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    Portable high gain fluorescence detection system
    93.
    发明授权
    Portable high gain fluorescence detection system 有权
    便携式高增益荧光检测系统

    公开(公告)号：US08431389B2

    公开(公告)日：2013-04-30

    申请号：US13245124

    申请日：2011-09-26

    Applicant: C. Frederick Battrell ,  Troy D. Daiber

    Inventor： C. Frederick Battrell ,  Troy D. Daiber

    IPC: C12M1/34

    CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

    Abstract: An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.

    Abstract translation: 公开了用于液体样品中荧光测定的仪器。 仪器可以包括用于监测与靶分析物相关联的第一荧光团的多个光学通道和与对照相关联的第二荧光团。 所公开的仪器可用于任何数量的应用，包括基于目标核酸的PCR扩增和荧光测定的微流体分子生物学测定。

    PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM
    95.
    发明申请
    PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM 有权
    便携式高增益荧光检测系统

    公开(公告)号：US20120135511A1

    公开(公告)日：2012-05-31

    申请号：US13191120

    申请日：2011-07-26

    Applicant: C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    Inventor： C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    IPC: C12M1/40

    CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

    Abstract: Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are shown to be improved by use of a heating block with reflective mirror face in intimate contact with a thermo-optical window enclosing the liquid sample.

    Abstract translation: 公开了一种用于液体样品中的荧光测定的紧凑型微处理器控制仪器，该仪器具有用于接收微流控盒的对接舱的浮动台和具有用于控制源LED的放射性嵌入式微处理器的扫描检测器头，发射信号放大和 在检测器头内的隔离，低噪声，高增益环境中进行滤波。 多个光通道可并入扫描头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。 通过使用具有与包围液体样品的热光学窗口紧密接触的反射镜面的加热块，可以改善扫描期间对气泡干扰的灵敏度和抗性。

    GAS ANALYZER
    96.
    发明申请
    GAS ANALYZER 有权
    气体分析仪

    公开(公告)号：US20120057160A1

    公开(公告)日：2012-03-08

    申请号：US12872207

    申请日：2010-08-31

    Applicant: Georgiy G. Burba ,  Daniel J. Anderson ,  Michael D. Furtaw ,  Robert D. Eckles ,  Dayle K. McDermitt ,  Jonathan M. Welles

    Inventor： Georgiy G. Burba ,  Daniel J. Anderson ,  Michael D. Furtaw ,  Robert D. Eckles ,  Dayle K. McDermitt ,  Jonathan M. Welles

    IPC: G01N21/59

    CPC classification number: G01N21/3504 ,  G01K13/02 ,  G01K2013/024 ,  G01N1/2247 ,  G01N21/05 ,  G01N2201/0245

    Abstract: Gas analyzer systems and methods for determining gas flux in a short intake tube configuration without using any Webb-Pearman-Leuning density correction. Gas analyzer systems and methods for measuring concentrations of gasses and in particular dry mole fraction of components of a gas. The systems and method allow for rapid measurement of the gas density and/or dry mole fraction of gases for a number of environmental monitoring applications, including high speed flux measurements. A novel coupling design allows for tool-free removal of a cell enclosing a flow path to enable in field cleaning of optical components.

    Abstract translation: 气体分析仪系统和方法，用于确定短进气管配置中的气体通量，而不使用任何Webb-Pearman-Leuning密度校正。 气体分析仪系统和测量气体浓度的方法，特别是气体组分的干摩尔分数。 这些系统和方法允许快速测量多种环境监测应用的气体密度和/或气体的干摩尔分数，包括高速通量测量。 新的耦合设计允许无需移除封闭流动通道的电池，从而可以对光学部件进行现场清洁。

    APPARATUS FOR OPTICALLY INSPECTING AN AT LEAST PARTIALLY REFLECTING SURFACE OF AN OBJECT
    97.
    发明申请
    APPARATUS FOR OPTICALLY INSPECTING AN AT LEAST PARTIALLY REFLECTING SURFACE OF AN OBJECT 有权
    用于光学检查物体的最小部分反射表面的装置

    公开(公告)号：US20110310242A1

    公开(公告)日：2011-12-22

    申请号：US13171105

    申请日：2011-06-28

    Applicant: Klaus-Georg Knupfer ,  Joachim Reimann ,  Volker Huss ,  Volker Schöllkopf

    Inventor： Klaus-Georg Knupfer ,  Joachim Reimann ,  Volker Huss ,  Volker Schöllkopf

    IPC: H04N7/18

    CPC classification number: G01N21/8806 ,  G01N21/15 ,  G01N21/9515 ,  G01N2021/151 ,  G01N2021/1772 ,  G01N2021/1774 ,  G01N2021/8812 ,  G01N2021/8816 ,  G01N2021/8835 ,  G01N2201/0245 ,  G01N2201/0614 ,  G01N2201/0626 ,  G01N2201/0634 ,  G01N2201/0694

