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公开(公告)号：US08008046B2
公开(公告)日：2011-08-30
申请号：US12335413
申请日：2008-12-15
Applicant: George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
Inventor： George Maltezos , Matthew Johnston , David Goodwin , Axel Scherer , Christopher I. Walker
CPC classification number: G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
Abstract: This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so as to have temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity.
Abstract translation: 本发明提供了一种用于进行核酸扩增反应的方法，其涉及使用包含液体的热块加热和冷却样品容器中的样品。 该方法可以同时进行多个核酸扩增反应，其中进行每个反应以具有温度分布。 该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。
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112.发明申请公开(公告)号：US20110207137A1
公开(公告)日：2011-08-25
申请号：US13009785
申请日：2011-01-19
Applicant: Imran R. MALIK , Axel Scherer
Inventor： Imran R. MALIK , Axel Scherer
CPC classification number: G01N21/6428 , B01L7/52 , B01L2300/023 , B01L2300/0654 , G01N21/0332 , G01N21/645 , G01N21/8483 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/0627
Abstract: Methods for measuring and analyzing biological or chemical samples using consumer electronic devices and systems are described. Moreover, an accessory to enable using devices such as cell phones and smartphones with fluidic illumination chambers are described.
Abstract translation: 描述了使用消费电子设备和系统测量和分析生物或化学样品的方法。 此外，描述了能够使用具有流体照明室的诸如手机和智能手机的装置的附件。
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公开(公告)号：US08002933B2
公开(公告)日：2011-08-23
申请号：US11934235
申请日：2007-11-02
Applicant: Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
Inventor： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
IPC: F15C1/06
CPC classification number: F15C1/06 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , C12Q1/6874 , F04B43/043 , F16K1/20 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/2224 , Y10T137/87981 , C12Q2535/125
Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
Abstract translation: 一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有第二凸起突起，所述第二凸起突起形成沿所述第二弹性体层的底表面延伸的第二凹槽; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道在第一和第二弹性体层之间的第二凹部中形成; 以及将第一弹性体层定位在平面基底的顶部上，使得流动通道在第一弹性体层和平面基底之间的第一凹部中形成。
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114.发明授权Electrically actuated valves made from shape memory alloy wires embedded in elastomer 有权由形状记忆合金丝线嵌入弹性体制成的电动阀公开(公告)号：US08002235B2
公开(公告)日：2011-08-23
申请号：US11853531
申请日：2007-09-11
Applicant: Saurabh Vyawahare , Suresh Situala , Dvin Adalian , Axel Scherer
Inventor： Saurabh Vyawahare , Suresh Situala , Dvin Adalian , Axel Scherer
IPC: F16K31/00
CPC classification number: F16K99/0001 , C08L2201/12 , F16K99/0015 , F16K99/0034 , F16K99/0038 , F16K99/004 , F16K99/0044 , F16K99/0059 , F16K2099/0078 , F16K2099/0084
Abstract: Microfluidic valves constructed from elastomeric materials as the valve body components and employing shape memory alloy in wire form as the valve actuator. Various configurations of individual valves having both normally open and normally closed states are described. Apparatus using such valves and providing logic functionality with fluidic logic outputs are discussed. Apparatus that can be used for materials processing at the nano- or micro-scale are presented. Various forms of logical control of valve arrays are explained.
Abstract translation: 由弹性体材料构成的微流体阀作为阀体部件，并采用线形式的形状记忆合金作为阀致动器。 描述具有常开和常闭状态的各个阀的各种构造。 讨论了使用这种阀并提供具有流体逻辑输出的逻辑功能的装置。 介绍了可用于纳米级或微尺度材料加工的设备。 说明阀阵列的各种形式的逻辑控制。
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115.发明授权公开(公告)号：US07817698B2
公开(公告)日：2010-10-19
申请号：US11836578
申请日：2007-08-09
Applicant: Zhenyu Li , Demetri Psaltis , Axel Scherer , Zhaoyu Zhang
Inventor： Zhenyu Li , Demetri Psaltis , Axel Scherer , Zhaoyu Zhang
IPC: H01S3/20
CPC classification number: H01S3/022 , H01S3/08036 , H01S3/1053 , H01S3/1055 , H01S3/213
Abstract: The invention relates to a microfluidic dye laser including a pump light source configured to provide light having a pump light wavelength. The microfluidic dye laser also includes an elastomer substantially optically transparent at the pump light wavelength and at a microfluidic dye laser wavelength. A microfluidic channel configured to accept a fluidic dye is defined in the elastomer. An optical grating is formed in a single mode 3D waveguide in the microfluidic channel in order to provide a single mode microfluidic dye laser light as output in response to illumination with light from the pump light source. In another aspect, the invention features a method of tuning a wavelength of a microfluidic dye laser light by mechanically deforming the elastomeric laser chip to change the grating period in the optical cavity.
