公开(公告)号：EP3019588A4

公开(公告)日：2017-02-22

申请号：EP14823434

申请日：2014-07-11

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON III GUY ,  FERNANDEZ-ALCON JOSE ,  HINOJOSA CHRISTOPHER DAVID

IPC: C12M3/00 ,  B01L3/00 ,  B01L3/02 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/36 ,  C12M3/06

CPC classification number: C12M29/10 ,  B01L3/0293 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0816 ,  C12M21/08 ,  C12M23/16 ,  C12M23/38 ,  C12M23/58 ,  C12M29/00 ,  C12M29/20 ,  C12M37/04 ,  C12M41/48

公开(公告)号：WO2014133624A3

公开(公告)日：2014-11-13

申请号：PCT/US2013074123

申请日：2013-12-10

Applicant: HARVARD COLLEGE

Inventor： THOMPSON GUY ,  LEVNER DANIEL ,  HINOJOSA CHRISTOPHER DAVID

IPC: G05D7/00

CPC classification number: B01L3/50273 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0848 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/082 ,  F04B19/006 ,  F04B43/12

Abstract: Described herein are fluid-flow control devices for transferring a fluid from a place to another and/or controlling a fluid flow. In some embodiments, fluid-flow control devices described herein can be used as pumping devices to transfer a fluid by peristaltic motion and/or as valve devices to control fluid flow for various applications, e.g., in a microfluidic platform.

Abstract translation: 这里描述的是用于将流体从一个地方转移到另一个地方和/或控制流体流动的流体流动控制装置。 在一些实施例中，本文描述的流体流量控制装置可以用作泵送装置以通过蠕动运动传送流体和/或用作阀装置以控制用于各种应用的流体流动，例如在微流体平台中。

公开(公告)号：EP2820147A4

公开(公告)日：2015-10-14

申请号：EP13755202

申请日：2013-02-28

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  INGBER DONALD E ,  CARTWRIGHT MARK J ,  WATTERS ALEXANDER ,  WORKMAN JOHN SAMUEL ,  LEVNER DANIEL ,  ROTTMAN MARTIN

IPC: C12Q1/18 ,  G01N33/569

CPC classification number: G01N33/56938 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2500/10

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

Abstract translation: 本文描述的各个方面的实施方案涉及用于在收集样品后几小时内快速测定微生物的抗生素敏感性的方法，组合物，试剂盒和系统。 在一些实施方案中，本文所述的方法，组合物，试剂盒和系统可以允许基于少量微生物测定微生物的抗生素敏感性，例如与本文所述的微生物靶向底物结合的少至5-10个微生物。

公开(公告)号：WO2014210364A3

公开(公告)日：2015-10-29

申请号：PCT/US2014044417

申请日：2014-06-26

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  HINOJOSA CHRISTOPHER DAVID ,  LEVNER DANIEL ,  RESNIKOFF JOSH ISAAC NIELSEN ,  THOMPSON III GUY

IPC: G01N1/00 ,  B01J4/00

CPC classification number: B01L3/563 ,  B01J19/0093 ,  B01J2219/00813 ,  B01J2219/00988 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2300/047 ,  B01L2300/069 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2300/16 ,  C12M23/16 ,  C12M23/40 ,  C12M29/00

Abstract: An interconnect adaptor for connecting a microfluidic device to a fluidic system. The interconnect adapter includes a base substrate and a nozzle array. The base substrate includes a first side and a second side. The nozzle array includes two or more nozzles extending away from the base substrate. Each nozzle includes an opening with a channel extending therefrom. The channels are configured to transport fluid between the microfluidic device and the fluidic system. Each of the nozzles is configured to be inserted into a respective hole in the microfluidic device. In some embodiments, the insertion forms a radially sealed connection between each nozzle and respective hole when the nozzles are inserted a predetermined distance into the respective holes.

Abstract translation: 用于将微流体装置连接到流体系统的互连适配器。 互连适配器包括基底基板和喷嘴阵列。 基底基板包括第一面和第二面。 喷嘴阵列包括远离基底基板延伸的两个或更多个喷嘴。 每个喷嘴包括具有从其延伸的通道的开口。 通道构造成在微流体装置和流体系统之间输送流体。 每个喷嘴构造成插入到微流体装置中的相应孔中。 在一些实施例中，当喷嘴在相应的孔中插入预定距离时，插入件在每个喷嘴和相应的孔之间形成径向密封的连接。

公开(公告)号：EP3169626A4

公开(公告)日：2018-04-04

申请号：EP15822409

申请日：2015-07-10

Applicant: HARVARD COLLEGE

Inventor： HINOJOSA CHRISTOPHER DAVID ,  SLIZ JOSIAH ,  LEVNER DANIEL ,  THOMPSON GUY ,  GEISLER HUBERT ,  FERNANDEZ ALCON JOSE ,  INGBER DONALD E

IPC: C12M1/00 ,  C12Q1/02

CPC classification number: C12M23/16 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y15/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/00 ,  C12M41/40 ,  C12M41/46 ,  G01N33/5005

