公开(公告)号：WO1995011904A1

公开(公告)日：1995-05-04

申请号：PCT/US1994012388

申请日：1994-10-28

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BELARDINELLI, Luiz ,  OLSSON, Ray ,  BAKER, Stephen ,  SCAMMELLS, Peter, J. ,  MILNER, Peter, Gerard ,  PFISTER, Jurg, Roland ,  SCHREINER, George, Frederic

IPC: C07D473/08

CPC classification number: C07H19/16 ,  C07D473/06

Abstract: Adenosine and xanthine derivatives, and compositions comprising those compounds, are potent selective agonists and antagonists of adenosine receptors. The derivatives and compositions are used to treat conditions, including certain cardiac arrhythmias.

Abstract translation: 腺苷和黄嘌呤衍生物以及包含这些化合物的组合物是腺苷受体的有效选择性激动剂和拮抗剂。 衍生物和组合物用于治疗包括某些心律失常的病症。

公开(公告)号：WO1995004152A1

公开(公告)日：1995-02-09

申请号：PCT/GB1994001611

申请日：1994-07-27

Applicant: ZENECA LIMITED ,  UNIVERSITY OF FLORIDA ,  GRIERSON, Donald ,  LAWRENCE, Susan, Dale ,  MOORE, Gloria, Andrews ,  SCHUCH, Wolfgang, Walter

Inventor： ZENECA LIMITED ,  UNIVERSITY OF FLORIDA

IPC: C12N15/82

CPC classification number: C07K14/415 ,  C12N15/52 ,  C12N15/8249

Abstract: The invention provides DNA homologous to a disclosed sequence which encodes a fruit ripening-related enzyme. Such DNA is incorporated into DNA constructs which are transformed into plants to increase or decrease expression of the related gene. This provides a method for modifying fruit-ripening characteristics.

Abstract translation: 本发明提供了与公开的编码水果成熟相关酶的序列同源的DNA。 将这样的DNA掺入转化到植物中以增加或减少相关基因表达的DNA构建体中。 这提供了一种改变果实成熟特征的方法。

公开(公告)号：WO1995000844A1

公开(公告)日：1995-01-05

申请号：PCT/US1994006866

申请日：1994-06-17

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  THOMAS, William, C., Jr. ,  BATICH, Christopher, D. ,  PURICH, Daniel, L.

IPC: G01N33/50

CPC classification number: A61K31/365 ,  C07D319/12 ,  G01N33/493 ,  Y10S435/975 ,  Y10S514/891 ,  Y10T436/142222 ,  Y10T436/200833

Abstract: Dicitrate cyclic diester (dicitrate) is a novel compound which is found in patients who do not exhibit symptoms or predisposition to idiopathic renal calculous disease. Dicitrate can be isolated and detected by novel chromatographic methods. Further, treating patients prophylactically and therapeutically with dicitrate cyclic diester can prevent or reduce the effects of calcification-related disease, including some types of kidney stones, or other disease or condition associated with the presence of metal ions. The metal ion complexing properties exhibited by dicitrate are also applicable to the use of the subject compounds as chelating agents and methods of binding, and thereby reducing, the amounts of metal ions in a substance.

Abstract translation: 糖尿病环状二酯（dicitrate）是一种新型化合物，在不显示特发性肾结石病症状或倾向的患者中发现。 可以通过新的色谱方法分离和检测赤霉素。 此外，预防和治疗患者用赤霉素环状二酯可以预防或减少钙化相关疾病（包括某些类型的肾结石）或与金属离子存在相关的其他疾病或病症的影响。 由赤霉素显示的金属离子络合性质也适用于本发明化合物作为螯合剂的用途以及结合物质的方法，从而减少物质中金属离子的量。

公开(公告)号：WO1994002600A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006786

申请日：1993-07-20

Applicant: UNIVERSITY OF FLORIDA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： UNIVERSITY OF FLORIDA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  HOY, Marjorie, Ann ,  PRESNAIL, James, Kevin

IPC: C12N15/00

CPC classification number: A01K67/033 ,  A01K67/0337 ,  C12N15/00

Abstract: This invention relates to methods for transforming arthropods with exogenous DNA. The methods are useful for arthropods that have not previously been amenable to DNA-mediated transformation, and also provide a simpler and more efficient means of transforming arthropods than have previously been described. The method involves microinjecting a nucleic acid sequence encoding a desired trait into the reproductive tract of a female arthropod before oviposition.

