公开(公告)号：JP2002187864A

公开(公告)日：2002-07-05

申请号：JP2001302191

申请日：2001-09-28

Applicant: BASF AG

Inventor： GRIMMER JOHANNES ,  MUELLER THOMAS ,  ERNST HANSGEORG

IPC: C07D317/46 ,  A61K31/045 ,  A61K31/12 ,  C07C45/00 ,  C07C45/62 ,  C07C49/743 ,  C07C49/753 ,  C07C403/08 ,  C07D317/00 ,  C07D317/12 ,  C07D317/48 ,  C07F7/18

Abstract: PROBLEM TO BE SOLVED: To provide a new method for partial reduction of an alkyne compound while avoiding disadvantageous points of the conventional techniques. SOLUTION: This method for producing a cyclohexene derivative represented by general formula I or II [R1 is a group of formula V, a group of formula VI, a group of formula VII or a group of formula VII; R2 is OH or a protective group convertible to OH by hydrolysis; R3 and R4 are each hydrogen or a 1-4C alkyl; R5 is hydrogen or a 1-4C acyl] comprises reducing an alkyne compound represented by general formula III or IV [R1 and R2 are each as defined above]. The reducing agent used is a mixture of zinc and at least one or more compounds B selected from the group consisting of an ammonium salt, a copper salt, an alkali metal salt and an alkaline earth metal salt.

公开(公告)号：JP2002348260A

公开(公告)日：2002-12-04

申请号：JP2002062483

申请日：2002-03-07

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  HENRICH KLAUS

IPC: C07D317/14 ,  C07C41/48 ,  C07C43/315 ,  C07C45/38 ,  C07C45/72 ,  C07C47/277 ,  C07C67/31 ,  C07C67/333 ,  C07C67/343 ,  C07C69/73 ,  C07C69/734 ,  C07C69/74 ,  C07D317/18 ,  C07D317/20 ,  C07D317/26 ,  C07D317/30 ,  C07D319/06

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a C10 -dialdehyde monoacetal on an industrial scale. SOLUTION: The method for producing 2,7-dimethyl-2,4,6-octatrienal monoacetal shown by formula I comprises (a) condensing an ester phosphonium salt shown by formula II or an ester phosphonate shown by formula III and an aldehyde shown by formula IV in a Wittig or Wittig-Horner reaction to form an acetal ester shown by formula V, (b) reducing the ester shown by formula V to form an acetal alcohol shown by formula VI and (c) oxidizing the alcohol shown by formula VI to form 2,7-dimethyl-2,4,6-octatrienal monoacetal shown by formula I, wherein, R , R , R , R and R are for example, a 1-8C alkyl; R is an aryl; X is an inorganic or organic anion.

公开(公告)号：JP2003113159A

公开(公告)日：2003-04-18

申请号：JP2002268971

申请日：2002-09-13

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  HENRICH KLAUS ,  DITRICH KLAUS

IPC: A61K31/045 ,  C07B61/00 ,  C07C29/74 ,  C07C35/17 ,  C07C35/18 ,  C07C43/196 ,  C07C47/21 ,  C07C47/225 ,  C07C69/013 ,  C07C69/14 ,  C07C69/16 ,  C07C69/63 ,  C07C69/65 ,  C07C403/08 ,  C07C403/24

Abstract: PROBLEM TO BE SOLVED: To provide a method for efficiently producing a meso-zeaxanthine in a high yield. SOLUTION: This method for producing the three-dimensionally homogeneous meso-zeaxanthine comprises (a) resolving a racemic mixture of acetylenediols (R-I) and (S-I) to enantiomers (R-I) and (S-I), (b) each converting the enantiomers (R-I) and (S-I) to 15C phosphonium salts (R-II) and (S-II), (c) reacting R-II or S-II with a 10C dialkylmonoacetal by Wittig reaction to provide 25C acetal R-IV or S-IV, (d) converting R-IV or S-IV to 25C aldehyde R-V or S-V and (e) reacting R-V with a 15C phosphonium salt S-II or reacting S-V with a 15C phosphonium salt R-II.

