公开(公告)号：WO2004104532A1

公开(公告)日：2004-12-02

申请号：PCT/CH2004/000320

申请日：2004-05-26

Applicant: TAWIL, Samir ,  MALHAS, Mahmoud ,  KAWASH, Fawzi, Ahmad ,  ROTHMAIER, Markus ,  BUSSE-GRAWITZ, Max, Erick ,  SCHMIDIGER, Thomas

Inventor： ROTHMAIER, Markus ,  BUSSE-GRAWITZ, Max, Erick ,  SCHMIDIGER, Thomas

IPC: G01J3/02

CPC classification number: G01N21/4738 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/10 ,  G01N21/645 ,  G01N21/78 ,  G01N2201/024

Abstract: The invention relates to an arrangement for continuous determination of a substance comprising a chemically reacting sensor element (21) arranged in or adjacent to a limiting wall of a volume (22) containing the substance, where in a housing (2) of a modular device (1) optical elements to read the sensor element (21) are arranged, comprising at least one light source (35) illuminating the sensor element (21) and at least one sample detector (29) detecting the light scattered by the sensor element (21), and where a front side of the housing (2) comprises a coupling for the sensor element (21), so that the sensor element (21) may be interchangeably and modularly coupled to the front side of the housing (2). A glass body (24) is arranged adjacent to the coupling for direct contact with the sensor element (21) and separate conduits (34, 31) for the illuminating and for the scattered light are arranged rearward of the glass body (24). The modular device (1) allows for easily interchanging the modular sensor element (21) and provides an optical connection between the sensor element (21) and the detector (29) which is steady and allows for high quality measurements.

Abstract translation: 本发明涉及用于连续确定物质的装置，该物质包括布置在容纳物质的容积（22）的限制壁中或附近的化学反应传感器元件（21），其中在模块化装置的壳体（2）中 （1）读取传感器元件（21）的光学元件被布置成包括照射传感器元件（21）的至少一个光源（35）和检测由传感器元件散射的光的至少一个样本检测器（29） 21），并且其中壳体（2）的前侧包括用于传感器元件（21）的联接器，使得传感器元件（21）可以可互换地并且模块地联接到壳体（2）的前侧。 玻璃体（24）被布置成与耦合件相邻以与传感器元件（21）直接接触，并且用于照明和用于散射光的分离导管（34,31）布置在玻璃体（24）的后方。 模块化装置（1）允许容易地交换模块化传感器元件（21）并且在传感器元件（21）和检测器（29）之间提供稳定的光学连接并且允许进行高质量测量。

公开(公告)号：WO01084125A1

公开(公告)日：2001-11-08

申请号：PCT/US2001/013228

申请日：2001-04-25

IPC: G01N21/64 ,  G01N21/59 ,  G02B6/24

CPC classification number: G01N21/645 ,  G01N2201/024 ,  Y10T436/25

Abstract: Described and claimed is a modular fluorometer and a method of using same to control an industrial water system, wherein said modular fluorometer comprises: one or more units with each unit comprising: a channel comprising an optically appropriate cell through which a water sample flows; a light source positioned outside said optically appropriate cell; an optional excitation filter positioned between the light source and the optically appropriate cell; a reference detector positioned outside the optically appropriate cell; an emission detector positioned outside the optically appropriate cell; an optional emission filter positioned between said emission detector and said optically appropriate cell; wherein if more than one unit is present in said modular fluorometer, said optically appropriate cells through which said water sample flows are aligned such that only one channel through which a water sample flows exists in said fluorometer.

Abstract translation: 描述和要求保护的是模块化荧光计及其使用方法来控制工业水系统，其中所述模块化荧光计包括：一个或多个单元，每个单元包括：通道，其包括水样品流过的光学合适的单元; 位于所述光学适当电池外部的光源; 位于光源和光学适当的电池之间的可选的激发滤光器; 位于光学适当细胞外的参考检测器; 位于光学适当电池外部的发射检测器; 位于所述发射检测器和所述光学适当电池之间的可选的发射滤光器; 其中如果在所述模块化荧光计中存在多于一个单元，则所述水样品流过的所述光学适当的单元对准，使得在所述荧光计中仅存在一个水样本流动的通道。

