公开(公告)号：US20230160832A1

公开(公告)日：2023-05-25

申请号：US17997152

申请日：2021-05-20

Applicant: BSD ROBOTICS PTY LTD

Inventor： Andrew Stewart

IPC: G01N21/88 ,  G01N21/01 ,  G01N33/48 ,  G01N35/00

CPC classification number: G01N21/88 ,  G01N21/01 ,  G01N33/48 ,  G01N35/00732 ,  G01N2201/10 ,  G01N2035/00752 ,  G01N2201/0636 ,  G01N2201/121 ,  G01N2201/0693

Abstract: The present invention relates to a biological sample quality apparatus for determining the quality of a biological sample. The apparatus includes a sample receiver for receiving the biological sample. One or more light sources are provided for supplying light to the sample. An image sensor is provided for capturing an image of the lit sample. The apparatus also includes an image processor for image processing the captured image to determine the quality of the sample. Advantageously, image processing may be used to determine the quality of a sample for use in collection sites and screening laboratories so that acceptability can be determined prior to analyzing the sample. Determination that the sample is of sufficient quality (e.g. sufficient biomaterial) prior to analyzing saves wastage of laboratory time and expense of materials and chemicals. The apparatus may be in the form of desktop or hand-held portable variations.

公开(公告)号：US20180363024A1

公开(公告)日：2018-12-20

申请号：US16111798

申请日：2018-08-24

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Ozan Akkus ,  Mikhail Slipchenko ,  Anna Akkus ,  Shan Yang ,  Bolan Li

IPC: C12Q1/40 ,  C12Q1/37 ,  G01N1/40 ,  G01N21/65

CPC classification number: C12Q1/40 ,  C12Q1/37 ,  G01N1/4077 ,  G01N21/65 ,  G01N2001/4088 ,  G01N2201/121 ,  G01N2333/928 ,  G01N2333/958 ,  G01N2800/107 ,  G01N2800/345

Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

公开(公告)号：US20180299373A1

公开(公告)日：2018-10-18

申请号：US15946887

申请日：2018-04-06

Applicant: GREENTROPISM

Inventor： Antoine LABORDE ,  Aude BOURDEAU ,  Anthony BOULANGER

IPC: G01N21/31

CPC classification number: G01N21/314 ,  G01J3/0264 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/2833 ,  G01J2003/2843 ,  G01J2003/2866 ,  G01J2003/2869 ,  G01J2003/2873 ,  G01N21/274 ,  G01N21/31 ,  G01N33/10 ,  G01N2201/121 ,  G01N2201/129 ,  G01N2201/1293

Abstract: The invention relates to a characterization device (50) for characterizing a sample (S) comprising: a memory (MEM) storing a measured spectrum (As+p) of said sample, performed through a translucent material, and a measured spectrum of the translucent material (Ap), a processing unit (PU) configured to: determine a spectral energy (Es+p) of the measured spectrum (As+p) of the sample through the translucent material (As+p), estimate a coefficient ({circumflex over (γ)}) from said spectral energy (Es+p) and, determine a corrected spectrum (Âs) of the sample from the measured spectrum (As+p) of the sample through the translucent material and from a corrected spectrum of the translucent material (Âp), said corrected spectrum of the translucent material (Âp) being determined from the measured spectrum of the translucent material (Ap) and from the estimated coefficient ({circumflex over (γ)}).

公开(公告)号：US20180059015A1

公开(公告)日：2018-03-01

申请号：US15690856

申请日：2017-08-30

Applicant: Sensii, Inc.

Inventor： Qiaochu Li ,  Wenting Xing

IPC: G01N21/3577 ,  G01N21/359 ,  G01N33/14 ,  G01N33/04 ,  G01N33/03

CPC classification number: G01N21/3577 ,  G01N21/359 ,  G01N33/03 ,  G01N33/04 ,  G01N33/146 ,  G01N2201/0221 ,  G01N2201/121 ,  G01N2201/129

Abstract: A personal liquid analysis system includes a portable liquid analyzer device, a mobile application as a user interface, and a cloud server for data analysis. The compact and portable liquid analyzer device is integrated by miniaturized near-infrared (NIR) optical sensors setup for spectroscopy measurement from a sample cell, control circuits, I/O user interface modules and wireless communication modules. The analyzer can be used to collect NIR spectra data from a liquid sample in the sample cell, and to transmit the data to a cloud server where compositional information is calculated, and presented to the user on the device and/or on a mobile application. The personal liquid analysis system enables the user to rapidly acquire qualitative and/or quantitative compositional information from liquid samples for a wide range of applications.