Abstract translation: 本发明涉及用外源DNA转化节肢动物的方法。 这些方法对于以前从未适应于DNA介导的转化的节肢动物是有用的，并且还提供了比先前描述的更简单和更有效的转化节肢动物的手段。 该方法包括在产卵前将编码期望性状的核酸序列显微注射到雌性节肢动物的生殖道中。

公开(公告)号：WO1993023998A1

公开(公告)日：1993-12-09

申请号：PCT/US1993005004

申请日：1993-05-26

Applicant: UNIVERSITY OF FLORIDA ,  DOWELANCO

Inventor： UNIVERSITY OF FLORIDA ,  DOWELANCO ,  NAN-YAO, Su ,  THOMS, Ellen, M. ,  PINKHAM, Jeff, D. ,  BURNS, Kevin, J. ,  DeVIRES, Donald, Henry

IPC: A01N25/00

CPC classification number: A01M1/2011 ,  A01M1/026 ,  A01M2200/011 ,  A01N25/006 ,  Y02A40/166

Abstract: The subject invention pertains to materials and methods useful for management of certain pests. The invention is particularly well suited for the control of social insect pests and, particularly, termites. The invention concerns unique toxicant-containing matrices as well as apparatuses for monitoring pest activity and presenting a toxicant. The invention is useful as part of an Integrated Pest Management Program and can greatly reduce the introduction of harmful chemicals into the environment.

Abstract translation: 本发明涉及可用于管理某些害虫的材料和方法。 本发明特别适用于控制社会害虫，特别是白蚁。 本发明涉及独特的含有毒物的基质以及用于监测有害生物活性和提供毒物的装置。 本发明作为“综合虫害管理计划”的一部分是有用的，可以大大减少有害化学物质进入环境。

公开(公告)号：WO1993013430A1

公开(公告)日：1993-07-08

申请号：PCT/US1992011094

申请日：1992-12-30

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  HOLBROOK, Noel, Michele ,  BURNS, Michael, J.

IPC: G01R19/00

CPC classification number: G01N27/223

Abstract: A system for the non-invasive monitoring of the hydration state of a plant comprising the elements: a timing capacitor comprising a plurality of conductive elements (100) adapted for mounting on a plant part (TREE) to sense the hydration state capacitance of the plant part; a capacitance-to-frequency converter electrically connected to the timing capacitor and providing the timing capacitor with an electrical potential said converter comprising an oscillator circuit having a frequency dependent upon the value of the timing capacitor and independent of the electrical losses in said timing capacitor; means for supply electrical power to the capacitance-to-frequency converter; means for measuring the frequency generated by the capacitance-to-frequency converter, the frequency bearing a known relationship to the dielectric constant and, hence, the water content of the plant part; and devices for electrically guarding conductive elements from capacitance extraneous to the plant part comprising means (106) for surrounding the conductive elements with shields having electrical potential substantially equal to that of the timing capacitor.

公开(公告)号：WO1993009088A1

公开(公告)日：1993-05-13

申请号：PCT/US1992008554

申请日：1992-10-13

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BERGERON, Raymond, J., Jr.

IPC: C07C239/00

CPC classification number: C07C259/06

Abstract: Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which provide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.

公开(公告)号：WO1992022200A1

公开(公告)日：1992-12-23

申请号：PCT/US1992005121

申请日：1992-06-15

Applicant: ICI AMERICAS INC. ,  THE UNITED NATIONS OF AMERICA as represented by ... ,  UNIVERSITY OF FLORIDA

Inventor： ICI AMERICAS INC. ,  THE UNITED NATIONS OF AMERICA as represented by ... ,  UNIVERSITY OF FLORIDA ,  PATTERSON, Richard, S. ,  KOEHLER, Philip, G. ,  GOUGER, Richard, J.

IPC: A01M01/02

CPC classification number: A01M1/2011 ,  A01M1/2005 ,  A01M2200/011

Abstract: The present invention is drawn to a device and process for killing cockroaches, which employ: a receptable (11, 12) defining at least one opening (15, 16) dimensioned to permit entry of a cockroach; and an amount of contact cockroach toxicant (18) effective to kill at least one cockroach, and an amount of cockroach attractant (17) effective to lure an adult cockroach, both of which one retained in said receptable (11, 12) in a spatial configuration such that a cockroach must come into contact with the toxicant (18) in order to reach (i.e. get to, or arrive at) the attractant (17). The instant invention may combine high acitivity fast-acting contact toxicant(s) (18) with a cockroach attractant(s) (17), in a manner which overcomes the previously encountered problem of a loss of attraction due to the presence of the toxicant (18).