    Abstract: An apparatus for optically inspecting an at least partially reflecting surface of an object includes first and second transverse carriers (12, 14) defining respective substantially circular segment-shaped cutouts (32). The transverse carriers (12, 14) are disposed at a longitudinal distance (D) from one another and the longitudinal distance (D) defines a longitudinal direction (17). A plurality of longitudinal members are configured to hold the first and second transverse carriers at the longitudinal distance (D). The longitudinal members are arranged at a defined radial distance to the circular segment-shaped cutouts. A translucent diffusing screen is held in the circular segment-shaped cutouts by the transverse carriers to form a tunnel-shaped inspection space. A multiplicity of light sources are arranged outside of the tunnel-shaped inspection space behind the diffusing screen. The light sources are configured to be controlled individually or in small groups to generate variable light-dark patterns on the diffusing screen. A workpiece receptacle is configured for accommodating the object in the tunnel-shaped inspection space. At least one camera is directed into the tunnel-shaped inspection space. An evaluation and control unit is configured to control the light sources and the camera to generate various light-dark patterns on the diffusing screen and to record and evaluate a plurality of images of the object in dependence on the light-dark patterns.

    Abstract translation: 用于光学检查物体的至少部分反射表面的装置包括限定相应的基本上圆形的段状切口（32）的第一和第二横向载体（12,14）。 横向载体（12,14）以纵向距离（D）彼此设置，并且纵向距离（D）限定纵向方向（17）。 多个纵向构件构造成以纵向距离（D）保持第一和第二横向载体。 纵向构件以规定的径向距离布置成圆形段状切口。 半透明的漫射屏幕由横向载体保持在圆形扇形切口中，以形成隧道形检查空间。 多个光源布置在漫射屏幕后面的隧道形检查空间的外侧。 光源被配置为单独地或以小组来控制，以在漫射屏幕上产生可变的亮暗图案。 工件容器构造成用于将物体容纳在隧道形状的检查空间中。 至少一个相机被引导到隧道形状的检查空间中。 评估和控制单元被配置为控制光源和相机以在扩散屏幕上产生各种亮暗图案，并且根据暗色图案来记录和评估对象的多个图像。

    Photometer with modular light emitter
    98.
    发明授权
    Photometer with modular light emitter 有权
    带模块化发光器的光度计

    公开(公告)号：US07623225B2

    公开(公告)日：2009-11-24

    申请号：US12256786

    申请日：2008-10-23

    Applicant: Charles W. Robertson, Jr. ,  Joel B. Hansen ,  Dale Heintzelman ,  Thomas A. Tokash ,  Paul S. Zdinak ,  Damian W. Ashmead ,  Jonathan Pundt

    Inventor： Charles W. Robertson, Jr. ,  Joel B. Hansen ,  Dale Heintzelman ,  Thomas A. Tokash ,  Paul S. Zdinak ,  Damian W. Ashmead ,  Jonathan Pundt

    IPC: G01J1/04

    CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0235 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/32 ,  G01N21/6445 ,  G01N21/645 ,  G01N2021/035 ,  G01N2021/6471 ,  G01N2201/0245

    Abstract: A photometer is provided with modular lighting units wherein each lighting unit includes one or more light emitters. A user may select a desired lighting unit and install it within a photometer base unit, and thereafter activate one or more of the emitters (which may emit light of different wavelengths) to illuminate a specimen. The light provided by the specimen in response can then be captured at a detector, and analyzed to provide an indication of the specimen's characteristics. Different lighting units may optionally include one or more input light adapters (filters or polarizers which modify the light provided by the emitter(s) to the specimen), and/or one or more output light adapters (filters or polarizers which modify the light provided by the specimen to the detector). Users may therefore select lighting units with emitters and light adapters which are particularly suited for detection/analysis of particular specimens and/or components therein.

    Abstract translation: 光度计设置有模块化照明单元，其中每个照明单元包括一个或多个发光器。 用户可以选择所需的照明单元并将其安装在光度计基座单元内，然后激活一个或多个发射器（其可以发射不同波长的光）以照射样本。 然后可以在检测器处捕获由样品提供的光，并分析以提供样品特征的指示。 不同的照明单元可以可选地包括一个或多个输入光适配器（将由发射器提供的光修改为样本的滤光器或偏振器）和/或一个或多个输出光适配器（改变所提供的光的滤光器或偏振器 通过样品到检测器）。 因此，用户可以选择具有发射器和光适配器的照明单元，其特别适于检测/分析其中的特定样品和/或部件。

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