公开(公告)号：US20030162690A1

公开(公告)日：2003-08-28

申请号：US10126976

申请日：2002-04-22

Applicant: COR Therapeutics, Inc.

Inventor： Bing-Yan Zhu ,  Penglie Zhang ,  Lingyan Wang ,  Wenrong Huang ,  Erick A. Goldman ,  Wenhao Li ,  Jingmei Zuckett ,  Yonghong Song ,  Robert M. Scarborough

IPC: A61K031/00

CPC classification number: A61K31/44 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/48 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/616 ,  A61K45/06 ,  A61K2201/094 ,  C07C237/42 ,  C07C255/60 ,  C07C257/18 ,  C07C259/18 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D249/08 ,  C07D295/125 ,  C07D333/38 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

Abstract: Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described Compositions containing such compounds are also described The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders

Abstract translation: 描述了包含其对哺乳动物因子Xa具有活性的其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物的新型苯甲酰胺化合物。还描述了含有这些化合物的组合物。化合物和组合物可用于体外或体内用于预防或治疗凝血障碍

公开(公告)号：US20030018184A1

公开(公告)日：2003-01-23

申请号：US10127691

申请日：2002-04-23

Applicant: COR THERAPEUTICS, INC.

Inventor： Johan Sundelin ,  Robert M. Scarborough

IPC: C07K014/715 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K48/00 ,  C07K7/08 ,  C07K14/705 ,  C07K14/723 ,  G01N2333/726 ,  G01N2500/00

Abstract: Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

Abstract translation: 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。

公开(公告)号：US20020086975A1

公开(公告)日：2002-07-04

申请号：US09947922

申请日：2001-09-07

Applicant: COR THERAPEUTICS, INC.

Inventor： Pamela B. Conley ,  Hans-Michael Jantzen

IPC: C07H021/04 ,  C07K001/00 ,  C07K014/00 ,  C07K017/00

CPC classification number: G01N33/5091 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5094 ,  G01N33/566 ,  G01N2500/10

Abstract: Novel purinergic receptors are provided, having research, diagnostic and therapeutic applications. Also provided are nucleic acids encoding these receptors, as well as expression systems for their production.

Abstract translation: 提供了新的嘌呤能受体，具有研究，诊断和治疗应用。 还提供了编码这些受体的核酸，以及用于其生产的表达系统。

公开(公告)号：US12201758B2

公开(公告)日：2025-01-21

申请号：US18116092

申请日：2023-03-01

Applicant: X-Cor Therapeutics Inc.

Inventor： Steven Paul Keller ,  Brian Yale Chang ,  Jayon Wang

IPC: A61M1/16 ,  A61M1/36 ,  B01D19/00 ,  B01D61/24 ,  B01D63/02

Abstract: Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

公开(公告)号：US20030059852A1

公开(公告)日：2003-03-27

申请号：US09801089

申请日：2001-03-08

Applicant: COR Therapeutics, Inc.

Inventor： David R. Phillips ,  Deborah Ann Law ,  Lisa Nannizzi Alaimo

IPC: G01N033/53 ,  A61K038/16 ,  C07K014/00

CPC classification number: C07K14/70546

Abstract: The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the null-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block integrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.

Abstract translation: 本发明公开了信号蛋白结合所需的整联蛋白β亚单位的细胞质酪氨酸残基的磷酸化。 本发明提供鉴定涉及整联蛋白介导的信号传导的信号载体的方法，鉴定阻断整联蛋白介导信号传导的试剂的方法，使用阻断整联蛋白介导的信号传导调节生物和病理过程的试剂的方法，以及阻断整合素介导的信号传导的试剂。

公开(公告)号：US20020137174A1

公开(公告)日：2002-09-26

申请号：US10071223

申请日：2002-02-11

Applicant: COR Therapeutics, Inc.

Inventor： Daniel R. Storm ,  Beth Hacker ,  James E. Tomlinson

IPC: C12N009/22 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C12N9/88

Abstract: A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described

Abstract translation: 描述了编码人腺苷酸环化酶的DNA序列。 还描述了腺苷酸环化酶的氨基酸序列

公开(公告)号：EP1378524A3

公开(公告)日：2004-06-09

申请号：EP03016689.6

申请日：1992-02-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  COR THERAPEUTICS, INC.

Inventor： Coughlin, Shaun R. ,  Scarborough, Robert M.

IPC: C07K16/28 ,  A61K39/395

CPC classification number: C12N9/6429 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C12Y304/21005 ,  Y10S530/837

Abstract: The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.

公开(公告)号：EP1183234A1

公开(公告)日：2002-03-06

申请号：EP00937699.7

申请日：2000-05-24

Applicant: COR THERAPEUTICS, INC.

Inventor： SONG, Yonghong ,  CLIZBE, Lane ,  MARLOWE, Charles ,  SCARBOROUGH, Robert, M. ,  SU, Ting ,  ZHU, Bing-Yan

IPC: C07C311/46 ,  A61K31/18 ,  A61P7/02

CPC classification number: C07D231/12 ,  C07C311/46 ,  C07C317/32 ,  C07C2601/08 ,  C07C2601/10 ,  C07D233/56 ,  C07D249/08 ,  C07D307/54 ,  C07D307/68 ,  C07D413/04

Abstract: The present application relates to compounds of the general formula A-Y-D-E-G-J-K-L, wherein A, Y, D, E, G, J, K and L have the meanings given in the description, having activity against mammalian factor Xa. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：EP1181270A2

公开(公告)日：2002-02-27

申请号：EP00937701.1

申请日：2000-05-24

Applicant: COR THERAPEUTICS, INC.

Inventor： ZHU, Bing-Yan ,  SU, Ting ,  ZHAOZHONG, Jon Jia ,  SCARBOROUGH, Robert, M. ,  SONG, Yonghong

IPC: C07C311/00

CPC classification number: C07C311/40 ,  C07C311/16 ,  C07C311/18 ,  C07C311/44 ,  C07C311/46

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：EP0785799A4

公开(公告)日：2001-11-21

申请号：EP95937663

申请日：1995-10-27

Applicant: COR THERAPEUTICS INC

Inventor： KING ROBERT S

IPC: A61K38/43 ,  A61P7/02 ,  A61P9/00 ,  C07K1/14 ,  C07K14/745 ,  C07K14/75 ,  C12N9/64 ,  C12P21/08 ,  A61K38/36 ,  C07K1/16 ,  C07K1/22

CPC classification number: C12N9/6432 ,  C07K14/75 ,  C12Y304/21006 ,  Y10S530/829