Abstract translation: 本发明涉及一种用于杀死蟑螂的装置和方法，其使用：容纳（11,12），其限定至少一个开口（15,16），其尺寸允许蟑螂进入; 和一定数量的有效杀死至少一只蟑螂的接触蟑螂毒物（18），以及一定量的蟑螂引诱剂（17），其有效地吸引成年蟑螂，其中一个保留在所述容器（11,12）中的空间 配置使得蟑螂必须与毒药（18）接触以达到（即，到达或到达）引诱剂（17）。 本发明可以将高活性快速接触有毒物质（18）与蟑螂引诱剂（17）结合在一起，以克服先前遇到的由于毒物的存在引起的吸引力损失的问题 （18）。

公开(公告)号：WO1992021253A1

公开(公告)日：1992-12-10

申请号：PCT/US1992004671

申请日：1992-06-04

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  CRANDALL, Philip, G. ,  DAVIS, Kathryn, C.

IPC: A23L02/02

CPC classification number: A23L2/10

Abstract: Method which, after concentration of a feed juice from about 65° Brix to about 80° Brix, involves applying a shear of sufficient magnitude and duration to prevent the formation of a high methoxyl gel in the juice concentrate.

公开(公告)号：WO1992016615A1

公开(公告)日：1992-10-01

申请号：PCT/US1992001807

申请日：1992-03-18

Applicant: UNIVERSITY OF FLORIDA ,  BIOENERGY INTERNATIONAL, L.C. ,  INGRAM, Lonnie, O. ,  BEALL, David, S. ,  BURCHHARDT, Gerhard, F., H. ,  GUIMARAES, Walter, V. ,  OHTA, Kazuyoshi ,  WOOD, Brent, E. ,  SHANMUGAM, Keelnatham, T. ,  FOWLER, David, A. ,  BEN-BASSAT, Arie

Inventor： UNIVERSITY OF FLORIDA ,  BIOENERGY INTERNATIONAL, L.C.

IPC: C12N05/00

CPC classification number: C12N9/0006 ,  C12N9/248 ,  C12N9/88 ,  C12N15/52 ,  C12P7/065 ,  C12Y101/01001 ,  E05Y2900/132 ,  G06T1/00 ,  Y02E50/17 ,  Y10S435/847 ,  Y10S435/854

Abstract: Novel plasmids comprising genes which code for the alcohol dehydrogenase and pyruvate decarboxylase are described. Also described are recombinant hosts which have been transformed with genes coding for alcohol dehydrogenase and pyruvate. By virtue of their transformation with these genes, the recombinant hosts are capable of producing significant amounts of ethanol as a fermentation product. Also disclosed are methods for increasing the growth of recombinant hosts and methods for reducing the accumulation of undesirable metabolic products in the growth medium of these hosts. Also disclosed are recombinant host capable of producing significant amounts of ethanol as a fermentation product of oligosaccharides and plasmids comprising genes encoding polysaccharases, in addition to the genes described above which code for the alcohol dehydrogenase and pyruvate decarboxylase. Further, methods are described for producing ethanol from oligomeric feedstock using the recombinant hosts described above. Also provided is a method for enhancing the production of functional proteins in a recombinant host comprising overexpressing an adhB gene in the host. Further provided are process designs for fermenting oligosaccharide-containing biomass to ethanol.

Abstract translation: 描述了包含编码醇脱氢酶和丙酮酸脱羧酶的基因的新型质粒。 还描述了已经用编码醇脱氢酶和丙酮酸的基因转化的重组宿主。 由于它们与这些基因的转化，重组宿主能够产生显着量的乙醇作为发酵产物。 还公开了增加重组宿主生长的方法和减少这些宿主生长培养基中不需要的代谢产物的积累的方法。 还公开了能够产生显着量的乙醇作为寡糖的发酵产物的重组宿主和包含编码多糖酶的基因的质粒，除了上述描述了醇脱氢酶和丙酮酸脱羧酶的基因之外。 此外，描述了使用上述重组宿主从低聚原料生产乙醇的方法。 还提供了用于增强重组宿主中功能蛋白质生产的方法，其包括在宿主中过表达adhB基因。 进一步提供了将含有寡糖的生物质发酵成乙醇的方法设计。