公开(公告)号：WO1994002066A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006598

申请日：1993-07-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GALLUP, David, A. ,  HUGHES, Timothy, J. ,  SPERINDE, John

IPC: A61B05/029

CPC classification number: A61B5/028 ,  A61B5/1459

Abstract: A multi-lumen multi-purpose catheter (10) which incorporates optical filaments (33) and an optical coupler (30) for use with an external apparatus for determining the oxygen concentration in the blood of a patient under critical care conditions, as well as incorporating therein a heater coil (55) useable with a second external apparatus for measurement of continuous cardiac output. The catheter (10) also includes a thermistor (54) and at least one injectate port (64) for enabling the user to also conduct thermal dilution readings and obtain intermittent measurements of cardiac output. The combination of a thermal dilution catheter with an SV02 catheter and a continuous cardiac output catheter gives the multipurpose catheter (10) substantial versatility as well as providing the user with a versatile cardiac catheter device which enables him to conduct multiple evaluations of disparate blood-related parameters which require the use of separate apparatuses.

Abstract translation: 一种多腔多用途导管（10），其包含光学灯丝（33）和光耦合器（30），用于与外部设备一起使用，用于确定危重护理条件下患者血液中的氧浓度，以及 其中结合有可用于测量连续心输出量的第二外部设备的加热器线圈（55）。 导管（10）还包括热敏电阻（54）和至少一个注射口（64），用于使使用者能够进行热稀释读数并获得心输出量的间歇测量。 热稀释导管与SV02导管和连续心输出导管的组合使得多用途导管（10）具有实质的多功能性，并为使用者提供通用的心脏导管装置，使得他能够进行与血液相关的不同的评估 需要使用单独设备的参数。

公开(公告)号：WO1997031568A1

公开(公告)日：1997-09-04

申请号：PCT/US1997002609

申请日：1997-02-21

Applicant: KUNIG, Sabine, V.

IPC: A61B05/029

CPC classification number: A61B5/0215 ,  A61B5/02028 ,  A61B5/021

Abstract: A diagnostic and monitoring device (4) is disclosed to determine functionality of the cardio-circulatory system from a performance diagram. The performance diagram diagnoses myocardial impairment, dysfunctions, critical illness, and physical fitness of a subject from the location of a subject's data point with respect to zones of physiological criticality.

Abstract translation: 公开了诊断和监测装置（4），以从性能图确定心脏循环系统的功能。 性能图从受试者的数据点位置相对于生理关键性区域诊断受试者的心肌损伤，功能障碍，危重疾病和身体健康。

公开(公告)号：WO1996000519A1

公开(公告)日：1996-01-11

申请号：PCT/US1995007853

申请日：1995-06-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CARLSON, Gary ,  NORRIS, Jeffrey, A.

IPC: A61B05/029

CPC classification number: H03F3/2171 ,  A61B5/0275 ,  A61B5/028 ,  A61B5/029

Abstract: A continuous cardiac output monitor includes a general-purpose monitoring console (32) with local display (34) and communications facilities, and a module (40) removably interfacing with the console (32) to configure the latter for performing continuous cardiac output monitoring. The module (40) includes a switch-mode high efficiency power amplifier (60) for providing electrical heating power at a selected voltage, frequency, and wave form to a heating element (50) of a continuous cardiac output monitoring catheter (16), which catheter (16) at a distal end portion thereof is immersed in the blood flow of a patient (10). The catheter (16) effects a temperature transient in the patient's blood flow by the controlled application of electrical resistance heating utilizing electrical power from the power amplifier (60), and this temperature transient is sensed and used to derive a value for the patient's cardiac output.

Abstract translation: 连续的心输出量监视器包括具有本地显示器（34）和通信设施的通用监视控制台（32）以及与控制台（32）可拆卸地对接的模块（40），以配置后者用于执行连续的心输出量监视。 模块（40）包括开关模式高效率功率放大器（60），用于以选定的电压，频率和波形向连续心输出监测导管（16）的加热元件（50）提供电加热功率， 其远端部分处的导管（16）浸入患者（10）的血液流中。 导管（16）通过利用来自功率放大器（60）的电力的受控应用电阻加热来对患者的血流进行温度瞬变，并且该温度瞬变被感测并用于导出患者心输出量的值 。

公开(公告)号：WO1993003668A1

公开(公告)日：1993-03-04

申请号：PCT/US1992006991

申请日：1992-08-20

Applicant: BAXTER INTERNATIONAL INC. ,  FONGER, James, D.

