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    101.
    发明专利
    未知

    公开(公告)号：PT94954A

    公开(公告)日：1991-04-18

    申请号：PT9495490

    申请日：1990-08-09

    Applicant: GLAXO INC.,

    Inventor： THOMAS N. WHEELER ,  JOEL E. SHAFFER ,  TERRENCE KENAKIN

    IPC: A61K31/50 ,  A61P9/00 ,  A61P9/04 ,  C07D237/04

    Abstract: Pyridazinones of the following formula (I): where R -R are a variety of substituents and L is a linking group, a pharmaceutical composition for treating congestive heart failure, novel intermediates, methods for such treatment and processes for preparing compounds of formula (I).

    105.
    发明专利
    未知

    公开(公告)号：PT93137A

    公开(公告)日：1990-08-31

    申请号：PT9313790

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  JAMES MICHAEL K ,  BRACKEEN MARCUS F ,  JOHNSON MICHAEL ROSS ,  LEIGHTON HARRY JEFFERSON

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    N-PHENYL-N-(4-PIPRIDINYL) AMIDES USEFUL AS ANALGESICS
    106.
    发明专利
    N-PHENYL-N-(4-PIPRIDINYL) AMIDES USEFUL AS ANALGESICS 未知

    公开(公告)号：CA2010011A1

    公开(公告)日：1990-08-15

    申请号：CA2010011

    申请日：1990-02-14

    Applicant: GLAXO INC

    Inventor： FELDMAN PAUL L ,  JAMES MICHAEL K ,  BRACKEEN MARCUS F ,  JOHNSON MICHAEL R ,  LEIGHTON HARRY J

    IPC: A61K20060101 ,  A61K31/445 ,  A61K31/4465 ,  A61P25/04 ,  C07B57/00 ,  C07D20060101 ,  C07D211/14 ,  C07D211/58 ,  C07D211/66

    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I). wherein: X is a member selected from the group consisting of: alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

    107.
    发明专利
    未知

    公开(公告)号：DK544888A

    公开(公告)日：1990-03-30

    申请号：DK544888

    申请日：1988-09-29

    Applicant: GLAXO INC

    Inventor： PALSON RICHARD CHARLES JULILUS ,  AMSTRONG JOHN CREIGHTON

    IPC: A61M11/08 ,  A61M15/00

    Abstract: A device for dispensing an aerosol from an aerosol module A includes a cocking device comprising lever 36 and spring 60 for readying it for release of the pressurized aerosol, a sear 64 for retaining the cocking device in a non-operative position following readying and a vane 79 operable by inhalation on the part of a user to disable the sear to thus release the cocking device to effect expulsion of aerosol from the aerosol module.

    109.
    发明专利
    未知

    公开(公告)号：NL8901199A

    公开(公告)日：1989-12-01

    申请号：NL8901199

    申请日：1989-05-12

    Applicant: GLAXO INC

    IPC: A61K9/30 ,  A61K9/28 ,  A61K9/36 ,  A61K31/34 ,  A61K47/14 ,  A61K47/30 ,  A61K47/38 ,  A61P43/00

    Abstract: This invention relates to an improved polymeric film coating for a ranitidine Hydrocholride (HCl) tablet in which the plasticizer triacetin had been added to the polymeric film coating medium. A tablet of this invention has been found to have great stability than a tablet coating with a polymeric film which does not contain triacetin.

    FILM COATED TABLET
    110.
    发明专利
    FILM COATED TABLET 未知

    公开(公告)号：IE891564L

    公开(公告)日：1989-11-13

    申请号：IE156489

    申请日：1989-05-12

    Applicant: GLAXO INC

    IPC: A61K9/30 ,  A61K9/28 ,  A61K9/36 ,  A61K31/34 ,  A61K47/14 ,  A61K47/30 ,  A61K47/38 ,  A61P43/00 ,  A61K9/00

    Abstract: This invention relates to an improved polymeric film coating for a ranitidine Hydrocholride (HCl) tablet in which the plasticizer triacetin had been added to the polymeric film coating medium. A tablet of this invention has been found to have great stability than a tablet coating with a polymeric film which does not contain triacetin.

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