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    Tunable laser-based infrared imaging system and method of use thereof
    1.
    发明授权
    Tunable laser-based infrared imaging system and method of use thereof 有权
    可调谐的基于激光的红外成像系统及其使用方法

    公开(公告)号：US08816279B2

    公开(公告)日：2014-08-26

    申请号：US13084287

    申请日：2011-04-11

    Applicant: Max Diem ,  Charles A. Dimarzio

    Inventor： Max Diem ,  Charles A. Dimarzio

    IPC: H01L31/0232

    CPC classification number: H01L27/14875 ,  H01L27/14649 ,  H04N5/33

    Abstract: Methods, devices, and systems for imaging tissue and other samples or samples using infrared (IR) transmissions from coherent transmission sources, such as a wide range, tunable, quantum cascade laser (QCL) designed for the rapid collection of infrared microscopic data for medical diagnostics across a wide range of discrete spectral increments. The infrared transmissions are transmitted through, reflected from, and/or transreflected through a sample, and then magnified and/or focused prior to being detected by a detector. After detection, the sample related image data is used to assess the sample. Such methods, devices, and systems may be used to detect abnormalities in tissue, for example, before such abnormalities can be diagnosed using art cytopathological methods. The methods, devices and systems may also optionally include a visible light detection subsystem and/or a motion control subsystem to assist in control and processing of imaging.

    Abstract translation: 用于使用来自相干传输源的红外（IR）传输成像组织和其他样品或样品的方法，装置和系统，例如宽范围，可调谐的量子级联激光器（QCL），其被设计用于快速收集用于医疗的红外微观数据 诊断跨越广泛的离散频谱增量。 红外线传输通过样品透射，反射和/或透反射，然后在被检测器检测到之前被放大和/或聚焦。 检测后，样品相关图像数据用于评估样品。 可以使用这样的方法，装置和系统来检测组织中的异常，例如在使用美术细胞病理学方法诊断出这种异常之前。 方法，装置和系统还可以可选地包括可见光检测子系统和/或运动控制子系统，以帮助控制和处理成像。

    System and method for mapping the distribution of normal and abnormal cells in sections of tissue
    3.
    发明授权
    System and method for mapping the distribution of normal and abnormal cells in sections of tissue 失效
    用于绘制组织切片中正常和异常细胞分布的系统和方法

    公开(公告)号：US5891619A

    公开(公告)日：1999-04-06

    申请号：US782424

    申请日：1997-01-14

    Applicant: David S. Zakim ,  Luis Chiriboga ,  Max Diem ,  Ping Xie

    Inventor： David S. Zakim ,  Luis Chiriboga ,  Max Diem ,  Ping Xie

    IPC: G01J3/44 ,  G01J3/453 ,  G06K9/00 ,  G01N33/48 ,  G01N33/574

    CPC classification number: G01J3/453 ,  G01J3/44

    Abstract: A system and method is described for permitting the simultaneous automated collection of data with regard to the presence of diseased cells, in particular neo-plastic, dysplastic or cancerous cells, or normal cells at a given site in a section of tissue. This is accomplished according to the following steps. First, IR spectral data are collected simultaneously for each cell or pixel of the tissue. Next, these data are analyzed by identifying the cell types encountered in the sample by comparing them with reference data sets for healthy and diseased cells. Finally, a false color mapping of the distribution of different types of cells in the tissue section is presented that permits assessment of the prevalence of diseased cells.

    Abstract translation: 描述了一种系统和方法，用于允许同时自动收集关于病变细胞，特别是新塑料，发育异常或癌细胞或组织部分中给定部位的正常细胞的存在的数据。 这是按照以下步骤完成的。 首先，对于组织的每个细胞或像素同时收集IR光谱数据。 接下来，通过将样本中遇到的细胞类型与健康和患病细胞的参考数据集进行比较来分析这些数据。 最后，提出了组织切片中不同类型细胞分布的虚拟色图，可以评估患病细胞的流行程度。

    TUNABLE LASER-BASED INFRARED IMAGING SYSTEM AND METHOD OF USE THEREOF
    6.
    发明申请
    TUNABLE LASER-BASED INFRARED IMAGING SYSTEM AND METHOD OF USE THEREOF 有权
    基于激光雷达的红外成像系统及其使用方法

    公开(公告)号：US20110248166A1

    公开(公告)日：2011-10-13

    申请号：US13084287

    申请日：2011-04-11

    Applicant: Max DIEM ,  Charles A. DIMARZIO

    Inventor： Max DIEM ,  Charles A. DIMARZIO

    IPC: H01L31/0232

    CPC classification number: H01L27/14875 ,  H01L27/14649 ,  H04N5/33

    Abstract: Methods, devices, and systems for imaging tissue and other samples or samples using infrared (IR) transmissions from coherent transmission sources, such as a wide range, tunable, quantum cascade laser (QCL) designed for the rapid collection of infrared microscopic data for medical diagnostics across a wide range of discrete spectral increments. The infrared transmissions are transmitted through, reflected from, and/or transreflected through a sample, and then magnified and/or focused prior to being detected by a detector. After detection, the sample related image data is used to assess the sample. Such methods, devices, and systems may be used to detect abnormalities in tissue, for example, before such abnormalities can be diagnosed using art cytopathological methods. The methods, devices and systems may also optionally include a visible light detection subsystem and/or a motion control subsystem to assist in control and processing of imaging.

    Abstract translation: 用于使用来自相干传输源的红外（IR）传输成像组织和其他样品或样品的方法，装置和系统，例如宽范围，可调谐的量子级联激光器（QCL），其被设计用于快速收集用于医疗的红外微观数据 诊断跨越广泛的离散频谱增量。 红外线传输通过样品透射，反射和/或透反射，然后在被检测器检测到之前被放大和/或聚焦。 检测后，样品相关图像数据用于评估样品。 可以使用这样的方法，装置和系统来检测组织中的异常，例如在使用美术细胞病理学方法诊断出这种异常之前。 方法，装置和系统还可以可选地包括可见光检测子系统和/或运动控制子系统，以帮助控制和处理成像。

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