公开(公告)号：US20160349187A1

公开(公告)日：2016-12-01

申请号：US15235154

申请日：2016-08-12

Applicant: Roche Diabetes Care, Inc.

Inventor： Karl Miltner ,  Robert Lorenz ,  Ulrich Porsch ,  Clemens Knapp

IPC: G01N21/84 ,  G01N35/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B2560/0223 ,  A61B2562/0295 ,  G01N21/8483 ,  G01N35/00009 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2035/0491 ,  G01N2201/062 ,  G01N2201/13

Abstract: There is provided a test method for analysing a body fluid in which a test tape is used in a test device to successively provide analytical test fields stored on the test tape, wherein body fluid is applied by a user to the test field provided at a time and the said test field is photometrically scanned using a measuring unit of the device to record measurement signals. To increase the measurement reliability, it is proposed that a control value is determined from a time-dependent and/or wavelength-dependent change in the measurement signals and that the measurement signals are processed as valid or discarded as erroneous depending on the control value.

公开(公告)号：US20160341667A1

公开(公告)日：2016-11-24

申请号：US14989491

申请日：2016-01-06

Applicant: AbbVie, Inc.

Inventor： Natarajan Ramasubramanyan ,  Li-Hong Malmberg ,  Martin Sternman

IPC: G01N21/65 ,  G01N33/68

CPC classification number: G01N21/65 ,  G01N33/6848 ,  G01N33/6854 ,  G01N2201/13

Abstract: A method of characterizing a multi-component mixture for use in a bioprocess operation that includes providing a multi-component mixture standard with pre-determined amounts of known components; performing a Raman Spectroscopy analysis on the multi-component mixture standard; providing a multi-component test mixture from the bioprocess operation; performing a Raman Spectroscopy analysis on the multi-component test mixture; and comparing the analysis of the multi-component mixture standard and the multi-component test mixture to characterize the multi-component test mixture. In one embodiment, the multi-component mixture standard and the multi-component test mixture both comprise one or more of, at least two, at least three of, or each of, a polysaccharide (e.g. sucrose or mannitol), an amino acid (e.g., L-arginine, L-histidine or L-ornithine), a surfactant (e.g. polysorbate 80) and a pH buffer (e.g., a citrate formulation).

Abstract translation: 一种表征用于生物过程操作的多组分混合物的方法，其包括提供具有预定量的已知组分的多组分混合物标准品; 对多组分混合物标准进行拉曼光谱分析; 从生物过程操作提供多组分测试混合物; 对多组分测试混合物进行拉曼光谱分析; 并比较多组分混合物标准品和多组分试验混合物的分析，以表征多组分试验混合物。 在一个实施方案中，多组分混合物标准品和多组分测试混合物都包含多糖（例如蔗糖或甘露糖醇），氨基酸（例如蔗糖或甘露醇）中的一种或多种，​​至少两种，至少三种， 例如L-精氨酸，L-组氨酸或L-鸟氨酸），表面活性剂（例如聚山梨酯80）和pH缓冲液（例如柠檬酸盐制剂）。

公开(公告)号：US20160313249A1

公开(公告)日：2016-10-27

申请号：US15105480

申请日：2014-12-09

Applicant: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG

Inventor： Helge PANNHOFF ,  Christian FEIRER

IPC: G01N21/64 ,  G01N21/27

CPC classification number: G01N21/6458 ,  G01N21/276 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/13

Abstract: The invention relates to a calibration standard (7) for a device (1) for image-based representation of biological material (6) which is excited to luminescence at least regionally during the examination. The device (1) has an illumination unit (2) comprising a radiation source, by which an electromagnetic excitation radiation (15) is emittable. Furthermore, a receptacle (3) is provided, which ensures that the biological material (6) arranged on a carrier (5) is positioned within a beam path of the excitation radiation (15). Moreover, the device has at least one image generating unit (4), which receives luminescence radiation (16) emitted by the biological material (6) on account of the excitation by the excitation radiation (15) and generates an image at least of the regions of the biological material (6) which are excited to luminescence. For calibration purposes, the device has a calibration standard (7), which emits a calibration radiation on account of the excitation by the excitation radiation (15), which calibration radiation is captured by the image generating unit (4), and a calibration signal is generatable in a controller (18) taking account of the captured calibration radiation. The technical solution described is distinguished by the fact that the calibration standard (7) has a housing (9) with, enclosed therein, a substance (12) which is excitable to luminescence, and is fixedly connected to the illumination unit (2) or the receptacle (3) with the aid of a fixing means (19).

