公开(公告)号：WO1994014019A1

公开(公告)日：1994-06-23

申请号：PCT/US1993010563

申请日：1993-11-01

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WRIGHT, Herschel, E.

IPC: F25D31/00

CPC classification number: F28D1/06 ,  B04B15/02 ,  B21D53/02 ,  F25D31/006

Abstract: A refrigerant tubing (34) is preformed to provide a flat contact surface (42) against the outside surface of a centrifuge chamber (32). The tubing (34) is tightly wound around the centrifuge chamber (32) in a continuous fashion including a flat spiral (46) at the base (33) of the centrifuge chamber. For the section of the tubing in contact with the vertical cylindrical wall (35) of the centrifuge chamber (32), the pressure for maintaining contact pressure between the flat surface (42) of the tubing (34) and the chamber wall (35) is provided by the tension in the wrapping of the tubing (34). For the section of the tubing (34) at the base (33) of the centrifuge chamber (32), contact pressure may be provided by a clamping mechanism (58). To further enhance heat transfer between the refrigerant coils and the centrifuge chamber (32), a high heat conductive epoxy (44) may be applied between the tubing (34) and the centrifuge chamber surface.

Abstract translation: 预制制冷剂管道（34）以提供抵靠离心机室（32）的外表面的平坦接触表面（42）。 管道（34）以连续的方式紧密地卷绕在离心机室（32）周围，包括在离心机室的底部（33）处的扁平螺旋（46）。 对于与离心机室（32）的垂直圆柱形壁（35）接触的管道的部分，用于维持管道（34）的平坦表面（42）和室壁（35）之间的接触压力的压力， 由管（34）的包裹中的张力提供。 对于离心机室（32）的底座（33）处的管道（34）的部分，接触压力可由夹紧机构（58）提供。 为了进一步增强制冷剂盘管与离心机室（32）之间的热传递，可以在管道（34）和离心机腔室表面之间施加高导热环氧树脂（44）。

公开(公告)号：WO1993005152A1

公开(公告)日：1993-03-18

申请号：PCT/US1992005122

申请日：1992-06-15

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  ADAMS, Craig, W. ,  PANG, Patty, P., Y.

IPC: C12N15/13

CPC classification number: C07K16/1267 ,  A61K38/00 ,  C07K14/315

Abstract: Disclosed are antibodies to derivatives and variants of Streptolysin O ("SLO"). Methodologies for generating such antibodies are further disclosed, as are purification protocols for wild-type SLO and assaying techniques for wild-type SLO.

Abstract translation: 公开了针对链球菌溶血素O（“SLO”）的衍生物和变体的抗体。 进一步公开了产生这种抗体的方法，野生型SLO的纯化方案和用于野生型SLO的测定技术也是如此。

公开(公告)号：WO1990013802A1

公开(公告)日：1990-11-15

申请号：PCT/US1990001962

申请日：1990-04-10

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BAKER, Josefina, T. ,  MERVINE, Robert, W. ,  HUCKO, Josephine, T.

IPC: G01N01/02

CPC classification number: A61B10/0038 ,  G01N33/726

Abstract: A method and specimen slide (10) for collecting fecal specimens for occult blood testing. The slide includes a front panel (12) and back panel (14). The front panel (12) includes an aperture (18). A sheet (20) is fixed between the front (12) and back (14) panels and is positioned for receiving the fecal specimen smear through the aperture (18). The sheet (20) includes a plurality of perforations (22) that define removable portions (24) of the sheet. The hinged cover (16) can close the front panel aperture (18) and a flap (36) in the rear panel (14) may be opened to conveniently remove one or more of the removable portions (24) for testing.

Abstract translation: 用于收集粪便标本进行隐血试验的方法和标本片（10）。 滑块包括前面板（12）和后面板（14）。 前面板（12）包括孔（18）。 片（20）固定在前（12）和后（14）面板之间，并且定位成用于通过孔（18）接收粪便标本污迹。 片材（20）包括限定片材的可移除部分（24）的多个穿孔（22）。 铰接盖（16）可以关闭前面板孔（18），并且可以打开后面板（14）中的挡板（36）以方便地移除一个或多个可拆卸部分（24）用于测试。

公开(公告)号：WO1989002089A1

公开(公告)日：1989-03-09

申请号：PCT/US1988001656

申请日：1988-05-16

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WUNDERLY, Stephen, W. ,  QUINT, Joseph, F.

IPC: G01T01/204

CPC classification number: G01T1/2047 ,  G01T1/204

Abstract: A method of scintillation counting utilizes a solid scintillator dispersed on a counting support (16), wherein a sample material is deposited on the counting support over the solid scintillator to produce light emissions in response to particles emitted by a radio-active substance labelling said sample.

