公开(公告)号：WO2011041304A2

公开(公告)日：2011-04-07

申请号：PCT/US2010/050532

申请日：2010-09-28

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  MONASH UNIVERSITY ,  MEDICINES FOR MALARIA VENTURE ,  PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  CHARMAN, Susan, A. ,  FLOYD, David ,  BURROWS, Jeremy ,  MATTHEWS, David ,  MARWAHA, Alka ,  GUJAR, Ramesh ,  COTERON-LOPEZ, Jose

Inventor： PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  CHARMAN, Susan, A. ,  FLOYD, David ,  BURROWS, Jeremy ,  MATTHEWS, David ,  MARWAHA, Alka ,  GUJAR, Ramesh ,  COTERON-LOPEZ, Jose

IPC: C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC classification number: C07D487/04

Abstract: Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

Abstract translation: 寄生虫二氢乳清酸脱氢酶（DHOD）抑制剂是治疗疟疾的候选治疗剂。 说明性的这种治疗剂包括符合式（IX）的化合物和三唑并嘧啶类化合物：及其溶剂化物，立体异构体，互变异构体和药学上可接受的盐。

公开(公告)号：WO2010065550A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066275

申请日：2009-12-01

Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM ,  HAMRA, F., Kent

Inventor： HAMRA, F., Kent

IPC: A01K67/027

CPC classification number: A01K67/0271 ,  A01K67/02 ,  A01K67/0275 ,  A01K2217/07 ,  A01K2227/10 ,  A01K2227/105 ,  C12N5/061 ,  C12N2500/44 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2800/90

Abstract: A spermatogonial stem cell line that is derived from testes of rats characterized by a desirable genetic background can serve as a source for cells to transplant into male-sterile recipient animals that are immuno-compatible with the spermatogonial line. Rat cells thus transplanted readily develop into fertilization-competent, haploid male gametes, with little or no endogenous sperm competition generated by the testes of the male-sterile recipient. This approach, constituting the first vector system for the use of rat spermatogonial lines from in vitro culture in generating mutant rats on a desired genetic background, effects maximal germline transmission of donor haplotypes from the transplanted spermatogonial cells.

Abstract translation: 来源于具有所需遗传背景的大鼠睾丸的精原干细胞系可以作为细胞移植到与精原细胞系免疫相容的雄性不育受体动物的来源。 因此移植的大鼠细胞很容易发育成受精能力的单倍体雄性配子，雄性不育接受者的睾丸产生的内源性精子竞争很少或没有。 构建用于在所需遗传背景下产生突变大鼠的来自体外培养的大鼠精原细胞系的第一载体系统影响来自移植的精原细胞的供体单倍型的最大种系传播。

公开(公告)号：WO2008134085A1

公开(公告)日：2008-11-06

申请号：PCT/US2008/005616

申请日：2008-05-01

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  ZHONG, Guangming

Inventor： ZHONG, Guangming

IPC: A61K39/118

CPC classification number: A61K39/118 ,  G01N33/56927 ,  G01N2333/295

Abstract: The present invention provides Chlamydia proteins and methods of use in diagnostic and detection assays as well as in treatment and immunization protocols.

Abstract translation: 本发明提供衣原体蛋白质和用于诊断和检测测定以及治疗和免疫方案的方法。

公开(公告)号：WO2007117572A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/008536

申请日：2007-04-06

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  FELDMAN, Marc, D. ,  MILNER, Thomas, E. ,  KIM, Jihoon ,  OH, Jung-hwan ,  SANGHI, Pramod ,  MANCUSO, Jake ,  JOHNSTON, Keith, P. ,  MA, Leo ,  EMELIANOV, Stanislav

Inventor： FELDMAN, Marc, D. ,  MILNER, Thomas, E. ,  KIM, Jihoon ,  OH, Jung-hwan ,  SANGHI, Pramod ,  MANCUSO, Jake ,  JOHNSTON, Keith, P. ,  MA, Leo ,  EMELIANOV, Stanislav

IPC: A61B6/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/416 ,  A61N1/403 ,  A61N2/02 ,  G01N21/1717 ,  G01N21/4795

Abstract: Provided herein are systems, methods and compositions for the use of optical coherence tomography for detection of cells and for killing detected cells.

Abstract translation: 本文提供了使用光学相干断层摄影术来检测细胞和杀死检测到的细胞的系统，方法和组合物。

公开(公告)号：WO2007056551A2

公开(公告)日：2007-05-18

申请号：PCT/US2006/043722

申请日：2006-11-08

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  HAMMER, Robert, E. ,  HAMRA, F., Kent ,  CRONKHITE, Jennifer, T.

Inventor： HAMMER, Robert, E. ,  HAMRA, F., Kent ,  CRONKHITE, Jennifer, T.

IPC: A01K67/027 ,  C12N5/06

CPC classification number: C12N5/0611 ,  C12N2500/90 ,  C12N2501/10 ,  C12N2501/115 ,  C12N2533/54

Abstract: A transgenic rat expresses a gene of interest, such as EGFP, exclusively in the germ cells of both males and females. From such a transgenic rat one can isolate a line of spermatogonial stem cells, which can renew and proliferate in culture.

Abstract translation: 转基因大鼠仅在雄性和雌性的生殖细胞中表达目的基因，例如EGFP。 从这样的转基因大鼠可以分离一系列精原干细胞，其可以在培养物中更新和增殖。

公开(公告)号：WO2006130152A2

公开(公告)日：2006-12-07

申请号：PCT/US2005/023830

申请日：2005-07-06

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  UNITED STATES OF AMERICA represented by THE SECRETARY OF THE AIR FORCE ,  AHUJA, Sunil, K. ,  DOLAN, Matthew, J. ,  KULKARNI, Hemant ,  GONZALEZ, Enrique

Inventor： AHUJA, Sunil, K. ,  DOLAN, Matthew, J. ,  KULKARNI, Hemant ,  GONZALEZ, Enrique

CPC classification number: C12Q1/6883 ,  C12Q1/703 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: The present invention provides compositions and methods for identifying persons at an increased risk of infection by, transmission of, or accelerated progression of a disease caused by an HIV-1 virus. Diagnostic and therapeutic kits are also provided.