Abstract translation: 本发明涉及用于生物材料（6）的基于图像的表示的装置（1）的校准标准（7），其在检查期间至少在区域上被激发以发光。 设备（1）具有包括辐射源的照明单元（2），通过该辐射源可以发射电磁激发辐射（15）。 此外，设置容器（3），其确保布置在载体（5）上的生物材料（6）位于激发辐射（15）的光束路径内。 此外，该装置具有至少一个图像生成单元（4），其接收由于激发辐射（15）的激发而由生物材料（6）发射的发光辐射（16），并且至少产生图像 激发发光的生物材料（6）的区域。 为了校准目的，该装置具有校准标准（7），该校准标准（7）由于由图像生成单元（4）捕获的校准辐射的激发辐射（15）的激发而发出校准辐射，并且校准信号 在控制器（18）中可以考虑到所捕获的校准辐射。 描述的技术方案的特征在于校准标准（7）具有壳体（9），壳体（9）包围有可发光的物质（12），并固定地连接到照明单元（2）或 所述容器（3）借助于固定装置（19）。

公开(公告)号：US20160116408A1

公开(公告)日：2016-04-28

申请号：US14893961

申请日：2014-05-30

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Josephus Arnoldus Henricus Maria KAHLMAN ,  Nicolaas LAMBERT ,  Hans Willem VAN KESTEREN

IPC: G01N21/64 ,  G01N33/84 ,  G01N33/497

CPC classification number: G01N21/6408 ,  A61B5/1468 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/497 ,  G01N33/84 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/775 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/13

Abstract: The present invention relates to a method for optically determining the concentration of a gas, using at least two luminescent dyes, the first being in-sensitive to the concentration of a gas with respect to the luminescence response (reference dye) and the second being sensitive to the concentration of a gas with respect to the luminescence response (indicator dye), wherein said dyes show different luminescence decay times so that the resultant phase angle is indicative for the concentration of a gas, characterized in that the detected luminescent amplitude of the reference dye at a first moment in time is utilized to correct for sensitivity changes after said moment. The present invention also relates to a corresponding method for quality assessment of the measurement of an optical sensor for determining the concentration of a gas.

Abstract translation: 本发明涉及一种使用至少两种发光染料光学测定气体浓度的方法，其中第一种与气体的浓度对应于发光响应（参考染料）敏感，而第二种是敏感的 相对于发光响应（指示剂染料）的气体浓度，其中所述染料显示不同的发光衰减时间，使得所得到的相位角指示气体的浓度，其特征在于检测到的参考的发光振幅 利用第一时刻的染料来校正所述时刻之后的灵敏度变化。 本发明还涉及用于确定气体浓度的光学传感器的测量的质量评估的相应方法。

公开(公告)号：US20160069929A1

公开(公告)日：2016-03-10

申请号：US14783403

申请日：2013-04-17

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Gennady Gauzner ,  Zhaoning Yu ,  Nobuo Kurataka ,  David S. Kuo ,  Kim Y. Lee ,  Yautzong Hsu ,  Hong Ying Wang

IPC: G01Q40/02 ,  G01N21/01 ,  H01J37/26

CPC classification number: G01Q40/02 ,  G01N21/01 ,  G01N2201/13 ,  G01Q40/00 ,  G03F7/0002 ,  H01J37/261 ,  H01J37/263 ,  H01J2237/2602 ,  H01J2237/2826

Abstract: Provided herein in an apparatus, including a substrate; a functional layer, wherein the functional layer has a composition characteristic of a workpiece of an analytical apparatus; and pre-determined features configured to calibrate the analytical apparatus. Also provided herein is an apparatus, including a functional layer overlying a substrate; and pre-determined features for calibration of an analytical apparatus configured to measure the surface of a workpiece, wherein the functional layer has a composition similar to the workpiece. Also provided herein is a method, including providing a lithographic calibration standard having a functional layer to an analytical apparatus, wherein the functional layer has a composition characteristic of a workpiece of the analytical apparatus; providing calibration standard specifications to a computer interfaced with the analytical apparatus; and calibrating the analytical apparatus in accordance with calibration standard readings and the calibration standard specifications.

