公开(公告)号：DK2681306T3

公开(公告)日：2019-04-23

申请号：DK12751920

申请日：2012-02-28

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  KIM HYUN JUNG

IPC: C12M3/02 ,  C12N1/14 ,  C12N1/20 ,  C12N5/071

公开(公告)号：AU2019202169A1

公开(公告)日：2019-04-18

申请号：AU2019202169

申请日：2019-03-28

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  KIM HYUN JUNG

IPC: C12M3/02 ,  C12N1/14 ,  C12N1/20 ,  C12N5/071

Abstract: Abstract The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora. - 61- WO 2012/118799 PCT/US2012/026934 - -% 0 -- - 2 'CYD C3 (nuzjIEL; - C= SUSIUTSET(UE6

公开(公告)号：CA3070447A1

公开(公告)日：2019-01-31

申请号：CA3070447

申请日：2018-07-27

Applicant: HARVARD COLLEGE

Inventor： JOLLY PAWAN ,  HENRY OLIVIER YVES FREDERIC ,  INGBER DONALD E ,  SABATE DEL RIO JONATHAN

IPC: C09D5/24 ,  C08K3/20

Abstract: Carbon nanotubes or graphene combined with proteinaceous material forming compositions that can be coated on surfaces are described. For example, the described compositions can be used as a coating on an electrode. The coatings can be functionalized with capture agents, targeting specific analytes. In addition to being conductive, the coatings prevent fouling and passivation of the electrodes by non-specific binding. This allows the coated electrodes to be used in complex matrices such as can be found in biological fluids and tissues. The coated electrodes can be regenerated and reused repeatedly.

公开(公告)号：MA44252A

公开(公告)日：2018-12-26

申请号：MA44252

申请日：2017-02-16

Applicant: HARVARD COLLEGE

Inventor： ALI OMAR ABDEL-RAHMAN ,  CARTWRIGHT MARK JOSEPH ,  DOHERTY EDWARD ,  GRAVELINE AMANDA ,  INGBER DONALD E ,  MOONEY DAVID J ,  SEILER BENJAMIN ,  STAFFORD ALEXANDER ,  SUPER MICHAEL ,  WHITE DES

IPC: A61K39/00 ,  A61K8/00 ,  A61K48/00 ,  C07K14/435 ,  C07K14/47 ,  C12N9/00

公开(公告)号：AU2016364932A2

公开(公告)日：2018-10-18

申请号：AU2016364932

申请日：2016-12-02

Applicant: HARVARD COLLEGE

Inventor： NOVAK RICHARD ,  MCPARTLIN LORI ,  INGBER DONALD E ,  CHOE YOUNGJAE ,  LENG LIAN ,  NGUYEN JUSTIN K ,  VARONE ANTONIO ,  WEN NORMAN ,  LEVNER DANIEL

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  C12M3/04 ,  C12Q1/02

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：AU2016364932A1

公开(公告)日：2018-07-19

申请号：AU2016364932

申请日：2016-12-02

Applicant: HARVARD COLLEGE

Inventor： VARONE ANTONIO ,  WEN NORMAN ,  LEVNER DANIEL ,  NOVAK RICHARD ,  MCPARTLIN LORI ,  INGBER DONALD E ,  CHOE YOUNGJAE ,  LENG LIAN ,  NGUYEN JUSTIN K

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  C12M3/04 ,  C12Q1/02

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：AU2014268603B2

公开(公告)日：2018-03-22

申请号：AU2014268603

申请日：2014-05-21

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  WATTERS ALEXANDER L ,  SNELL PHILIP T ,  INGBER DONALD E

IPC: C07K14/805 ,  A61K38/00

Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.

公开(公告)号：AU2016233335A2

公开(公告)日：2017-12-07

申请号：AU2016233335

申请日：2016-03-16

Applicant: HARVARD COLLEGE

Inventor： COON JAMES ,  HAMKINS-INDIK TIAMA ,  INGBER DONALD E ,  INGRAM MILES ,  LEVNER DANIEL ,  NOVAK RICHARD ,  PUERTA JEFFERSON ,  SHEA DANIEL E ,  SLIZ JOSIAH ,  WEN NORMAN

IPC: B29C41/18 ,  B29C33/20 ,  B29C41/38

Abstract: A method for micro-molding a polymeric membrane and including pouring a predetermined volume of curable polymer unto a micro-fabricated mold having a post array with pillars, and overlaying the polymer with a support substrate. A spacer, such as a rubber spacer, is placed in contact with the support substrate and a force is applied to an exposed side of the spacer to compress the support substrate and the polymer together. While applying the force, the polymer is cured on the mold for a predetermined time period and at a predetermined temperature to form a polymeric membrane having a pore array with a plurality of pores corresponding to the plurality of pillars of the post array. The polymeric membrane is removed from the support substrate.

公开(公告)号：AU2016285700A1

公开(公告)日：2017-11-30

申请号：AU2016285700

申请日：2016-04-25

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  VAN DER MEER ANDRIES ,  HERLAND ANNA

IPC: C12M1/02 ,  C12M1/18

Abstract: Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types.

公开(公告)号：AU2016233335A1

公开(公告)日：2017-10-26

申请号：AU2016233335

申请日：2016-03-16

Applicant: HARVARD COLLEGE

Inventor： COON JAMES ,  HAMKINS-INDIK TIAMA ,  INGBER DONALD E ,  INGRAM MILES ,  LEVNER DANIEL ,  NOVAK RICHARD ,  PUERTA JEFFERSON ,  SHEA DANIEL E ,  SLIZ JOSIAH ,  WEN NORMAN

IPC: B29C41/18 ,  B29C33/20 ,  B29C41/38

Abstract: A method for micro-molding a polymeric membrane and including pouring a predetermined volume of curable polymer unto a micro-fabricated mold having a post array with pillars, and overlaying the polymer with a support substrate. A spacer, such as a rubber spacer, is placed in contact with the support substrate and a force is applied to an exposed side of the spacer to compress the support substrate and the polymer together. While applying the force, the polymer is cured on the mold for a predetermined time period and at a predetermined temperature to form a polymeric membrane having a pore array with a plurality of pores corresponding to the plurality of pillars of the post array. The polymeric membrane is removed from the support substrate.