公开(公告)号：US20190187155A1

公开(公告)日：2019-06-20

申请号：US16324769

申请日：2017-08-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Daniel BEACHAM ,  Kyle GEE ,  Aleksey RUKAVISHNIKOV

IPC: G01N33/68 ,  C07D493/10 ,  G01N33/84

CPC classification number: G01N33/6872 ,  C07C201/00 ,  C07C229/18 ,  C07C251/30 ,  C07C2603/24 ,  C07D311/90 ,  C07D493/10 ,  C09B1/00 ,  C09B11/24 ,  G01N33/84 ,  G01N2333/705

Abstract: Compositions and methods for detecting the activity of an ion channel in a cell are described. The methods include providing a loading buffer solution to the cell, where the loading buffer includes a thallium ion indicator and optionally chloride ions, and providing a stimulus buffer that includes thallium ions to the cell. Providing the stimulus buffer can cause thallium ion influx into or efflux out of the cell through the ion channel. After providing the stimulus buffer, a change in at least one optical property of the thallium ion indicator is detected in response to thallium influx or efflux, thereby detecting the activity of the ion channel.

公开(公告)号：US20130197245A1

公开(公告)日：2013-08-01

申请号：US13827809

申请日：2013-03-14

Applicant: Shubhangi Bhalchandra Umbarkar ,  Mohan Keraba Dongare ,  Ankush Biradar ,  Vaibhav Ravindrakumar Acham

Inventor： Shubhangi Bhalchandra Umbarkar ,  Mohan Keraba Dongare ,  Ankush Biradar ,  Vaibhav Ravindrakumar Acham

IPC: B01J31/22 ,  C07C29/48 ,  C07C315/02 ,  C07C45/29 ,  C07C51/285 ,  C07C201/00 ,  C07D301/12 ,  C07C45/28

CPC classification number: B01J31/2295 ,  C07C29/48 ,  C07C45/28 ,  C07C45/294 ,  C07C51/285 ,  C07C201/00 ,  C07C315/02 ,  C07D301/12 ,  C07F17/00

Abstract: An organometallic molybdenum acetylide dioxo complex of formula (η5-C5H5)MoO2(—Cs≡CPh) and provides a simple, short, efficient process for the synthesis of organometallic molybdenum dioxo complex which is used as catalyst for a number of oxidation reactions.

Abstract translation: 式（eta5-C5H5）MoO2（-Cs = CPh）的有机金属钼乙炔二氧化物络合物，提供用于合成有机金属钼二氧化物络合物的简单，短期，有效的方法，其用作许多氧化反应的催化剂。

公开(公告)号：US4314089A

公开(公告)日：1982-02-02

申请号：US129959

申请日：1980-03-13

Applicant: Hans Zengel ,  Manfred Bergfeld ,  Werner Klostermeier

Inventor： Hans Zengel ,  Manfred Bergfeld ,  Werner Klostermeier

IPC: C07C207/00 ,  C07B61/00 ,  C07C20060101 ,  C07C67/00 ,  C07C201/00 ,  C07C207/02 ,  C07C76/00 ,  C07C81/02

CPC classification number: C07C201/00

Abstract: An improved process for the preparation of nitrosobenzene by catalytically reducing nitrobenzene with the use of a reducing agent selected from the group consisting of aliphatic compounds containing from about 1 to about 20 carbon atoms, cycloaliphatic compounds containing from about 4 to about 12 carbon atoms, benzene, naphthalene, and ethylenically unsaturated compounds containing from about 2 to about 10 carbon atoms is disclosed. The improvement comprises performing the reduction in the presence of from about 0.05 to about 4.0 moles of water per mole of nitrobenzene.

