公开(公告)号：WO2013105859A2

公开(公告)日：2013-07-18

申请号：PCT/NL2013/050017

申请日：2013-01-14

Applicant: UNIVERSITEIT TWENTE

Inventor： BROOKHUIS, Robert Anton ,  LAMMERINK, Theodorus Simon Josef ,  WIEGERINK, Remco John

IPC: G01L1/14 ,  G01L5/16

CPC classification number: G01L1/148 ,  G01L1/142 ,  G01L1/144 ,  G01L3/02 ,  G01L5/165 ,  G01P15/125 ,  G01R27/2605

Abstract: A sensing device for measuring force and/or torque includes a top part with a top electrode structure, a bottom part with a bottom electrode structure, and a support structure. The support structure includes spring elements for supporting the top part on the bottom part with the top electrode structure parallel to and facing the bottom electrode structure. The spring elements provide a gap between the top and bottom electrode structures and allow displacement of the top part relative to the bottom part in three orthogonal directions two parallel and one perpendicular to the bottom plate, and for rotation of the top part relative to the bottom part around three orthogonal axes, corresponding with said two parallel and one perpendicular directions. The displacement and/or rotation induce a change in distance between and/or overlap area of the top and bottom electrodes and a corresponding change of capacitance.

Abstract translation: 用于测量力和/或扭矩的感测装置包括具有顶部电极结构的顶部部分，具有底部电极结构的底部部分和支撑结构。 支撑结构包括用于支撑底部顶部的弹簧元件，顶部电极结构平行于并面向底部电极结构。 弹簧元件在顶部和底部电极结构之间提供间隙，并且允许顶部相对于底部部分在垂直于底板的平行和垂直的三个正交方向上移位，并且允许顶部部分相对于底部 部分围绕三个正交轴线，对应于所述两个平行和一个垂直方向。 位移和/或旋转引起顶部和底部电极之间和/或重叠区域之间的距离和相应的电容变化的变化。

公开(公告)号：WO2013060362A1

公开(公告)日：2013-05-02

申请号：PCT/EP2011/068718

申请日：2011-10-26

Applicant: UNIVERSITEIT TWENTE ,  RIJKSUNIVERSITEIT GRONINGEN ,  ACADEMISCH ZIEKENHUIS GRONINGEN ,  GRIJPMA, Dirk Wybe ,  BOS, Rudolf Robert Maria ,  VAN LEEUWEN, Anne Cornelis

Inventor： GRIJPMA, Dirk Wybe ,  BOS, Rudolf Robert Maria ,  VAN LEEUWEN, Anne Cornelis

IPC: A61L24/00 ,  A61L27/42 ,  A61L31/12

CPC classification number: A61L27/46 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/18 ,  A61L27/425 ,  A61L27/54 ,  A61L27/58 ,  A61L31/123 ,  A61L31/127 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2430/02 ,  C08L67/04

Abstract: The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.

Abstract translation: 本发明涉及用于提供具有骨形成的聚合物复合物的方法，例如具有成骨和/或骨诱导和/或骨传导性质。 本发明还涉及通过本方法提供的聚合物复合材料及其用于骨植入物或移植物的具体用途，用于轨道底层重建。 具体地说，本发明涉及提供具有骨形成特性的复合材料的方法，该方法包括以下步骤：a）提供1,3-三亚甲基碳酸酯（TMC）的均聚物或共聚物的液体或液化的聚合物组合物; b）向所述液体或液化的聚合物组合物中加入一种或多种具有成骨和/或骨诱导和/或骨传导性质的试剂，从而提供所述药物在所述液体或液化聚合物组合物中的分散体; 和c）使获得的产物交联，从而提供具有骨形成性质的复合物。

公开(公告)号：WO2013036115A1

公开(公告)日：2013-03-14

申请号：PCT/NL2012/050616

申请日：2012-09-06

Applicant: UNIVERSITEIT LEIDEN ,  UNIVERSITEIT TWENTE ,  VAN DER MAADEN, Koen ,  BOUWSTRA, Johanna Aaltje ,  JISKOOT, Wim ,  TAS, Niels Roelof

