公开(公告)号：AU2005233302B2

公开(公告)日：2010-07-15

申请号：AU2005233302

申请日：2005-04-15

Applicant: STICHTING VUMC

Inventor： BEUSECHEM VICTOR WILLEM VAN ,  CARETTE JAN EDUARD

IPC: C12N15/861 ,  A61K35/13 ,  A61K48/00 ,  C12N15/11 ,  C12N15/113

Abstract: Described is a replication competent virus, being capable to replicate and having lytic capacity in target cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor.