公开(公告)号：WO1996010394A1

公开(公告)日：1996-04-11

申请号：PCT/US1995013176

申请日：1995-10-03

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MARGALIT, Rimona

IPC: A61K09/127

CPC classification number: A61K9/1271 ,  Y10S436/829 ,  Y10S514/801 ,  Y10T428/2984

Abstract: Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular or an extracellular matrix (ECM) target site. These "bioadhesive" liposomes offer several advantages including the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.

Abstract translation: 识别物质，包括表皮生长因子，明胶，胶原和透明质酸已经共价结合到脂质体表面，并用于将脂质体附着到细胞或细胞外基质（ECM）靶位点上。 这些“生物粘附”脂质体提供了几个优点，包括药物和生物环境的相互保护; 药物生物利用度的提高和目标地点的保留; 并改善对指定目标地点的粘附或粘附。

公开(公告)号：WO1996005959A1

公开(公告)日：1996-02-29

申请号：PCT/US1995008684

申请日：1995-07-11

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  YANG, Sungwook ,  SEVERS, Dale, R. ,  FRANKENBERGER, David ,  KEMP, Michael

IPC: B31B19/84

CPC classification number: B29C66/8511 ,  B29C65/02 ,  B29C65/04 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/133 ,  B29C66/24221 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/723 ,  B29C66/8242 ,  B29C66/83221 ,  B29K2023/06 ,  B29K2023/083 ,  B29K2023/12 ,  B29K2027/06 ,  B29K2077/00 ,  B29L2031/7148 ,  B31B70/00 ,  B31B70/844 ,  B31B2155/00 ,  B31B2155/002 ,  B31B2160/10 ,  B29K2069/00 ,  B29K2067/00 ,  B29K2033/08 ,  B29K2025/08

Abstract: An apparatus (31) and a method are disclosed for temporarily separating multiple webs (51, 53) while performing an operation (123, 125, 133) thereon, including the feeding of multiple webs (51, 53), the provision of a retractable web separator (68) for temporarily separating the webs, the performance of an operation (123, 125, 133) upon the webs, the provision of a gripping device (65) for gripping the webs and assisting in moving the webs (51, 53) along a predetermined path (83), and the provision of a sealing device (71) for sealing the webs together to form a package seal (73). The retractable separators (68) are mounted on a conveyor (83) and each separator (68) in turn temporarily separates the webs (51, 53), for insertion of a port (45), fitting or the like, whereupon the separator (68) may be retracted and the port (45) may be sealed into the packages (41) being manufactured. The preferred separator (68) has a shaped head (170) on the end of a reciprocating shaft (158). The head (170) may be enlarged and may have a tapered end (171) for insertion between the webs (51, 53).

Abstract translation: 公开了一种在执行其上的操作（123,125,133）的同时临时分离多个卷筒纸（51,53）的装置（31）和方法，包括多个卷筒纸（51,53）的进给，提供可伸缩的 用于临时分离腹板的腹板分离器（68），在腹板上的操作（123,125,133）的性能，提供用于夹紧腹板并帮助移动腹板（51,53）的夹持装置（65） ），并且设置密封装置（71），用于将腹板密封在一起以形成包装密封件（73）。 可伸缩分离器（68）安装在输送机（83）上，并且每个分离器（68）依次临时分离腹板（51,53），用于插入端口（45），配件等，于是隔板 68）可以缩回，并且端口（45）可以被密封到正在制造的包装（41）中。 优选的分离器（68）在往复轴（158）的端部上具有成形头部（170）。 头部（170）可以被扩大，并且可以具有用于插入腹板（51,53）之间的锥形端部（171）。

公开(公告)号：WO1996005875A1

公开(公告)日：1996-02-29

申请号：PCT/US1995010702

申请日：1995-08-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DESECKI, Vincent, C. ,  BROWNE, Glennie

IPC: A61M05/00

CPC classification number: A61B5/155 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150259 ,  A61B5/150992

Abstract: The invention comprises a closed system blood sampling device comprising a bifurcated capillary tube (10) which has a first branch (12) having a cannula shaped end (14) for withdrawing and conveying blood to a communicating blood collection zone. The second branch of the bifurcated capillary tube (32) is connected to and is in fluid communication with the blood collection zone. It terminates in an opening adapted to receive a blood withdrawal device.

