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    Light-Blocking System for a Diagnostic Analyzer
    91.
    发明申请
    Light-Blocking System for a Diagnostic Analyzer 有权
    用于诊断分析仪的遮光系统

    公开(公告)号：US20140287516A1

    公开(公告)日：2014-09-25

    申请号：US14214190

    申请日：2014-03-14

    Applicant: ABBOTT LABORATORIES

    Inventor： Joseph P. Donohue

    IPC: G01N35/04

    CPC classification number: G01N35/021 ,  G01N21/76 ,  G01N35/0099 ,  G01N35/02 ,  G01N35/04 ,  G01N2035/0429 ,  G01N2201/0642 ,  G01N2201/0648 ,  Y10T436/113332 ,  Y10T436/114165

    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.

    Abstract translation: 诊断分析仪包括轨道，遮光构件，电动机和光学测试装置。 轨道移动由轨道保持的反应容器。 遮光构件邻近轨道设置。 遮光构件从远离轨道的第一位置移动到靠近轨道的第二位置。 当遮光构件设置在第一位置时，容纳在由轨道保持的反应容器内的样品暴露于光。 当遮光构件设置在第二位置时，包含在由轨道保持的反应容器内的样品被阻挡以暴露于光。 电动机在第一和第二位置之间移动遮光构件。 当所述至少一个遮光构件设置在所述第二位置时，所述光学测试装置邻近所述轨道设置用于光学地测试由所述轨道保持的所述反应容器内的样本。

    OPTICAL BACKGROUND SUPPRESSION SYSTEMS AND METHODS FOR FLUORESCENCE IMAGING
    92.
    发明申请
    OPTICAL BACKGROUND SUPPRESSION SYSTEMS AND METHODS FOR FLUORESCENCE IMAGING 有权
    光学背景抑制系统和荧光成像方法

    公开(公告)号：US20110284765A1

    公开(公告)日：2011-11-24

    申请号：US12785308

    申请日：2010-05-21

    Applicant: Sean B. Pieper ,  Ahmed Bouzid ,  Donald T. Lamb ,  Andrew G. Ragatz

    Inventor： Sean B. Pieper ,  Ahmed Bouzid ,  Donald T. Lamb ,  Andrew G. Ragatz

    IPC: G01N21/64

    CPC classification number: G01N21/6456 ,  G01N2201/064 ,  G01N2201/0642

    Abstract: A fluorescence imaging system having an enclosure having an optical excitation and detection system and features designed to suppress or reduce background fluorescence. In certain aspects, all or a portion of the interior walls has a material finish and texture that provides a surface that absorbs at least a portion of any impinging excitation light and which has low auto-fluorescing properties. In certain aspects, a baffle structure is provided on the interior of the structure and is configured to mask portions of the interior and reduce the opening through which light impinges on the detector. In certain aspects, a platform having an optically transparent window is located in the interior of the housing structure for holding a sample for excitation by excitation light from an excitation source, wherein a light-trap structure is positioned or located on an opposite side of the platform relative to the excitation source and configured to receive and contain a substantial portion of any scattered or transmitted excitation light.

    Abstract translation: 一种荧光成像系统，其具有具有光学激发和检测系统的外壳和被设计为抑制或减少背景荧光的特征。 在某些方面，内壁的全部或一部分具有提供吸收至少一部分任何入射激发光并且具有低自发荧光特性的表面的材料表面和纹理。 在某些方面，挡板结构设置在结构的内部，并且构造成掩盖内部的一部分并且减小光照射在检测器上的开口。 在某些方面，具有光学透明窗口的平台位于壳体结构的内部，用于通过来自激发源的激发光来保持用于激发的样品，其中光阱结构被定位或位于 平台相对于激发源并且被配置为接收和容纳任何散射或透射的激发光的实质部分。

    OPTICAL SAMPLE DETECTION SYSTEM AND SAMPLE ANALYSIS DEVICE
    93.
    发明申请
    OPTICAL SAMPLE DETECTION SYSTEM AND SAMPLE ANALYSIS DEVICE 有权
    光学样本检测系统和样品分析装置

    公开(公告)号：US20110255086A1

    公开(公告)日：2011-10-20

    申请号：US13085343

    申请日：2011-04-12

    Applicant: Yang Zhou ,  Zefei Jiang ,  Jinhong Qiu

    Inventor： Yang Zhou ,  Zefei Jiang ,  Jinhong Qiu

    IPC: G01J3/28

    CPC classification number: G01N21/01 ,  G01N21/31 ,  G01N2201/06 ,  G01N2201/0642

    Abstract: An optical sample detection system is provided, including a light source; a convergence projection component for converging light rays emitted by the light source; a sample accommodation component for accommodating a detected sample; a light beam collection component for receiving light rays carrying sample characteristic information and transmitted from the sample accommodation component; a light splitting component for splitting polychromatic lights collected by the light beam collection component into independent spectrums or spectral bands; and a photoelectric detection component for receiving optical signals of different wavelengths separated through the light splitting component.

