公开(公告)号：WO2019038408A1

公开(公告)日：2019-02-28

申请号：PCT/EP2018/072824

申请日：2018-08-23

Applicant: STAMFORD DEVICES LIMITED

Inventor： GREHAN, Joseph ,  COYLE, Noel ,  GREANEY, Russell ,  THORNTON, Stephen

IPC: B05B17/06 ,  B05B12/08 ,  A61M15/00

Abstract: An aerosol delivery system has an aerosol generator with a vibrating aperture plate (10) and an actuator (11, 16, 17, 19), a controller (18, 19). The controller in real time monitors (201) the aerosol generator as it is driven for vibration of the aperture plate, and detects (202) a change in an electrical characteristic in response to a transition from a wet state to a dry state of the aperture plate. It automatically modifies (203, 205, 206), during the transition, operation of the aerosol generator in response to the detected change. The modification includes reducing applied power (203). The controller continues (204) to monitor during the transition, including monitoring the aperture plate for presence of residual liquid on the aperture plate first surface. The controller monitors at a number of drive frequencies and maintains data representing trends in a combination of the electrical characteristic signals at the different frequencies, and identifies a start of a transition if a calculated value rises above a threshold. There is one threshold for triggering a check scan for residual volume and a higher threshold to trigger an immediate shut down.

公开(公告)号：WO2013164253A1

公开(公告)日：2013-11-07

申请号：PCT/EP2013/058646

申请日：2013-04-25

Applicant: STAMFORD DEVICES LIMITED

Inventor： CASEY, Michael ,  GREHAN, Joseph ,  HYLAND, Kieran ,  POWER, John

IPC: A61M15/00 ,  B05B17/00

CPC classification number: A61M11/00 ,  A61M11/005 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2205/70 ,  B05B12/00 ,  B05B17/0646

Abstract: A nebulizer (1) comprises a controller (2) linked at its output to a vibrating mesh nebulizer head (3), and at its input to a USB cable 5 and plug (4) for connection to a host system. The link between the plug (4) and the controller (2) is a USB cable (5) with power and data channels. The controller (2) comprises a boost circuit (10), a micro-controller (11), and a drive circuit (12). The latter provides power and control signals via a cable (6) and plug (7) to the head (3). These signals provide power and control for a vibrating membrane receiving a liquid to be aerosolised from a feed container. The controller (2) has a housing (25) with LED status lamps (30), and an ON/OFF button (32). Communication can take place between the controller (2) and the USB power source (4), in compliance with the USB protocol. This allows the controller (2) to be controlled via a host, either locally or remotely. The controller may be a slave device, with the dosing regime determined by the host. This allows comprehensive control and treatment monitoring for a wide variety of situations such as in the home or in hospitals.

Abstract translation: 雾化器（1）包括在其输出处连接到振动筛网雾化器头（3）的控制器（2），并且在其输入端处连接到用于连接到主机系统的USB电缆5和插头（4）。 插头（4）和控制器（2）之间的连接是具有电源和数据通道的USB电缆（5）。 控制器（2）包括升压电路（10），微控制器（11）和驱动电路（12）。 后者通过电缆（6）和插头（7）向头部（3）提供电力和控制信号。 这些信号为接收从进料容器雾化的液体的振动膜提供动力和控制。 控制器（2）具有带有LED状态灯（30）的壳体（25）和一个ON / OFF按钮（32）。 根据USB协议，可以在控制器（2）和USB电源（4）之间进行通信。 这允许控制器（2）通过主机进行本地或远程控制。 控制器可以是从设备，其中配给方案由主机确定。 这允许对各种情况进行综合的控制和治疗监测，例如在家中或医院中。

