公开(公告)号：US20180256829A1

公开(公告)日：2018-09-13

申请号：US15762387

申请日：2016-09-22

Applicant: Stamford Devices Limited

Inventor： Joseph GREHAN ,  Michael CASEY ,  Shaun PORTER ,  Niall SMITH

IPC: A61M11/00

Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.

公开(公告)号：US09572950B2

公开(公告)日：2017-02-21

申请号：US13829044

申请日：2013-03-14

Applicant: STAMFORD DEVICES LIMITED

Inventor： John Sylvester Power ,  James B. Fink ,  Conor Paul Duffy ,  Trevor Stephen Fahy

IPC: A61M11/00 ,  A61M16/16 ,  A61M15/00 ,  A61M16/14 ,  A61M16/00 ,  A61M16/06 ,  A61M16/08 ,  B05B12/08 ,  B05B17/00 ,  B05B17/06

CPC classification number: A61M16/14 ,  A61M11/002 ,  A61M11/003 ,  A61M11/005 ,  A61M15/0085 ,  A61M16/0057 ,  A61M16/0666 ,  A61M16/0672 ,  A61M16/0833 ,  A61M16/0875 ,  A61M16/147 ,  A61M16/16 ,  A61M2202/0208 ,  A61M2206/14 ,  B05B12/081 ,  B05B17/0646 ,  B05B17/0669

Abstract: A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula or a face mask. An aerosol generator is mounted to the housing and delivers aerosol into an oxygen stream flowing between an inlet and an outlet of the housing. The housing also has a removable plug in the base thereof for draining any liquid that accumulates in the housing. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.

Abstract translation: 描述了补充氧气输送系统，其中气溶胶被输送到从辅助氧气供应和可选的加湿器位于电路中的壳体中。 补充的氧气通过气溶胶所在的腔室，并将通过鼻插管或面罩将其运送到患者的气溶胶收集。 将气溶胶发生器安装到壳体并将气溶胶输送到在壳体的入口和出口之间流动的氧气流中。 壳体还在其底部具有可移除的塞子，用于排出积聚在壳体中的任何液体。 使用鼻腔插管的患者不会中断输氧，目前在接受雾化药物时必须使用单独的面罩。

公开(公告)号：US20150336115A1

公开(公告)日：2015-11-26

申请号：US14719036

申请日：2015-05-21

Applicant: Stamford Devices Limited

Inventor： Brendan HOGAN ,  Hong XU

IPC: B05B1/02 ,  C25D7/04

CPC classification number: B05B1/02 ,  A61M11/005 ,  A61M15/0085 ,  A61M2207/00 ,  B05B17/0638 ,  B05B17/0653 ,  C25D1/08 ,  C25D7/04

Abstract: An aperture plate is manufactured by plating metal around a mask of resist columns having a desired size, pitch, and profile, which yields a wafer about 60 μm thickness. This is approximately the full desired target aperture plate thickness. The plating is continued so that the metal overlies the top surfaces of the columns until the desired apertures are achieved. This needs only one masking/plating cycle to achieve the desired plate thickness. Also, the plate has passageways formed beneath the apertures, formed as an integral part of the method, by mask material removal. These are suitable for entrainment of aerosolized droplets exiting the apertures.

Abstract translation: 通过在具有期望的尺寸，间距和轮廓的抗蚀剂柱的掩模上镀覆金属来制造孔板，其产生约60μm厚度的晶片。 这大约是完全期望的目标孔板厚度。 继续进行电镀，使得金属覆盖在柱的顶表面上，直到达到所需的孔。 这只需要一个掩模/电镀周期来实现所需的板厚度。 此外，板具有形成在孔下方的通道，其形成为该方法的整体部分，通过掩模材料去除。 这些适合于夹带离开孔的雾化液滴。

公开(公告)号：US20150122248A1

公开(公告)日：2015-05-07

申请号：US14530173

申请日：2014-10-31

Applicant: Stamford Devices Limited

Inventor： Patrick Joseph POWER ,  Jimmy EATON-EVANS

IPC: A61M11/02 ,  A61M16/20 ,  A61M11/00 ,  A61M15/00 ,  A61M16/06

CPC classification number: A61M11/02 ,  A61M11/003 ,  A61M15/0021 ,  A61M15/0085 ,  A61M16/06 ,  A61M16/208 ,  A61M2202/0208 ,  A61M2202/04

Abstract: A system for delivery of aerosol therapy to spontaneously breathing patients comprises a housing which defines a chamber. The housing has a base, a top and a main body extending between the base and the top. An ambient air inlet is located adjacent to the base and is normally closed by an inlet valve. The housing also has a patient port for receiving a mouthpiece or a face mask. The mouthpiece has an exhaust outlet closed by an exhaust valve. Similarly, the face mask has an exhaust outlet closed by an exhaust valve. Exhaled air is exhausted through the valves and to prevent recirculation through the chamber which would adversely affect dose efficiencies. The housing also has an aerosol port for receiving a vibrating mesh aerosol generating device. The aerosol port is located in a side of the main body of the housing for delivery of aerosol into the chamber between the inlet valve and the patient port. A boss extends upwardly from the base and is spaced-apart inwardly of the main body of the housing to define a reception space or well.

