公开(公告)号：CA1058626A

公开(公告)日：1979-07-17

申请号：CA256969

申请日：1976-07-14

Applicant: BASF AG

Inventor： PAUST JOACHIM ,  SCHNEIDER JOACHIM ,  JAEDICKE HAGEN

IPC: C07B61/00 ,  B01J21/00 ,  B01J23/00 ,  C07C20060101 ,  C07C49/21 ,  C07C49/653 ,  C07C67/00 ,  C07C67/30 ,  C07C69/52 ,  C07C401/00 ,  C07C403/00 ,  C07C403/24 ,  C07C175/00

Abstract: Process for the manufacture of canthaxanthin by oxidizing B-carotene, retro-dehydro-carotene or echinenone with a salt of chloric or bromic acid in the presence of a catalyst and of an inert diluent or solvent.

公开(公告)号：AU7760675A

公开(公告)日：1976-07-29

申请号：AU7760675

申请日：1975-01-24

Applicant: BASF AG

Inventor： HOFFMANN WERNER ,  HIMMELE WALTER ,  PAUST JOACHIM ,  FRANUBERG KARL VON ,  SIEGEL HARDO ,  PFOHL SIGBERG

IPC: B01D9/02 ,  C07B31/00 ,  C07B57/00 ,  C07C51/00 ,  C07C59/105 ,  C07C67/00 ,  C07C209/00 ,  C07C209/26 ,  C07C211/19 ,  C07D307/33 ,  C07C87/06 ,  C07D5/06

Abstract: A process for resolving racemic alpha -hydroxy- beta , beta -dimethyl- gamma -butyrolactone, referred to as D,L-pantolactone, into its optical antipodes, based on the separation of diastereomeric salts of D,L-pantoic acid ( alpha , gamma -dihydroxy- beta , beta -dimethylbutyric acid), produced from D,L-pantolactone, by means of (-)-3-aminomethylpinane, (+)-3-aminomethylpinane or one of their acid addition salts, as a new resolving agent.

公开(公告)号：AU7728975A

公开(公告)日：1976-07-15

申请号：AU7728975

申请日：1975-01-14

Applicant: BASF AG

Inventor： HOFFMANN WERNER ,  HIMMELE WALTER ,  PAUST JOACHIM ,  FRAUNBERG KARL VON ,  SIEGEL HARDO ,  PFOHL SIEGBERG

IPC: C07C31/137 ,  C07B61/00 ,  C07C27/00 ,  C07C29/14 ,  C07C29/141 ,  C07C41/00 ,  C07C43/303 ,  C07C45/00 ,  C07C45/50 ,  C07C47/347 ,  C07C47/45 ,  C07C51/00 ,  C07C61/13 ,  C07C67/00 ,  C07C69/753 ,  C07C209/00 ,  C07C209/26 ,  C07C209/28 ,  C07C209/52 ,  C07C209/88 ,  C07C211/03 ,  C07C211/17 ,  C07C211/19 ,  C07C211/27 ,  C07C211/38 ,  C07C211/44 ,  C07C213/08 ,  C07C231/00 ,  C07C231/02 ,  C07C233/55 ,  C07D295/02 ,  C07D295/03 ,  C07D295/22 ,  C07D29/10 ,  C07C31/02 ,  C07C43/30 ,  C07C103/19 ,  C07D27/04 ,  C07C87/36 ,  C07C87/50 ,  C07C87/08 ,  C07C87/28 ,  C07C61/10 ,  C07C69/74 ,  C07C47/30 ,  C07C49/43

Abstract: Pinanes substituted by a group X in the 3-position which group is formyl, or its alkyl-acetals or alkyl-hemiacetals, carboxylic acid, carboxylic acid chloride, carboxylic acid amide, hydroxymethyl or aminomethyl substituted in a specific manner at the nitrogen, the optical isomers of these compounds and a process for their manufacture by hydroformylation of alpha -pinene in the presence of rhodium catalysts, and conversion of the 3-formylpinane first produced into the above derivatives by conventional methods.

公开(公告)号：ES2266299T3

公开(公告)日：2007-03-01

申请号：ES01990455

申请日：2001-11-29

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM

IPC: C07D339/04

Abstract: Procedimiento para la obtención del ácido R- o S- dihidrolipoico, que comprende (a) la reacción de o sus estereoisómeros, donde MS significan SO2-R¿ y R y R¿ significan, independientemente entre sí, alquilo con 1 a 6 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono, cicloalquilalquilo con 3 a 8 átomos de carbono, arilo o aralquilo, con sulfuro de sodio y azufre en metanol.