公开(公告)号：WO2022263049A1

公开(公告)日：2022-12-22

申请号：PCT/EP2022/061596

申请日：2022-04-29

Applicant: STAMFORD DEVICES LIMITED

Inventor： GREHAN, Joseph ,  CASEY, Micheal ,  CONNOLLY, Diarmuid

IPC: A61M16/00 ,  A61M11/00

Abstract: A ventilator system (1) comprising a ventilator (2) and a nebulizer (3), and an interface (4) linking said ventilator with said nebulizer in a manner allowing a degree of control of nebulizer operation by the ventilator controller. The interface (4) has a coupler to the ventilator (2), a cable linking said coupler to an interface controller (5), a cable linking said interface controller (5) to a coupler (11) for fitting to the nebulizer (3). The interface controller (5) performs phasic delivery control of the nebulizer in response to commands from the ventilator, and it implements a time-out monitor in which it generates a command to cease nebulization if a start command has not been received from the ventilator controller before expiry of a time-out period.

公开(公告)号：WO2018007245A1

公开(公告)日：2018-01-11

申请号：PCT/EP2017/066225

申请日：2017-06-29

Applicant: STAMFORD DEVICES LIMITED

Inventor： KELLY, Patrick Martin ,  GREHAN, Joseph ,  MAGUIRE, Finbarr

IPC: A61M11/00 ,  A61F9/00 ,  B05B17/06

CPC classification number: B05B17/0646 ,  A61F9/0008 ,  A61M11/00

Abstract: An aperture plate 1 comprises an inlet surface 2 for receiving a liquid to be aerosolised, an outlet surface 3 and a plurality of apertures 4 extending therebetween. The apertures 4 are tapered from an inlet opening 10 at the inlet surface 2 to an outlet or exit opening 12. The aperture plate is convex in the direction of the inlet openings 10 and concave in the direction of the exit openings 12. The aerosol exits on the concave side of the aperture plate. The aperture plate of the invention generates an aerosol plume which converges and is particularly suitable for application to the eye.

Abstract translation: 孔板1包括用于接收待气雾化的液体的入口表面2，出口表面3和在其间延伸的多个孔4。 孔4从入口表面2处的入口10到出口或出口12逐渐变细。孔板在入口10的方向上凸出并且在出口12的方向上凹入。气溶胶出口 在孔板的凹侧上。 本发明的孔板产生会聚并特别适用于眼睛的气溶胶羽流。

公开(公告)号：WO2017055166A1

公开(公告)日：2017-04-06

申请号：PCT/EP2016/072541

申请日：2016-09-22

Applicant: STAMFORD DEVICES LIMITED

Inventor： GREHAN, Joseph ,  CASEY, Michael ,  PORTER, Shaun ,  SMITH, Niall

IPC: B05B17/06 ,  A61M11/00

CPC classification number: B05B17/0646 ,  A61M11/005 ,  A61M2205/3317 ,  A61M2205/3386 ,  B05B12/081 ,  B05B15/14 ,  B05B17/0669 ,  B06B1/0253 ,  B06B2201/77

Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.

Abstract translation: 喷雾器控制器的数字处理器控制和监视施加到孔板的驱动电流（I）。 驱动电流被检测为多个测量点中的每一个的一系列离散值，每个测量点具有特定的驱动频率。处理器实时地计算驱动电流与频率的斜率或速率，并另外确定驱动电流的最小值 导致峰值。 处理器在扫描期间使用最小驱动电流的值，并且当孔板变干时也使用最大斜率值来实现剂量结束的可靠预测。

公开(公告)号：WO2015010809A1

公开(公告)日：2015-01-29

申请号：PCT/EP2014/060723

申请日：2014-05-23

Applicant: STAMFORD DEVICES LIMITED

Inventor： GREHAN, Joseph ,  SMITH, Niall

IPC: B05B17/06 ,  B05B12/08

CPC classification number: A61M11/005 ,  A61M11/001 ,  A61M2205/33 ,  A61M2205/3317 ,  B05B12/004 ,  B05B12/081 ,  B05B15/14 ,  B05B17/0646 ,  B05B17/0669 ,  B06B1/0253 ,  G01N29/22 ,  G01N29/42 ,  G06F19/00 ,  G06F19/3456 ,  G16H20/13

Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2- 4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.

