公开(公告)号：WO1996012483A1

公开(公告)日：1996-05-02

申请号：PCT/US1995013788

申请日：1995-10-25

Applicant: WASHINGTON UNIVERSITY ,  WILLIAMSON, Joseph, R. ,  CORBETT, John, A. ,  McDANIEL, Michael, L. ,  TILTON, Ronald, G.

Inventor： WASHINGTON UNIVERSITY

IPC: A61K31/155

CPC classification number: A61K31/155

Abstract: A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal afflicted with an acute or chronic inflammatory disease which comprises administering to said mammal an effective nitric oxide inhibitory amount of methyl-, or 1,1-dimethyl-, or amino-substituted guanidines.

Abstract translation: 公开了一种用于抑制患有急性或慢性炎性疾病的温血动物中一氧化氮形成的方法，其包括对所述哺乳动物施用有效的一氧化氮抑制量的甲基 - ，或1,1-二甲基 - 或氨基取代 胍。

公开(公告)号：WO1995032061A1

公开(公告)日：1995-11-30

申请号：PCT/US1995006394

申请日：1995-05-23

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  AXLEBAUM, Richard, L. ,  DUFAUX, Douglas, P. ,  ROSEN, Lee, Jonathan

IPC: B05D07/00

CPC classification number: B82Y30/00 ,  B01J2/003 ,  B22F1/02 ,  B22F9/28 ,  C01B13/22 ,  C01B35/04 ,  C01G23/07 ,  C01P2002/72 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/80 ,  C23C16/30 ,  C23C16/453 ,  C23C16/56

Abstract: A method and apparatus for reacting sodium vapor with gaseous chlorides in a flame to produce nanoscale particles of un-oxidized metals, composites and ceramics. The flame is operated under conditions which lead to condensation of a NaCl by-product onto the particles. The condensate encapsulates the particles and aids in controlling desired particle size and preventing undesirable agglomeration among the particles during synthesis. Following synthesis, oxidation of the particles is inhibited by the encapsulation, and handling character of the products is greatly enhanced. Electron microscopy has revealed that synthesized products are composed of discrete nanoparticles in a NaCl matrix. The NaCl encapsulate has been effectively removed from the particles by both washing and known sublimation technique at 800 DEG C under low pressure.

Abstract translation: 一种用于在火焰中使钠蒸汽与气态氯化物反应以产生未氧化金属，复合材料和陶瓷的纳米级颗粒的方法和装置。 火焰在导致NaCl副产物冷凝到颗粒上的条件下运行。 冷凝物包封颗粒并有助于控制期望的颗粒尺寸并防止在合成过程中颗粒之间的不期望的团聚。 合成后，通过封装抑制了颗粒的氧化，大大提高了产品的处理性能。 电子显微镜已经显示合成产物由NaCl基质中的离散纳米颗粒组成。 通过洗涤和已知的升华技术在800℃低压下，已经将有机物从颗粒中去除。

公开(公告)号：WO1995011312A1

公开(公告)日：1995-04-27

申请号：PCT/US1994012095

申请日：1994-10-21

Applicant: WASHINGTON UNIVERSITY ,  SCHREIBER, Robert, D. ,  FARRAR, Michael, A. ,  GREENLUND, Andrew, C.

Inventor： WASHINGTON UNIVERSITY

IPC: C12Q01/00

CPC classification number: C07K14/715 ,  A61K38/00

Abstract: Novel compositions and methods for inhibiting cytokine-induced intracellular activation of STAT family transcription factors by binding to the transcription factors and inhibiting the transcriptional activity of the factors are disclosed. The method comprises introducing into a cell an effective amount of a peptide or derivative thereof, in which the peptide contains a sequence that is derived from a receptor for the cytokine, but with a tyrosine residue being phosphorylated. The compositions comprise isolated peptides or derivatives thereof in which the peptide contains an amino acid sequence derived from a receptor for a cytokine but with a tyrosine residue phosphorylated. A method for identifying derivatives of the isolated peptides comprising detecting the inhibition of the binding of said peptide from a STAT family transcription factor by said derivative is also provided.

