公开(公告)号：WO1997005823A1

公开(公告)日：1997-02-20

申请号：PCT/US1996012537

申请日：1996-08-05

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  KYNOR, David, B.

IPC: A61B05/05

CPC classification number: A61B5/0452 ,  A61B5/04007 ,  Y10S128/901

Abstract: A measured magnetocardiography signal has a relatively small heart signal mixed with a large noise signal. To produce a heart signal having a reduced noise content, the times of occurrence of a time series of isoelectric intervals (54) of the measured signal is first determined (42) and a time series isoelectric artifact curve is formed from the measurements made at those times of occurrence (44). A time series non-isoelectric artifact curve for other times is determined from this information. The time series isoelectric and non-isoelectric artifact curve is subtracted from the measured cardiography time series signal (46) to yield a time series heart amplitude signal having reduced noise and undistorted form.

Abstract translation: 测量的心电图信号具有与大噪声信号混合的相对较小的心脏信号。 为了产生具有降低的噪声含量的心脏信号，首先确定测量信号的等电位间隔（54）的时间序列的出现次数（42），并根据这些测量形成时间序列等电赝像曲线 发生次数（44）。 根据该信息确定其他时间的时间序列非等电赝像曲线。 从测量的心电图时间序列信号（46）中减去时间序列等电点和非等电赝像曲线，以产生具有降低的噪声和未失真形式的时间序列心脏振幅信号。

公开(公告)号：WO1996033652A1

公开(公告)日：1996-10-31

申请号：PCT/US1996005479

申请日：1996-04-19

Applicant: CARE WISE MEDICAL PRODUCTS CORPORATION

Inventor： CARE WISE MEDICAL PRODUCTS CORPORATION ,  MADDEN, Norman ,  PEHL, Richard, H. ,  CARROLL, Robert, G. ,  McKELLAR, Louis, A.

IPC: A61B05/05

CPC classification number: A61B6/482 ,  A61B6/4057 ,  A61B6/4258 ,  A61B2090/392 ,  G01T1/161

Abstract: A system (20) and method for diagnostic testing of structures within a body, e.g., organs within the body of a living being, which has been provided with a radioactive imaging agent, e.g., a radiotracer, to cause the structure to produce gamma rays, associated characteristics X-rays, and a continuum of Compton-scattered photons. The system (20) includes a radiation receiving device, e.g., a hand-held probe (22) or camera, an associated signal processor (30B), and an analyzer (30I-30R). The radiation receiving device is arranged to be located adjacent the body and the structure for receiving gamma rays and characteristic X-rays emitted from the structure and for providing a processed electrical signal representative thereof. The processed electrical signal includes a first portion representing the characteristics X-rays received and a second portion representing the gamma rays received.

Abstract translation: 用于诊断身体内结构的系统（20）和方法，所述系统（20）和方法用于诊断身体内的结构，例如活体内的器官，其已经设置有放射性示踪剂，例如放射性示踪器，以使结构产生γ射线 ，相关特征X射线和康普顿散射光子的连续体。 系统（20）包括辐射接收装置，例如手持探针（22）或相机，相关联的信号处理器（30B）和分析器（30I-30R）。 放射线接收装置被布置成邻近身体和用于接收伽马射线的结构和从结构发射的特征X射线并且用于提供代表其的经处理的电信号。 经处理的电信号包括表示所接收的特征X射线的第一部分和表示所接收的伽马射线的第二部分。

公开(公告)号：WO1996029930A1

公开(公告)日：1996-10-03

申请号：PCT/US1996004384

申请日：1996-03-29

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  DIMAROGONAS, Andrew, D.