Inventor： BAXTER INTERNATIONAL INC. ,  SWENDSON, David, L. ,  CURRIER, Clifford, E. ,  EVANS, David, J. ,  BOBO, Donald, E., Jr.

IPC: A61B05/029

CPC classification number: A61K31/445 ,  A61B5/029 ,  A61B5/411 ,  A61B5/416 ,  A61M27/00 ,  C07D498/18

Abstract: A cardiac output probe assembly (10) is disclosed wherein the assembly includes a chest tube (12) which carries a cardiac output probe (14) therein. The chest tube (12) includes a main lumen (40) for draining fluids from the thoracic cavity of the chest and a secondary lumen (18) which carries leads (24) attached to the probe (14). The probe (14) is attached to the pulmonary artery or aorta vessel with detachable tines (52) and/or sutures. The tines (52) are uniquely configured to ensure that good contact between the probe (14) and vessel is maintained. When cardiac output monitoring is complete, a pulling force is applied to the probe leads (24) extending out through a proximal end (18) of the tube (12). The pulling force detaches the tines (52) and sutures, releasing the probe (14) from connection with the vessel. Further withdrawal of the leads (24) through the tube (12) retracts the probe (14) within the tube (12), where it is housed until the tube (12) is removed from the thoracic cavity.

公开(公告)号：WO1998012963A1

公开(公告)日：1998-04-02

申请号：PCT/DE1997002194

申请日：1997-09-26

Applicant: TECHNISCHE UNIVERSITÄT DRESDEN ,  GAMA DE ABREU, Marcelo ,  ALBRECHT, Detlev, Michael

Inventor： TECHNISCHE UNIVERSITÄT DRESDEN

IPC: A61B05/029

CPC classification number: A61B5/029

Abstract: The invention relates to a device to determine effective pulmonary blood flow (PBF) by means of partial CO2 rebreathing. The device is characterized in that it comprises an endotracheal tube whose conduit leading from the patient to the respirator is divided up into two lanes between a controllable three-way valve (4) and a Y-piece; one lane builds a larger dead area (6) for CO2 rebreathing whereby, in order to measure CO2 elimination and end expiratory partial CO2 pressure a CO2 sensor (3) and a respiration flow sensor (1) are provided on the endotracheal tube of the patient. The calculation of effective pulmonary blood flow is provided by a microprocessor/controller (7) which also controls the three-way valve (4) which provides the switching between both lanes.

Abstract translation: 用于确定的有效肺血流量（PBF）通过部分CO2再呼吸的装置的布置包含一个气管内导管，其患者的可控三通阀（4）之间的呼吸机的线和Y型件（5）被分成两股，的一条链 较大尺寸的死空间（6）形成用于CO2再呼吸。 CO 2传感器（3）和呼吸流量传感器（1）被设置在气管内插管用于CO 2去除和呼气末CO2分压的测量。 微处理器/控制器用于（7）的有效pulvonalen血液流动，这还提供了用于控制由所述三通阀（4）的两条链之间切换的计算。

公开(公告)号：WO1997023162A1

公开(公告)日：1997-07-03

申请号：PCT/US1996019315

申请日：1996-12-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HUGHES, Timothy, J.