公开(公告)号：ES2186065T3

公开(公告)日：2003-05-01

申请号：ES98114885

申请日：1998-08-07

Applicant: BASF AG

Inventor： WEGNER CHRISTOPH ,  PAUST JOACHIM ,  JOHN MICHAEL

IPC: C07C403/24 ,  C07C11/21 ,  C07F9/54

Abstract: New and known phosphonium salts are prepared by reacting an alcohol with a triarylphosphine and a sulfonic acid in a solvent. Preparation of phosphonium salts of formula (I) comprises reaction of 3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol (II) with a triarylphosphine and a sulfonic acid of formula XH (III) in a solvent. X = Q-SO3 ; Q = CnH2n+1, Ar' or CF3; R = aryl; n = 1, 2, 3 or 4; Ar' = phenyl or toluyl Independent claims are included for: (1) compounds (I) when Q is other than Ar'; and (2) preparation of lycopine by reaction of a compound of formula (I) with 2,7-dimethyl-2,4,6- octatrienedial.

公开(公告)号：CA2417842A1

公开(公告)日：2003-01-30

申请号：CA2417842

申请日：2001-07-24

Applicant: BASF AG

Inventor： PAUST JOACHIM ,  KLATT MARTIN JOCHEN ,  NIEBEL MARKUS

IPC: A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04

Abstract: The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents SO2-R', and R and R' independently mean C1-C6-alkyl, C3-C8- cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulphide and sulphur in ethanol and reaction with a complex hydride, (c) extraction of a protic solution of R dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent at a pH value of 9 -10, or (d) extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with an organic solvent from a protic solution at a pH value of 4 - 5, or a combination of individual or several steps (a) - (d). The invention also relates to a method for producing dihydrolipoic acid and the compound 1,6,8 octane triol.

公开(公告)号：AU751485B2

公开(公告)日：2002-08-15

申请号：AU4909499

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L1/30 ,  A61K31/385 ,  C07B57/00 ,  C07D339/04

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.

公开(公告)号：CA2430073A1

公开(公告)日：2002-06-06

申请号：CA2430073

申请日：2001-11-29

Applicant: BASF AG

Inventor： NIEBEL MARKUS ,  KLATT MARTIN JOCHEN ,  PAUST JOACHIM

IPC: C07D339/04

Abstract: The invention relates to a method for producing R- and S-lipoic acid and R- dihydrolipoic acid comprising the following steps: (a) reaction of the compound of formula (2) with sodium sulphide and sulphur in methanol, whereby Ms represents SO2R', and R and R' independently of one another represent C1-C6 alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl. The invention relates in particular to methods for producing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to obtain R- and S- lipoic acid. The method is also used to produce medicaments. The invention also relates to a solution of sodium sulphide-trihydrate and sulphur in methanol, whereby the sulphur is present as a molar surplus in relation to the sodium sulphide-trihydrate, and to a kit that comprises the inventive solution.

公开(公告)号：BR9912622A

公开(公告)日：2001-04-24

申请号：BR9912622

申请日：1999-07-12

Applicant: BASF AG

Inventor： KLATT MARTIN JOCHEN ,  NIEBEL MARKUS ,  PAUST JOACHIM ,  RIEGER JENS

IPC: A23L1/30 ,  A61K31/385 ,  C07B57/00 ,  C07D339/04

Abstract: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.

公开(公告)号：DE19940641A1

公开(公告)日：2001-03-01

申请号：DE19940641

申请日：1999-08-26

Applicant: BASF AG

Inventor： PAUST JOACHIM ,  ERNST HANSGEORG ,  KACZMAREK REINHARD ,  JAEDICKE HAGEN

IPC: C07B61/00 ,  C07C231/08 ,  C07C233/18 ,  C07C233/47 ,  C07C233/69 ,  C07C233/83 ,  C07C231/12 ,  C07C233/46 ,  C07C233/17

Abstract: Preparation of N-acyl derivatives (I) using readily available starting materials. N-acyl derivatives of formula R -C(O)N(H)C(R )X (I) are prepared by reacting, in the presence of a compound of formula R -COOH (II), a carbonic acid amide of formula R -CONH2 (III) and a glyoxalmonoacetal derivative of formula R C(O)C(OR )OR (IV). R , R = H or optionally substituted alkyl or aryl; R ,R = 1 - 12C alkyl; and X = CH(OR ) or COOR . An Independent claim is also included for a compound of formula R -C(O)N(H)C(R )C(OR )OR (V).