Inventor： VAN DER MAADEN, Koen ,  BOUWSTRA, Johanna Aaltje ,  JISKOOT, Wim ,  TAS, Niels Roelof

IPC: A61B17/20 ,  B81C1/00 ,  A61M37/00 ,  A61K9/00

CPC classification number: A61K9/0021 ,  A61B17/205 ,  A61M2037/0046 ,  A61M2037/0053

Abstract: The invention is directed to a process to prepare an object coated with an active agent by contacting an object, wherein the surface of the object has a pKa of between 4 and 7.4, with a buffered aqueous coating solution comprising a negatively charged active agent and wherein said buffered solution has a pH below the pKa, or by contacting an object, wherein the surface of the object has a pKa of between 7.4 and 10, with a buffered aqueous coating solution comprising a positively charged active agent and wherein said buffered solution has a pH above the pKa of the surface. The surface of the object may also be modified with organic molecules comprising ionisable groups which are bases and ionisable groups which are acids.

Abstract translation: 本发明涉及一种制备用活性剂涂覆的物体的方法，该物体通过使物体的表面与pKa在4和7.4之间的接触与包含带负电荷的活性剂的缓冲水性涂布溶液接触，并且其中 所述缓冲溶液具有低于pKa的pH，或通过使物体的表面具有7.4至10的pKa与包含带正电荷的活性剂的缓冲水性涂布溶液接触，并且其中所述缓冲溶液具有 pH高于表面的pKa。 物体的表面也可以用包含可电离基团的有机分子进行改性，所述可离子基团是作为酸的碱和可离子化基团。

公开(公告)号：WO2012173471A1

公开(公告)日：2012-12-20

申请号：PCT/NL2012/050409

申请日：2012-06-12

Applicant: UNIVERSITEIT TWENTE ,  CNRS ,  UNIVERSITÉ MONTPELLIER 2 ,  VAN DER WIJK, Volkert ,  KRUT, Sébastien Christophe ,  PIERROT, François ,  HERDER, Justus Laurens

Inventor： VAN DER WIJK, Volkert ,  KRUT, Sébastien Christophe ,  PIERROT, François ,  HERDER, Justus Laurens

IPC: B25J9/10

CPC classification number: B25J9/107

Abstract: Manipulator (1) comprising a fixed base and a movable platform (2), wherein there are four motor-driven chains (3, 4, 5, 6) of articulated links (3', 3", 4', 4", 5', 5", 6', 6") that connect the base to the movable platform, wherein each chain has two links, and wherein the platform is movable in a plane with a predefined orientation in said plane and that in every position of the platform in the plane, said platform divides the plane in a left portion that is located left of the platform and in a right portion that is located right of the platform, and that there are two motor-driven chains (3, 4) in the said left portion and two motor-driven chains (5, 6) in the said right portion, wherein the chains in the left portion comprise upper links (3', 3") and lower links (4', 4") that are in every position of the platform parallel in pairs, and wherein the chains in the right portion comprise upper links (5', 5") and lower links (6', 6") that are in every position of the platform parallel in pairs.

Abstract translation: 机械手（1）包括固定基座和可移动平台（2），其中有四个电动机驱动的链条（3,4,5,6）铰接的连杆（3'，3“，4”，4“，5 '，5“，6'，6”），其将所述基座连接到所述可移动平台，其中每个链条具有两个连杆，并且其中所述平台可在具有所述平面中的预定取向的平面中移动， 平台在平面中，所述平台将平面在位于平台左侧的左侧部分中并且位于位于平台右侧的右部分中，并且在该平台中存在两个电动机驱动链条（3,4） 所述左部分和所述右部分中的两个电动驱动链条（5,6），其中所述左部分中的链条包括上连杆（3'，3“）和下连杆（4'，4”）， 平台的每个位置成对平行，并且其中右侧部分中的链条包括在平台的每个位置平行的上连杆（5'，5“）和下连杆（6​​'，6”） 成对。