Abstract translation: 本发明涉及一种微流体染料激光器，其包括被配置为提供具有泵浦光波长的光的泵浦光源。 微流体染料激光器还包括在泵浦光波长处和微流体染料激光波长基本上光学透明的弹性体。 在弹性体中限定了构造成接受流体染料的微流体通道。 在微流体通道中的单模3D波导中形成光栅，以便响应于来自泵浦光源的光的照明，提供单模微流体染料激光作为输出。 在另一方面，本发明的特征在于通过机械地使弹性体激光芯片变形以改变光腔中的光栅周期来调谐微流体染料激光的波长的方法。
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Patent Agency Ranking
公开(公告)号：US07814928B2
公开(公告)日：2010-10-19
申请号：US11869718
申请日：2007-10-09
Applicant: George Maltezos , Axel Scherer
Inventor： George Maltezos , Axel Scherer
IPC: F15B21/00
CPC classification number: G05D23/19 , Y10T137/6579 , Y10T137/6606 , Y10T137/8376
Abstract: A microfluidic assembly comprising a replaceable microfluidic circuit and a thermal unit, the microfluidic circuit adapted to contact the thermal unit by contact between one or more membranes in the microfluidic circuit and the at least one temperature controlling element in the thermal unit to achieve temperature control of a substance or substances inside one or more fluidic compartments in the microfluidic circuit. A related method to control temperature and/or physical state of a substance in the fluidic compartments and related testing systems are also described.
Abstract translation: 一种包括可替换的微流体电路和热单元的微流体组件，所述微流体电路适于通过所述微流体回路中的一个或多个膜与所述热单元中的所述至少一个温度控制元件之间的接触来接触所述热单元，以实现温度控制 在微流体回路内的一个或多个流体室内的物质或物质。 还描述了用于控制流体隔间和相关测试系统中的物质的温度和/或物理状态的相关方法。
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公开(公告)号：US07813401B2
公开(公告)日：2010-10-12
申请号：US11777904
申请日：2007-07-13
Applicant: Axel Scherer
Inventor： Axel Scherer
CPC classification number: H01S5/10 , B82Y20/00 , H01S5/0207 , H01S5/0218 , H01S5/041 , H01S5/0425 , H01S5/105 , H01S5/18 , H01S5/183 , H01S5/2045 , H01S5/34326 , H01S5/4087 , H01S5/423
Abstract: The invention is a photonic crystal laser including a photonic crystal slab laser cavity including InGaP/InGaAlP crystalline layers, the InGaP/InGaAlP crystalline layers having a relaxed strain at one or more etched surfaces and a higher strain at a plurality of quantum wells and at a distance from the one or more etched surfaces. The photonic crystal laser also includes electrical pads configured to receive an electrical signal the electrical pads attached to the photonic crystal slab laser cavity via an insulating layer, the photonic crystal laser configured to emit a laser light in response to the electrical signal. In another aspect, the invention features a photonic crystal detector including a photonic crystal slab cavity including InGaP/InGaAlP crystalline layers. In yet another aspect, the invention features a process to fabricate a photonic crystal laser cavity.
