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    RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING
    3.
    发明公开
    RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING 审中-公开
    对抗生素敏感性的快速测试

    公开(公告)号：EP2820147A4

    公开(公告)日：2015-10-14

    申请号：EP13755202

    申请日：2013-02-28

    Applicant: HARVARD COLLEGE

    Inventor： SUPER MICHAEL ,  INGBER DONALD E ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  WORKMAN JOHN SAMUEL ,  LEVNER DANIEL ,  ROTTMAN MARTIN

    IPC: C12Q1/18 ,  G01N33/569

    CPC classification number: G01N33/56938 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2500/10

    Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

    Abstract translation: 本文描述的各个方面的实施方案涉及用于在收集样品后几小时内快速测定微生物的抗生素敏感性的方法，组合物，试剂盒和系统。 在一些实施方案中，本文所述的方法，组合物，试剂盒和系统可以允许基于少量微生物测定微生物的抗生素敏感性，例如与本文所述的微生物靶向底物结合的少至5-10个微生物。

    Organomimetic devices and methods of use and manufacturing thereof
    6.
    发明专利
    Organomimetic devices and methods of use and manufacturing thereof 未知

    公开(公告)号：AU2019253903B2

    公开(公告)日：2021-10-07

    申请号：AU2019253903

    申请日：2019-10-25

    Applicant: HARVARD COLLEGE

    Inventor： FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E ,  HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG

    IPC: B01L3/00 ,  C12M3/00

    Abstract: An organomimetic device comprising: a. a first microchannel height-defining layer having a bottom surface and a first microchannel disposed in the bottom surface wherein the first microchannel height-defining layer comprises: i. a first lamination layer having a first microchannel aperture therein, wherein thickness of the first lamination layer defines the height of the first microchannel; and ii. a first sealing layer disposed on top of the first lamination layer, wherein the first sealing layer provides a top closure of the first microchannel aperture, thereby forming the first microchannel; b. a second microchannel height-defining layer having a top surface and a second microchannel disposed in the top surface; and c. a membrane layer having a membrane portion, the membrane layer being laminated between the bottom surface of the first microchannel height-defining layer and the top surface of the second microchannel height-defining layer, wherein a first surface portion of the membrane portion provides a lower boundary of the first microchannel and a second surface portion of the membrane portion provides an upper boundary of the second microchannel; and wherein at least a portion of the first microchannel is aligned with at least a portion of the second microchannel on an opposite side of the membrane portion. 242 200 244 207 206 202 209 230 -- ,232

    Systems and methods for cell culture device interconnection and fluidic device interconnection
    9.
    发明专利
    Systems and methods for cell culture device interconnection and fluidic device interconnection 未知

    公开(公告)号：AU2014287013B2

    公开(公告)日：2020-01-23

    申请号：AU2014287013

    申请日：2014-07-11

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON III GUY ,  FERNANDEZ-ALCON JOSE ,  HINOJOSA CHRISTOPHER DAVID

    IPC: C12M3/00 ,  B01L3/02 ,  C12M1/26

    Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.

    CELL CULTURE SYSTEM
    10.
    发明专利
    CELL CULTURE SYSTEM 未知

    公开(公告)号：AU2019268194A1

    公开(公告)日：2019-12-12

    申请号：AU2019268194

    申请日：2019-11-22

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  KIM HYUN JUNG

    IPC: C12M3/02 ,  C12N1/14 ,  C12N1/20 ,  C12N5/071

    Abstract: Abstract The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora. - 61- WO 2012/118799 PCT/US2012/026934 - -% 0 -- - 2 'CYD C3 (nuzjIEL; - C= SUSIUTSET(UE6

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