    Abstract translation: 提供了一种光学样本检测系统，包括光源; 用于会聚由光源发射的光线的会聚投影部件; 用于容纳检测到的样本的样本容纳部件; 光束采集部件，用于接收携带样品特征信息并从样品容纳部件传输的光线; 用于将由光束收集部件收集的多色光分解成独立光谱或光谱带的光分离部件; 以及用于接收通过分光部件分离的不同波长的光信号的光电检测部件。

    Light scattering detector
    94.
    发明授权
    Light scattering detector 有权
    光散射检测器

    公开(公告)号：US08040509B2

    公开(公告)日：2011-10-18

    申请号：US12325890

    申请日：2008-12-01

    Applicant: David W. Larsen ,  Zhi Xu

    Inventor： David W. Larsen ,  Zhi Xu

    IPC: G01N21/00 ,  G01N21/53

    CPC classification number: G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

    Abstract: The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

    Abstract translation: 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

    LIGHT SCATTERING DETECTOR
    95.
    发明申请
    LIGHT SCATTERING DETECTOR 失效
    光散射检测器

    公开(公告)号：US20070296971A1

    公开(公告)日：2007-12-27

    申请号：US11853682

    申请日：2007-09-11

    Applicant: David Larsen ,  Zhi Xu

    Inventor： David Larsen ,  Zhi Xu

    IPC: G01N21/00

    CPC classification number: G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

    Abstract: The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

    Abstract translation: 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

    Ultrasensitive spectrophotometer
    96.
    发明授权
    Ultrasensitive spectrophotometer 有权
    超声分光光度计

    公开(公告)号：US07262844B2

    公开(公告)日：2007-08-28

    申请号：US11035034

    申请日：2005-01-13

    Applicant: David W. Larsen ,  Zhi Xu

    Inventor： David W. Larsen ,  Zhi Xu

    IPC: G01J3/42

    CPC classification number: G01N21/31 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J2003/425 ,  G01N21/274 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/0642 ,  G01N2201/127

    Abstract: The invention concerns measurements in which light interacts with matter to generate light intensity changes, and spectrophotometer devices of the invention provide ultrasensitive measurements. Light source noise in these measurements can be reduced in accordance with the invention. Exemplary embodiments of the invention use sealed housings lacking an internal light source. In some embodiments a substantially solid thermally conductive housing is used. Other embodiments include particular reflection based sample and reference cells. One embodiment includes a prism including an interaction surface, a detector, a lens that focuses a prism beam output onto the detector, and a closed interaction volume for delivering gas or liquid to the interaction surface. Another embodiment replaces a prism with a reflective surface. Another embodiment replaces a prism with a scattering matte surface. Aspects of the invention identify noise-contributing components in spectrophotometry and realize noise levels very near the shot noise limit.

    Abstract translation: 本发明涉及光与物质相互作用以产生光强度变化的测量，本发明的分光光度计装置提供超灵敏测量。 根据本发明，可以减少这些测量中的光源噪声。 本发明的示例性实施例使用缺少内部光源的密封外壳。 在一些实施例中，使用基本上固体的导热壳体。 其他实施方案包括特定的基于反射的样品和参比细胞。 一个实施例包括棱镜，其包括相互作用表面，检测器，将棱镜束输出聚焦到检测器上的透镜以及用于将气体或液体输送到相互作用表面的封闭相互作用体积。 另一个实施例用反射表面代替棱镜。 另一个实施例用散射磨砂表面代替棱镜。 本发明的方面在分光光度法中识别噪声贡献的组件，并且实现非常接近喷射噪声极限的噪声水平。

    Spectrophotometer with digital camera
    99.
    发明授权
    Spectrophotometer with digital camera 有权
    带数码相机的分光光度计

    公开(公告)号：US07230707B2

    公开(公告)日：2007-06-12

    申请号：US11016033

    申请日：2004-12-17

    Applicant: Alan Ingleson ,  David Slocum ,  Michael H. Brill

    Inventor： Alan Ingleson ,  David Slocum ,  Michael H. Brill

    IPC: G01J3/46

    CPC classification number: G01N21/255 ,  G01J3/0251 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/50 ,  G01N21/274 ,  G01N21/57 ,  G01N2201/0642 ,  G01N2201/065 ,  G06T7/90

    Abstract: Systems, methodologies, media, and other embodiments associated with color measuring are described. One exemplary system embodiment includes a spectrophotometer, one or more light sources for illuminating an interior of the spectrophotometer, and a digital camera configured at a port of the spectrophotometer and being configured to measure light components from a sample. In the present invention, segmentation logic is provided for the spectrophotometer that is configured to employ computational image segmentation to characterize specular reflection from a sample and to characterize a selected patch or portion from the test sample, such as a selected color in a multicolor pattern. In accordance with the present invention, the spectrophotometer and the included digital camera may be color-characterized in situ.

    Abstract translation: 描述了与颜色测量相关联的系统，方法，介质和其它实施例。 一个示例性系统实施例包括分光光度计，用于照亮分光光度计内部的一个或多个光源，以及配置在分光光度计的端口处并被配置为测量来自样品的光分量的数字照相机。 在本发明中，为分光光度计提供分割逻辑，其被配置为采用计算图像分割来表征来自样本的镜面反射并且从所述测试样品（例如多色图案中的所选颜色）表征所选择的贴片或部分。 根据本发明，分光光度计和所附的数码相机可以原位进行颜色表征。

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