Abstract translation: 本文提供的装置包括基板; 功能层，其中所述功能层具有分析装置的工件的成分特征; 以及配置成校准分析装置的预定特征。 本文还提供了一种装置，包括覆盖衬底的功能层; 以及用于校准配置成测量工件表面的分析装置的预定特征，其中所述功能层具有类似于所述工件的组成。 本文还提供了一种方法，包括向分析装置提供具有功能层的光刻校准标准，其中功能层具有分析装置的工件的成分特征; 向与分析仪器连接的计算机提供校准标准规格; 并根据校准标准读数和校准标准规格校准分析仪器。

公开(公告)号：US20160025649A1

公开(公告)日：2016-01-28

申请号：US14781953

申请日：2014-04-01

Applicant: KOH YOUNG TECHNOLOGY INC.

Inventor： Hyun-Seok LEE ,  Jae-Sik YANG ,  Ja-Geun KIM ,  Hee-Tae KIM ,  Hee-Wook YOU

IPC: G01N21/94 ,  G06T7/00 ,  G06T11/60 ,  G01N21/88

CPC classification number: G01N21/94 ,  G01N21/8806 ,  G01N2021/8845 ,  G01N2021/95638 ,  G01N2201/061 ,  G01N2201/13 ,  G06T7/001 ,  G06T11/60 ,  G06T2207/10004 ,  G06T2207/10024 ,  G06T2207/30141

Abstract: In order to inspect a substrate, an image information of a substrate before applying solder is displayed. Then, at least one inspection region on the substrate is image-captured to obtain an image of the inspection region that is image-captured. Then, image information that is to be displayed is renewed and the renewed image information is displayed. And, in order to inspect a foreign substance, obtained image of the inspection region is compared with a reference image of the substrate. Therefore, an operator can easily catch a region corresponding to a specific region of the image that is displayed, and easily detect a foreign substance on the substrate.

Abstract translation: 为了检查基板，显示在施加焊料之前的基板的图像信息。 然后，对基板上的至少一个检查区域进行图像拍摄，以获得被图像捕获的检查区域的图像。 然后，更新要显示的图像信息，并显示更新的图像信息。 并且，为了检查异物，将获得的检查区域的图像与基板的参考图像进行比较。 因此，操作者可以容易地捕捉与所显示的图像的特定区域对应的区域，并容易地检测基板上的异物。

公开(公告)号：US09052293B2

公开(公告)日：2015-06-09

申请号：US13209708

申请日：2011-08-15

Applicant: Karl Miltner ,  Robert Lorenz ,  Ulrich Porsch ,  Clemens Knapp

Inventor： Karl Miltner ,  Robert Lorenz ,  Ulrich Porsch ,  Clemens Knapp

IPC: G01N21/77 ,  G01N21/84 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/8483 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0223 ,  A61B2562/0295 ,  G01N35/00009 ,  G01N2021/8488 ,  G01N2021/8494 ,  G01N2035/0491 ,  G01N2201/062 ,  G01N2201/13

Abstract: There is provided a test method for analysing a body fluid in which a test tape is used in a test device in order to successively provide analytical test fields stored on the test tape, wherein body fluid is applied by a user to the test field provided at a time and the said test field is photometrically scanned using a measuring unit of the device to record measurement signals. In order to increase the measurement reliability, it is proposed that a control value is determined from a time-dependent and/or wavelength-dependent change in the measurement signals and that the measurement signals are processed as valid or discarded as erroneous depending on the control value.

Abstract translation: 提供了一种用于分析在测试装置中使用测试带的体液的测试方法，以便连续提供存储在测试带上的分析测试领域，其中体液由用户施加到在 使用该装置的测量单元对所述测试场进行光度扫描以记录测量信号。 为了提高测量可靠性，提出根据测量信号的时间依赖性和/或波长相关的变化来确定控制值，并且根据控制值将测量信号处理为有效或丢弃为错误 值。

公开(公告)号：US20110267623A1

公开(公告)日：2011-11-03

申请号：US12915904

申请日：2010-10-29

Applicant: Steven R. Matejka ,  Robert Adam Modavis ,  David Andrew Pastel ,  Jeffrey G Ulbrandt

Inventor： Steven R. Matejka ,  Robert Adam Modavis ,  David Andrew Pastel ,  Jeffrey G Ulbrandt

IPC: G01N21/47

CPC classification number: G01N21/278 ,  B01L2200/148 ,  B01L2300/0829 ,  G01N21/7743 ,  G01N2201/13

Abstract: A multi-wavelength reference microplate for a label-independent optical reader is disclosed. The microplate includes a support plate that supports a plurality of reference wells. At least one of the reference wells is configured as a multi-wavelength reference well having disposed therein two or more resonant waveguide grating sections that respectively reflect two or more different reference resonant wavelengths within the light source wavelength band. Methods for making and using the microplates are also disclosed.