公开(公告)号：WO00022417A1

公开(公告)日：2000-04-20

申请号：PCT/EP1999/006925

申请日：1999-09-18

IPC: G01N21/25 ,  G01N21/64 ,  G01N35/00 ,  G02B3/00 ,  G02B5/04 ,  G02B13/08

CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N2201/024 ,  G02B3/005 ,  G02B3/0068 ,  G02B5/045

Abstract: The invention relates to an imaging system for optical automatic analysers, especially fluorescence readers. On the sample side, the imaging system contains a cylindrical lens array (6) and a prism array (7), which is arranged upstream of the cylindrical lens array. The prismatic effect of the prisms (7a-7c) of the prism array (7) lies in the direction of the cylinder axes of the cylindrical lenses (6a-6c). Together with a telescopic imaging system (8, 11), the inventive imaging system creates a number of parallel cylindrical focussing volumes between the cylindrical lens array (6) and a detector array (10), these focussing volumes being slanted towards the optical axis of the telescopic system in relation to the vertical. The arrangement enables the detection of fluorescence with a large aperture in one direction, and at the same time enables depth selective analysis of the fluorescence signal, especially the discrimination of the fluorescent radiation originating from the areas around the bases of the sample containers from the fluorescent radiation originating from the solution above. With the focussing volumes that are slanted towards the bases of the sample containers, the imaging system ensures that the fluorescence from the areas around the bases of the sample containers (5a-5c) is detected with the same sensitivity even when the heights of the bases vary in the individual sample containers.

Abstract translation: 本发明涉及一种用于光学自动分析装置，尤其是荧光读取器的成像系统。 含有样品侧的成像系统，一个柱面透镜阵列（6）和柱面透镜阵列棱镜阵列（7）的上游，其中，在所述柱面透镜（图6A-6C）的气缸轴线的方向上的棱镜阵列（7）的棱晶（图7A-7C）的棱镜效应。 由成像系统，与柱面透镜阵列（6）和探测器阵列（10）之间的可伸缩的成像系统（8,11）一起创建许多平行的圆柱形聚焦体积相对于垂直倾斜于telekopischen系统的光轴它们是。 这种安排使得在一个方向上，高孔径荧光检测可能的，同时允许荧光信号的深度选择性的评价，特别是从试样容器的荧光辐射的底部附近导出相对于所述从上覆溶液的荧光辐射衍生的判别。 由于倾斜到样品容器体积的底部聚焦成像系统提供了一种检测来自具有相同灵敏度的近表面区域的荧光的，即使在各个样品容器不同楼层高度（5A-5C）。

公开(公告)号：WO99023474A1

公开(公告)日：1999-05-14

申请号：PCT/EP1998/006468

申请日：1998-10-12

IPC: G01J3/457 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/64 ,  G01N37/00 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36

CPC classification number: G01N21/6452 ,  B01L3/5085 ,  B01L2300/0829 ,  G01N21/253 ,  G01N21/6456 ,  G01N2201/024

Abstract: An optical system made up of lens arrays (2i, 7) and normal lenses (41, 5, 42) is particularly suitable for use as a massive parallel reader (approx. 10 channels) for micro titer plates (1) and the like in absorption, fluorescence and luminescence.

Abstract translation: 包括透镜阵列的光学系统（2 1，7）和正常透镜（41，5,42）是特别适合作为大规模并行（大约10 <2>信道）读取器用于微量滴定板（1）和在吸收，荧光和发光等。

公开(公告)号：WO1997011351A1

公开(公告)日：1997-03-27

申请号：PCT/FI1996000497

申请日：1996-09-20

Applicant: LABSYSTEMS OY ,  TUUNANEN, Jukka ,  PRIHA, Matti ,  TUPAKKA, Heikki ,  KÄRMENIEMI, Timo

Inventor： LABSYSTEMS OY

IPC: G01N21/01

CPC classification number: G01N21/253 ,  G01N2201/024

Abstract: The invention relates to an optical analyser wherein measuring light is directed from a sample to the detector. The apparatus has an optics module (15) which has a detector and optical means for directing light emitted by the sample to the detector and which module can be positioned alternatively either so that light is directed to the detector from above the sample or so that light is directed to the detector from below the sample. The invention is usable in particular in fluorometers and in luminometers.