公开(公告)号：JP2002241340A

公开(公告)日：2002-08-28

申请号：JP2002030768

申请日：2002-02-07

Applicant: BASF AG

Inventor： KLEIN DANIELA ,  ERNST HANSGEORG ,  KOPPENHOFER JURGEN

IPC: C07B61/00 ,  C07C51/09 ,  C07C57/03 ,  C07C67/343

Abstract: PROBLEM TO BE SOLVED: To provide a new method for producing cis-6-hexadecenoic acid, progressing with high Z/E selectivity, and having no defect concerning safety, possessed by a conventional well-known process. SOLUTION: This method for producing the cis-6-hexadecenoic acid represented by formula I comprises (a1) reacting a triphenylphosphonium salt represented by formula II with decanal represented by formula III, or (a2) reacting a triphenylphosphonium salt represented by formula IV with an aldehyde represented by formula V by a Witting reaction, and (b) saponifying the ester produced in the steps (a1) or (a2) and represented by formula VI. (In the formulas, substituents R1, R2 and X- are same as those defined in the specification).

公开(公告)号：JP2004155752A

公开(公告)日：2004-06-03

申请号：JP2003000492

申请日：2003-01-06

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： ERNST HANSGEORG ,  HENRICH KLAUS

IPC: C07C45/47 ,  C07C47/19 ,  C07D317/20 ,  C07D317/26 ,  C07D317/30 ,  C07D319/06

CPC classification number: C07D317/30 ,  C07D317/20 ,  C07D317/26 ,  C07D319/06

Abstract: PROBLEM TO BE SOLVED: To provide an industrially practicable new method for the production of a polyene dialdehyde monoacetal.
SOLUTION: An ester (formula IV) is produced according to the reaction formula by the Wittig or Wittig-Horner reaction of a polyene aldehyde (formula II). In the formula 1, R
1 and R
2 are each a 1-8C alkyl or form a dioxolane or dioxane group of the formulas together with the carbon atom bonding to the groups. In the formulas, R
3 , R
4 and R
5 are each H or an alkyl and R
6 is a 1-8C alkyl. The ester (formula IV) is reduced and then oxidized to obtain the polyene dialdehyde monoacetal (formula I).
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2001316377A

公开(公告)日：2001-11-13

申请号：JP2001094120

申请日：2001-03-28

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  FRAUENKRON MATTHIAS ,  MELDER JOHANN-PETER ,  FUNKE FRANK ,  KELLER ANDREAS

IPC: C07B61/00 ,  C07D239/42

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing 2-methyl-4-amino-5- aminomethylpyrimidine by starting from β-alkoxypropionitrile of a precursor. SOLUTION: This method for producing the 2-methyl-4-amino-5- aminomethylpyrimidine of formula 1 comprises reacting 2-methyl-4-amino-5- alkoxymethylpyrimidine of formula 2 (wherein, R is a 1-6C alkyl) with ammonia in the presence of a catalyst.

公开(公告)号：JP2004292461A

公开(公告)日：2004-10-21

申请号：JP2004202237

申请日：2004-07-08

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： ERNST HANSGEORG ,  DOBLER WALTER ,  PAUST JOACHIM ,  RHEUDE UDO

IPC: C07C41/18 ,  C07C45/45 ,  C07C49/303 ,  C07C403/24 ,  C07D317/46 ,  C07D317/50 ,  C07D317/54 ,  C07D407/06 ,  C07D407/12 ,  C07F9/54 ,  C09B23/10

CPC classification number: C07C403/24 ,  C07C403/04 ,  C07C403/08 ,  C07C403/10 ,  C07C2601/16 ,  C07D317/46 ,  C07F9/5435 ,  C07F9/5442 ,  Y02P20/55

Abstract: PROBLEM TO BE SOLVED: To improve a known method for synthesizing astaxanthin so as to avoid defects of a conventional technology for connecting a 9C unit with a 6C unit. SOLUTION: The 9C unit is connected with the proper 6C unit by using a 3-methylpentenyn-3-ol derivative represented by formula (I) (wherein, R 3 is an ether transformable into hydroxy by hydrolysis, a silyl ether or an acetal protective group) in an organic solvent in the presence of lithium amide instead of butyllithium or a Grignard reagent. The method for synthesizing is more economical than ones using butyllithium or a Grignard reagent. COPYRIGHT: (C)2005,JPO&NCIPI