IPC: A61B05/029

CPC classification number: A61B5/028 ,  A61B5/7257 ,  G01K7/25

Abstract: A method and apparatus for correcting thermal drift in cardiac output measurements based upon a temperature signal indicative of the change in temperature of blood leaving the heart is disclosed. In a first preferred embodiment of a cardiac output monitoring system (10), the catheter (14) is provided with an electrical resistance heater (22). An electrical current having a sinusoidal waveform with a period of from 30 to 60 seconds is applied to the heater, causing power to be dissipated into the blood within a patient's heart (12). A temperature sensor (24) disposed near a distal end of the catheter produces a signal indicative of the temperature of blood leaving the heart. The temperature signal and the signal corresponding to the electrical power dissipated in the heater (an input signal) are filtered at a frequency omega n corresponding to the frequency of the applied electrical current, i.e., the frequency of the input signal. An output signal indicative of the temperature of the blood leaving the heart corrected for the effects of thermal drift is then calculated. The blood temperature output signal is first split into two equal overlapping time periods. The two signals are then filtered separately to produce two partially independent output signals in the frequency domain. These two frequency domain output signals are then combined into a single corrected frequency domain output signal with the effects of thermal drift removed. The amplitude of the input power, the amplitude of the temperature signal corrected for thermal drift, and their phase difference are then used in calculating cardiac output.

Abstract translation: 公开了一种基于指示离开心脏的血液温度变化的温度信号来校正心输出量测量中的热漂移的方法和装置。 在心输出量监测系统（10）的第一优选实施例中，导管（14）设置有电阻加热器（22）。 将具有30至60秒周期的正弦波形的电流施加到加热器，使得电力消散到患者心脏（12）内的血液中。 设置在导管的远端附近的温度传感器（24）产生指示离开心脏的血液的温度的信号。 对应于在加热器（输入信号）中消耗的电功率的温度信号和信号以与所施加的电流的频率即输入信号的频率相对应的频率ωn被滤波。 然后计算表示为热漂移的影响而校正的离开心脏的血液的温度的输出信号。 首先将血液温度输出信号分为两个等重叠时间段。 然后分别对两个信号进行滤波，以在频域中产生两个部分独立的输出信号。 然后将这两个频域输出信号组合成单个校正的频域输出信号，并消除热漂移的影响。 输入功率的振幅，热漂移校正的温度信号的振幅及其相位差用于计算心输出量。

公开(公告)号：WO1997009928A1

公开(公告)日：1997-03-20

申请号：PCT/EP1996003918

申请日：1996-09-06

Applicant: HEINEMANN & GREGORI GMBH ,  MEIER, Bernd, Horst ,  HEINEMANN, Helmut, Otto ,  FÖRSTER, Harald

Inventor： HEINEMANN & GREGORI GMBH

IPC: A61B05/029

CPC classification number: A61B5/0535 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0538

Abstract: The invention relates to a process for determining the cardiac output by detecting a systolic impedance change in a tissue with at least one first and at least one second measuring electrode, where the first is applied to the skin in the region of an a.c. path through the tissue, in which the second measuring electrode is inserted into a vessel lying substantially opposite the heart in relation to the first electrode and held in a predetermined projection on the first electrode passing through the heart.

Abstract translation: 本发明涉及：一种用于心输出量检测方法，通过检测的织物的收缩阻抗变化与至少一个第一测量电极和至少一个第二测量电极，其中，所述第一测量电极是在AC电流路径的场穿过组织到皮肤施加，其特征在于，所述第二测量电极 被插入到心脏相对于所述第一测量电极基本相对容器中并在预定的，心脏连续在所述第一测量电极投影保持。

公开(公告)号：WO1992012669A1

公开(公告)日：1992-08-06

申请号：PCT/NL1992000022

申请日：1992-01-28

Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- ... ,  WESSELING, Karel, Hendrik

Inventor： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- ...

IPC: A61B05/029

CPC classification number: A61B5/029

Abstract: Method of determining the stroke volume of the human heart from the pulse-type blood-stream pressure signal derived from the aorta and consisting in each case of a systolic and a diastolic period. Said method comprises calculating the flow q(t) from the pressure p(t) and integrating the flow over the systolic period, the aorta being regarded as a transmission line supplemented with a windkessel compliance and the pressure/volume relationship in the aorta as an arctangent relationship. The pressure represented by the pressure signal - for each stroke prior to the calculation of the flow - is linearised by means of the arctangent relationship, for fixed aorta length, of the aorta pressure/cross section, the values, associated with the final diastolic pressure, of the characteristic impedance of the transmission line and windkessel compliance being adhered to or is used without modification. The characteristic impedance of the transmission line and the windkessel compliance are continuously adapted to the pressure of the windkessel compliance for each stroke concerned. Additionally, to calculate the flow, the flow through the peripheral resistance is added.

