公开(公告)号：WO0230974A3

公开(公告)日：2003-04-17

申请号：PCT/US0131922

申请日：2001-10-12

Applicant: CURAGEN CORP ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  MISHRA VISHNU ,  KEKUDA RAMESH ,  LI LI ,  PADIGARU MURALIDHARA ,  SHIMKETS RICHARD A ,  ZERHUSEN BRYAN D ,  SPYTEK KIMBERLY A ,  EDINGER SHLOMIT ,  GERLACH VALERIE ,  MACDOUGALL JOHN ,  MILLET ISABELLE ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN

Inventor： GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  MISHRA VISHNU ,  KEKUDA RAMESH ,  LI LI ,  PADIGARU MURALIDHARA ,  SHIMKETS RICHARD A ,  ZERHUSEN BRYAN D ,  SPYTEK KIMBERLY A ,  EDINGER SHLOMIT ,  GERLACH VALERIE ,  MACDOUGALL JOHN ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN

IPC: A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K14/81 ,  C12N1/21 ,  C12N9/12 ,  C12N15/12 ,  C12N15/54 ,  A61K38/00 ,  C07K16/18 ,  C07K16/42 ,  C12N15/70 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/68

CPC classification number: C12N9/12 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4741 ,  C07K14/70571 ,  C07K14/70596 ,  C07K14/78 ,  C07K14/8139

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003029424A2

公开(公告)日：2003-04-10

申请号：PCT/US2002/031373

申请日：2002-10-02

Applicant: CURAGEN CORPORATION ,  SMITHSON, Glennda ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  KEKUDA, Ramesh ,  JU, Jingfang ,  LI, Li ,  GUO, Xiaojia ,  PATTURAJAN, Meera ,  SPYTEK, Kimberly, A. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  MALYANKAR, Uriel, M. ,  ORT, Tatiana ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  ANDERSON, David, W. ,  ZHONG, Mei ,  CATTERTON, Elina ,  JI, Weizhen ,  MILLER, Charles, E. ,  RASTELLI, Luca ,  STONE, David, J. ,  PENA, Carol, E., A. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  ROTHENBERG, Mark, E. ,  LEACH, Martin, D. ,  AGEE, Michele, L. ,  BERGHS, Constance ,  DIPIPPO, Vincent, A. ,  EISEN, Andrew, J. ,  GANGOLLI, Esha, A. ,  RIEGER, Daniel, K. ,  SPADERNA, Steven, K.

Inventor： SMITHSON, Glennda ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  KEKUDA, Ramesh ,  JU, Jingfang ,  LI, Li ,  GUO, Xiaojia ,  PATTURAJAN, Meera ,  SPYTEK, Kimberly, A. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  MALYANKAR, Uriel, M. ,  ORT, Tatiana ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  ANDERSON, David, W. ,  ZHONG, Mei ,  CATTERTON, Elina ,  JI, Weizhen ,  MILLER, Charles, E. ,  RASTELLI, Luca ,  STONE, David, J. ,  PENA, Carol, E., A. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  ROTHENBERG, Mark, E. ,  LEACH, Martin, D. ,  AGEE, Michele, L. ,  BERGHS, Constance ,  DIPIPPO, Vincent, A. ,  EISEN, Andrew, J. ,  GANGOLLI, Esha, A. ,  RIEGER, Daniel, K. ,  SPADERNA, Steven, K.

IPC: C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More speficically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO02098900A3

公开(公告)日：2003-02-20

申请号：PCT/US0217558

申请日：2002-06-04

Applicant: CURAGEN CORP ,  ZERHUSEN BRYAN D ,  KEKUDA RAMESH ,  SPYTEK KIMBERLY A ,  SHENOY SURESH G ,  MILLER CHARLES E ,  HJALT TORD ,  GERLACH VALERIE L ,  BAUMGARTNER JASON C ,  GUO XIAOJIA ,  GANGOLLI ESHA A ,  VERNET CORINE A M ,  PADIGARU MURALIDHARA ,  LI LI ,  PENA CAROL E A ,  GORMAN LINDA ,  ANDERSON DAVID W ,  EDINGER SHLOMIT R ,  PATTURAJAN MEERA ,  STONE DAVID J

Inventor： ZERHUSEN BRYAN D ,  KEKUDA RAMESH ,  SPYTEK KIMBERLY A ,  SHENOY SURESH G ,  MILLER CHARLES E ,  HJALT TORD ,  GERLACH VALERIE L ,  BAUMGARTNER JASON C ,  GUO XIAOJIA ,  GANGOLLI ESHA A ,  VERNET CORINE A M ,  PADIGARU MURALIDHARA ,  LI LI ,  PENA CAROL E A ,  GORMAN LINDA ,  ANDERSON DAVID W ,  EDINGER SHLOMIT R ,  PATTURAJAN MEERA ,  STONE DAVID J

