公开(公告)号：US09506859B2

公开(公告)日：2016-11-29

申请号：US14777188

申请日：2014-02-24

Applicant: Robert Bosch GmbH

Inventor： Ulrich Stopper ,  Stephan Lenor ,  Stefan Weber

IPC: G01N21/47 ,  B60R16/023 ,  G01N21/53 ,  G06K9/00 ,  G01J1/44 ,  G01W1/00 ,  G01N15/00 ,  G01N15/06

CPC classification number: G01N21/47 ,  B60R16/0237 ,  G01J1/44 ,  G01N21/538 ,  G01N2015/0026 ,  G01N2015/0693 ,  G01N2201/0616 ,  G01N2201/126 ,  G01W1/00 ,  G06K9/00791

Abstract: A method is provided for determining a visual range in daytime fog, the method (800) including a step of reading in and a step of ascertaining. In the step of reading in, coordinates of at least one characteristic point of a brightness curve of a camera image of the fog are read in. The brightness curve represents brightness values of image points of the camera image along a reference axis of the camera image. In the step of ascertaining, a meteorological visual range in the camera image is ascertained using the coordinates, a meteorological contrast threshold, and a processing specification, in order to estimate the visual range in fog. The processing specification images location-dependent and/or direction-dependent scattered light through the fog in the camera image.

Abstract translation: 提供了一种用于确定白天雾中的视觉范围的方法，所述方法（800）包括读入步骤和确定步骤。 在读入的步骤中，读取雾的照相机图像的亮度曲线的至少一个特征点的坐标。亮度曲线表示摄像机图像沿摄像机图像的参考轴的图像点的亮度值 。 在确定的步骤中，使用坐标，气象对比阈值和处理规范来确定摄像机图像中的气象视觉范围，以估计雾中的视觉范围。 处理规范通过摄像机图像中的雾图像取决于位置和/或方向依赖的散射光。

公开(公告)号：US09470640B2

公开(公告)日：2016-10-18

申请号：US15042598

申请日：2016-02-12

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shunichi Matsumoto ,  Atsushi Taniguchi ,  Toshifumi Honda ,  Yukihiro Shibata ,  Yuta Urano

IPC: G01N21/00 ,  G01N21/95 ,  G01N21/956 ,  H01L21/66

CPC classification number: G01N21/9501 ,  G01N21/956 ,  G01N2201/126 ,  G01N2201/127 ,  H01L22/12 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A defect inspection method and device for irradiating a linear region on a surface-patterned sample mounted on a table, with illumination light from an inclined direction to the sample, next detecting in each of a plurality of directions an image of the light scattered from the sample irradiated with the illumination light, then processing signals obtained by the detection of the images of the scattered light, and thereby detecting a defect present on the sample; wherein the step of detecting the scattered light image in the plural directions is performed through oval shaped lenses in which elevation angles of the optical axes thereof are different from each other, within one plane perpendicular to a plane formed by the normal to the surface of the table on which to mount the sample and the longitudinal direction of the linear region irradiated with the irradiation light.

公开(公告)号：US20160161422A1

公开(公告)日：2016-06-09

申请号：US15042598

申请日：2016-02-12

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shunichi MATSUMOTO ,  Atsushi TANIGUCHI ,  Toshifumi HONDA ,  Yukihiro SHIBATA ,  Yuta URANO

IPC: G01N21/95 ,  G01N21/956

CPC classification number: G01N21/9501 ,  G01N21/956 ,  G01N2201/126 ,  G01N2201/127 ,  H01L22/12 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A defect inspection method and device for irradiating a linear region on a surface-patterned sample mounted on a table, with illumination light from an inclined direction to the sample, next detecting in each of a plurality of directions an image of the light scattered from the sample irradiated with the illumination light, then processing signals obtained by the detection of the images of the scattered light, and thereby detecting a defect present on the sample; wherein the step of detecting the scattered light image in the plural directions is performed through oval shaped lenses in which elevation angles of the optical axes thereof are different from each other, within one plane perpendicular to a plane formed by the normal to the surface of the table on which to mount the sample and the longitudinal direction of the linear region irradiated with the irradiation light.

Abstract translation: 一种缺陷检查方法和装置，用于将安装在台上的表面图案样品上的线性区域照射到具有来自倾斜方向的样品的照明光，并在多个方向上检测从所述多个方向散射的光的图像 用照射光照射的样品，然后处理通过检测散射光的图像获得的信号，从而检测样品上存在的缺陷; 其特征在于，通过椭圆形透镜，其光轴的仰角彼此不同，在垂直于由所述平面形成的法线形成的平面的一个平面内，通过椭圆形透镜来检测多个方向上的散射光图像的步骤 用于安装样品的台面和用照射光照射的线性区域的纵向方向。

公开(公告)号：US09222875B2

公开(公告)日：2015-12-29

申请号：US14133199

申请日：2013-12-18

Applicant: NEXUS DX, INC.

