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    Image processing apparatus and image processing method
    101.
    发明授权
    Image processing apparatus and image processing method 有权
    图像处理装置和图像处理方法

    公开(公告)号：US09294656B2

    公开(公告)日：2016-03-22

    申请号：US14522814

    申请日：2014-10-24

    Applicant: Sony Corporation

    Inventor： Yuichiro Ikenaga ,  Toru Shiono ,  Tetsuro Hoshino

    IPC: G06K9/00 ,  H04N1/60 ,  G01N21/64 ,  G01J3/44 ,  G01J3/46 ,  G02B21/36

    CPC classification number: H04N1/603 ,  G01J3/4406 ,  G01J3/46 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/121 ,  G02B21/365 ,  G06K9/00127

    Abstract: An image processing apparatus includes: an interface unit configured to input an image signal from an imaging apparatus that exposes a specimen dyed with a fluorescent dye to excitation light and images fluorescence by a color imaging element; and a color correction circuit configured to retain information on a percentage of each of a component of a second color and a component of a third color with respect to a component of a first color corresponding to the excitation light in the image signal, which is determined in advance based on color filter spectral characteristics of the color imaging element, and reduce each of an amount corresponding to the percentage of the component of the second color and an amount corresponding to the percentage of the component of the third color from the input image signal.

    Abstract translation: 一种图像处理装置，包括：接口单元，被配置为从成像装置输入图像信号，所述成像装置将用荧光染料染色的样本曝光到激发光，并通过彩色成像元件对荧光图像进行成像; 以及颜色校正电路，被配置为相对于所确定的图像信号中与激发光对应的第一颜色的分量，保持关于第二颜色和第三颜色的分量的分量中的每一个的百分比的信息 基于彩色成像元件的滤色器光谱特性预先提取，并且减少对应于第二颜色的分量的百分比的量和对应于来自输入图像信号的第三颜色的分量的百分比的量 。

    DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY
    102.
    发明申请
    DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY 审中-公开
    使用拉曼光谱法测定悬浮液中的固体含量

    公开(公告)号：US20150369743A1

    公开(公告)日：2015-12-24

    申请号：US14840116

    申请日：2015-08-31

    Applicant: MannKind Corporation

    Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

    IPC: G01N21/65 ,  G01G9/00 ,  G01N15/06

    CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

    Abstract translation: 提供了使用拉曼光谱测定悬浮液中固体重量百分比的方法和装置。 这些方法可用于从悬浮液中获得拉曼光谱数据，并确定例如在容器中进行的方法中固体的重量百分比，而不需要除去样品进行分析。 固体的重量百分比可以在相对较短的时间（通常为10分钟或更短）内以期望的精度确定。 获得的拉曼光谱数据可以通过化学计量学软件使用例如偏最小二乘法算法和数据预处理来提供重量百分比固体的预测值。 在一些实施方案中，本发明用于测定水溶液中二酮哌嗪微粒的重量百分比。

    Method for Compensating for the Aging of a Reagent During Fluorescence Measurements Carried out on Particles, and Biological Analysis Device Implementing the Method
    103.
    发明申请
    Method for Compensating for the Aging of a Reagent During Fluorescence Measurements Carried out on Particles, and Biological Analysis Device Implementing the Method 有权
    用于补偿在颗粒进行的荧光测量期间试剂的老化的方法和实施该方法的生物分析装置

    公开(公告)号：US20150241352A1

    公开(公告)日：2015-08-27

    申请号：US14423030

    申请日：2013-08-19

    Applicant: HORIBA ABX SAS

    Inventor： Alexandra Urankar ,  Philippe Nerin ,  Moustapha Hariche ,  Gilles Cauet

    IPC: G01N21/64 ,  G01N33/49

    CPC classification number: G01N21/6486 ,  G01N15/147 ,  G01N21/274 ,  G01N21/6428 ,  G01N33/49 ,  G01N35/00663 ,  G01N2015/1006 ,  G01N2035/00673 ,  G01N2201/121

    Abstract: The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

    Abstract translation: 本发明涉及一种用于补偿存储在包含至少一种荧光化合物的水相中的试剂的分解的方法，并且能够鉴定颗粒，包括以下步骤：（i）测量荧光水平FLUOm（t） 用所述试剂标记的颗粒; （ii）在接近所述荧光水平FLUOm（t）测量时间的时间t测量所述试剂溶液的至少一个波长处的吸光度，以便确定至少一个当前光密度DO（t） 的试剂; 以及（iii）使用所述至少一个当前光密度DO（t）和至少一个未被分解的试剂的初始光密度DO（0）来计算荧光水平测量的校正。 本发明还涉及实现该方法的生物分析装置。

    Compensating for system delay and/or extraneous illumination in analyte analyzation
    110.
    发明授权
    Compensating for system delay and/or extraneous illumination in analyte analyzation 有权
    补偿分析物分析中的系统延迟和/或外来照明

    公开(公告)号：US08108173B2

    公开(公告)日：2012-01-31

    申请号：US12194112

    申请日：2008-08-19

    Applicant: Jesus D. Martin ,  John R. DelFavero

    Inventor： Jesus D. Martin ,  John R. DelFavero

    IPC: G06F19/00

    CPC classification number: G01N21/6428 ,  A61B5/083 ,  G01N21/6408 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/121

    Abstract: A sensor that determines information related to a gaseous analyte in a body of fluid. The sensor comprises an emitter, a luminescable medium, a radiation sensor, and a processor. The emitter emits electromagnetic radiation having an oscillating intensity. The luminescable medium communicates with the body of fluid and emits luminescent radiation in response to the received electromagnetic radiation. The radiation sensor receives the luminescent radiation, and generates an output signal based on the intensity of the received luminescent radiation. The processor samples the output signal generated by the radiation sensor at two or more predetermined periodic points over the oscillation of the intensity of the electromagnetic radiation to determine information from the samples related to a phase difference between the oscillation of the intensity of the electromagnetic radiation emitted by the emitter and oscillation of the intensity of the luminescent radiation received by the radiation sensor.

    Abstract translation: 确定与流体体内的气态分析物相关的信息的传感器。 传感器包括发射器，可发光介质，辐射传感器和处理器。 发射器发射具有振荡强度的电磁辐射。 可发光介质与流体本体连通并响应于接收的电磁辐射发射发光辐射。 辐射传感器接收发光辐射，并且基于所接收的发光辐射的强度产生输出信号。 处理器在电磁辐射强度的振荡的两个或更多个预定周期点上对由辐射传感器产生的输出信号进行采样，以确定来自与所发射的电磁辐射的强度的振荡之间的相位差有关的信息的信息 通过发射器和由辐射传感器接收的发光辐射的强度的振荡。

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