IPC: A61B05/05

CPC classification number: A61B5/4509 ,  A61B5/0051 ,  A61B9/00

Abstract: The density of a discrete piece of hard tissue such as a bone in a patient may be determined by either of two methods. In a first method, an impulse of energy is introduced into the tissue, and the resulting vibration in the hard tissue is sensed and analyzed to compute the modal damping factor of the tissue, the modal damping factor being directly related to the density of the tissue. In a second method, a continuous energy input is introduced into the hard tissue. The resulting vibration in the tissue is measured with a mechano-electrical vibration transducer (26) and a modal damping factor is calculated. The electro-mechanical vibration transducer (26) of the preferred embodiment measures the pressure with which the transducer (26) is pressed against the patient's flesh and only produces the continuous energy input when a predetermined pressure is achieved which is sufficient to prevent any significant vibration of the flesh surrounding the bone.

Abstract translation: 诸如患者体内的骨骼的分散的硬组织的密度可以通过两种方法中的任一种来确定。 在第一种方法中，将能量脉冲引入到组织中，并且感测和分析硬组织中产生的振动以计算组织的模态阻尼因子，模态阻尼因子与组织的密度直接相关 。 在第二种方法中，将连续的能量输入引入硬组织。 用机械电振动传感器（26）测量组织中产生的振动，并计算模态阻尼系数。 优选实施例的机电振动换能器（26）测量换能器（26）被压靠在患者肉上的压力，并且仅在达到预定压力时才产生连续能量输入，这足以防止任何明显的振动 的骨头周围的肉体。

公开(公告)号：WO1996022729A1

公开(公告)日：1996-08-01

申请号：PCT/US1996000568

申请日：1996-01-11

Applicant: EIDELBERG, David ,  MOELLER, James, R.

IPC: A61B05/05

CPC classification number: G16H50/70 ,  A61B6/037 ,  G06F19/00

Abstract: A method and apparatus for screening patients for nervous system dysfunction including neurological capacity and dysfunction comprises producing a patient profile of actual functional activity of a brain of a patient and comparing the patient profile with at least one marker comprising a profile of predetermined functional activity at a plurality of sets of predetermined coordinates of a given brain geometry.

Abstract translation: 用于筛选患者神经系统功能障碍（包括神经能力和功能障碍）的方法和装置包括产生患者脑的实际功能活动的患者概况，并将患者概况与至少一个标记进行比较，所述标记包括在 给定脑几何的多组预定坐标。

公开(公告)号：WO1996016596A1

公开(公告)日：1996-06-06

申请号：PCT/US1995015694

申请日：1995-12-04

Applicant: NON-INVASIVE TECHNOLOGY, INC. ,  CHANCE, Britton

Inventor： NON-INVASIVE TECHNOLOGY, INC.

IPC: A61B05/05

CPC classification number: A61B5/0091 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/14555 ,  A61B5/4312 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6456

Abstract: Methods and systems are described that examine tissue (8) positioned between input ports (101, 103) and a detection port (107). At least one source of a visible or infrared wavelength (102, 104) is provided that introduces electromagnetic radiation into the subject. The detection port is optically coupled to a detector (106) that is connected to a detector circuit (101). Radiation intensities are selected for introduction at the input ports to define a null plane (105) in the tissue. The detection port is positioned relative to the null plane. Radiation is introduced into the subject at the first input port and the radiation that migrates through the tissue is detected. The detector circuit stores a first detector signal corresponding to the first detected radiation. Radiation is introduced at the second input port and is detected. The first detector signal is substracted from a second detector signal corresponding to the second detected radiation to obtain processed data.

Abstract translation: 描述了检查位于输入端口（101,103）和检测端口（107）之间的组织（8）的方法和系统。 提供将电磁辐射引入到受试者中的至少一个可见光或红外波长的源（102,104）。 检测端口光耦合到与检测器电路（101）连接的检测器（106）。 选择辐射强度以在输入端口处引入以在组织中限定空平面（105）。 检测端口相对于空平面定位。 在第一输入端口将辐射引入受试者，检测通过组织迁移的辐射。 检测器电路存储对应于第一检测到的辐射的第一检测器信号。 在第二输入端口引入辐射并被检测。 第一检测器信号从对应于第二检测到的辐射的第二检测器信号减去，以获得处理的数据。