Abstract translation: 通过使用选自含有约1至约20个碳原子的脂族化合物，含有约4至约12个碳原子的脂族化合物，苯，苯， ，萘和含有约2至约10个碳原子的烯属不饱和化合物。 改进之处在于每摩尔硝基苯减少存在约0.05至约4.0摩尔的水。

公开(公告)号：US4229595A

公开(公告)日：1980-10-21

申请号：US945367

申请日：1978-09-25

Applicant: Erik Bengtsson ,  Boris Holm

Inventor： Erik Bengtsson ,  Boris Holm

IPC: C07C67/00 ,  C07C201/00 ,  C07C205/22 ,  C07C207/04 ,  C07C79/26

CPC classification number: C07C201/00 ,  C07C201/06

Abstract: Preparation of nitro compounds of phenols and alkyl substituted derivatives thereof which includes nitrosating phenols or alkyl derivative thereof, oxidizing the nitroso compound, separating off nitrogen oxides, separating nitro compounds from reaction mixture, and subjecting mother liquor and washing liquids to destructive oxidation at elevated temperatures and recycling nitrogen oxides and nitric acid.

Abstract translation: 制备苯酚和其烷基取代衍生物的硝基化合物，包括亚硝化酚或其烷基衍生物，氧化亚硝基化合物，分离出氮氧化物，将硝基化合物与反应混合物分离，并使母液和洗涤液体在高温下进行破坏性氧化 并回收氮氧化物和硝酸。

公开(公告)号：US4145360A

公开(公告)日：1979-03-20

申请号：US781869

申请日：1977-03-28

Applicant: John Crosby ,  John A. Milner

Inventor： John Crosby ,  John A. Milner

IPC: C07C67/00 ,  C07C207/00 ,  C07C241/00 ,  C07C265/00 ,  C07D271/12 ,  C07D273/00 ,  C07D273/01 ,  C08G18/00 ,  C08G18/70 ,  C08G18/80 ,  C07C118/00

CPC classification number: C07D273/00 ,  C07C201/00 ,  C07D271/12 ,  C08G18/701

Abstract: Process for the preparation of organic isocyanates in which a furoxan is heated in the presence of a vicinal diketo compound containing two adjacent keto carbonyl groups. When the furoxan ring is fused to an organic ring system di-isocyanates are produced. An adduct of the furoxan and the diketo compound may be isolated from the reaction mixture and used as a stable isocyanate precursor, for example, a "one-pot" polyurethane composition.

Abstract translation: 有机异氰酸酯的制备方法，其中呋喃糖在含有两个相邻酮基羰基的连续二酮化合物的存在下被加热。 当呋喃环与有机环系稠合时，产生二异氰酸酯。 呋喃糖和二酮化合物的加合物可以从反应混合物中分离出来，并用作稳定的异氰酸酯前体，例如“一锅”的聚氨酯组合物。

公开(公告)号：US3956410A

公开(公告)日：1976-05-11

申请号：US581468

申请日：1975-05-28

Applicant: Fred W. Koff

Inventor： Fred W. Koff

IPC: C07C81/02

CPC classification number: C07C201/00

Abstract: Purification of chloronitrosocyclohexane dimer (CNCD) is effected by dissolving the crude CNCD in a chlorinated aliphatic hydrocarbon or a lower aromatic hydrocarbon solvent and thereafter displacing the solvent of the solution with an aliphatic alcohol of higher boiling point. Pure CNCD crystallizes and is separated from the liquors, which retain colored matter and other impurities.

Abstract translation: 通过将粗制CNCD溶解在氯化脂族烃或低级芳族烃溶剂中，然后用沸点较高的脂族醇置换溶液来实现氯亚硝基环己烷二聚体（CNCD）的纯化。 纯CNCD结晶并与液体分离，保留着色物质和其他杂质。

公开(公告)号：US3933926A

公开(公告)日：1976-01-20

申请号：US365208

申请日：1973-05-30

Applicant: David Anthony Salter ,  Robert John James Simkins

Inventor： David Anthony Salter ,  Robert John James Simkins

IPC: C07C201/10 ,  C07C201/16 ,  C07C205/23 ,  C07C205/24 ,  C07C205/25 ,  C07C205/37 ,  C07C207/04 ,  C07C79/26 ,  C07C79/30

CPC classification number: C07C201/16 ,  C07C201/00 ,  C07C201/06 ,  C07C201/08

Abstract: A process for the preparation of nitrophenols by adding over a period of time a suspension containing from about 4 to about 20 per cent weight/volume of nitrosated phenol to a nitric acid solution containing between 45 and 100 per cent by weight of nitric acid, said solution being maintained at a temperature in the range from about 45.degree. to 100.degree.C.