Inventor： Richard Egan ,  Graham Lidgard ,  David Booker

IPC: G01N21/01 ,  G01N21/55 ,  G01N21/84 ,  G01N33/487 ,  G06F19/00

CPC classification number: G01N21/01 ,  G01N21/84 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/0446 ,  G01N2201/126 ,  G16H10/40 ,  Y02A90/26

Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.

Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。

公开(公告)号：US20150037877A1

公开(公告)日：2015-02-05

申请号：US13956212

申请日：2013-07-31

Applicant: The Arizona Board of Regents on behalf of the University of Arizona

Inventor： Leilei Peng ,  Ming Zhao

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2201/10 ,  G01N2201/126

Abstract: A fast fluorescence lifetime microscopic system images FRET between multiple labels in live cells and deep tissue, using a quantitative analysis method to reconstruct the molecular machinery behind the multiplexed FRET phenomenon. The system measures fluorescence lifetime, intensity and anisotropy as images of excitation-emission matrices (EEM) in real time and high speed within a single image scan, performs high-resolution deep-penetrating 3D FRET imaging in live samples, and fully analyzes all possible photon pathways of multiplexed FRET. The system provides a way for systematic and dynamic imaging of biochemical networks in cells, tissue and live animals, which will help to understand mechanisms of genetic disorders, cancers, and more.

Abstract translation: 快速荧光寿命显微镜系统在活细胞和深部组织中的多个标记之间的FRET图像，使用定量分析方法重建多重FRET现象背后的分子机制。 该系统在单次图像扫描中以实时和高速的方式测量荧光寿命，强度和各向异性作为激发发射矩阵（EEM）的图像，在活样品中进行高分辨率深穿透3D FRET成像，并全面分析所有可能的 复用FRET的光子通路。 该系统为细胞，组织和活体动物中生物化学网络的系统和动态成像提供了一种途径，有助于了解遗传疾病，癌症等机制。

公开(公告)号：US20140353524A1

公开(公告)日：2014-12-04

申请号：US14461779

申请日：2014-08-18

Applicant: GE HEALTCARE BIO-SCIENCES CORP.

Inventor： GAUDENZ DANUSER ,  PAUL C. GOODWIN

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/636 ,  G01N21/6458 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/126 ,  G02B21/365 ,  G02B21/367 ,  G06T3/4053

Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

Abstract translation: 本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。 本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。 本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量 最终图像。 本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

公开(公告)号：US08815537B2

公开(公告)日：2014-08-26

申请号：US12785337

申请日：2010-05-21

Applicant: James Winkelman ,  Milenko Tanasijevic ,  David Zahniser

Inventor： James Winkelman ,  Milenko Tanasijevic ,  David Zahniser

IPC: C12Q1/24 ,  C12Q1/08 ,  C12Q1/06 ,  C12Q1/04 ,  C12M1/36 ,  G01N1/28 ,  A01N1/02 ,  C12M1/14 ,  C12M3/04 ,  G01N15/14

CPC classification number: G01N15/1475 ,  G01N1/2813 ,  G01N1/312 ,  G01N21/255 ,  G01N33/49 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/1016 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2035/00138 ,  G01N2035/00465 ,  G01N2035/0091 ,  G01N2201/062 ,  G01N2201/126 ,  G01N2333/805 ,  G06K9/4652 ,  G06K9/6267 ,  G06T7/0012 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/265

Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.

Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

公开(公告)号：US08638441B2

公开(公告)日：2014-01-28

申请号：US12756157

申请日：2010-04-07

Applicant: Richard Egan ,  Graham Lidgard ,  David Booker

Inventor： Richard Egan ,  Graham Lidgard ,  David Booker

IPC: G01N21/55

CPC classification number: G01N21/01 ,  G01N21/84 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/0446 ,  G01N2201/126 ,  G16H10/40 ,  Y02A90/26

Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.

Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。

公开(公告)号：US20120325783A1

公开(公告)日：2012-12-27

申请号：US13602267

申请日：2012-09-03

Applicant: Peter Morrisroe

Inventor： Peter Morrisroe

IPC: B23K10/00

CPC classification number: G01N21/73 ,  G01J3/443 ,  G01N21/68 ,  G01N2201/126 ,  H01J49/105

Abstract: A device for sustaining a plasma in a torch is provided. In certain examples, the device comprises a first electrode configured to couple to a power source and constructed and arranged to provide a loop current along a radial plane of the torch. In some examples, the radial plane of the torch is substantially perpendicular to a longitudinal axis of the torch.

Abstract translation: 提供了一种用于在割炬中维持等离子体的装置。 在某些示例中，该装置包括被配置为耦合到电源并被构造和布置成沿着焊炬的径向平面提供回路电流的第一电极。 在一些示例中，焊炬的径向平面基本上垂直于焊炬的纵向轴线。

公开(公告)号：US08264687B2

公开(公告)日：2012-09-11

申请号：US13102551

申请日：2011-05-06

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。