Abstract translation: 用于将气溶胶疗法递送到自发呼吸患者的系统包括限定腔室的壳体。 壳体具有在基部和顶部之间延伸的基部，顶部和主体。 环境空气入口位于基座附近，并且通常由入口阀封闭。 外壳还具有用于接收口器或面罩的患者口。 接口具有由排气阀关闭的排气口。 类似地，面罩具有由排气阀封闭的排气口。 呼出的空气通过阀排出，并防止通过室的再循环，这将不利地影响剂量效率。 壳体还具有用于接收振动网孔气溶胶发生装置的气溶胶口。 气溶胶口位于壳体的主体的一侧，用于将气溶胶输送到入口阀和患者端口之间的腔室中。 凸台从基座向上延伸并且与壳体的主体向内间隔开以限定接收空间或井。

公开(公告)号：US20150101596A1

公开(公告)日：2015-04-16

申请号：US14401480

申请日：2013-05-24

Applicant: Stamford Devices Limited

Inventor： Brendan Hogan

IPC: A61M11/00 ,  C25D7/00

Abstract: A photo-resist (21) is applied in a pattern of vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.

Abstract translation: 光刻胶（21）以要制造的孔板的孔或孔的尺寸的垂直列的图案施加。 该掩模图形提供限定气溶胶颗粒尺寸的孔，每平方毫米具有多达2500个孔。 将金属（22）电沉积到柱（21）周围的空间中。 进一步应用包括多个第一列（21）的区域的更大（更宽和更高）的列的第二光刻胶掩模（25）。 根据期望的流速选择第二镀层中的孔直径。

公开(公告)号：WO2022013088A1

公开(公告)日：2022-01-20

申请号：PCT/EP2021/069137

申请日：2021-07-09

Applicant: STAMFORD DEVICES LIMITED

Inventor： POWER, John ,  MACLOUGHLIN, Ronan ,  CASEY, Micheal ,  DUFFY, Conor ,  DUFFY, Aidan

IPC: A61M15/00 ,  B65D83/00 ,  G07F7/06 ,  G07F13/10 ,  A61M15/08 ,  A61M16/06 ,  A61M11/00 ,  G07F13/08 ,  G07F13/02 ,  G07F17/00 ,  G16H20/13

Abstract: A dispensing apparatus (100) is for use by users to take a chamber (110), fill the chamber with an aerosolized vaccine or other medicament (104), and dispose of used chambers (120). A display (103) provides instructions to encourage prompt inhalation by the user from a dispensed and filled chamber. The apparatus allows very fast administration of vaccines to large numbers of people. The aerosol dispenser apparatus detects the chamber is in correct position and delivers a predetermined dose of aerosol. Once the dose is delivered a visual and/or audible indicator informs the user that the chamber is filled and that they can take the inhalation. The single dose aerosol chamber (110) is optimized for efficient administration of an aerosol.

公开(公告)号：WO2021023522A1

公开(公告)日：2021-02-11

申请号：PCT/EP2020/070890

申请日：2020-07-23

Applicant: STAMFORD DEVICES LIMITED

Inventor： TELFER, Colin ,  POWER, Patrick

IPC: A61M11/00 ,  A61M15/00

Abstract: A nebulizer device (1) has an aerosol generator mounted in a housing (2), and a mouthpiece (3). The device is adapted for delivery of an active agent in an aerosol into the buccal cavity, with droplet size greater than 10µm. Aerosolization is started at or after the end of breath inhalation and is stopped at or before the start of breath inhalation. The flow is via mouthpiece (25) with internal ridges (21) which periodically narrow the flow path volume to so that droplets coalesce in the flow path 25 before the mesh (3)

公开(公告)号：WO2019007950A1

公开(公告)日：2019-01-10

申请号：PCT/EP2018/067937

申请日：2018-07-03

Applicant: STAMFORD DEVICES LIMITED

Inventor： MACLOUGHLIN, Ronan ,  PORTER, Shaun ,  DUFFY, Conor ,  POWER, John

IPC: A61M11/00 ,  A61M15/08 ,  A61M16/14 ,  A61M16/16

Abstract: A gas therapy system (1) has a flow line (3, 2), a coupler (6) to a gas source, and an aerosol generator (4) for aerosol delivery, and a patient interface such as a nasal interface (2). A controller (10) is configured to modulate gas flow and aerosol delivery in real time. The controller changes gas flow rate and dynamically reduces aerosol delivery during upper gas flow rates such as 60 LPM, and activates aerosol delivery during lower gas flow rates of for example 10 LPM. The control may also include sensors to detect breathing, so that there is a bias towards increased aerosol delivery during inhalation in addition to during lower level gas flow.