Abstract translation: 公开了通过结合转录因子并抑制因子的转录活性来抑制细胞因子诱导的STAT家族转录因子的细胞内活化的新型组合物和方法。 该方法包括向细胞中引入有效量的肽或其衍生物，其中肽含有源自细胞因子受体的序列，但酪氨酸残基被磷酸化。 组合物包含分离的肽或其衍生物，其中肽含有源自细胞因子受体的氨基酸序列，但酪氨酸残基被磷酸化。 还提供了鉴定分离肽衍生物的方法，包括通过所述衍生物检测所述肽与STAT家族转录因子结合的抑制。

公开(公告)号：WO1995005811A1

公开(公告)日：1995-03-02

申请号：PCT/US1994009541

申请日：1994-08-23

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  WILLIAMSON, Joseph, P. ,  CORBETT, John, A. ,  McDANIEL, Michael, L. ,  TILTON, Ronald, G.

IPC: A61K31/155

CPC classification number: A61K31/195 ,  A61K31/155

Abstract: A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal afflicted with an acute or chronic inflammatory disease which comprises administering to said mammal an effective nitric oxide inhibitory amount of methyl-, or 1,1-dimethyl-, or amino-substituted guanidines.

Abstract translation: 公开了一种用于抑制患有急性或慢性炎性疾病的温血动物中一氧化氮形成的方法，其包括向所述哺乳动物施用有效的一氧化氮抑制量的甲基 - 或1,1-二甲基 - 或氨基取代 胍。

公开(公告)号：WO1994024794A1

公开(公告)日：1994-10-27

申请号：PCT/US1994004486

申请日：1994-04-22

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  TURNER, Jonathan, S.

IPC: H04L12/56

CPC classification number: H04L12/5601 ,  H04L12/18 ,  H04L49/106 ,  H04L49/203 ,  H04L49/3081 ,  H04L2012/565 ,  H04L2012/5681 ,  H04Q11/0478

Abstract: Multicasting is implemented in a virtual circuit switch (23) for an ATM network by recycling data cells through the switch fabric (23) a multiple number of times with a copy-by-two network (IPP) creating an additional data cell upon each recycle to thereby satisfy the number of connection addresses in the multicast connection. Resequencing of the data cells may be implemented at the exit to the switch fabric (23) as well as upon each recycle of data cells through the switch fabric (23).

Abstract translation: 在用于ATM网络的虚拟电路交换机（23）中实现组播，通过在每次回收时创建附加数据单元的双副网络（IPP）通过交换结构（23）多次重复数据信元 从而满足组播连接中的连接地址的数量。 数据单元的重新排序可以在交换结构（23）的出口以及数据单元通过交换结构（23）进行每次回收时实现。

公开(公告)号：WO1994024291A2

公开(公告)日：1994-10-27

申请号：PCT/US1994004168

申请日：1994-04-15

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  CURTISS, Roy, III ,  SCHODEL, Florian

IPC: C12N15/62

CPC classification number: C07K14/445 ,  A61K39/015 ,  A61K39/0275 ,  A61K2039/522 ,  A61K2039/523 ,  C07K14/005 ,  C07K14/35 ,  C07K2319/40 ,  C12N2730/10122 ,  Y02A50/412 ,  Y02A50/482 ,  Y02A50/484

Abstract: Vaccines and immunogenic compositions which contain at least one immunogenic antigenic determinant, the antigenic determinant being fused to a Hepatitis B virus core antigen and heterologous thereto and methods for making same are provided.

Abstract translation: 提供含有至少一种免疫原性抗原决定簇的疫苗和免疫原性组合物，该抗原决定簇与乙型肝炎病毒核心抗原融合并且与其异源，并且其制备方法。

公开(公告)号：WO1994020024A1

公开(公告)日：1994-09-15

申请号：PCT/US1994002173

申请日：1994-03-01

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  DIMAROGONAS, Andrew, D.

