Abstract:
Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
Abstract:
PROBLEM TO BE SOLVED: To solve such problems that, since a detector having high gain is required for performing high speed inspection with weak defective scattered light in a defect inspection used in a step for manufacturing a semiconductor or the like, dark current noise becomes large and defect detection sensitivity is reduced in a general detector, typically a photomultiplier tube in accordance with an increase in gain.SOLUTION: A detection optical system for detecting reflective scattered light from a sample includes a plurality of detectors. A photon counting type detector having the small number of pixels is applied to a detector for detecting a weak amount of background scattered light, while a photon counting type detector having the large number of pixels is applied to a detector for a strong amount of background scattered light or an analog type detector, and furthermore non-linearity of detection intensity of scattered light generated by application of the photon counting type detector is corrected to correct a defective scattered light detection signal.
Abstract:
A laser scanning microscope (100; 200; 300; 400; 500; 600; 700) includes: an objective (5; 5a; 5b) that irradiates a specimen with a laser beam; a detection lens (7) that condenses the laser beam that passes through the specimen, the detection lens (7) being arranged so as to face the objective (5; 5a; 5b); an optical element (8; 26; 27; 28) that is removably arranged between an image plane on which the detection lens (7) forms an image of the specimen and a first surface that is a lens surface closest to the specimen of the detection lens (7), the optical element (8; 26; 27; 28) converting the laser beam made incident on the optical element (8; 26; 27; 28) into diffused light or deflecting a portion of the laser beam made incident on the optical element (8; 26; 27; 28); and a photodetector (12) that detects detection light emitted from the optical element (8; 26; 27; 28) arranged between the image plane and the first surface to the image plane.
Abstract:
The present invention relates to a device for obtaining images of bacterial cultures in a dish. The proposed device includes a support for a culture dish to be analyzed surrounded by an annular light emitting source facing an image capturing device and a non-reflective surface which, in conjunction with a reflective surface arranged in the periphery of the support, form a preferably spherical-shaped contrast observation chamber, providing a glare- and reflection-free, uniform tangent illumination of the support.
Abstract:
Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
Abstract:
Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.
Abstract:
Disclosed are systems and methods for monitoring chemical reaction processes in or near real-time. One method may include containing a fluid within a flow path, the fluid having a chemical reaction occurring therein, optically interacting at least one integrated computational element with the fluid, thereby generating optically interacted light, and producing an output signal based on the optically interacted light that corresponds to a characteristic of the chemical reaction.
Abstract:
A planar sample, particularly of the type used in biological laboratories for detection and sometimes analysis of two-dimensional arrays of proteins, nucleic acids, or other biological species, is illuminated by epi-illumination using optically filtered line lights that are arranged along opposing parallel sides of a rectangle in which the sample array resides, with two coaxial line lights on each side of the rectangle, and the two on any given side being separated by a gap whose optimal width depends on the wavelength band transmitted by the optical filter. Surprisingly, the gap eliminates the peak in intensity at the center of the sample area and the decrease that occurs from the center outward that would otherwise occur with a single continuous filtered line light, producing instead a substantially uniform intensity along the direction parallel to the line lights.