公开(公告)号：WO2013164253A1

公开(公告)日：2013-11-07

申请号：PCT/EP2013/058646

申请日：2013-04-25

Applicant: STAMFORD DEVICES LIMITED

Inventor： CASEY, Michael ,  GREHAN, Joseph ,  HYLAND, Kieran ,  POWER, John

IPC: A61M15/00 ,  B05B17/00

CPC classification number: A61M11/00 ,  A61M11/005 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2205/70 ,  B05B12/00 ,  B05B17/0646

Abstract: A nebulizer (1) comprises a controller (2) linked at its output to a vibrating mesh nebulizer head (3), and at its input to a USB cable 5 and plug (4) for connection to a host system. The link between the plug (4) and the controller (2) is a USB cable (5) with power and data channels. The controller (2) comprises a boost circuit (10), a micro-controller (11), and a drive circuit (12). The latter provides power and control signals via a cable (6) and plug (7) to the head (3). These signals provide power and control for a vibrating membrane receiving a liquid to be aerosolised from a feed container. The controller (2) has a housing (25) with LED status lamps (30), and an ON/OFF button (32). Communication can take place between the controller (2) and the USB power source (4), in compliance with the USB protocol. This allows the controller (2) to be controlled via a host, either locally or remotely. The controller may be a slave device, with the dosing regime determined by the host. This allows comprehensive control and treatment monitoring for a wide variety of situations such as in the home or in hospitals.

Abstract translation: 雾化器（1）包括在其输出处连接到振动筛网雾化器头（3）的控制器（2），并且在其输入端处连接到用于连接到主机系统的USB电缆5和插头（4）。 插头（4）和控制器（2）之间的连接是具有电源和数据通道的USB电缆（5）。 控制器（2）包括升压电路（10），微控制器（11）和驱动电路（12）。 后者通过电缆（6）和插头（7）向头部（3）提供电力和控制信号。 这些信号为接收从进料容器雾化的液体的振动膜提供动力和控制。 控制器（2）具有带有LED状态灯（30）的壳体（25）和一个ON / OFF按钮（32）。 根据USB协议，可以在控制器（2）和USB电源（4）之间进行通信。 这允许控制器（2）通过主机进行本地或远程控制。 控制器可以是从设备，其中配给方案由主机确定。 这允许对各种情况进行综合的控制和治疗监测，例如在家中或医院中。

公开(公告)号：WO2013092701A1

公开(公告)日：2013-06-27

申请号：PCT/EP2012/076135

申请日：2012-12-19

Applicant: STAMFORD DEVICES LIMITED

Inventor： HOGAN, Brendan ,  BUTAN, Daniela ,  CLIFFORD, Seamus ,  POMEROY, Michael ,  SOUTHERN, Mark ,  SHEIL, David

IPC: C25D3/56 ,  C22C5/04

CPC classification number: B05B17/0646 ,  B05B17/0669 ,  C22C5/04 ,  C25D1/10 ,  C25D3/567

Abstract: An aperture plate is formed from a palladium nickel alloy comprising about 89% palladium and about 11% nickel. There is a generally fine substantially equiaxed grain microstructure throughout the thickness of the aperture plate. The average grain width (W) is in the range of from 0.2 μm to 5.0 μm, in some cases from 0.2 μm to 2.0 μm. Because the grain structure is equiaxed (L/W =1) the grain length (L) is the same as the grain width. The improved aperture plate extends the life of nebulisers, eliminates the risk of premature and unpredictable failure of a nebuliser in service, eliminates the risk of product returns from hospitals and patients, and eliminates the possible risk of fragments of the aperture plate breaking free from the nebulizer.

Abstract translation: 孔板由包含约89％钯和约11％镍的钯镍合金形成。 在孔板的整个厚度上存在通常细的基本上等轴晶粒微观结构。 平均晶粒宽度（W）在0.2μm至5.0μm的范围内，在一些情况下为0.2μm至2.0μm。 由于晶粒结构为等轴（L / W = 1），晶粒长度（L）与晶粒宽度相同。 改进的孔板延长了雾化器的寿命，消除了雾化器在使用过程中过早和不可预测的故障的风险，消除了医院和患者的产品返回风险，并消除了孔板破碎的可能性， 喷雾器。