Abstract translation: 公开了一种用于标签无关光学读取器的多波长参考微孔板。 微板包括支撑多个参考孔的支撑板。 参考阱中的至少一个被配置为多波长参考阱，其中布置有分别反射光源波长带内的两个或更多个不同参考谐振波长的两个或更多个谐振波导光栅部分。 还公开了制造和使用微孔板的方法。

公开(公告)号：US5157455A

公开(公告)日：1992-10-20

申请号：US563648

申请日：1990-08-07

Applicant: James N. Macri ,  Edward J. Cook

Inventor： James N. Macri ,  Edward J. Cook

IPC: G01N21/27

CPC classification number: G01N21/274 ,  G01N2201/0446 ,  G01N2201/13

Abstract: An apparatus for the calibration and quality assurance of a multichannel spectrophotometer, particularly an ELISA spectrophotometer, comprises film selectively exposed in the presence of a color to produce a series of filters having a known first color and linearly increasing optical density. The response of the spectrophotometer is measured against the known color and linearly increasing optical density. Additional filters of at least one additional color permit checking the color response of the spectrophotometer. An algorithm determines whether the response conforms to predetermined conditions. An output is produced to provide a record of the calibration and quality assurance of the spectrophotometer. The invention has particular utility for conducting calibration and quality assurance of ELISA spectrophotometers used in clinical laboratory screening for infectious diseases, such as Hepatitis B. and the AIDS viruses.

Abstract translation: 用于多通道分光光度计，特别是ELISA分光光度计的校准和质量保证的装置包括在存在颜色的情况下选择性地曝光的膜以产生具有已知第一颜色和线性增加的光密度的一系列滤光片。 根据已知的颜色和线性增加的光密度测量分光光度计的响应。 至少一种额外的颜色的附加过滤器允许检查分光光度计的颜色响应。 算法确定响应是否符合预定条件。 产生输出以提供分光光度计的校准和质量保证的记录。 本发明特别用于进行临床实验室筛查感染性疾病如乙型肝炎和艾滋病病毒的ELISA分光光度计的校准和质量保证。

公开(公告)号：US5047652A

公开(公告)日：1991-09-10

申请号：US509589

申请日：1990-04-16

Applicant: Khaim Lisnyansky ,  Martin A. Hubbe

Inventor： Khaim Lisnyansky ,  Martin A. Hubbe

IPC: G01N21/86

CPC classification number: G01N21/86 ,  G01N2021/8663 ,  G01N2201/13

Abstract: Systems for the on-line optical measurement of properties of a translucent moving web, such as paper or plastic, as it is continually produced, colored or otherwise converted. Measured properties include color, reflectance and opacity. A backing roll has a cylindrical or approximately cylindrical surface which comprises at least one optical standard. The roll is positioned such that a circumferential portion of the roll surface contacts the back web surface where the web characteristic is to be measured, with the web curving around the circumferential portion. An optical sensing device is positioned so as to view the front web surface backed by the optical standard or standards. In several embodiments, two sets of reflectance data are collected, one with a "white" optical standard backing and the other with a "black" optical standard backing. The backing roll surface and the optical sensing device can be arranged such that the sensing device either alternately or simultaneously views portions of the front web surface backed by each of the optical standards. In other embodiments, the backing roll has a uniform optical standard surface.

Abstract translation: 用于连续生产，着色或以其他方式转换的半透明移动幅材（例如纸或塑料）的在线光学测量的系统。 测量性质包括颜色，反射率和不透明度。 背衬辊具有包括至少一个光学标准的圆柱形或近似圆柱形的表面。 辊被定位成使得辊表面的圆周部分接触纸幅特性被测量的背面纸表面，纸幅围绕圆周部分弯曲。 定位光学传感装置以便观察由光学标准或标准支撑的前纤维网表面。 在几个实施例中，收集两组反射率数据，一组具有“白色”光学标准背衬，另一组具有“黑色”光学标准背衬。 背衬辊表面和光学感测装置可以布置成使得感测装置交替地或同时地观察由每个光学标准支撑的前腹板表面的部分。 在其他实施例中，背衬辊具有均匀的光学标准表面。