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    VASCULAR WOUND CLOSURE DEVICE
    104.
    发明公开
    VASCULAR WOUND CLOSURE DEVICE 有权
    DEVICE FOR闭幕血管伤口

    公开(公告)号：EP1656069A2

    公开(公告)日：2006-05-17

    申请号：EP04781320.9

    申请日：2004-08-16

    Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

    Inventor： ZHU, Yong, Hua ,  KIRSCH, Wolff, M.

    IPC: A61B17/00

    CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B17/02 ,  A61B2017/00637 ,  A61B2017/00654

    Abstract: An apparatus (430) for closing a vascular wound includes an apparatus that can be threaded over a guidewire(458) into place at or adjacent the wound. The apparatus includes a chamber(520) that encloses a hemostatic material (270) therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.

    RENILLA LUCIFERASE AND GREEN FLUORESCENT PROTEIN FUSION GENES
    108.
    发明授权
    RENILLA LUCIFERASE AND GREEN FLUORESCENT PROTEIN FUSION GENES 失效
    绿色荧光蛋白荧光蛋白融合蛋白

    公开(公告)号：EP0934425B1

    公开(公告)日：2003-11-19

    申请号：EP97943558.3

    申请日：1997-09-24

    Applicant: LOMA LINDA UNIVERSITY

    Inventor： SZALAY, Aldar, A. ,  WANG, Gefu ,  WANG, Yubao

    IPC: C12P21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N9/02 ,  C12N15/09 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04

    CPC classification number: C12N9/001 ,  C07K14/43595 ,  C07K16/40 ,  C07K2319/00

    Abstract: A fusion gene is provided comprising the cDNA of Renilla luciferase and the cDNA of the 'humanized' Aequorea green fluorescent protein. The fusion gene was used to produce a novel protein, the 'Renilla-GFP fusion protein', which displayed both the luciferase activity of Renilla luciferase, and the green fluorescence of GFP. The Renilla-GFP fusion gene is useful as a double marker for monitoring gene expression quantitatively in UV light and by enzyme activity.

    Abstract translation: 提供融合基因，其包含海肾萤光素酶的cDNA和“人源化”水母绿色荧光蛋白的cDNA。 融合基因用于产生新的蛋白质，“Renilla-GFP融合蛋白”，其显示了海肾萤光素酶的荧光素酶活性和GFP的绿色荧光。 Renilla-GFP融合基因可用作紫外光和酶活性定量监测基因表达的双重标记。

    NANODOSIMETER BASED ON SINGLE ION DETECTION
    109.
    发明公开
    NANODOSIMETER BASED ON SINGLE ION DETECTION 有权
    基于单离子检测的纳米流变仪

    公开(公告)号：EP1289627A1

    公开(公告)日：2003-03-12

    申请号：EP01941462.2

    申请日：2001-04-27

    Applicant: LOMA LINDA UNIVERSITY ,  Yeda Ltd.

    Inventor： BASHKIROV, Vladimir ,  SCHULTE, Reinhard, W. ,  SHCHEMELININ, Sergi ,  BRESKIN, Amos ,  CHECHIK, Rachel ,  GARTY, Guy ,  MILLIGAN, Jamie

    IPC: B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/40 ,  G01N27/64

    Abstract: A nanodosimeter device (15) for detecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles; an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time; a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume; and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.

    Abstract translation: 1。一种用于检测由初级粒子的辐射场在敏感气体体积中感应的正离子的纳米测压装置（15），包括用于保持要由初级粒子的辐射场照射的敏感气体体积的电离室（10） 连接到电离室（10）的离子计数器系统，用于检测在到达时间穿过孔径开口并到达离子计数器（12）的正离子; 用于位置敏感检测穿过敏感气体体积的初级颗粒的颗粒跟踪系统; 以及数据采集系统，其能够协调所有数据信号的读出并且执行数据分析，使得由离子计数器系统检测到的正离子的到达时间与由粒子追踪系统检测到的初级粒子的位置敏感数据相关。 本发明进一步包括纳米剂量计用于校准辐射暴露并对样品内的核酸造成损害的方法的用途。 一定体积的组织等效气体用辐射场辐射以诱导正离子。 测量得到的正离子并与通过用相等剂量的辐射照射核酸样品所导致的损伤的存在或程度的确定进行比较。

    SYSTEM FOR MULTIPLE PARTICLE THERAPY
    110.
    发明授权
    SYSTEM FOR MULTIPLE PARTICLE THERAPY 失效
    SYSTEM FOR多粒子治疗

    公开(公告)号：EP0822848B1

    公开(公告)日：2002-10-30

    申请号：EP96911792.8

    申请日：1996-04-17

    Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

    Inventor： SLATER, James, M. ,  MILLER, Daniel, W. ,  SLATER, Jon, W.

    IPC: A61N5/10

    CPC classification number: A61N5/10 ,  A61N2005/1085 ,  A61N2005/1087 ,  A61N2005/109 ,  A61N2005/1095

    Abstract: A system (100) for delivering two types of particles to a target within the body of a patient (142). A proton beam therapy system (100) produces a beam of protons (151) that is directed from a nozzle (150) towards a target isocenter (144) located within the body of a patient (142). The beam of protons (151) can pass directly to the patient or pass through a neutron source (104) comprised of a plate of neutron-rich material (154). Collisions between some of the protons and neutrons cause neutrons to be emitted from the material thereby generating a multiple particle beam (170) comprised of both protons and neutrons. Preferably, the neutrons comprise only a small percent of the total particles in the beam. In the preferred embodiment, the neutron source (104) is comprised of a plate of Beryllium (154) that is interposed between the nozzle (150) and the patient (142).

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