公开(公告)号：WO1996010951A1

公开(公告)日：1996-04-18

申请号：PCT/NO1995000184

申请日：1995-10-09

Applicant: MARTINSEN, Orjan, G. ,  GRIMNES, Sverre

IPC: A61B05/05

CPC classification number: A61B5/442 ,  A61B5/0531

Abstract: In order to measure the moisture content in skin, especially in the keratinous layer (stratum corneum), at least two electrodes are employed, at least one of which electrodes is placed on the skin where the moisture has to be measured, the electrodes are supplied with a periodic voltage with a frequency of less than 50 kHz, and the susceptance in the keratinous layer is measured beneath the electrode or electrodes. In an apparatus for measuring the moisture content in skin three electrodes are employed, a periodic voltage being applied to two of these. The susceptance is measured below one of the electrodes, uninfluenced by the other electrodes, the measurement thus being truly monopolar.

Abstract translation: 为了测量皮肤，特别是角质层（角质层）中的水分含量，使用至少两个电极，其中至少一个电极被放置在必须测量水分的皮肤上，电极被供应 具有频率小于50kHz的周期性电压，并且在电极或电极下方测量角质层中的电纳。 在用于测量皮肤中的水分含量的装置中，采用三个电极，周期性电压施加到这两个电极中。 在一个电极下面测量电纳，不受其他电极的影响，因此测量是真正的单极性的。

公开(公告)号：WO1996008199A1

公开(公告)日：1996-03-21

申请号：PCT/US1994010533

申请日：1994-09-16

Applicant: FISCHER IMAGING CORPORATION

Inventor： FISCHER IMAGING CORPORATION ,  SICZEK, Bernard

IPC: A61B05/05

CPC classification number: G01R33/285 ,  A61B5/0555 ,  A61B8/0825 ,  A61B8/406 ,  A61B17/3403

Abstract: The disclosed system (10) employs an MRI device to identify the location of an area of interest within a patient's breast (28) and guide a medical instrument (26) for insertion to the identified location. The patient (30) is positioned on a table top (18) having an opening (52) through which the patient's breast (28) pendulantly projects. The pendulant breast (28) is immobilized by a basket (36). The table top (18) and patient (30) are then introduced into magnetic field generator (12) and MRI signals are received by receiver (14). The location of an area of interest within the patient's breast (28) is determined based on the received signals. A guidance assembly (24) can then be used to aim the medical instrument (26) towards the location of interest via a penetration path selected so as to avoid the receiver (14) and basket (36).

Abstract translation: 所公开的系统（10）使用MRI装置来识别患者胸部（28）内的感兴趣区域的位置，并引导用于插入到所识别位置的医疗器械（26）。 患者（30）位于具有开口（52）的台面（18）上，患者的乳房（28）通过该开口弯曲地突出。 吊坠乳房（28）被篮子（36）固定。 然后将台面（18）和患者（30）引入磁场发生器（12），并且接收器（14）接收MRI信号。 基于接收到的信号确定患者胸部（28）内的感兴趣区域的位置。 然后可以使用引导组件（24）来将医疗器械（26）经由穿过路径瞄准感兴趣的位置，以便避免接收器（14）和筐（36）。

公开(公告)号：WO1995023552A1

公开(公告)日：1995-09-08

申请号：PCT/US1995002554

申请日：1995-03-02

Applicant: KRAKOVITZ, Mark

IPC: A61B05/05

CPC classification number: A61B8/08 ,  A61B6/4258 ,  G01T1/161

Abstract: Hybrid probes for locating and characterizing disease. The probes (30, 40) comprise nuclear probes (40) which detect gamma radiation emitted from the diseased area, and ultrasound probes (30). The nuclear probes (40) locate and initially characterize the diseased area, and the ultrasound probe (30) fully characterizes the disease. With hybrid probes (30, 40) described herein, potentially diseased areas can be efficiently identified and diagnosed early.