公开(公告)号：JP2001097912A

公开(公告)日：2001-04-10

申请号：JP2000292408

申请日：2000-09-26

Applicant: BASF AG

Inventor： WEGNER CHRISTOPH ,  PAUST JOACHIM ,  ERNST HANSGEORG

IPC: C07C41/28 ,  C07B61/00 ,  C07C41/50 ,  C07C43/15

Abstract: PROBLEM TO BE SOLVED: To find one method capable of producing tetramethoxybutene by an industrially simple process especially continuously in an excellent yield and reducing formation of pentamethoxybutane in the production. SOLUTION: In this method for producing 1,1,4,4-tetramethoxybutene-2 by reacting 2,5-dimethoxy-dihydrofuran with methanol in the presence of an acid, the reaction is carried out in the presence of an acidic organic ion exchanger selected from the group H type zeolite, a mixed oxide of acid and a laminar silicate containing an acid center or an inorganic oxide catalyst containing an acid center.

公开(公告)号：JP2001072652A

公开(公告)日：2001-03-21

申请号：JP2000252489

申请日：2000-08-23

Applicant: BASF AG

Inventor： PAUST JOACHIM ,  ERNST HANSGEORG ,  KACZMAREK REINHARD ,  HAGEN IEEDIKKE

IPC: C07B61/00 ,  C07C231/08 ,  C07C233/18 ,  C07C233/47 ,  C07C233/69 ,  C07C233/83

Abstract: PROBLEM TO BE SOLVED: To produce the subject compound in high yield by reacting a carboxamide with a glyoxal monoacetal derivative in the presence of a carboxylic acid. SOLUTION: (A) A carboxamide represented by the formula: R1-CONH2 [R1 is H, a 1-12C alkyl or a (substituted) aryl] is reacted with (B) a glyoxal monoacetal derivative represented by formula I [R2 is H, a 1-12C alkyl or a (substituted) aryl; R3 is a 1-12C alkyl] in the presence of (C) a carboxylic acid represented by the formula; R4-COOH (R4 is a 1-12C alkyl), preferably at 40-200 deg.C under 200-1,000 mbars to thereby produce a compound represented by formula II [X is CH(OR3)2 or COOR3]. In the above reaction, the components A and C are used in respective amounts of 250-800 mol% based on the component B. The ratio of the components A:C is preferably 1:1 expressed in terms of molar ratio.

公开(公告)号：WO2006032425A3

公开(公告)日：2006-04-27

申请号：PCT/EP2005010057

申请日：2005-09-17

Applicant: BASF AG ,  BERL VOLKER ,  WETTERICH FRANK ,  ERNST HANSGEORG ,  SCHEIN KARIN

Inventor： BERL VOLKER ,  WETTERICH FRANK ,  ERNST HANSGEORG ,  SCHEIN KARIN

IPC: C07C17/32 ,  C07C50/28

CPC classification number: C07C46/00 ,  C07C46/08 ,  C07C50/28

Abstract: The present invention relates to a practical and cost-effective method for the synthesis of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones by direct chloromethylation of the corresponding 2,3-dialkoxy-6-alkyl-1,4-benzoquinones. The invention further relates to a method for the preparation of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones starting from a 3,4,5-trialkoxy-1-alkyl-benzene. The invention also relates to a method for the production of Coenzymes Q n , especially coenzyme Q 10 .

Abstract translation: 本发明涉及通过相应的2,3-二烷氧基-6-烷基-1,4-苯醌的直接氯甲基化合成5-氯甲基化2,3-二烷氧基-6-烷基-1,4-苯醌的实用和成本有效的方法。 1,4-苯醌。 本发明还涉及从3,4,5-三烷氧基-1-烷基 - 苯开始制备5-氯甲基化2,3-二烷氧基-6-烷基-1,4-苯醌的方法。 本发明还涉及生产辅酶Q 1，特别是辅酶Q 10的方法。