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公开(公告)号:WO2017001566A1
公开(公告)日:2017-01-05
申请号:PCT/EP2016/065314
申请日:2016-06-30
Applicant: IMEC VZW
Inventor: ROTTENBERG, Xavier
CPC classification number: G01N21/0303 , B01L3/502715 , B01L2300/0816 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , G01N21/03 , G01N21/31 , G01N21/314 , G01N2021/0346 , G01N2021/3137 , G01N2021/3166 , G01N2021/3181 , G01N2201/062 , G01N2201/0633 , G01N2201/0636 , G01N2201/066 , G01N2201/0873
Abstract: The present disclosure describes a device (1) for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source (2) for emitting light, a plurality of integrated optical waveguides (3) for guiding this light and a light coupler (10) for coupling the emitted light into the integrated optical waveguides (3) such that the light coupled into each integrated optical waveguide (3) has substantially the same spectral distribution. The device also comprises a microfluidic channel (5) for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide (3) with the fluid in the microfluidic channel (5), and a plurality of spectral analysis devices (8) optically coupled to corresponding waveguides (3) such as to receive the light after interaction with the fluid. The spectral analysis devices (8) are adapted for generating a signal representative of a plurality of spectral components of the light.
Abstract translation: 本公开描述了用于测量作为波长的函数的流体的光吸收特性的装置(1)。 该装置包括用于发射光的宽带光源(2),用于引导该光的多个集成光波导(3)和用于将发射的光耦合到集成光波导(3)中的光耦合器(10),使得 耦合到每个集成光波导(3)中的光具有基本上相同的光谱分布。 该装置还包括用于容纳流体的微流体通道(5),其布置成允许通过每个波导(3)传播的光与微流体通道(5)中的流体相互作用,以及多个光谱分析装置 (8),光耦合到对应的波导(3),以便在与流体相互作用之后接收光。 光谱分析装置(8)适于产生表示光的多个光谱分量的信号。
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102.
公开(公告)号:WO2015177373A1
公开(公告)日:2015-11-26
申请号:PCT/EP2015/061479
申请日:2015-05-22
Applicant: IMEC VZW
Inventor: VAN DORPE, Pol , LAGAE, Liesbet , PEUMANS, Peter , STASSEN, Andim , HELIN, Philippe , DU BOIS, Bert , SEVERI, Simone
IPC: G01N21/64
CPC classification number: G01N21/6428 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2201/0873
Abstract: The invention provides an integrated semiconductor device (100) for detecting fluorescent tags, comprising a first layer (101) comprising a detector element (107), a second layer (102) located on top of the first layer (101) and comprising a rejection filter, a third layer (103) located on top of the second layer (102) and being fabricated from a dielectric material, a fourth layer (104) located on top of the third layer (103) and comprising an optical waveguide, and furthermore a fifth layer located on top of the fourth layer comprising a microfluidic channel (106). The optical waveguide is configured and positioned such that the micro-fluidic channel (106) is illuminated with an evanescent tail of excitation light guided by the optical waveguide. The rejection filter is positioned such that fluorescence from activated fluorescent tags present on top of the fourth layer (104) is filtered before falling onto the detector element (107). The rejection filter is configured to reject the wavelength range of the excitation light and configured to transmit the wavelength range of fluorescence from the activated fluorescent tags towards the detector element (107).
Abstract translation: 本发明提供了一种用于检测荧光标签的集成半导体器件(100),包括:第一层(101),包括检测器元件(107),位于第一层(101)顶部的第二层(102) 过滤器,位于第二层(102)的顶部并由电介质材料制成的第三层(103),位于第三层(103)的顶部上并包括光波导的第四层(104),此外 位于第四层顶部的第五层包括微流体通道(106)。 光波导被配置和定位成使得微流体通道(106)被由光波导引导的激发光的渐逝尾部照亮。 排斥滤光器被定位成使得存在于第四层(104)的顶部上的来自活化荧光标签的荧光在落到检测器元件(107)之前被过滤。 拒绝滤波器被配置为拒绝激发光的波长范围并且被配置为将荧光的波长范围从激活的荧光标签朝向检测器元件(107)传输。
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103.