Abstract translation: 本发明是一种包括InGaP / InGaAlP结晶层的光子晶体激光腔的光子晶体激光器，InGaP / InGaAlP结晶层在一个或多个蚀刻表面具有松弛应变，在多个量子阱处具有较高的应变， 距离一个或多个蚀刻表面的距离。 光子晶体激光器还包括被配置为经由绝缘层接收附接到光子晶体板激光器腔的电焊盘的电信号的电焊盘，所述光子晶体激光器被配置为响应于电信号而发射激光。 另一方面，本发明的特征在于包括包含InGaP / InGaAlP晶体层的光子晶体平板腔的光子晶体检测器。 在另一方面，本发明的特征在于制造光子晶体激光腔的方法。
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公开(公告)号：US20100256551A1
公开(公告)日：2010-10-07
申请号：US12816972
申请日：2010-06-16
Applicant: George Maltezos , Axel Scherer
Inventor： George Maltezos , Axel Scherer
CPC classification number: A61N5/0616 , A61F7/007 , A61F2007/0046 , A61N2005/0645 , A61N2005/0661
Abstract: Aspects of the invention disclosed herein relate to devices that provide heat and/or ultraviolet light to fingernails or toenails that are afflicted by onychomycosis, as well as methods for treating onychomycosis by application of heat and/or ultraviolet light. The devices of the present invention may be used in connection with systemic and/or topical anti-fungal agents to treat onychomycosis.
Abstract translation: 本文公开的本发明的方面涉及向由甲真菌病所折磨的指甲或脚趾甲提供热和/或紫外光的装置以及通过施加热和/或紫外线治疗甲真菌病的方法。 本发明的装置可以与全身和/或局部抗真菌剂结合使用以治疗甲真菌病。
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公开(公告)号：US20090260692A1
公开(公告)日：2009-10-22
申请号：US12349365
申请日：2009-01-06
Applicant: Sameer WALAVALKAR , Axel Scherer
Inventor： Sameer WALAVALKAR , Axel Scherer
CPC classification number: F04B19/006 , B01L3/50273 , B01L2300/0816 , B01L2300/0874 , B01L2300/10 , B01L2300/1827 , B01L2400/0421 , B01L2400/046 , Y10T29/494 , Y10T29/49826 , Y10T137/0391 , Y10T137/2191 , Y10T137/2213 , Y10T137/2224
Abstract: A microfluidic structure with an electrically controlled pressure source is shown. The pressure source is an electrolyte connected with electrodes. Dissociation of the electrolyte generates the pressure, which is used to obtain a valve-like or pump-like behavior inside the microfluidic structure. A process for manufacturing the microfluidic structure and a method to circulate fluids in a microfluidic channel are also described.
Abstract translation: 示出了具有电控压力源的微流体结构。 压力源是与电极连接的电解质。 电解质的离解产生压力，其用于在微流体结构内获得阀状或泵状行为。 还描述了用于制造微流体结构的方法和在微流体通道中循环流体的方法。
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公开(公告)号：US20090151422A1
公开(公告)日：2009-06-18
申请号：US11932263
申请日：2007-10-31
Applicant: Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Markus M. Enzelberger , Mark L. Adams , Carl L. Hansen
Inventor： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Markus M. Enzelberger , Mark L. Adams , Carl L. Hansen
CPC classification number: B05D3/04 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/06 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B65B31/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6832 , C12Q1/6874 , C30B29/54 , F04B43/043 , F15C1/06 , F15C3/00 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0324 , Y10T137/0379 , Y10T137/0424 , Y10T137/206 , Y10T137/2082 , Y10T137/2164 , Y10T137/2169 , Y10T137/2174 , Y10T137/2202 , Y10T137/2224 , Y10T137/3084 , Y10T137/7837 , Y10T137/86027 , Y10T156/10 , Y10T428/24479 , Y10T428/24612 , C12Q2535/125
Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
Abstract translation: 一种制造弹性体结构的方法，包括：在第一微加工模具的顶部上形成第一弹性体层，所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层，所述第二微加工模具具有第二凸起突起，所述第二凸起突起形成沿所述第二弹性体层的底表面延伸的第二凹槽; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上，使得控制通道在第一和第二弹性体层之间的第二凹部中形成; 以及将第一弹性体层定位在平面基底的顶部上，使得流动通道在第一弹性体层和平面基底之间的第一凹部中形成。
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