Abstract translation: 闪烁计数的方法利用分散在计数支撑体（16）上的固体闪烁体，其中样品材料沉积在固体闪烁体上的计数支持物上，以产生响应由标记所述样品的放射性活性物质发射的颗粒的光发射 。

公开(公告)号：WO1989000689A1

公开(公告)日：1989-01-26

申请号：PCT/US1988002419

申请日：1988-07-15

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GURSKE, William, A. ,  BLESSUM, Cynthia, R. ,  CHENG, Min-Lee ,  ANDRADE, Mark, S.

IPC: G01N27/26

CPC classification number: G01N27/44747

Abstract: A novel agarose gel is provided for use in the high resolution electrophoretic (HRE) separation of serum proteins. The agarose gel employs a novel gel buffer which contains either hippurate, glycine, or a mixture thereof, in combination with barbital and Tris. The agarose gel of the present invention yields improved electrophoretic separation of the serum proteins in a sample whether the same gel buffer is also used as the running buffer or whether a standard barbital running buffer is used.

公开(公告)号：WO1988009219A1

公开(公告)日：1988-12-01

申请号：PCT/US1988001425

申请日：1988-05-22

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GIEBELER, Robert ,  DURLAND, Douglas, H.

IPC: B04B15/02

CPC classification number: B04B15/02

Abstract: To enable centrifuging to occur at precisely determined sample temperatures, a method of calibration, of the measured rotor temperature, which permits rapid and accurate refrigeration of the rotor containing the sample, is disclosed. A rotor (R, R1) with sample to be centrifuged is placed within a centrifuge can (C). Temperature of the radiometer (T), Tra, and temperature of the surrounding refrigerating can Tc is determined at a first time, t0. Thereafter, and at a second time t1, temperature of the radiometer Tra, and the temperature of the surrounding refrigerating can Tc are equilibrated. The temperature excursion between t0 and t1 for the temperatures of the radiometer Tra and the temperature of the refrigerating can Tc are measured to yield respective DELTA Tra and DELTA Tc. The ratio of DELTA Tra/DELTA Tc is taken to give a constant which comprises the ''view factor'' (u) from the radiometer for the particular shape of rotor and the surrounding can. Thereafter, the temperature of the rotor (Tr) will equal the temperature of the radiometer plus the difference in temperature between the refrigerating can (Tc) and the radiometer (Tra), times the determined view factor. It is thereafter possible to maintain a large temperature differential between the refrigerating can and the rotor and bring the rotor (and necessarily the sample) rapidly to a precise temperature where centrifuging can rapidly follow.

公开(公告)号：WO1988002785A2

公开(公告)日：1988-04-21

申请号：PCT/US1987002548

申请日：1987-10-06

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BEEBE, Joan, Marlyn ,  GLANVILLE, Linda, Lee ,  LEARY, Jeffry, Joseph ,  RICE, Edward, Gray

IPC: C12Q01/68

CPC classification number: C12Q1/6816 ,  C12Q1/6813 ,  C12Q1/683 ,  C12Q2565/518 ,  C12Q2537/125 ,  C12Q2563/131

Abstract: A method for detecting a polynucleotide in a sample comprising: combining in liquid phase the sample with a first and second probe, each binding to different sequences of the target polynucleotide. The ''target/probe'' complex is immobilized subsequently with a solid carrier able to bind the first probe. The second probe carries a detectable label. A kit for use with the method and the use thereof for the diagnosis of genetic diseases, such as sickle cell anaemia, and for cancer is disclosed.

Abstract translation: 一种用于检测样品中多核苷酸的方法，包括：在液相中将样品与第一和第二探针结合，每个探针与靶多核苷酸的不同序列结合。 “靶/探针”复合物随后固定有能够结合第一探针的固体载体。 第二个探针携带可检测的标记。 公开了一种用于诊断遗传疾病如镰状细胞性贫血和癌症的方法及其用途的试剂盒。

公开(公告)号：WO1987006008A2

公开(公告)日：1987-10-08

申请号：PCT/US1987000501

申请日：1987-03-05

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  PFOST, Dale, R. ,  BJORNSON, Torleif, O. ,  COPPOCK, Robert, M. ,  KOWALSKI, Carl ,  MARQUISS, Samuel, A. ,  MURRAY, Donald, S. ,  PFOST, R., Fred ,  SANFORD, Brian ,  PUCKETT, Katherine, L.