Abstract translation: 本发明包括封闭系统采血装置，其包括分叉的毛细管（10），其具有第一分支（12），该第一分支具有插管形端（14），用于将血液抽出并输送到通信采血区。 分叉毛细管（32）的第二分支与血液收集区连接并与其进行流体连通。 它终止于适于接收抽血装置的开口中。

公开(公告)号：WO1996003166A1

公开(公告)日：1996-02-08

申请号：PCT/US1995009054

申请日：1995-07-18

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  LAL, Birendra, K. ,  DING, Yuan-pang, Samuel ,  PRISCO, Michael, R. ,  BLACK, Rebecca, S. ,  PASSAGLIA, Robert ,  RICHARDSON, James

IPC: A61M01/00

CPC classification number: A61M5/16881 ,  G05D7/0113 ,  Y10T137/7879

Abstract: The present invention provides an intravenous fluid flow regulator (10) for controlling the I.V. administration of medical fluid to a patient. The fluid flow regulator (10) provides a housing (12) having a top (18) and a bottom (20). A flexible diaphragm (14) is positioned within housing (12). A diaphragm holder (16) is provided inside housing (12) for holding a sealing edge (56) of flexible diaphragm (14) in fluid sealing engagement with diaphragm holder (16). The housing (12) and flexible diaphragm (14) define an inlet fluid reservoir (62) and an outlet fluid reservoir (64). The diaphragm holder (16) defines a by-pass fluid channel (54) from inlet fluid reservoir (62), around diaphragm (14), to outlet fluid reservoir (64). The flexible diaphragm (14) being flexible to alternatively move into inlet fluid reservoir (62) and outlet fluid reservoir (64) depending on a fluid pressure differential between inlet fluid reservoir (62) and outlet fluid reservoir (64).

Abstract translation: 本发明提供一种用于控制I.V.的静脉内流体流动调节器（10）。 向患者施用医用流体。 流体流量调节器（10）提供具有顶部（18）和底部（20）的壳体（12）。 柔性隔膜（14）定位在壳体（12）内。 膜片保持器（16）设置在壳体（12）内部，用于保持与隔膜保持器（16）流体密封接合的柔性隔膜（14）的密封边缘（56）。 壳体（12）和柔性隔膜（14）限定入口流体储存器（62）和出口流体储存器（64）。 隔膜保持器（16）限定来自入口流体储存器（62），隔膜（14）周围的旁路流体通道（54）到出口流体储存器（64）。 柔性隔膜（14）根据入口流体储存器（62）和出口流体储存器（64）之间的流体压力差，灵活地交替地进入入口流体储存器（62）和出口流体储存器（64）。

公开(公告)号：WO1996000519A1

公开(公告)日：1996-01-11

申请号：PCT/US1995007853

申请日：1995-06-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CARLSON, Gary ,  NORRIS, Jeffrey, A.

IPC: A61B05/029

CPC classification number: H03F3/2171 ,  A61B5/0275 ,  A61B5/028 ,  A61B5/029

Abstract: A continuous cardiac output monitor includes a general-purpose monitoring console (32) with local display (34) and communications facilities, and a module (40) removably interfacing with the console (32) to configure the latter for performing continuous cardiac output monitoring. The module (40) includes a switch-mode high efficiency power amplifier (60) for providing electrical heating power at a selected voltage, frequency, and wave form to a heating element (50) of a continuous cardiac output monitoring catheter (16), which catheter (16) at a distal end portion thereof is immersed in the blood flow of a patient (10). The catheter (16) effects a temperature transient in the patient's blood flow by the controlled application of electrical resistance heating utilizing electrical power from the power amplifier (60), and this temperature transient is sensed and used to derive a value for the patient's cardiac output.