Abstract translation: 本发明涉及一种光学分析仪，其中测量光从样品指向检测器。 该装置具有光学模块（15），其具有检测器和用于将样品发射的光引导到检测器的光学装置，并且该模块可以交替地定位，使得光从样品上方引导到检测器，或者使得光 从样品下方引导到检测器。 本发明特别可用于荧光计和发光计。

公开(公告)号：US12053774B2

公开(公告)日：2024-08-06

申请号：US17185177

申请日：2021-02-25

Applicant: The General Hospital Corporation

Inventor： Robert Granier ,  Ramin Haghgooie ,  Ken Kotz ,  Anne C. Petrofsky ,  Ronald G. Tompkins

IPC: G01N1/00 ,  B01L3/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/53 ,  G01N21/64 ,  G01N21/78 ,  G01N35/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/532 ,  G01N21/6486 ,  G01N21/78 ,  G01N35/00029 ,  G01N35/00871 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/12 ,  G01N15/1459 ,  G01N2021/6493 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00881 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

Abstract: A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.

公开(公告)号：US20190195768A1

公开(公告)日：2019-06-27

申请号：US16322370

申请日：2017-07-28

Applicant: PCME Limited

Inventor： David Christopher Unitt ,  Trevor Allan Lye ,  Bruce Greetham

IPC: G01N15/10 ,  G01F1/74 ,  G08B17/107

CPC classification number: G01N15/10 ,  G01F1/74 ,  G01N15/0205 ,  G01N21/15 ,  G01N21/53 ,  G01N2015/0096 ,  G01N2015/1075 ,  G01N2021/536 ,  G01N2201/024 ,  G01N2201/12707 ,  G08B17/107

Abstract: A method and apparatus (1) for monitoring particles flowing in a stack are disclosed. The method comprises emitting light from a light source along an optical path for scattering from the particles, rotating a rotatable monitoring assembly (15) mounted in the optical path, and detecting the scattered light using a detector. The rotatable monitoring assembly (15) contains at least two in apertures, and the method further comprises rotating the rotatable monitoring assembly (15) into a plurality of different configurations. In an operation configuration, light passes through the rotatable monitoring assembly (15) and into the stack unimpeded. In a zero-check configuration, the rotatable monitoring assembly (15) blocks the light from reaching the stack. In a span-check configuration, light of varying intensity passes from the light source through the rotatable monitoring assembly (15) into the stack. In a contamination-check configuration, the light is reflected through the rotatable monitoring assembly (15) onto the detector, without entering the stack. In the safety-shutter configuration, the rotatable monitoring assembly (15) protects optical components in the instrument from particles in the stack.

公开(公告)号：US09976996B2

公开(公告)日：2018-05-22

申请号：US15294877

申请日：2016-10-17

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01N21/00 ,  G01N30/78 ,  G01N21/05 ,  G01N21/33 ,  G01J3/02 ,  G01N30/02 ,  G01N30/74 ,  G01N33/00 ,  G01N21/15 ,  G01N21/03

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

公开(公告)号：US20180020985A1

公开(公告)日：2018-01-25

申请号：US15520973

申请日：2015-10-22

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： John Wong ,  Ken Kang-Hsin Wang ,  Iulian Loan Iordachita

IPC: A61B5/00

CPC classification number: A61B5/704 ,  A61B5/0064 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0077 ,  A61B5/0079 ,  A61B6/032 ,  A61B2503/40 ,  G01N21/01 ,  G01N21/763 ,  G01N2201/024

Abstract: An optical imaging system for interfacing with a separate examination apparatus and methods of making and using the same are disclosed. The optical imaging system can include an imaging housing including a housing enclosure and a housing receptor plate, a subject support mount, a cart including an extendable arm, an optical arrangement including an optical source, a cantilever mirror system, and the housing enclosure, and a detection optical path providing optical communication between the cantilever mirror system and an optical detector. The subject support mount allows optical illumination via at least one optical port. The extendable arm is affixed to the cart at one end and the optical arrangement at another end. The extendable arm can move from a retracted position to an extended position without contacting the subject support mount or the subject.

公开(公告)号：US09810704B2

公开(公告)日：2017-11-07

申请号：US14183500

申请日：2014-02-18

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Joy Roy ,  Timothy Smith ,  Daniel Young

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.