公开(公告)号：WO2011159161A2

公开(公告)日：2011-12-22

申请号：PCT/NL2011/050440

申请日：2011-06-20

Applicant: UNIVERSITEIT TWENTE ,  ENGBERSEN, Johannes, Franciscus, Joseph ,  PIEST, Martin

Inventor： ENGBERSEN, Johannes, Franciscus, Joseph ,  PIEST, Martin

IPC: C08G73/02

CPC classification number: A61K47/34 ,  A61K9/06 ,  A61K9/5146 ,  C08G65/337 ,  C08G69/42 ,  C08G69/48 ,  C08G73/02 ,  C08G73/028 ,  C08G2650/50 ,  C08L79/02

Abstract: The present invention relates to a boronated polymer according to Formula (1): a process for making the boronated polymer according to Formula (1), drug 10 delivery systems, aggregates, nanoparticles and hydrogels comprising the boronated polymer according to Formula (1).

Abstract translation: 本发明涉及根据式（1）的硼化聚合物：制备根据式（1）的硼化聚合物，包含根据式（1）的硼化聚合物的药物10递送系统，聚集体，纳米颗粒和水凝胶的方法。

公开(公告)号：WO2011108929A2

公开(公告)日：2011-09-09

申请号：PCT/NL2011/050151

申请日：2011-03-04

Applicant: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN ,  UNIVERSITEIT TWENTE ,  WESSLING, Matthias ,  STAMATIALIS, Dimitrios ,  KOPEC, Karina Katarzyna ,  DUTCZAK, Szymon Maria

Inventor： WESSLING, Matthias ,  STAMATIALIS, Dimitrios ,  KOPEC, Karina Katarzyna ,  DUTCZAK, Szymon Maria

IPC: D01D5/24 ,  B01D69/08 ,  B01D71/58

CPC classification number: B01D69/125 ,  B01D69/088 ,  B01D69/12 ,  B01D71/60 ,  D01D5/24

Abstract: The present invention relates to a process for manufacturing a hollow fibre membrane having a supporting layer and a separating layer, said process comprising: (a)extruding a spinning composition comprising a first polymer and a solvent for the first polymer through an inner annular orifice of a hollow-fibre die; (b)co-extruding a composition comprising an organic nucleophilic reagent and a mixtures of a solvent and a non-solvent for the first polymer, wherein the composition is either extruded through a central annular orifice of the hollow-fibre die or through an outer annular orifice of a hollow-fibre die; and (c)passing the hollow-fibre through a coagulation bath. The hollow fibre membrane according to the present invention can be used in gas separation processes, vapour separation processes and liquid filtration processes.

Abstract translation: 本发明涉及一种制造具有支撑层和分离层的中空纤维膜的方法，所述方法包括：（a）通过内部环形孔挤出第一聚合物的第一聚合物和溶剂的纺丝组合物， 中空纤维模; （b）共挤出包含有机亲核试剂的组合物和用于第一聚合物的溶剂和非溶剂的混合物，其中所述组合物通过中空纤维模头的中心环形孔口挤出或通过外部 中空纤维模具的环形孔; 和（c）使中空纤维通过凝固浴。 根据本发明的中空纤维膜可用于气体分离过程，蒸气分离过程和液体过滤过程。

公开(公告)号：WO2011062493A1

公开(公告)日：2011-05-26

申请号：PCT/NL2010/050776

申请日：2010-11-19

Applicant: UNIVERSITEIT TWENTE ,  WIJNANT, Ysbrand, Hans

Inventor： WIJNANT, Ysbrand, Hans

IPC: G01H3/10

CPC classification number: G01H3/10 ,  G01H3/12 ,  G01H9/002 ,  G01N29/46

Abstract: A method for determining the acoustic absorption coefficient and/or the transmission coefficient at a chosen position in a space in which a certain sound field prevails as a result of the operation of a sound-emitting source.