Abstract translation: 一种通过在一段时间内加入含有约4至约20重量/体积的亚硝化苯酚的悬浮液至含有45至100重量％硝酸的硝酸溶液来制备硝基酚的方法，所述方法 溶液保持在约45℃至100℃的温度范围内。

公开(公告)号：US3848002A

公开(公告)日：1974-11-12

申请号：US27721572

申请日：1972-08-02

Applicant: CHEMINOVE AS

Inventor： WEIS J ,  PEDERSEN B

IPC: C07C67/00 ,  C07C201/00 ,  C07C205/22 ,  C07C207/04 ,  C07C79/24

CPC classification number: C07C201/00 ,  C07C201/06 ,  C07C207/04 ,  C07C205/22

Abstract: 1. A PROCESS FOR THE PRODUCTION OF P-NITROPHENOLS WHICH COMPRISES (A) MIXING (1) A NITRILE OF THE FORMULA R.O.NO, IN WHICH R IS AN ALKYL GROUP HAVING 1-6 CARBON ATOMS WITH (2) PHENOLS SELECTED FROM THE GROUP CONSISTING ESSENTIALLY OF PHENOL, M-CRESOL AND A MIXTURE OF MAND P-CRESOL IN AN ACIDIC AQUEOUS MEDIUN WHICH IS AN AQUEOUS SOLUTION OF A STRONG ACID AT TEMPERATURES RANGING FROM -20* TO 20*C TO FORM A PRECURSOR P-NITROSOPHENOL; AND (B) TREATING THE P-NITROSOPHENOL WITH NITRIC ACID IN THE PRESENCE OF AN ALCOHOL OF THE FORMULA R1OH, IN WHICH R1 IS AN ALKYL GROUP HAVING 1-6 CARBON ATOMS, AT TEMPERATURES RANGING FROM ABOUT -10* TO 25*C.; AND (C) RECOVERING A P-NITRO-PHENOL

公开(公告)号：US3751490A

公开(公告)日：1973-08-07

申请号：US3751490D

申请日：1972-01-25

Applicant: ICI LTD

Inventor： WOOLLEY J ,  DODMAN D ,  WILKINS M

IPC: C07C201/16 ,  C07C81/02

CPC classification number: C07C201/00 ,  C07C207/00

Abstract: C-NITROSO COMPOUNDS, ESPECIALLY NITROSOBENZENE, ARE STABILIZED BY THE ADDITION OF COMPOUNDS SUCH AS SALTS OR CHELATES OF HEAVY METALS, ESPECIALLY MANGANESE, COPPER OR COBALT.

公开(公告)号：US3616359A

公开(公告)日：1971-10-26

申请号：US3616359D

申请日：1968-08-20

Applicant: THIOKOL CHEMICAL CORP

Inventor： PAUSTIAN JOHN E ,  BURWASSER HERMAN

IPC: B01J1/10

CPC classification number: C07C201/00 ,  Y10S204/903

Abstract: A process has been provided for preparing perhalo nitroso alkanes from a halocarbon compound of the formula RCX2H wherein X is fluorine, chlorine, or bromine and R is a halogen or a perhalo radical and wherein the halogens substituents are fluorine, chlorine, or bromine. The process is carried out by reacting the halocarbon with nitrosyl chloride in a vapor phase at a pressure of one atmosphere or less and at a temperature from 160* C. and lower while irradiating the reaction mixture with radiant energy at the characteristic wavelength displayed by nitrosyl chloride.