公开(公告)号：US20170276609A1

公开(公告)日：2017-09-28

申请号：US15480530

申请日：2017-04-06

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Austin B. TOMANEY ,  Mark F. OLDHAM

IPC: G01N21/64 ,  H04N5/225 ,  H04N5/357 ,  H04N5/361 ,  H04N5/367

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/121 ,  H04N5/225 ,  H04N5/357 ,  H04N5/361 ,  H04N5/367

Abstract: A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.

公开(公告)号：US20170146463A1

公开(公告)日：2017-05-25

申请号：US15127686

申请日：2015-01-22

Applicant: Hitachi High-Technologies Corporation

Inventor： Toshifumi HONDA ,  Yuta URANO ,  Shunichi MATSUMOTO ,  Taketo UENO ,  Yuko OTANI

IPC: G01N21/956 ,  G01N21/47 ,  G01N21/95

CPC classification number: G01N21/956 ,  G01N21/4738 ,  G01N21/9501 ,  G01N2021/4792 ,  G01N2021/8848 ,  G01N2201/121

Abstract: A defect inspection method includes irradiating a sample with laser, condensing and detecting scattered light beams, processing signals that detectors have detected and extracting a defect on a sample surface, and outputting information on the extracted defect. Detection of the scattered light beams is performed by condensing the scattered light beams, adjusting polarization directions of the condensed scattered light beams, mutually separating the light beams depending on the polarization direction, and detecting the light beams by a plurality of detectors. Extraction of the defect is performed by processing output signals from the detectors by multiplying each detection signal by a gain, discriminating between a noise and the defect, and detecting the defect.

公开(公告)号：US09494417B2

公开(公告)日：2016-11-15

申请号：US13978143

申请日：2011-12-19

Applicant: Frank Stefan

Inventor： Frank Stefan

IPC: G01B11/24 ,  G01B11/08 ,  G01B11/12 ,  G01N21/27 ,  G01N21/59 ,  G01N35/00 ,  G01N21/03 ,  G01N21/25 ,  B01L3/00

CPC classification number: G01B11/24 ,  B01L3/5082 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0832 ,  B01L2300/0858 ,  G01B11/08 ,  G01B11/12 ,  G01N21/03 ,  G01N21/251 ,  G01N21/274 ,  G01N21/5911 ,  G01N35/00732 ,  G01N2201/121

Abstract: A method for determining a shape correction value F for a laboratory liquid-analysis cuvette comprising a cuvette body with a circular cross-section for a photometric liquid analysis includes optically measuring an inside diameter d1 or an outside diameter d0 of the cuvette body to obtain a measured cuvette body diameter d1;d0. A shape correction value F is calculated from the measured cuvette body diameter d1;d0. The shape correction value F for the cuvette body is stored.

Abstract translation: 用于确定实验室液体分析试管的形状校正值F的方法包括用于光度分析液分析的具有圆形横截面的比色皿体，包括光学测量反应杯体的内径d1或外径d0，以获得 测量的比杯杯体直径d1; d0。 从测量的比色杯体直径d1; d0计算出形状校正值F. 存储比色杯体的形状校正值F.

公开(公告)号：US09448175B2

公开(公告)日：2016-09-20

申请号：US14423030

申请日：2013-08-19

Applicant: HORIBA ABX SAS

Inventor： Alexandra Urankar ,  Philippe Nerin ,  Moustapha Hariche ,  Gilles Cauet

IPC: G01N21/64 ,  G01N21/27 ,  G01N15/14 ,  G01N33/49 ,  G01N35/00 ,  G01N15/10

CPC classification number: G01N21/6486 ,  G01N15/147 ,  G01N21/274 ,  G01N21/6428 ,  G01N33/49 ,  G01N35/00663 ,  G01N2015/1006 ,  G01N2035/00673 ,  G01N2201/121

Abstract: The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

Abstract translation: 本发明涉及一种用于补偿存储在包含至少一种荧光化合物的水相中的试剂的分解的方法，并且能够鉴定颗粒，包括以下步骤：（i）测量荧光水平FLUOm（t） 用所述试剂标记的颗粒; （ii）在接近所述荧光水平FLUOm（t）测量时间的时间t测量所述试剂溶液的至少一个波长处的吸光度，以便确定至少一个当前光密度DO（t） 的试剂; 以及（iii）使用所述至少一个当前光密度DO（t）和至少一个未被分解的试剂的初始光密度DO（0）来计算荧光水平测量的校正。 本发明还涉及实现该方法的生物分析装置。