Abstract translation: 一种用于确定作为声发射源的操作的结果，在某个声场占优势的空间中的选定位置处的声吸收系数和/或透射系数的方法。

公开(公告)号：WO2011049454A2

公开(公告)日：2011-04-28

申请号：PCT/NL2010/050706

申请日：2010-10-22

Applicant: UNIVERSITEIT TWENTE ,  WIJNANT, Ysbrand Hans

Inventor： WIJNANT, Ysbrand Hans

IPC: E01C1/00 ,  E01F8/00

CPC classification number: E01C1/002 ,  E01C9/00 ,  E01F8/0094

Abstract: The invention relates to a road with at least one traffic lane for motorized vehicular traffic, to which road are added sound attenuating means which limit, at least for determined frequency ranges, the lateral emission of sound caused by traffic travelling over the road, and has the feature that a pattern of resonators placed in distributed manner is arranged at least locally over a chosen length along the traffic lane, which resonators each comprise an acoustically hard, non-absorbing resonance space placed under the surface and debouching in an orifice situated at least roughly at a level of the surface of a roadside edge adjacent to the traffic lane, which resonators have resonance frequencies lying in the range of the frequencies of the sound for attenuating, in particular frequencies around about 1 kHz.

Abstract translation: 本发明涉及一种具有用于机动车辆交通的至少一个行车道的道路，道路加上声音衰减装置，至少对于确定的频率范围限制由在道路上行驶的交通造成的横向声发射，并且具有 以分布式布置的谐振器的图案的特征至少局部地沿着行车道布置在选定的长度上，该谐振器各自包括设置在表面下方的声学上，非吸收的共振空间，并且至少位于至少 大体上在与行车道相邻的路边边缘的表面的水平处，这些谐振器具有位于用于衰减的声音的频率范围内的谐振频率，特别是约1kHz左右的频率。

公开(公告)号：WO2011049439A1

公开(公告)日：2011-04-28

申请号：PCT/NL2010/050690

申请日：2010-10-19

Applicant: UNIVERSITEIT TWENTE ,  DE BOER, Jan

Inventor： DE BOER, Jan

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C12Q2600/158

Abstract: The invention relates to a method for determining the bone forming potential of a mesenchymal stem cell comprising determining the level of expression of a marker gene, characterised in that said gene is CADM1.

Abstract translation: 本发明涉及确定间充质干细胞的骨形成潜能的方法，包括确定标记基因的表达水平，其特征在于所述基因是CADM1。

公开(公告)号：WO2011021933A1

公开(公告)日：2011-02-24

申请号：PCT/NL2010/050517

申请日：2010-08-17

Applicant: UNIVERSITEIT TWENTE ,  ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC ,  VAN APELDOORN, Aart, Alexander ,  KARPERIEN, Hermanus, Bernardus, Johannes ,  VAN BLITTERSWIJK, Clemens, Antoni ,  DE KONING, Eelco, Johan, Paul ,  ENGELSE, Marten, Alexander

Inventor： VAN APELDOORN, Aart, Alexander ,  KARPERIEN, Hermanus, Bernardus, Johannes ,  VAN BLITTERSWIJK, Clemens, Antoni ,  DE KONING, Eelco, Johan, Paul ,  ENGELSE, Marten, Alexander

IPC: A61K35/39 ,  A61L27/14 ,  A61L27/38

CPC classification number: C12N5/0677 ,  A61K35/39 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/56 ,  C12N5/0068 ,  C12N2533/30 ,  C08L71/02

Abstract: The invention is directed to a treatment of diabetes, a scaffold and a method of preparing a scaffold. In a first aspect, this object is met by providing a scaffold comprising beta cell aggregates, wherein the aggregates are distributed over the scaffold in a predetermined pattern.

Abstract translation: 本发明涉及治疗糖尿病，支架和制备支架的方法。 在第一方面，通过提供包含β细胞聚集体的支架来满足该目的，其中聚集体以预定图案分布在支架上。