Abstract translation: 连续的心输出量监视器包括具有本地显示器（34）和通信设施的通用监视控制台（32）以及与控制台（32）可拆卸地对接的模块（40），以配置后者用于执行连续的心输出量监视。 模块（40）包括开关模式高效率功率放大器（60），用于以选定的电压，频率和波形向连续心输出监测导管（16）的加热元件（50）提供电加热功率， 其远端部分处的导管（16）浸入患者（10）的血液流中。 导管（16）通过利用来自功率放大器（60）的电力的受控应用电阻加热来对患者的血流进行温度瞬变，并且该温度瞬变被感测并用于导出患者心输出量的值 。

公开(公告)号：WO1995035124A1

公开(公告)日：1995-12-28

申请号：PCT/US1995006788

申请日：1995-05-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  KESHAVIAH, Prakash, R. ,  EMERSON, Paul, F. ,  RUAN, Jian

IPC: A61M01/28

CPC classification number: A61M1/28 ,  A61M1/1611 ,  A61M1/1643 ,  A61M1/1696 ,  A61M1/281 ,  A61M2205/3393 ,  Y10S210/929

Abstract: An improved peritoneal dialysis method and system. The method utilizes a purified pulse peritoneal dialysis system. To this end, a system for providing peritoneal dialysis to a patient is provided. The system comprises a single catheter that is placed in the patient, a source of dialysate, and a dialyzer in fluid communication with the source of dialysate and the catheter. A single sterile fluid pump is used for pumping the dialysate into and out of the patient.

Abstract translation: 改进的腹膜透析方法和系统。 该方法利用纯化的脉搏腹膜透析系统。 为此，提供了一种用于向患者提供腹膜透析的系统。 系统包括放置在患者体内的单个导管，透析液源和与透析液源和导管流体连通的透析器。 单个无菌流体泵用于将透析液泵入和流出患者。

公开(公告)号：WO1995034817A1

公开(公告)日：1995-12-21

申请号：PCT/US1995007491

申请日：1995-06-13

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  TSENG-LAW, Janet ,  KOBORI, Joan, A. ,  AL-ABDALY, Fahad, A. ,  GUILLERMO, Roy ,  HELGERSON, Sam, L. ,  DEANS, Robert, J.

IPC: G01N33/569

CPC classification number: G01N33/56972 ,  C07K1/047 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/08 ,  C07K16/2896 ,  C07K16/3015 ,  C07K2317/34 ,  C12N5/0081 ,  G01N33/56966

Abstract: The invention provides a non-enzymatic method for the release of cells which have beem positively selected from a heterogeneous cell suspension by antibody-mediated binding to beads or other solid support. The method entails forming within the cell suspension a complex comprising the solid support linked to a primary monoclonal antibody, which in turn is bound to a cell surface antigen on the target cells. The complex is separated from the cell suspension, and then contacted with a specific peptide which binds to the primary antibody, displacing the antibody from the cell surface antigen, thereby releasing the target cell from the complex. The invention also provides methods for positive/negative cell selection wherein target cells having a first antigen are selected from a heterogeneous cell suspension containing undesired cells having a second antigen. The invention also provides methods for identifying a specific peptide useful for the release of a target cell from the binding of a specific monoclonal antibody. The methods of the invention are particularly useful for the positive selection of CD34+ hematopoietic stem cells and the concomitant purging of undesired tumor cells or lymphocytes from the positively selected cell population. The purified CD34+ cell composition is then useful for reinfusion to a cancer patient after high-dose therapy in order to reconstitute the patient's immune system.