IPC: A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C12N1/21 ,  C07K14/00

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码它们的多肽和核酸。 还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO2002098900A2

公开(公告)日：2002-12-12

申请号：PCT/US2002/017558

申请日：2002-06-04

Applicant: CURAGEN CORPORATION ,  ZERHUSEN, Bryan, D. ,  KEKUDA, Ramesh ,  SPYTEK, Kimberly, A. ,  SHENOY, Suresh, G. ,  MILLER, Charles, E. ,  HJALT, Tord ,  GERLACH, Valerie, L. ,  BAUMGARTNER, Jason, C. ,  GUO, Xiaojia ,  GANGOLLI, Esha, A. ,  VERNET, Corine, A., M. ,  PADIGARU, Muralidhara ,  LI, Li ,  PENA, Carol, E., A. ,  GORMAN, Linda ,  ANDERSON, David, W. ,  EDINGER, Shlomit, R. ,  PATTURAJAN, Meera ,  STONE, David, J.

Inventor： ZERHUSEN, Bryan, D. ,  KEKUDA, Ramesh ,  SPYTEK, Kimberly, A. ,  SHENOY, Suresh, G. ,  MILLER, Charles, E. ,  HJALT, Tord ,  GERLACH, Valerie, L. ,  BAUMGARTNER, Jason, C. ,  GUO, Xiaojia ,  GANGOLLI, Esha, A. ,  VERNET, Corine, A., M. ,  PADIGARU, Muralidhara ,  LI, Li ,  PENA, Carol, E., A. ,  GORMAN, Linda ,  ANDERSON, David, W. ,  EDINGER, Shlomit, R. ,  PATTURAJAN, Meera ,  STONE, David, J.

IPC: C07K

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

公开(公告)号：WO2002081510A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/001467

申请日：2002-01-18

Applicant: CURAGEN CORPORATION ,  ANDERSON, David ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  COLMAN, Steven ,  EDINGER, Schlomit ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GUNTHER, Erik ,  KEKUDA, Ramesh ,  MACDOUGALL, John, R. ,  MEHRABAN, Fuad ,  PATTURAJAN, Meera ,  ROTHENBERG, Mark ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ANDERSON, David ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  COLMAN, Steven ,  EDINGER, Schlomit ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GUNTHER, Erik ,  KEKUDA, Ramesh ,  MACDOUGALL, John, R. ,  MEHRABAN, Fuad ,  PATTURAJAN, Meera ,  ROTHENBERG, Mark ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: C07K14/00

CPC classification number: C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/555 ,  C07K14/705 ,  C12N9/6421

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体，以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

公开(公告)号：WO2002077671A2

公开(公告)日：2002-10-03

申请号：PCT/US2001/051399

申请日：2001-10-19

Applicant: VISCOTEK CORPORATION ,  STONE, David, Edward, Jr. ,  HANEY, Max, A.

Inventor： HANEY, Max, A.

IPC: G02B

CPC classification number: G01N21/49 ,  G01N30/74 ,  G01N30/02 ,  B01D15/34

Abstract: A light scattering detector is provided for measuring elastic light scattered at low and right angles from polymer solutions contained in a small flow-through cell. Applications include detection in gel permeation chromatography (GPC). A laser is provided for emitting an incident beam along a centerline that is coaxial with a first window, a test cell, a second window, and a first mirror. The test cell has an test channel through which a test fluid (solution) is directed along the instance beam of the laser, thereby causing the emission of analyte beams, as well as front and back interface scatter beams in addition to the remnants of the laser incident beam. The first mirror has a hole that allows the remains of the incident beam of the laser to pass through, thereby eliminating the errors induced by the laser beam itself. The first mirror can reflect the analyte beams into a first photo-detector. Alternatively, a second mirror can aligned with the first mirror to reflect the analyte beams into the first photo-detector. The test cell can be equipped with a window that is perpendicular to the incident laser beam in order to detect right angle reflection of the beam in the test fluid (solution) that flows through the test channel of the test cell. Lenses can be used to focus the analyte beams into their respective detectors. Masks and screens can be used to eliminate stray light from various sources in order to enhance detection of valid results. Still other embodiments can increase the number of mirrors used to achieve similar results.

