公开(公告)号：US20120244549A1

公开(公告)日：2012-09-27

申请号：US13429066

申请日：2012-03-23

Applicant: Robert G. Lowery ,  Matt Staeben ,  Tony A. Klink

Inventor： Robert G. Lowery ,  Matt Staeben ,  Tony A. Klink

IPC: G01N21/64

CPC classification number: C12Y201/01 ,  G01N21/6445 ,  G01N33/6815 ,  G01N2333/91011

Abstract: This invention provides methods to determine the activity of methyltransferase enzymes which employ S-adenosylmethionine (SAM) as a substrate and transfer a methyl group to convert this substrate to S-adenosylhomocysteine (SAH), by measuring SAH conversion to AMP.

Abstract translation: 本发明提供了通过测量SAH转化为AMP来测定使用S-腺苷甲硫氨酸（SAM）作为底物并转移甲基以将该底物转化为S-腺苷高半胱氨酸（SAH）的甲基转移酶的活性的方法。

公开(公告)号：KR101893522B1

公开(公告)日：2018-08-31

申请号：KR1020170054579

申请日：2017-04-27

Applicant: 한국생명공학연구원

Inventor： 오희목 ,  이형관 ,  이준우 ,  김희식 ,  하지산

IPC: C12N15/79 ,  C12N9/10 ,  C12P7/64

CPC classification number: Y02E50/13 ,  C12N15/79 ,  C12N9/1007 ,  C12P7/6463 ,  C12P7/649 ,  C12Y201/01

Abstract: 클라미도모나스()의 bta1 (betaine lipid synthase) 유전자넉다운을통해당지질함량은감소하고, 중성지질(TAG, triacylglycerol) 함량은야생형에비해 2.5~3배증가된것을특징으로하는형질전화된클라미도모나스, 상기형질전환된클라미도모나스를제조하는방법, 상기형질전환된클라미도모나스를포함하는바이오디젤생산용조성물및 바이오디젤제조방법을제공한다.

公开(公告)号：KR1020150132395A

公开(公告)日：2015-11-25

申请号：KR1020157029177

申请日：2014-03-14

Applicant: 더 제너럴 하스피탈 코포레이션

Inventor： 중,제이.케이쓰 ,  차이,솅다르

IPC: C12N9/22 ,  C12N15/63 ,  C12N15/113 ,  C12N15/85 ,  C07K14/005 ,  C07K14/195

CPC classification number: C12N15/102 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: RNA-안내게놈편집, 예를들어, CRISPR/Cas9 시스템을이용하는편집의특이성을증가시키는방법.

Abstract translation: 使用截短的引导RNA（tru-gRNA）增加RNA指导基因组编辑的特异性的方法，例如使用CRISPR / Cas9系统的编辑。

公开(公告)号：EP2971041B1

公开(公告)日：2018-11-28

申请号：EP14764159.1

申请日：2014-03-14

Applicant: The General Hospital Corporation

Inventor： JOUNG, J. Keith ,  TSAI, Shengdar

IPC: C12Q1/68 ,  C12N15/00 ,  C07H21/04

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：EP3137618A4

公开(公告)日：2017-12-13

申请号：EP15785253

申请日：2015-04-27

Applicant: EPIMERON INC

Inventor： FACCHINI PETER JAMES

IPC: C12N13/00 ,  C12N15/00 ,  C12N15/10 ,  C12N15/52 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63 ,  C12P13/00 ,  C12P17/00 ,  C12P17/12 ,  C12Q1/68 ,  C40B10/00 ,  C40B20/00 ,  C40B30/00

CPC classification number: C12P17/12 ,  C12N15/1082 ,  C12N15/1096 ,  C12N15/63 ,  C12Y201/01 ,  C40B10/00 ,  C40B20/00

Abstract: Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.

公开(公告)号：EP3237017A2

公开(公告)日：2017-11-01

申请号：EP15872084.7

申请日：2015-12-24

Applicant: Dana-Farber Cancer Institute, Inc. ,  The Johns Hopkins University

Inventor： NOVINA, Carl ,  MEISTER, Glenna ,  OSTERMEIER, Marc ,  XIONG, Tina

IPC: A61K48/00 ,  C12N15/85

CPC classification number: C12N9/1007 ,  A61K48/00 ,  C07K2319/09 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/24 ,  C12N2800/40 ,  C12Q1/6897 ,  C12Q2600/154 ,  C12Y201/01 ,  C12Y201/01037 ,  C12Y301/00

Abstract: The present invention provides methods of systems and methods of site specific methylation.

Abstract translation: 本发明提供了位点特异性甲基化的系统和方法的方法。

公开(公告)号：EP2971125A4

公开(公告)日：2016-08-24

申请号：EP14763916

申请日：2014-03-14

Applicant: GEN HOSPITAL CORP

Inventor： JOUNG J KEITH ,  SANDER JEFFRY D ,  FU YANFANG ,  MAEDER MORGAN

IPC: C12Q1/68 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12N9/22 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

Abstract translation: 方法增加RNA引导的基因组编辑，E. G.的特异性，使用CRISPR / Cas9系统编辑，使用截短的RNA导（TRU-gRNAs）。

公开(公告)号：EP3011018A2

公开(公告)日：2016-04-27

申请号：EP14737481.3

申请日：2014-06-20

Applicant: Danisco US Inc.

Inventor： SCOTCHER, Miles, C. ,  WELLS, Derek, H.

IPC: C12N9/10

CPC classification number: C12N15/74 ,  C12N9/1007 ,  C12N15/70 ,  C12P5/007 ,  C12P7/065 ,  C12Y201/01 ,  Y02E50/17

Abstract: The invention provides compositions and methods for clostridial bacteria that have been engineered to produce and/or to improve efficiency of production of industrial bioproducts.

Abstract translation: 本发明提供已被工程化以生产和/或提高工业生物产品的生产效率的梭菌的组合物和方法。

公开(公告)号：EP2992006A1

公开(公告)日：2016-03-09

申请号：EP13883373.6

申请日：2013-04-28

Applicant: Institute of Botany of The Chinese Academy of Sciences

Inventor： WANG, Liangsheng ,  DU, Hui ,  SHU, Qingyan

IPC: C07K14/415 ,  C12N9/10 ,  C12N15/54 ,  C12N15/63 ,  C12N5/10 ,  A01H5/00

CPC classification number: C12N15/825 ,  C12N9/1007 ,  C12N15/8205 ,  C12Y201/01

Abstract: The present invention provides novel protein and gene related to flavonoid O-methyltransferase (FOMT) and their uses therefore. The said protein having an amino acid sequence shown in SEQ ID NO: 3, or an amino acid sequence having deletion, substitution or insertion of one or plural amino acids in said amino acid sequence. The said gene comprising the nucleotide sequence shown in SEQ ID NO: 1, or a gene which hybridizes with said gene under stringent conditions and encodes a protein, which has anthocyanin 3'-O-methyltransferase or 3',5'-O-methyltrasnferase activity. The present invention also provides a method for obtaining the transgenic plant used the above-mentioned gene.

公开(公告)号：EP2971041A1

公开(公告)日：2016-01-20

申请号：EP14764159.1

申请日：2014-03-14

Applicant: The General Hospital Corporation

Inventor： JOUNG, J. Keith ,  TSAI, Shengdar

IPC: C12P21/06 ,  C12P19/34 ,  A61K38/43 ,  A61K38/47

CPC classification number: C12N15/102 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).

Abstract translation: 方法增加RNA引导的基因组编辑，E. G.的特异性，使用CRISPR / Cas9系统编辑，使用截短的RNA导（TRU-gRNAs）。