Abstract translation: 用于定位和表征疾病的混合探针。 探针（30,40）包括检测从患病区域发射的γ射线的核探头（40）和超声波探头（30）。 核探针（40）定位并最初表征患病区域，超声探头（30）完全表征疾病。 利用本文所述的混合探针（30,40），可以有效地识别和诊断潜在的患病区域。

公开(公告)号：WO1995002991A1

公开(公告)日：1995-02-02

申请号：PCT/FR1994000930

申请日：1994-07-25

Applicant: BOUR, Jean ,  BOUR, Frank ,  SCHANG, Daniel ,  NOTTON, Philippe

IPC: A61B05/05

CPC classification number: A61B5/0535 ,  A61B5/7232 ,  A61B5/7239

Abstract: An apparatus for measuring and processing physiological signals and an automatic method therefor are disclosed. The preferably portable apparatus is characterised in that it mainly consists of devices for continuously acquiring (3, 3'), shaping (4, 4') and digitising (5) at least one electrocardiographic signal and a signal representative of changes in the impedance of a predetermined volume (V) in the body (6) of a patient, as well as a digital preprocessing unit (7) interacting with a controller (8), a display (9) and a removable device (10) for storing digitised signals or values derived from significant parameters. The apparatus further consists of a central digital processing device (12) for collecting and storing successive transfers of data from the storage device (10), and comparing said data.

Abstract translation: 公开了一种用于测量和处理生理信号的装置及其自动方法。 优选便携式设备的特征在于其主要包括用于连续获取（3,3'），整形（4,4'）和数字化（5）至少一个心电图信号和表示阻抗变化的信号的装置 在患者的身体（6）中的预定体积（V）以及与控制器（8）相互作用的数字预处理单元（7），显示器（9）和可移除设备（10），用于存储数字化信号 或从重要参数导出的值。 该设备还包括一个中央数字处理设备（12），用于收集和存储来自存储设备（10）的数据的连续传送，以及比较所述数据。

公开(公告)号：WO1994024932A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004035

申请日：1994-04-13

Applicant: MEDICAL SCIENTIFIC, INC.

Inventor： MEDICAL SCIENTIFIC, INC. ,  NARDELLA, Paul, C.

IPC: A61B05/05

CPC classification number: A61B5/0538 ,  A61B5/0535

Abstract: A diagnostic impedance measuring system (10) having an elongate tissue-penetrating probe member (12) with a plurality of axially spaced reference electrodes (20A-C) disposed about a distal portion of the probe (12). The reference electrodes (20A-C) measure the impedance of the biological tissue adjacent each electrode. A comparator (42) compares the measured impedance of at least a first and a second of the reference electrodes (20A-C), and generates a first signal indicative of the impedance difference between the two electrodes. The comparator compares the measured impedance between either the first or second electrode and one additional electrode, and generates a second signal indicative of the impedance difference between the two electrodes. The comparator compares the first and second signals and generates a third signal indicative of the impedance difference between the two signals. The third signal communicates with a signal evaluation element that determines the relative position of the probe (12).

Abstract translation: 一种诊断阻抗测量系统（10），其具有细长的组织穿透探针部件（12），所述细长的组织穿透探针部件（12）具有围绕探针（12）的远端部分设置的多个轴向间隔开的参考电极（20A-C）。 参考电极（20A-C）测量邻近每个电极的生物组织的阻抗。 比较器（42）比较至少第一和第二参考电极（20A-C）的测量阻抗，并产生指示两个电极之间的阻抗差的第一信号。 比较器比较第一或第二电极与一个附加电极之间的测量阻抗，并产生指示两个电极之间的阻抗差的第二信号。 比较器比较第一和第二信号，并产生指示两个信号之间的阻抗差的第三信号。 第三信号与确定探针（12）的相对位置的信号评估元件通信。