Abstract translation: 本发明提供了通过抗体介导的与珠粒或其它固体支持物的结合来释放细胞的非酶法，所述细胞通过抗体介导的结合到阳性细胞悬液中。 该方法需要在细胞悬浮液内形成一种复合物，该复合物包含与一级单克隆抗体连接的固体支持物，其又与靶细胞上的细胞表面抗原结合。 将复合物与细胞悬浮液分离，然后与结合第一抗体的特异性肽接触，将抗体从细胞表面抗原置换，从而从复合物释放靶细胞。 本发明还提供了用于阳性/阴性细胞选择的方法，其中具有第一抗原的靶细胞选自含有具有第二抗原的不想要的细胞的异质细胞悬浮液。 本发明还提供了鉴定可用于从特异性单克隆抗体的结合释放靶细胞的特异性肽的方法。 本发明的方法特别可用于CD34 +造血干细胞的阳性选择和伴随的从正选择的细胞群中清除不需要的肿瘤细胞或淋巴细胞。 然后，纯化的CD34 +细胞组合物可用于在高剂量治疗后向癌症患者输回，以重建患者的免疫系统。

公开(公告)号：WO1995034373A1

公开(公告)日：1995-12-21

申请号：PCT/US1995006691

申请日：1995-05-25

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  REINHART, Frederick, J. ,  CARTER, R., Sykes

IPC: B01D69/08

CPC classification number: B01D69/08 ,  B01D63/02 ,  B01D2313/146

Abstract: Disclosed are improved hollow fiber semipermeable membranes having monofilamentous spacer members spirally disposed or formed on the outer surface thereof, and extracorporeal blood treatment devices incorporating such improved hollow fiber membranes. Also disclosed are methods for manufacturing the hollow fiber membranes and a continuous method for manufacturing a blood processing apparatus which incorporates the hollow fiber membranes.

Abstract translation: 公开了一种改进的中空纤维半透膜，其具有螺旋地设置或形成在其外表面上的单丝间隔件，以及结合有这种改进的中空纤维膜的体外血液处理装置。 还公开了制造中空纤维膜的方法和连续的包含中空纤维膜的血液处理装置的制造方法。

公开(公告)号：WO1995032010A1

公开(公告)日：1995-11-30

申请号：PCT/US1995004715

申请日：1995-04-18

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  KESHAVIAH, Prakash, R.

IPC: A61M01/16

CPC classification number: A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1615 ,  A61M1/1617 ,  A61M2202/0498 ,  A61M2205/15

Abstract: A system and method using same are provided for determining the optimum operating conditions of a dialysis process that yields the highest whole body dialysis clearance. The system varies a parameter that effects dialysis efficiency during part of a dialysis run. The system then measures a metabolite concentration in an outflow dialysate. The system develops a metabolite concentration profile as a function of the varied parameter. Based on these measurements, the system correlates the metabolite concentration measurements to determine the optimum parameter setting that yields the maximum metabolite concentration.

Abstract translation: 提供了一种使用该系统和方法的系统和方法，用于确定产生最高全身透析间隙的透析过程的最佳操作条件。 在透析运行的一部分期间，系统会改变影响透析效率的参数。 然后系统测量出血透析液中的代谢物浓度。 该系统根据变化的参数产生代谢物浓度分布。 基于这些测量，系统将代谢物浓度测量值相关联，以确定产生最大代谢物浓度的最佳参数设置。

公开(公告)号：WO1995026195A1

公开(公告)日：1995-10-05

申请号：PCT/US1995003788

申请日：1995-03-27

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  McKENZIE, Jack, E. ,  BURHOP, Kenneth, E.

IPC: A61K35/14

CPC classification number: A61K38/42

Abstract: Administration of low doses of hemoglobin minimizes damage to the myocardium after blockage and significantly reduces reperfusion injury. Hemoglobin exerts a pharmacological effect by increasing perfusion and blocking the molecular events leading to permanent injury following an ischemic episode. Additional benefits include a reduction in the number of post-ischemic arrhythmias, reduction in the incidence of restenosis, and improved contractile function in the area of risk.

Abstract translation: 低剂量血红蛋白的施用可使堵塞后对心肌的损伤最小化，并显着降低再灌注损伤。 血红蛋白通过增加灌注并阻断导致缺血发作后永久性损伤的分子事件而发挥药理作用。 额外的好处包括减少缺血后心律失常的数量，减少再狭窄的发生率，改善风险领域的收缩功能。