at a pH value of 9 -10, or (d) extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent from a protic solution at a pH value of 4 - 5, or a combination of individual or several steps (a) - (d). The invention also relates to a method for producing dihydrolipoic acid and the compound 1,6,8 octane triol.
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公开(公告)号:AU751485B2
公开(公告)日:2002-08-15
申请号:AU4909499
申请日:1999-07-12
Applicant: BASF AG
Inventor: KLATT MARTIN JOCHEN , NIEBEL MARKUS , PAUST JOACHIM , RIEGER JENS
IPC: A23L1/30 , A61K31/385 , C07B57/00 , C07D339/04
Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.
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公开(公告)号:CA2430073A1
公开(公告)日:2002-06-06
申请号:CA2430073
申请日:2001-11-29
Applicant: BASF AG
Inventor: NIEBEL MARKUS , KLATT MARTIN JOCHEN , PAUST JOACHIM
IPC: C07D339/04
Abstract: The invention relates to a method for producing R- and S-lipoic acid and R- dihydrolipoic acid comprising the following steps: (a) reaction of the compound of formula (2) with sodium sulphide and sulphur in methanol, whereby Ms represents SO2R', and R and R' independently of one another represent C1-C6 alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl. The invention relates in particular to methods for producing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to obtain R- and S- lipoic acid. The method is also used to produce medicaments. The invention also relates to a solution of sodium sulphide-trihydrate and sulphur in methanol, whereby the sulphur is present as a molar surplus in relation to the sodium sulphide-trihydrate, and to a kit that comprises the inventive solution.
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公开(公告)号:BR9912622A
公开(公告)日:2001-04-24
申请号:BR9912622
申请日:1999-07-12
Applicant: BASF AG
Inventor: KLATT MARTIN JOCHEN , NIEBEL MARKUS , PAUST JOACHIM , RIEGER JENS
IPC: A23L1/30 , A61K31/385 , C07B57/00 , C07D339/04
Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.
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公开(公告)号:DE19940641A1
公开(公告)日:2001-03-01
申请号:DE19940641
申请日:1999-08-26
Applicant: BASF AG
Inventor: PAUST JOACHIM , ERNST HANSGEORG , KACZMAREK REINHARD , JAEDICKE HAGEN
IPC: C07B61/00 , C07C231/08 , C07C233/18 , C07C233/47 , C07C233/69 , C07C233/83 , C07C231/12 , C07C233/46 , C07C233/17
Abstract: Preparation of N-acyl derivatives (I) using readily available starting materials. N-acyl derivatives of formula R -C(O)N(H)C(R )X (I) are prepared by reacting, in the presence of a compound of formula R -COOH (II), a carbonic acid amide of formula R -CONH2 (III) and a glyoxalmonoacetal derivative of formula R C(O)C(OR )OR (IV). R , R = H or optionally substituted alkyl or aryl; R ,R = 1 - 12C alkyl; and X = CH(OR ) or COOR . An Independent claim is also included for a compound of formula R -C(O)N(H)C(R )C(OR )OR (V).
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