IPC: G01N35/00

CPC classification number: G01N21/253 ,  G01N35/028 ,  G01N2035/103 ,  G01N2035/106

Abstract: An automated multi-purpose analytical chemistry processing center and laboratory work station having a movable table (28) for supporting microtiter plates (27) and other fluid receptacles, a movable arm (44), and a modular mobile pod (42) affixed for reciprocal movement along the arm (44). The workstation combines into a single programmable system the capabilities for automation of a wide range of bioanalytical procedures including, not only sample pipetting, serial dilution, reagent additions, mixing, reaction timing and similar known manual procedures, but also programmable spectrophotometric measurements and other physical parameters, further processing based on these measurements and automatic data recording. The work station is adapted to transfer, dispense, and aspirate liquid from one location to another automatically in accordance with user programmed instructions. The work station is capable of measuring physical characteristics of selected samples and performing experimental assays in a closed loop manner in accordance with those measurements. Fluid is dispensed and aspirated using an interchangeable modules (52) having one or a selected plurality of nozzles (54). Affixed to the modules nozzles are disposable pipettor tips (56), which are automatically picked up by the pod (42) and ejected by a tip ejector mechanism (58) at the control of the user. Additional modules may be used to perform Measurement Functions. The work station is designed for interactive connection with a remote computer.

Abstract translation: 一种自动多功能分析化学处理中心和实验室工作站，其具有用于支撑微量滴定板（27）和其它流体容器的活动台（28），可移动臂（44）和用于往复运动的模块化移动容器（42） 沿着臂（44）的运动。 该工作站将单个可编程系统结合成一系列生物分析程序的自动化功能，包括样品移液，连续稀释，试剂添加，混合，反应时间和类似的已知手动程序，还可编程分光光度测量和其他物理 参数，基于这些测量和自动数据记录的进一步处理。 工作站适合于根据用户编程的指令自动将液体从一个位置传输，分配和吸出。 工作站能够测量所选样品的物理特性，并根据这些测量以闭环方式进行实验测定。 使用具有一个或所选择的多个喷嘴（54）的可互换模块（52）来分配和抽吸流体。 与模块喷嘴相连的是一次性移液器吸头（56），其由容器（42）自动拾取并由用户的控制下的尖端喷射器机构（58）喷射。 附加模块可用于执行测量功能。 工作站设计用于与远程计算机进行交互式连接。

公开(公告)号：WO1987003960A1

公开(公告)日：1987-07-02

申请号：PCT/US1986002776

申请日：1986-12-22

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  THEOBALD, Paul, E. ,  SEYMOUR, Daniel, B. ,  OKAWA, Dobson, M.

IPC: G01N21/47

CPC classification number: G01N21/82 ,  G01N21/47 ,  G01N2021/1748 ,  G01N2201/122 ,  G01N2201/125

Abstract: A scatter signal is produced from light scattered by a precipitate formed by a chemical reaction and non-specific scatter sources. A blanking signal is produced for a scatter signal from light scattered only by the non-specific scatter sources that contribute to the scatter signal, and the blanking signal is subtracted from the scatter signal to dynamically produce a signal indicative of the difference between the scatter signals to reduce the effects of non-specific scattering sources in determining the rate of change of the light scattered by the precipitate. One of the scatter signals may be stored and then combined with the other, or the signals may be measured simultaneously and then combined.

Abstract translation: 由通过化学反应和非特异性散射源形成的沉淀散射的光产生散射信号。 产生用于散射信号的消隐信号，该散射信号仅由有助于散射信号的非特定散射光散射，并且从散射信号中减去消隐信号，以动态产生指示散射信号之间的差异的信号 以减少非特异性散射源在确定由沉淀物散射的光的变化率的影响。 可以存储一个散射信号，然后与另一个散射信号组合，或者可以同时测量信号，然后组合。

公开(公告)号：WO1986003137A1

公开(公告)日：1986-06-05

申请号：PCT/US1985002276

申请日：1985-11-15

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  LEYTES, Lev, J. ,  PENHASI, Harry, A.

IPC: B01F15/00

CPC classification number: B01F5/008 ,  B01F5/0077

Abstract: A mixing valve includes a housing having inlet ports (14, 16) and an outlet port (18) that intersect at a valve chamber. A valve core (20) within the valve chamber includes passages (34-36) in fluid communication with the inlet and outlet ports. The passages intersect at a cavity (38) within the valve core. An elastomeric seal (44) retained within the cavity sealingly engages the valve core around the passages in the absence of fluid pressure in the inlets. Injection of a pressurized fluid in one of the inlets causes the seal to move away from both the corresponding inlet passage to permit fluid flow from the pressurized inlet port to the outlet port and compresses the seal around the other inlet port to provide a tighter seal than existed before application of pressure to the first port.

Abstract translation: 混合阀包括具有入口端口（14,16）的壳体和在阀室处相交的出口端口（18）。 阀室内的阀芯（20）包括与入口和出口流体连通的通道（34-36）。 通道在阀芯内的空腔（38）处相交。 保持在腔内的弹性体密封件（44）在入口中没有流体压力的情况下密封地接合通道周围的阀芯。 在一个入口中注入加压流体使得密封件从相应的入口通道移开，以允许流体从加压入口端口流到出口端口并且压缩围绕另一个入口端口的密封件以提供更紧密的密封件 在向第一港口施加压力之前存在。