Abstract translation: 本发明提供用于鉴定由HIV-1病毒引起的疾病的感染，传播或加速进展的风险增加的人的组合物和方法。 还提供了诊断和治疗试剂盒。

公开(公告)号：WO2006110367A2

公开(公告)日：2006-10-19

申请号：PCT/US2006/012266

申请日：2006-03-31

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BASEMAN, Joel, Barry ,  KANNAN, Thirumalai, Rengasamy

Inventor： BASEMAN, Joel, Barry ,  KANNAN, Thirumalai, Rengasamy

IPC: C07K16/12 ,  C07K16/30

CPC classification number: A61K39/0011 ,  A61K47/6829 ,  A61K47/6851 ,  A61K2039/6037 ,  C07K14/30

Abstract: The present invention provides Mycoplasma toxins, biologically active fragments/domains of the toxins, antibodies to the toxins, therapeutic fusion proteins comprising the toxins and/or biologically active fragments/domains of the toxins and nucleic acids encoding the toxins and fusion proteins. Also provided are methods of treating and/or preventing diseases and disorders using the compositions provided herein.

Abstract translation: 本发明提供了支原体毒素，毒素的生物活性片段/结构域，毒素抗体，包含毒素的毒素和/或生物活性片段/结构域的治疗性融合蛋白和编码 毒素和融合蛋白。 还提供了使用本文提供的组合物治疗和/或预防疾病和病症的方法。

公开(公告)号：WO2003012048A2

公开(公告)日：2003-02-13

申请号：PCT/US2002/024121

申请日：2002-07-30

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BASEMAN, Joel, B. ,  ALVAREZ, Rene ,  KANNAN, Thirumalai, R.

Inventor： BASEMAN, Joel, B. ,  ALVAREZ, Rene ,  KANNAN, Thirumalai, R.

IPC: C12N

CPC classification number: C12Y102/01051 ,  A61K38/00 ,  C07K14/47 ,  C12N9/0008 ,  C12Y102/05001

Abstract: This application describes intracellular, cytoplasmic molecules that are translocated to the surface of a microorganism and participate in binding the microorganism to the surface of a host cell. Examples of such translocated molecules include glycerahdehyde 3-phosphate dehydrogenase, pyruvate dehydrogenase, and elongation factor-Tu. Regions oftranslocated molecules important for binding, as well as molecules which disrupt binding, are described. Antibodies directed to translocated molecules are also described.

Abstract translation: 本申请描述了易位于微生物表面并参与将微生物结合到宿主细胞表面的细胞内的细胞质分子。 这种易位分子的实例包括甘油醛3-磷酸脱氢酶，丙酮酸脱氢酶和延伸因子-Tu。 描述了对于结合重要的释放分子的区域以及破坏结合的分子。 还描述了针对易位分子的抗体。

公开(公告)号：WO1996015780A1

公开(公告)日：1996-05-30

申请号：PCT/US1995015536

申请日：1995-11-22

Applicant: ISIS PHARMACEUTICALS, INC. ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BENNETT, C., Frank ,  STEPKOWSKI, Stanislaw, M.

Inventor： ISIS PHARMACEUTICALS, INC. ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

IPC: A61K31/00

CPC classification number: A61K31/711 ,  A61K38/00 ,  A61K39/39533 ,  A61K48/00 ,  A61K2300/00 ,  C07K14/70525 ,  C07K14/70542 ,  C07K14/70564 ,  C12N15/1138 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

Abstract: Compositions and methods are provided for the prevention and treatment of allograft rejection. Compositions are provided which comprise an antisense oligonucleotide targeted to a nucleic acid sequence encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, or endothelial leukocyte adhesion molecule-1 in combination with an immunosuppressive agent. Methods of preventing or treating allograft rejection by treating an allograft recipient with such a composition are provided. Methods for preventing allograft rejection comprising pretreatment of the graft are also provided.

Abstract translation: 提供组合物和方法用于预防和治疗同种异体移植排斥反应。 提供了组合物，其包含靶向编码细胞间粘附分子-1的核酸序列的反义寡核苷酸，血管细胞粘附分子-1或内皮细胞粘附分子-1与免疫抑制剂的组合。 提供了通过用这种组合物处理同种异体移植受体来预防或治疗同种异体移植排斥的方法。 还提供了用于预防同种异体移植物排斥反应的方法，包括接枝的预处理。

公开(公告)号：WO2019232521A1

公开(公告)日：2019-12-05

申请号：PCT/US2019/035178

申请日：2019-06-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： RUSSELL, Rod ,  SHARMA, Mukul

IPC: E21B47/01 ,  F17D5/08

Abstract: A device for measuring strain on the exterior of a pipe includes a body comprising a top portion and a bottom portion; one or more elastically deformable members coupled between the top portion and the bottom portion, wherein each of the one or more elastically deformable members have an outer contact surface and an inner non-contact surface. One or more sensors are disposed on the inner non-contact surface of one or more of the elastically deformable members. The sensors, during use, provide data that can be used to determine changes in strain on the exterior of the pipe. In another embodiment, one or more sensors are embedded in, or attached to, a casing disposed in a wellbore. In an embodiment, a method includes pressurizing or depressurizing the wellbore with a fluid and measuring the strain induced in the casing (or in an open wellbore) in response to this change in wellbore pressure.