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：EP3014329A4

公开(公告)日：2016-07-06

申请号：EP14818128

申请日：2014-06-26

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON GUY ,  HINOJOSA CHRISTOPHER D ,  FERNANDEZ-ALCON JOSE

IPC: G02B21/24 ,  G02B21/26

CPC classification number: G02B21/24 ,  G02B7/04 ,  G02B21/02 ,  G02B21/06 ,  G02B21/14 ,  G02B21/16 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36

Abstract: A microscopy system for monitoring of one or more specimens includes a plurality of microscope blades, each microscope blade having at least one objective, at least one illuminator, and at least one detector. The microscopy system also includes a plurality of carriages, each carriage being connected to one or more of the microscope blades, and one or more actuators configured to drive the plurality of carriages along one or more axes, at least some of the plurality of carriages having at least partially overlapping ranges of motion along at least one of the one or more axes. The microscopy system also includes a master controller configured to drive each of the carriages, using the actuator(s), along the one or more axes.

Abstract translation: 用于监测一个或多个试样的显微镜系统包括多个显微镜刀片，每个显微镜刀片具有至少一个物镜，至少一个照明器和至少一个检测器。 显微镜系统还包括多个滑架，每个滑架连接到一个或多个显微镜刀片，以及一个或多个致动器，其配置成沿着一个或多个轴线驱动多个滑架，多个滑架中的至少一些具有 沿着所述一个或多个轴中的至少一个的至少部分重叠的运动范围。 显微镜系统还包括主控制器，其构造成沿着一个或多个轴线使用致动器来驱动每个托架。

公开(公告)号：EP3024582A4

公开(公告)日：2017-03-08

申请号：EP14829645

申请日：2014-07-22

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  LEVNER DANIEL ,  THOMPSON GUY II ,  HINOJOSA CHRISTOPHER DAVID

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/56 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655

Abstract: According to aspects of the present invention, a cartridge assembly for transporting fluid into or out of one or more fluidic devices includes a first layer and a second layer. The first layer includes a first surface. The first surface includes at least one partial channel disposed thereon. The second layer abuts the first surface, thereby forming a channel from the at least one partial channel. At least one of the first layer and the second layer is a resilient layer formed from a pliable material. At least one of the first layer and the second layer includes a via hole. The via hole is aligned with the channel to pass fluid thereto. The via hole is configured to pass fluid through the first layer or the second layer substantially perpendicularly to the channel. Embossments are also used to define aspects of a fluidic channel.

公开(公告)号：ES2991004T3

公开(公告)日：2024-12-02

申请号：ES23174395

申请日：2012-12-21

Applicant: HARVARD COLLEGE

Inventor： LEVNER DANIEL ,  LEE JEHYUK ,  CHURCH GEORGE ,  SUPER MICHAEL

IPC: C12Q1/6804 ,  C12N15/11 ,  C12Q1/6816 ,  G01N33/53 ,  G01N33/532 ,  G01N33/68

Abstract: Las invenciones proporcionadas en el presente documento se refieren a reactivos de detección, composiciones, métodos y kits que comprenden los reactivos de detección para su uso en la detección, identificación y/o cuantificación de analitos en una muestra. Dichos reactivos de detección y métodos descritos en el presente documento permiten la multiplexación de muchas más especies marcadas en el mismo procedimiento que los métodos convencionales, en los que la multiplexación está limitada por el número de colores disponibles y prácticamente utilizables. (Traducción automática con Google Translate, sin valor legal)

公开(公告)号：AU2023282260A1

公开(公告)日：2024-01-18

申请号：AU2023282260

申请日：2023-12-14

Applicant: HARVARD COLLEGE

Inventor： VARONE ANTONIO ,  WEN NORMAN ,  LEVNER DANIEL ,  NOVAK RICHARD ,  MCPARTLIN LORI ,  INGBER DONALD E ,  CHOE YOUNGJAE ,  LENG LIAN ,  NGUYEN JUSTIN K

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  C12M3/04 ,  C12Q1/02

Abstract: Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：AU2019268161B2

公开(公告)日：2021-12-02

申请号：AU2019268161

申请日：2019-11-21

Applicant: HARVARD COLLEGE

Inventor： FERNANDEZ-ALCON JOSE ,  WEN NORMAN ,  NOVAK RICHARD ,  INGBER DONALD E ,  HAMILTON GERALDINE A ,  HINOJOSA CHRISTOPHER ,  DOMANSKY KAREL ,  LEVNER DANIEL ,  THOMPSON II GUY ,  HAJIPOURAN BENAM KAMBEZ ,  VILLENAVE REMI ,  UMUNDUM THOMAS ,  PARIS ALFRED ,  BAUER GEORG

IPC: B01L3/00 ,  C12M3/00

Abstract: A method of producing a microfluidic device comprising: a) providing a first body and a second body; b) compression molding a polymer to create a porous membrane; and c) positioning the membrane within the central channel. 242 200 244 207 206 202 209 230 -- ,232