Abstract translation: 从源自主动脉的脉冲型血流压力信号确定人心脏的搏动体积的方法，并且包括收缩期和舒张期的每种情况。 所述方法包括从压力p（t）计算流量q（t）并对收缩期的流量进行积分，主动脉被认为是补充有风心顺应性的传输线，并且主动脉中的压力/体积关系为 反正交关系。 由压力信号表示的压力 - 在计算流量之前的每个行程 - 通过主动脉压力/横截面的固定主动脉长度的反正切关系线性化，与最终舒张压相关的值 ，传输线的特性阻抗和风标顺应性被粘附或被使用而没有修改。 传输线的特性阻抗和风标顺应性连续地适应于每个相关行程的风标顺应性的压力。 另外，为了计算流量，加入通过外围电阻的流量。

公开(公告)号：WO1997024982A1

公开(公告)日：1997-07-17

申请号：PCT/GB1997000017

申请日：1997-01-03

Applicant: MONITORING TECHNOLOGY LIMITED ,  BAND, David, Marston ,  LINTON, Nicholas, William, Fox ,  LINTON, Robert, Anthony, Fox ,  O'BRIEN, Terence, Kevin

Inventor： MONITORING TECHNOLOGY LIMITED

IPC: A61B05/029

CPC classification number: A61B5/029

Abstract: A method for the measurement of cardiac output in a patient in which the arterial blood pressure waveform of a patient from a blood pressure monitoring device over a period of time is subjected to various transformations and corrections, including autocorrelation, whereby the pulsatility and heart rate of the patient are obtained. The nominal stroke volume is then calculated from the pulsatility and the nominal caridac output obtained by multiplying the stroke volume by the heart rate.

Abstract translation: 一种用于测量患者心输出量的方法，其中来自血压监测装置的患者的动脉血压波形在一段时间内经受包括自相关在内的各种变换和校正，其中脉动和心率 获得患者。 然后通过将搏动量乘以心率获得的脉动和标称caridac输出计算额定行程量。

公开(公告)号：WO1997012547A1

公开(公告)日：1997-04-10

申请号：PCT/IB1996001052

申请日：1996-10-04

Applicant: PYROTEC LIMITED ,  SHOSHAN, Ofer

Inventor： PYROTEC LIMITED

IPC: A61B05/029

CPC classification number: A61B8/06 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/029

Abstract: The present invention measures cardiac power and power increase under stress, thus calculating contractile reserve (CR), the difference between cardiac peak power and cardiac power at rest by connecting a person to an electrocardiograph and determining the pressure-volume loop (PVL) of a patient's heart. While deflating an inflated cuff on the person's arm at a controlled rate, a series of data points from peak systolic to diastolic pressure is obtained, each point consisting of cuff pressure at penetration coupled with the time of its occurrence after the corresponding ORS complex; a curve-fitting procedure is applied to turn said data points into a pressure curve resembling the ascending limb of the aortic pressure wave. The end systolic pressure (ESP) is calculated using the expression ESP = DP + 2/3 (PSP - DP), where DP = diastolic pressure and PSP = peak systolic pressure. The volume at point ESP is calculated by integrating said flow curve throughout the ejection phase of the patient's heart.

Abstract translation: 本发明通过将人与心电图仪连接并确定压力容积回路（PVL）来测量心脏功率和应力下的功率增加，从而计算收缩储备（CR），心脏峰值功率与静息心脏之间的差异 病人的心。 在以可控速率放松人体手臂上的充气袖带的同时，获得从收缩压峰值到舒张压的一系列数据点，每个点由渗透时的袖带压力加上相应的ORS复合体后发生的时间; 应用曲线拟合程序将所述数据点转换成类似于主动脉压波上升肢的压力曲线。 使用ESP = DP + 2/3（PSP-DP）计算终末收缩压（ESP），其中DP =舒张压，PSP =收缩压峰值。 通过在患者心脏的整个喷射阶段整合所述流动曲线来计算点ESP处的体积。