公开(公告)号：CA2217880A1

公开(公告)日：1996-11-14

申请号：CA2217880

申请日：1996-05-07

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  LADNER WOLFGANG

IPC: C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/52 ,  C07C233/23 ,  C07C271/24 ,  C07C271/56 ,  C07C215/44

Abstract: A process for preparing enantiomer-pure cis1-amino-2-hydroxyindane is characterised in that: (a) racemic trans1-aminoindan-2-ol is reacted according to known processes with acids or acid derivatives having the general formula RCOX, yielding type (A) amides, in which the substituents have the following meanings: R stands for hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl and phenyl, groups that may carry one to three halogen atoms and/or one to three among the following residues: cyano, C1-C6 alkoxy, C1-C6 alkylthio phenyl, phenylthio and phenoxy, the phenyl residues in turn carrying one to three among the following groups: C1-C4 alkyl, C1-C4 alkoxy, halogen, cyano and nitro; X stands for OH, halogen, OR1 and SR1, in which R1 stands for alkyl C1-C6, phenyl and COR. In a second step (b), a supersaturated solution or melt of racemic amide (A) is blended with seed crystals of an enantiomer, then (c) the precipitated crystals are isolated and the remaining mother liquor or melt is again supersaturated, after separation of racemic amide (A), and blended with seed crystals of the other enantiomer in order to selectively crystallise said enantiomer. Finally (d), the thus obtained enantiomer-pure transamide is reacted according to known methods to yield enantiomer-pure cis1-amino-2-hydroxyindane.

公开(公告)号：CA2188834A1

公开(公告)日：1995-11-02

申请号：CA2188834

申请日：1995-04-12

Applicant: BASF AG

Inventor： DINGLER CHRISTOPH ,  LADNER WOLFGANG ,  KREI GEORG ARNOLD

IPC: C12P7/42 ,  C12P1/00 ,  C12P7/40 ,  C12P7/62 ,  C12R1/645

Abstract: A process for the biotransformation of carboxylic acid in the presence of a microorganism in which the best possible concentration of undissociated carboxylic acid for biotransformation is set by controlling the pH throughout the biotransformation process.

公开(公告)号：HU211056B

公开(公告)日：1995-10-30

申请号：HU224292

申请日：1991-07-13

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  PRESSLER UWE ,  SIEGEL WOLFGANG

IPC: C12N1/20 ,  C12N1/21 ,  C12N15/01 ,  C12P13/08 ,  C12R1/13 ,  C12R1/15

公开(公告)号：DE59103718D1

公开(公告)日：1995-01-12

申请号：DE59103718

申请日：1991-07-13

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  PRESSLER UWE ,  SIEGEL WOLFGANG

IPC: C12N1/20 ,  C12N1/21 ,  C12N15/01 ,  C12P13/08 ,  C12R1/13 ,  C12R1/15

公开(公告)号：CA2121048A1

公开(公告)日：1993-04-29

申请号：CA2121048

申请日：1992-09-25

Applicant: BASF AG

Inventor： STAUDENMAIER HORST R ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  MUELLER URSULA ,  PRESSLER UWE ,  MEYER JOACHIM

IPC: C12P7/42 ,  C12R1/645 ,  C12R1/66 ,  C12R1/69

Abstract: 2121048 9308295 PCTABS00021 The invention concerns a new method of preparing, by fermentation, compounds of general formula (I) in which R1 is a hydrogen, fluorine, chlorine or bromine atom.

公开(公告)号：DE4023576A1

公开(公告)日：1992-01-30

申请号：DE4023576

申请日：1990-07-25

Applicant: BASF AG

Inventor： LADNER WOLFGANG ,  PRESSLER UWE ,  SIEGEL WOLFGANG

IPC: C12N1/20 ,  C12N1/21 ,  C12N15/01 ,  C12P13/08 ,  C12R1/13 ,  C12R1/15

Abstract: Described is a method for the preparation of microorganisms which have an elevated L-lysine production capability by mutation of microorganisms of the genuses Corynebacterium and Brevibacterium with known mutagens in a known manner, characterized in that strains of said genuses are mutated, selecting those wich are resistant to regenerative inhibition by 2-azido- epsilon -caprolactam.

公开(公告)号：DE3681845D1

公开(公告)日：1991-11-14

申请号：DE3681845

申请日：1986-07-11

Applicant: BASF AG

Inventor： MARCINOWSKI STEFAN ,  SANNER AXEL ,  TSCHANG CHUNG-JI ,  LADNER WOLFGANG ,  GREIF NORBERT

IPC: C12N11/08 ,  C07K17/08 ,  C12N11/04

Abstract: Enzymes or microorganisms are immobilised by mixing them with an aq. soln. contg. a water-soluble glycidyl ether (I) and a water-soluble amine (II) contg. at least 2 NH gps., opt. in partially neutralised form, and allowing the mixt. to gel. (I) is a prod. obtd. by reacting 1-30 equivs. of an epoxide of formula (III) with 1 equiv. of a 2-6C polyhydric alcohol or a mono- or disaccharide, reacting the prod. with epichlorohydrin, and opt. cyclising the prod. to form an epoxide. In (III), R1-R3 = H, Me or Et.

公开(公告)号：DK277889D0

公开(公告)日：1989-06-07

申请号：DK277889

申请日：1989-06-07

Applicant: BASF AG

Inventor： URBAN DIETER ,  LADNER WOLFGANG ,  PAUL AXEL ,  SANNER AXEL

IPC: C12N11/08 ,  C12P17/02 ,  C12P41/00

Abstract: Process for preparing a biocatalyst by mixing a) polyolefin fibres which have been rendered hydrophilic, b) crude porcine pancreatic lipase, c) at least one water-soluble dihydric to hexahydric alcohol with 2 to 6 carbon atoms and d) an aqueous buffer solution of pH 5 to 9 at 0 to 40 DEG C, filtering after 1 minute to 3 days, and washing the filter cake, and the use of the biocatalyst obtained in this way for resolving esters of racemic alcohols in aqueous medium.

公开(公告)号：DE3527014A1

公开(公告)日：1987-02-05

申请号：DE3527014

申请日：1985-07-27

Applicant: BASF AG

Inventor： MARCINOWSKI STEFAN ,  SANNER AXEL ,  TSCHANG CHUNG-JI ,  LADNER WOLFGANG ,  GREIF NORBERT

IPC: C12N11/08 ,  C07K17/08 ,  C12N11/04 ,  C12N9/20 ,  C12N9/50 ,  C12N9/78 ,  C12N9/92 ,  C12N9/02

Abstract: Enzymes are immobilized by mixing the following components with one another in aqueous solution: (a) an enzyme or a dispersed microorganism, (b) a water-soluble glycidyl ether, prepared by subjecting from 1 to 30 equivalents of an epoxide of the formula I (I) where R1, R2 and R3 are each hydrogen, methyl or ethyl, to an addition reaction with 1 equivalent (based on OH groups) of a polyfunctional alcohol of 2 to 6 carbon atoms or of a mono- or disaccharide to produce an adduct, reacting the adduct with epichlorohydrin and, if required, then carrying out cyclization to give the epoxide, and (c) a water-soluble amine possessing two or more NH groups, if necessary in a partially neutralized form, and allowing the mixture thus obtained to gel.