公开(公告)号：US20160259792A1

公开(公告)日：2016-09-08

申请号：US15060260

申请日：2016-03-03

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Karl NEDWED ,  Ty ABSHEAR

IPC: G06F17/30 ,  G06K9/52 ,  G06T11/20 ,  G06K9/62

CPC classification number: G06F17/3053 ,  G01N21/35 ,  G01N21/552 ,  G01N2201/121 ,  G01N2201/127 ,  G01N2201/129 ,  G06F17/30554 ,  G06K9/4661 ,  G06K9/52 ,  G06K9/6215 ,  G06K9/6218 ,  G06K2209/05 ,  G06T11/203

Abstract: Systems, methods, and apparatuses are provided for identifying an optimal spectral match and potentially display the compared spectra. A sample spectrum of a sample substance can be compared to reference spectra to identify matches, thereby determining possibilities for what the sample substance is. Correction parameter(s) may be used for the sample spectrum and/or the reference spectrum. Initial value(s) for the correction parameter(s) can be applied to the sample spectrum and/or a reference spectrum, and a similarity score can be determined. The value(s) for the correction parameter(s) can be updated and iteratively improved to provide an optimal similarity score that satisfies a convergence criterion. Data about the reference substances having optimal similarity scores that are above a threshold can be output to a user, e.g., the reference spectra can overlay the sample spectrum. A user can then make a final determination of which reference substance corresponds to the sample substance.

Abstract translation: 提供系统，方法和装置用于识别最佳光谱匹配并潜在地显示所比较的光谱。 可以将样品物质的样品光谱与参考光谱进行比较以鉴定匹配，从而确定样品物质的可能性。 校正参数可用于样品光谱和/或参考光谱。 校正参数的初始值可以应用于采样频谱和/或参考频谱，并且可以确定相似性分数。 校正参数的值可以被更新和迭代地改进，以提供满足收敛准则的最佳相似度得分。 关于具有高于阈值的最佳相似性评分的参考物质的数据可以输出给用户，例如参考光谱可以覆盖样本光谱。 然后用户可以对哪个参考物质对应于样品物质进行最终确定。

公开(公告)号：US20160223468A1

公开(公告)日：2016-08-04

申请号：US15021341

申请日：2014-09-11

Applicant: KOH YOUNG TECHNOLOGY INC

Inventor： Seungwon JUNG ,  Jongjin CHOI ,  Heewook YOU

IPC: G01N21/88 ,  G01N21/956

CPC classification number: G01N21/8851 ,  G01N21/956 ,  G01N21/95607 ,  G01N21/95684 ,  G01N2021/8896 ,  G01N2021/95638 ,  G01N2201/121 ,  G06T5/006 ,  G06T2207/20076 ,  G06T2207/30141

Abstract: The present invention relates to a method for generating a compensation matrix during a substrate inspection. The method comprises the steps of: selecting information of N1 (N1≧2) feature objects which are randomly predetermined within a field of view (FOV) on a substrate; generating a first compensation matrix on the basis of information of the feature objects which are extracted on the substrate; comparing an offset value of each of all the feature objects with a predetermined reference value by applying all the feature objects within the FOV to the compensation matrix to count the number of the feature objects of which the offset value of the each of all the feature objects is less than the predetermined reference value; and repeatedly performing the above steps N2 times (N2≧1), and generating a second compensation matrix using information of the feature objects which have the offset value which is less than the predetermined reference value, in case the number of the counted feature objects is the maximum.

Abstract translation: 本发明涉及在衬底检查期间产生补偿矩阵的方法。 该方法包括以下步骤：在衬底上选择在视场（FOV）内随机地预定的N1（N1≥2）个特征对象的信息; 基于在所述基板上提取的特征对象的信息生成第一补偿矩阵; 通过将FOV内的所有特征对象应用于补偿矩阵来对所有特征对象中的每一个的偏移值与预定的参考值进行比较，以对所有特征对象中的每一个的偏移值进行计数的特征对象的数量 小于预定的参考值; 并重复执行上述步骤N2次（N2≥1），并且使用具有小于预定参考值的偏移值的特征对象的信息生成第二补偿矩阵，在计数特征对象的数量为 最大值。