Abstract translation: 提供了一种光散射检测器，用于测量从小流通池中包含的聚合物溶液以低角度和直角散射的弹性光。 应用包括在凝胶渗透色谱（GPC）中的检测。 提供激光器，沿着与第一窗口，测试单元，第二窗口和第一反射镜同轴的中心线发射入射光束。 测试电池具有测试通道，测试流体（溶液）通过该测试通道沿着激光的实例光束引导，从而导致分析物束的发射，以及除了激光残余之外的前和后界面散射光束 入射光束。 第一镜具有允许激光的入射光束的残余物通过的孔，从而消除由激光束本身引起的误差。 第一镜可以将分析物束反射成第一光检测器。 或者，第二反射镜可以与第一反射镜对准以将分析物束反射到第一光检测器中。 测试电池可以配备有垂直于入射激光束的窗口，以便检测流过测试电池的测试通道的测试流体（溶液）中的光束的直角反射。 可以使用透镜将分析物束聚焦到其各自的检测器中。 掩模和屏幕可用于消除各种来源的杂散光，以增强对有效结果的检测。 其他实施例可以增加用于实现类似结果的反射镜的数量。

公开(公告)号：WO2002029058A3

公开(公告)日：2002-04-11

申请号：PCT/US2001/031248

申请日：2001-10-05

Applicant: CURAGEN CORPORATION ,  SHIMKETS, Richard, A. ,  TAUPIER, Raymond, J., Jr. ,  BURGESS, Catherine, E. ,  ZERHUSEN, Bryan, D. ,  MEZES, Peter, S. ,  RASTELLI, Luca ,  MALYANKAR, Uriel, M. ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  SPYTEK, Kimberly, Ann ,  LI, Li ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  ELLERMAN, Karen ,  MACDOUGALL, John ,  GUNTHER, Erik ,  MILLET, Isabelle ,  STONE, David ,  SMITHSON, Glennda ,  SZEKERES, Edward, S., Jr.

Inventor： SHIMKETS, Richard, A. ,  TAUPIER, Raymond, J., Jr. ,  BURGESS, Catherine, E. ,  ZERHUSEN, Bryan, D. ,  MEZES, Peter, S. ,  RASTELLI, Luca ,  MALYANKAR, Uriel, M. ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  SPYTEK, Kimberly, Ann ,  LI, Li ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  ELLERMAN, Karen ,  MACDOUGALL, John ,  GUNTHER, Erik ,  MILLET, Isabelle ,  STONE, David ,  SMITHSON, Glennda ,  SZEKERES, Edward, S., Jr.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2001088135A3

公开(公告)日：2001-11-22

申请号：PCT/US2001/015526

申请日：2001-05-15

Applicant: CURAGEN CORPORATION ,  PADIGARU, Muralidhara ,  GROSSE, William, M. ,  SZERKERES, Edward, D. ,  CASMAN, Stacie, J. ,  ALSOBROOK, John, P., III ,  BURGESS, Catherine, E. ,  TAYLOR, Sarah ,  VERNET, Corine, A., M. ,  BAUMGARTNER, Jason, C. ,  TCHERNEV, Velizar, T. ,  SPYTEK, Kimberly, A. ,  LI, Li ,  SHENOY, Suresh ,  KEKUDA, Ramesha ,  GANGOLLI, Esha, A. ,  STONE, David, J. ,  SMITHSON, Glennda ,  MACDOUGALL, John, R.

Inventor： PADIGARU, Muralidhara ,  GROSSE, William, M. ,  SZERKERES, Edward, D. ,  CASMAN, Stacie, J. ,  ALSOBROOK, John, P., III ,  BURGESS, Catherine, E. ,  TAYLOR, Sarah ,  VERNET, Corine, A., M. ,  BAUMGARTNER, Jason, C. ,  TCHERNEV, Velizar, T. ,  SPYTEK, Kimberly, A. ,  LI, Li ,  SHENOY, Suresh ,  KEKUDA, Ramesha ,  GANGOLLI, Esha, A. ,  STONE, David, J. ,  SMITHSON, Glennda ,  MACDOUGALL, John, R.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO1992013881A1

公开(公告)日：1992-08-20

申请号：PCT/AU1992000051

申请日：1992-02-12

Applicant: LUMINIS PTY. LTD. ,  TYLER, Michael, James ,  BOWIE, John, Hamilton ,  STONE, David, James, Muir

Inventor： LUMINIS PTY. LTD.