IPC: A61B08/00

CPC classification number: A61B5/4509 ,  A61B5/0051 ,  A61B9/00

Abstract: The integrity (density) of discrete pieces of hard tissue (bones) in a patient may be determined by either one of two methods. In a first method, an impulse of energy is introduced into the bone, such as by striking the patient's bone, and the induced vibration is sensed and analyzed in order to compute the damping factor thereof, the damping factor being directly related to the density thereof. With this method, a transducer (26) is coupled to the bone (24) and its output is amplified by an amplifier (28) before input to a computer (30) which determines the damping factor. In a second method, a continuous energy input is provided to the bone, such as by utilizing a frequency generator (36) coupled to a power amplifier (38) whose output drives a transducer (40) such as a speaker for inducing a continuous vibration in the bone. This continuous vibration is measured with a transducer (26), an amplifier (28), and a damping factor calculated with a computer (30) as in the first method.

Abstract translation: 可以通过两种方法之一来确定患者中不连续的硬组织块（骨骼）的完整性（密度）。 在第一种方法中，例如通过打击患者的骨骼将能量的冲动引入骨骼，并且感测和分析感应的振动以计算其阻尼因子，阻尼因子与其密度直接相关 。 利用这种方法，换能器（26）耦合到骨骼（24），并且其输出在输入到确定阻尼因子的计算机（30）之前被放大器（28）放大。 在第二种方法中，例如通过利用耦合到功率放大器（38）的频率发生器（36）将连续的能量输入提供给骨骼，功率放大器（38）的输出驱动诸如扬声器的换能器（40），用于引起连续振动 在骨头里 如第一种方法那样，使用换能器（26），放大器（28）和用计算机（30）计算的阻尼因子来测量该连续振动。

公开(公告)号：WO1993021947A1

公开(公告)日：1993-11-11

申请号：PCT/US1993004051

申请日：1993-04-30

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  BOIME, Irving

IPC: A61K37/38

CPC classification number: C07K14/59

Abstract: Improved methods for recombinant production of human reproductive hormones are disclosed. These methods involve the use of animal-derived cells that contain regulated secretory granules as host cells for expression systems capable of expressing DNA encoding human reproductive hormones or their beta subunits.

Abstract translation: 公开了用于重组生产人生殖激素的改进方法。 这些方法涉及使用含有调节分泌颗粒的动物来源的细胞作为能够表达编码人生殖激素或其β亚基的DNA的表达系统的宿主细胞。

公开(公告)号：WO1993006844A1

公开(公告)日：1993-04-15

申请号：PCT/US1992008424

申请日：1992-10-02

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  BOIME, Irving

IPC: A61K37/02

CPC classification number: C07K16/26 ,  A61K38/00 ,  C07K14/59 ,  C07K2319/00 ,  C07K2319/75 ,  Y10S930/11 ,  Y10S930/141

Abstract: The invention provides peptide and protein pharmaceuticals with extended half-lives. The modified peptides and proteins of the invention contain at least two tandem extensions at their C-terminus comprising the carboxy terminal portion of human chorionic gonadotropin. These "CTP units" consist essentially of the native HCG- beta sequence from position 112-118 to position 145 or conservative modifications thereof.

Abstract translation: 本发明提供具有延长半衰期的肽和蛋白质药物。 本发明的修饰的肽和蛋白质在其包含人绒毛膜促性腺激素的羧基末端的C末端含有至少两个串联延伸。 这些“CTP单元”基本上由位置112-118到位置145的天然HCG-β序列或其保守修饰组成。

公开(公告)号：WO1992014319A1

公开(公告)日：1992-08-20

申请号：PCT/US1992000671

申请日：1992-01-29

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  TUNER, Jonathan, S.

IPC: H04L12/56

CPC classification number: H04L12/5601 ,  H04L49/106 ,  H04L49/203

Abstract: A packet switch having broadcasting capability for an ATM network includes a copy network stage having an increased number of copy outputs over the number of switch inputs and outputs to improve data throughput under worst case conditions, broadcast translation circuits with inputs connected to a multiple number of copy network outputs for multiplexing the data packets therethrough, partitioned memories for the broadcast translation circuits to reduce their memory requirements, and techniques for aligning broadcast copies of data packets for minimizing the number of copies each BTC must translate and thereby reduce each of their memories. All of these enhancements to a prior art broadcast ATM switch substantially reduce its memory requirements to thereby enable broadcasting in an ATM switch to be practically realized.