Abstract translation: 喷雾器具有孔板，安装件，致动器和孔板驱动电路（2-4）。 控制器测量多个测量点中的每一个的电驱动参数，每个测量点具有驱动频率; 并且基于测量点处的参数的值来确定最佳驱动频率以及剂量结束预测。 控制器以规定的次秒间隔执行短扫描，在两个间隔，在具有不同驱动频率的两个测量点处测量驱动电流。 根据这些点的驱动参数测量，控制器确定是否应执行扫描更大数量的测量点的全扫描。 全扫描可为设备提供最佳的驱动频率，同时也为剂量指示结束。

公开(公告)号：EP3478347A1

公开(公告)日：2019-05-08

申请号：EP17733477.8

申请日：2017-06-29

Applicant: Stamford Devices Limited

Inventor： KELLY, Patrick Martin ,  GREHAN, Joseph ,  MAGUIRE, Finbarr

IPC: A61M11/00 ,  A61F9/00 ,  B05B17/06

公开(公告)号：EP4355397A1

公开(公告)日：2024-04-24

申请号：EP22726675.6

申请日：2022-04-29

Applicant: Stamford Devices Limited

Inventor： GREHAN, Joseph ,  CASEY, Micheal ,  CONNOLLY, Diarmuid

IPC: A61M16/00 ,  A61M11/00

CPC classification number: A61M16/022 ,  A61M11/005 ,  A61M2205/601820130101 ,  A61M2205/358420130101

公开(公告)号：EP3024590A1

公开(公告)日：2016-06-01

申请号：EP14725733.1

申请日：2014-05-23

Applicant: Stamford Devices Limited

Inventor： GREHAN, Joseph ,  SMITH, Niall

IPC: B05B17/06 ,  B05B12/08

CPC classification number: A61M11/005 ,  A61M11/001 ,  A61M2205/33 ,  A61M2205/3317 ,  B05B12/004 ,  B05B12/081 ,  B05B15/14 ,  B05B17/0646 ,  B05B17/0669 ,  B06B1/0253 ,  G01N29/22 ,  G01N29/42 ,  G06F19/00 ,  G06F19/3456 ,  G16H20/13

Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.

Abstract translation: 喷雾器具有孔板，安装件，致动器和孔板驱动电路（2-4）。 控制器测量多个测量点中的每一个的电驱动参数，每个测量点具有驱动频率; 并且基于测量点处的参数的值来确定最佳驱动频率以及剂量终止预测。 控制器以规定的次秒间隔执行短扫描，在两个不同驱动频率的测量点处测量驱动电流。 根据这些点的驱动参数测量，控制器确定是否应执行扫描更大数量的测量点的全扫描。 全扫描提供了设备的最佳驱动频率以及剂量指示的结束。

公开(公告)号：EP2844321B1

公开(公告)日：2018-10-17

申请号：EP13718842.1

申请日：2013-04-25

Applicant: STAMFORD DEVICES LIMITED

Inventor： CASEY, Michael ,  GREHAN, Joseph ,  HYLAND, Kieran ,  POWER, John

IPC: B05B12/00 ,  B05B17/00

CPC classification number: A61M11/00 ,  A61M11/005 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2205/70 ,  B05B12/00 ,  B05B17/0646

Abstract: A nebulizer comprises a controller linked at its output to a nebulizer head, and at its input to a USB cable and USB plug for connection to a host system. The link between the USB plug and the controller is a USB cable with power and data channels. The controller comprises a boost circuit, a microcontroller 11, and a drive circuit. The latter provides power and control signals via a cable and proprietary plug to the nebulizer head. These signals provide power and control for a vibrating membrane receiving a liquid to be aerosolized. The controller has a housing with LED status lamps, and an ON/OFF button. The controller can be controlled via a host, either locally or remotely.