公开(公告)号:WO2015152717A1
公开(公告)日:2015-10-08
申请号:PCT/NL2015/050207
申请日:2015-03-31
IPC: G01N21/84
CPC classification number: G01N21/0303 , G01N21/05 , G01N21/552 , G01N21/7746 , G01N21/8483 , G01N2021/0321 , G01N2021/0367 , G01N2201/06 , G01N2201/0873 , G02B6/34 , G02B6/4225
Abstract: The present disclosure concerns an apparatus (10) and method for reading out an optical chip (20). A light source (13) is arranged for emitting single mode source light (S1) from its emitter surface (A1) towards an optical input (21) of the optical chip (20). A light detector (14) is arranged for receiving measurement light (S2) impinging onto its receiver surface (A2) from an optical output (22) of the optical chip (20), and measuring said received measurement light (S2). The emitted source light (S1) is aligned to enter the optical input (21) of the optical chip (20) and the measurement light (S2) is aligned back onto the receiver surface (A2). The receiver surface (A2) is larger than the emitter surface (A1) for facilitating the overall alignment.
Abstract translation: 本公开涉及用于读出光学芯片(20)的装置(10)和方法。 光源(13)被布置用于从其发射表面(A1)朝向光学芯片(20)的光学输入端(21)发射单模光源(S1)。 光检测器(14)被布置成用于接收从光学芯片(20)的光学输出端(22)入射到其接收器表面(A2)上的测量光(S2),并测量所接收的测量光(S2)。 发射源光(S1)对准以进入光学芯片(20)的光学输入(21),并且测量光(S2)对准回到接收器表面(A2)上。 接收器表面(A2)大于发射体表面(A1),以便于整体对准。
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公开(公告)号:WO1994017447A1
公开(公告)日:1994-08-04
申请号:PCT/US1994000859
申请日:1994-01-21
Inventor: THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON , KEANA, John, F., W. , WYBOURNE, Martin, N. , CAI, Sui, Xiong , YAN, Mingdi
IPC: G03C05/00
CPC classification number: G01N33/54373 , C08F8/32 , G01N21/7703 , G01N2201/0873 , G03F7/2041 , Y10S430/143 , C08F8/30 , C08F112/08
Abstract: Methods for covalently modifying surfaces of various substrates are disclosed, along with various substrates having surfaces modified by such methods. Candidate surfaces include various polymeric, siliceous, metallic, allotropic forms of carbon, and semiconductor surfaces. The surfaces are exposed to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The nitrene covalently reacts with any of various chemical groups present on the substrate surface, thereby effecting nitrene addition of the functionalizing groups to the substrate surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface, thereby dramatically altering the chemical behavior of the surface. Such functionalizations of the surface can be done in a single reactive step or in multiple reactive steps.
Abstract translation: 公开了共价修饰各种基材的表面的方法,以及具有通过这些方法修饰的表面的各种基材。 候选表面包括各种聚合物,硅质,金属,同素异形体的碳和半导体表面。 表面暴露于试剂,其具有各自包含硝基衍生基团和官能化基团的分子,在激发带电粒子例如电子和离子,光子或热的存在下,其将硝化试剂转化为硝酸中间体。 所述氮烯与存在于所述基材表面上的各种化学基团共价反应,由此将所述官能团添加到所述基材表面上。 官能化基团然后可以参与下游化学,由此可以将大量各种官能团(包括生物分子)中的任何一个共价键合到表面,从而显着地改变表面的化学行为。 表面的这种功能化可以在单个反应步骤中或在多个反应步骤中进行。
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公开(公告)号:US20240044776A1
公开(公告)日:2024-02-08
申请号:US18072655
申请日:2022-11-30
Applicant: AUO Corporation
Inventor: Shu-Jiang Liu , Chun-Cheng Hung , Wen-Jen Li , Zhi-Jain Yu , Han-Chung Lai
CPC classification number: G01N21/0303 , B01L3/502715 , G02B6/43 , G01N2201/0873 , G01N2201/0668
Abstract: Disclosed is a microfluidic detection device including a circuit substrate and a transparent substrate. The circuit substrate is provided with at least one first light-emitting device used to emit a detection beam, a photodetector used to receive the detection beam and send out a sensing signal, and a control circuit electrically connected to the first light-emitting device and the photodetector. The transparent substrate overlaps the circuit substrate and is provided with a microfluidic channel and a light guide structure. The light guide structure has a light incident surface disposed corresponding to the first light-emitting device and a light exiting surface disposed corresponding to the photodetector. The light guide structure extends from each of the light incident surface and the light exiting surface to the microfluidic channel and is adapted to transmit the detection beam into and out of the microfluidic channel.