IPC: C07K07/10

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/46

Abstract: The first group of peptides of the invention are known as Caerins. These peptides have the formula: W-Gly-Leu-X-Z, wherein W is hydrogen, C1-6 alkyl, C6-10 aryl, C7-16 aralkyl or C1-20 acyl; X is a peptide sequence comprising 20 to 23 amino acid residues; and Z is hydroxy, amino, C1-6 alkylamino, di-(C1-6 alkyl)-amino, C1-18 alkoxy or C7-18 aralkoxy. Generally, Caerins have a molecular weight of between 2300 and 2700. The second group of peptides of the invention are known as Caeridins. These peptides have the formula: W-Gly-Leu-Y-Z, wherein W is hydrogen, C1-6 alkyl, C6-10 aryl, C7-16 aralkyl or C1-20 acyl; Y is a peptide sequence comprising 8 to 13 amino acid residues; and Z is hydroxy, amino, C1-6 alkylamino, di-(C1-6 alkyl)-amino, C1-18 alkoxy or C7-18 aralkoxy. Generally, Caeridins have a molecular weight of between 1100 and 1600. Representative members of both groups of peptides may be isolated from the skin or glands of Litoria splendida and Litoria caerulea. Some of the present peptides have potent physiological activity. For example, one of the Caerins has potent antibiotic activity against a variety of bacteria. Some of the peptides also have anti-viral activity, and may have anti-fungal activity. The peptides may also be used for food preservation.

Abstract translation: 本发明的第一组肽被称为Caerins。 这些肽具有下式：W-Gly-Leu-X-Z，其中W是氢，C 1-6烷基，C 6-10芳基，C 7-16芳烷基或C 1-20酰基; X是包含20-23个氨基酸残基的肽序列; 并且Z是羟基，氨基，C 1-6烷基氨基，二 - （C 1-6烷基） - 氨基，C 1-18烷氧基或C 7-18芳烷氧基。 通常，Caerins的分子量在2300和2700之间。本发明的第二组肽被称为Caeridins。 这些肽具有下式：W-Gly-Leu-Y-Z，其中W是氢，C 1-6烷基，C 6-10芳基，C 7-16芳烷基或C 1-20酰基; Y是包含8至13个氨基酸残基的肽序列; 并且Z是羟基，氨基，C 1-6烷基氨基，二 - （C 1-6烷基） - 氨基，C 1-18烷氧基或C 7-18芳烷氧基。 一般来说，Caeridins的分子量在1100和1600之间。两组肽的代表性成员可以分离自spl藜和Litoria caerulea的皮肤或腺体。 一些本发明的肽具有强烈的生理活性。 例如，其中一种Caerins对各种细菌具有有效的抗生素活性。 一些肽还具有抗病毒活性，并且可能具有抗真菌活性。 肽也可用于食物保存。

公开(公告)号：WO2004061073A9

公开(公告)日：2013-10-31

申请号：PCT/US0224498

申请日：2002-08-02

Applicant: CURAGEN CORP ,  GORMAN LINDA ,  ZERHUSEN BRYAN D ,  EDINGER SHLOMIT R ,  PADIGARU MURALIDHARA ,  GUO XIAOJIA ,  KEKUDA RAMESH ,  ZHONG MEI ,  PATTURAJAN MEERA ,  MILLER CHARLES E ,  JI WEIZHEN ,  PENA CAROL E A ,  BURGESS CATHERINE E ,  SCIORE PAUL ,  STONE DAVID J ,  TAUPIER RAYMOND J JR ,  CASMAN STACIE J ,  ROTHENBERG MARK E ,  MALYANKAR URIEL M ,  BOLDOG FERENC L

Inventor： GORMAN LINDA ,  ZERHUSEN BRYAN D ,  EDINGER SHLOMIT R ,  PADIGARU MURALIDHARA ,  GUO XIAOJIA ,  KEKUDA RAMESH ,  ZHONG MEI ,  PATTURAJAN MEERA ,  MILLER CHARLES E ,  JI WEIZHEN ,  PENA CAROL E A ,  BURGESS CATHERINE E ,  SCIORE PAUL ,  STONE DAVID J ,  TAUPIER RAYMOND J JR ,  CASMAN STACIE J ,  ROTHENBERG MARK E ,  MALYANKAR URIEL M ,  BOLDOG FERENC L

IPC: A61K38/00 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P17/06 ,  A61P21/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07K14/47 ,  C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N5/02 ,  C12N5/08 ,  C12N15/12 ,  C12N15/16 ,  C12N15/18 ,  C12N15/19 ,  C12N15/53 ,  C12N15/54 ,  C12N15/57

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.