公开(公告)号：AU2011343253B2

公开(公告)日：2016-08-04

申请号：AU2011343253

申请日：2011-12-15

Applicant: STICHTING VUMC

Inventor： KOOYK VAN YVETTE ,  UNGER WENDY

IPC: A61K39/00 ,  A61P25/16 ,  A61P25/28 ,  A61P37/00

Abstract: The invention is in the field of molecular immunology, more in particular in the field of medical treatment of animals such as humans suffering from unwanted immune reactions. The invention relates to methods for the treatment of unwanted immune reactions and provides means and methods for suppressing an immune response. The present invention relates in particular to regulatory T cells and methods of long-term, culture-expanding, activating and using same in immunotherapy and for the suppression of autoimmune responses, allergies and inflammatory diseases. The invention provides a sia alpha 2,3-conjugated antigen for use in the suppression of an immune response in a patient in need of such a treatment.

公开(公告)号：CA2948812A1

公开(公告)日：2015-10-15

申请号：CA2948812

申请日：2015-04-10

Applicant: STICHTING VUMC

Inventor： VAN DER VLIET JOHANNES JELLE ,  DE BRUIN RENEE CORNELIA GERARDA ,  DE GRUIJL TANJA DENISE ,  VERHEUL HENDRIK MARINUS WILLEM

IPC: C07K16/28 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/13 ,  C12P21/08

Abstract: The invention is in the field of medicine and relates to immunology, and relates in particular to human V?9Vd2 T cell receptor bindingimmunoglobulin molecules. Human V?9Vd2 T cell receptor binding immunoglobulin molecules are in particular for use in medical treatment and/or useful in assays with human V?9Vd2 T cells, wherein human V?9Vd2 T cells may be modulated.

公开(公告)号：AU2005233302B2

公开(公告)日：2010-07-15

申请号：AU2005233302

申请日：2005-04-15

Applicant: STICHTING VUMC

Inventor： BEUSECHEM VICTOR WILLEM VAN ,  CARETTE JAN EDUARD

IPC: C12N15/861 ,  A61K35/13 ,  A61K48/00 ,  C12N15/11 ,  C12N15/113

Abstract: Described is a replication competent virus, being capable to replicate and having lytic capacity in target cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor.

公开(公告)号：EP3618817A1

公开(公告)日：2020-03-11

申请号：EP18725004.8

申请日：2018-05-04

Applicant: Stichting VUmc

Inventor： VAN DER KNAAP, Margo Sientje ,  HEINE, Vivi Majella ,  ABBINK, Gertrude Elise Maria

IPC: A61K31/00 ,  A61K31/4168 ,  A61P25/28

公开(公告)号：EP2841947B1

公开(公告)日：2019-10-09

申请号：EP13720130.7

申请日：2013-04-26

Applicant: Stichting VUmc

Inventor： BOSCH, Linda Janna Willemien ,  DE WIT, Meike ,  PINTO MORAIS DE CARVALHO, Beatriz ,  FIJNEMAN, Remondus Johannes Adriaan ,  MEIJER, Gerrit Albert ,  JIMENEZ, Cornelia Ramona ,  PIERSMA, Sander Rogier ,  PHAM, Viet Thang ,  OUDGENOEG, Gideon

IPC: G01N33/574

公开(公告)号：EP3494128A1

公开(公告)日：2019-06-12

申请号：EP17754837.7

申请日：2017-08-04

Applicant: Stichting VUmc

Inventor： GRIFFIOEN , Arjan Willem ,  HUIJBERS, Elisabeth Johanna Maria ,  NOWAK-SLIWINSKA, Patrycja

IPC: C07K14/245 ,  C12N15/09 ,  C12N15/62

公开(公告)号：EP2593787B1

公开(公告)日：2018-07-04

申请号：EP11736199.8

申请日：2011-07-15

Applicant: Stichting VUmc

Inventor： WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

IPC: G01N33/48

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：EP3129404A1

公开(公告)日：2017-02-15

申请号：EP15722781.0

申请日：2015-04-10

Applicant: Stichting VUmc

Inventor： VAN DER VLIET, Johannes Jelle ,  DE BRUIN, Renée Cornelia Gerarda ,  DE GRUIJL,Tanja Denise ,  VERHEUL, Hendrik Marinus Willem

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention is in the field of medicine and relates to immunology, and relates in particular to human Vγ9Vδ2 T cell receptor binding immunoglobulin molecules. Human Vγ9Vδ2 T cell receptor binding immunoglobulin molecules are in particular for use in medical treatment and/or useful in assays with human Vγ9Vδ2 T cells, wherein human Vγ9Vδ2 T cells may be modulated.

Abstract translation: 本发明涉及医学领域，涉及免疫学，特别涉及人Vγ9Vδ2T细胞受体结合免疫球蛋白分子。 人Vγ9Vδ2T细胞受体结合免疫球蛋白分子特别用于医学治疗和/或用于与人Vγ9Vδ2T细胞的测定中，其中可以调节人Vγ9Vδ2T细胞。

公开(公告)号：EP4021898A1

公开(公告)日：2022-07-06

申请号：EP20761920.6

申请日：2020-08-26

Applicant: Stichting VUmc ,  Stichting VU

Inventor： RUIJTER, Eelco ,  RONG, Mark Karsten ,  SPEER, Alexander ,  BITTER, Wilhelmus ,  COLE, Stewart Thomas

IPC: C07D285/08 ,  C07D417/04 ,  A61K31/4436 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/506 ,  A61P31/04 ,  A61P31/06

公开(公告)号：EP4004549A1

公开(公告)日：2022-06-01

申请号：EP20746310.0

申请日：2020-07-23

Applicant: Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis ,  Stichting VUmc

Inventor： KOMÓR, Malgorzata Anna ,  PINTO MORAIS DE CARVALHO, Beatriz ,  FIJNEMAN, Remondus Johannes Adriaan ,  JIMENEZ, Cornelia Ramona ,  MEIJER, Gerrit Albert ,  DE WIT, Meike

IPC: G01N33/574