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公开(公告)号:US20180340883A1
公开(公告)日:2018-11-29
申请号:US15603084
申请日:2017-05-23
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor: Jason S. Orcutt
CPC classification number: G01N21/255 , G01N21/27 , G01N21/31 , G01N33/0022 , G01N33/0047 , G01N2201/0873 , G02B6/29338
Abstract: Methods and systems for detecting a gas or liquid in an environment include measuring a reference signal at each of a set of wavelengths by passing a signal at each wavelength through a reference cell having a gas or liquid to be detected. A sensing signal is measured at each of the plurality of wavelengths by coupling each wavelength to a ring resonator in the environment. A set of wavelengths that correspond to an absorption curve of the gas or liquid to be detected is determined. A concentration of the gas or liquid to be detected in the environment is determined based on amplitudes of the sensing signal at each of the set of wavelengths.
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公开(公告)号:US20180266964A1
公开(公告)日:2018-09-20
申请号:US15764954
申请日:2016-10-07
IPC: G01N21/77
CPC classification number: G01N21/7746 , G01N2021/7793 , G01N2201/0873 , G02B6/12004 , G02B2006/12109 , G02B2006/12138
Abstract: The present disclosure concerns a method and apparatus for measuring a sensor (10) comprising multiple optical resonators (11,12) optically connected to a single optical output interface (16). The optical resonators (11,12) are interrogated with a light input signal (Si). A light output signal (So) is measured from the optic al output interface (16) to determine a combined spectral response (Sa) covering a wavelength range (W) including a plurality of resonance peaks (λ1,i, λ2,j) for each of the optical resonators (11,12). A Fourier transform spectrum (FT) of the combined spectral response (Sa) is calculated and a harmonic series of periodic peaks (n·f1) is identified in the Fourier transform spectrum (FT). The harmonic series of periodic peaks is filtered to obtain a filtered Fourier transform spectrum (FT1) and a sensor signal is calculated (X1) based on the filtered Fourier transform spectrum (FT1).
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公开(公告)号:US20180180548A1
公开(公告)日:2018-06-28
申请号:US15900608
申请日:2018-02-20
Applicant: Pacific Biosciences of California, Inc.
Inventor: Annette GROT , Ravi SAXENA , Paul LUNDQUIST
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号:US20180164214A1
公开(公告)日:2018-06-14
申请号:US15580265
申请日:2016-06-30
Applicant: IMEC VZW
Inventor: Xavier Rottenberg
CPC classification number: G01N21/59 , B01L3/502715 , B01L2300/0816 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , G01N21/31 , G01N21/3577 , G01N21/552 , G01N21/61 , G01N21/7746 , G01N2021/0346 , G01N2021/3137 , G01N2021/3166 , G01N2021/3181 , G01N2201/062 , G01N2201/0633 , G01N2201/0636 , G01N2201/066 , G01N2201/0873
Abstract: The present disclosure relates to a device for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source for emitting light, a plurality of integrated optical waveguides for guiding this light, and a light coupler for coupling the emitted light into the integrated optical waveguides such that the light coupled into each integrated optical waveguide has substantially the same spectral distribution. The device also comprises a microfluidic channel for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide with the fluid in the microfluidic channel. Each integrated optical waveguide comprises an optical resonator for filtering the light guided by the waveguide according to a predetermined spectral component. The spectral component corresponding to each waveguide is substantially different from the spectral component corresponding to another of the waveguides.
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公开(公告)号:US20180113072A1
公开(公告)日:2018-04-26
申请号:US15847758
申请日:2017-12-19
Inventor: Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
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