公开(公告)号：EP3194525A4

公开(公告)日：2018-05-23

申请号：EP15841357

申请日：2015-09-16

Applicant: CARBO CERAMICS INC ,  SANDIA CORP ,  STC UNM

Inventor： CANNAN CHAD ,  PALISCH TERRENCE ,  KEMP RICHARD A ,  BOYLE TIMOTHY J ,  HERNANDEZ-SANCHEZ BERNADETTE A ,  MILLER JAMES E

IPC: C09K8/80 ,  E21B43/267 ,  E21B47/11

CPC classification number: C09K8/80 ,  C09K8/805 ,  E21B43/267 ,  E21B47/1015

Abstract: Proppant compositions for use in hydraulic fracturing and methods of using same are disclosed herein. The proppant compositions include a plurality of proppant particulates and at least one particulate of the plurality of proppant particulates containing at least one tracer, wherein the at least one tracer separates from the at least one particulate located inside a fracture of a subterranean formation after a period of time.

公开(公告)号：EP3074134A4

公开(公告)日：2017-07-12

申请号：EP14865949

申请日：2014-11-26

Applicant: STC UNM

Inventor： BRUECK STEVEN R J ,  EDWARDS JEREMY SCOTT ,  NEUMANN ALEXANDER ,  KUZNETSOVA YULIYA ,  MENDOZA EDGAR A

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0896 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2400/0421 ,  C12Q1/6869 ,  C23C16/345 ,  C23C16/45525 ,  C23C16/50 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/061 ,  C12Q2563/155 ,  C12Q2565/631

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract translation: 用于长读取，无标记，光学纳米孔长链分子测序的方法和设备。 通常，本公开内容描述了基于纳米通道整合以递送具有宽间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子的新型测序技术，其缓慢移位足以提供大规模平行， 使用光学技术的单基准分辨率。 使用简单的胶体纳米粒子的新型定向自组装纳米制造方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程等离子体激元/极化激元结构中的强局部电磁场允许使用光学技术实现单基极分辨率。

公开(公告)号：EP3055431A4

公开(公告)日：2017-05-10

申请号：EP14852570

申请日：2014-09-24

Applicant: STC UNM

Inventor： EDWARDS JEREMY SCOTT

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q1/6853 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2525/161 ,  C12Q2525/179 ,  C12Q2563/179

Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

Abstract translation: 本公开描述了通过组装多个较短的多核苷酸读数对DNA序列的长部分进行测序的方法。 通常，该方法包括将多个引物退火至变性的DNA分子，将条形码多核苷酸附加至引物的5'末端，使DNA分子经历多次（1）合并，（2）分裂和 （3）将条形码多核苷酸附加到引物的5'末端，对条形码多核苷酸和基因组DNA进行测序，并组装具有相同条形码多核苷酸的短读取多核苷酸序列。

公开(公告)号：EP2906347A4

公开(公告)日：2016-05-18

申请号：EP13847996

申请日：2013-10-15

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B ,  HALEVI BARR ,  SHORT PAUL

IPC: H01M4/86 ,  B01J31/18 ,  H01M4/88 ,  H01M4/90 ,  H01M8/1011 ,  H01M8/1018

CPC classification number: H01M4/9091 ,  B01J31/1805 ,  H01M4/8652 ,  H01M4/8814 ,  H01M4/8846 ,  H01M4/8885 ,  H01M4/9008 ,  H01M8/1011 ,  H01M2008/1095 ,  Y02E60/50 ,  Y02E60/523

Abstract: Novel catalytic materials and novel methods of preparing M-N—C catalytic materials utilizing a sacrificial support approach and using inexpensive active polymers as the carbon and nitrogen source and readily available metal precursors are described.

公开(公告)号：EP2840894A4

公开(公告)日：2016-01-06

申请号：EP12857809

申请日：2012-10-31

Applicant: STC UNM

Inventor： DURVASULA RAVI ,  FORSHAW ADAM

IPC: A01N25/28 ,  A01N25/26 ,  A01N63/02 ,  A01P1/00

CPC classification number: A01N25/26 ,  A01N25/28 ,  A01N63/00

公开(公告)号：EP2765997A4

公开(公告)日：2015-06-24

申请号：EP12840155

申请日：2012-10-12

Applicant: STC UNM ,  SANDIA CORP

Inventor： ASHLEY CARLEE ERIN ,  BRINKER C JEFFREY ,  CARNES ERIC C ,  FEKRAZAD MOHAMMAD HOUMAN ,  FELTON LINDA A ,  NEGRETE OSCAR ,  PADILLA DAVID PATRICK ,  WILKINSON BRIAN S ,  WILKINSON DAN C ,  WILLMAN CHERYL L

IPC: A61K9/16 ,  A61K9/107 ,  A61K9/127 ,  A61K9/50 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/17 ,  A61K45/06 ,  A61K47/48 ,  A61K48/00 ,  A61K49/04 ,  A61K49/08 ,  B82Y5/00 ,  C07K7/06 ,  C12N15/88

CPC classification number: A61K47/48823 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/5078 ,  A61K31/192 ,  A61K31/465 ,  A61K31/506 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K33/24 ,  A61K38/00 ,  A61K38/17 ,  A61K38/45 ,  A61K38/47 ,  A61K45/06 ,  A61K47/483 ,  A61K47/48561 ,  A61K47/48815 ,  A61K47/48861 ,  A61K47/6923 ,  A61K48/0008 ,  A61K49/0082 ,  A61K49/0423 ,  B82Y5/00 ,  C07K7/06 ,  C07K2319/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40 ,  C12Y204/02036 ,  C12Y302/02022 ,  A61K2300/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：EP2720793A4

公开(公告)日：2015-01-14

申请号：EP12801152

申请日：2012-06-15

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  HALEVI BARR ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B ,  MARTINEZ ULISES ANDRES

IPC: H01M4/90 ,  B01J23/70 ,  B01J23/889 ,  B01J35/00 ,  B01J37/08 ,  H01M4/88

CPC classification number: H01M4/8652 ,  B01J23/70 ,  B01J23/8892 ,  B01J35/0033 ,  B01J37/084 ,  H01M4/8621 ,  H01M4/8885 ,  H01M4/9041 ,  H01M4/9083 ,  H01M4/9091 ,  H01M2004/8689

Abstract: A method of preparing M-N—C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include non-porphyrin precursors with no initial catalytic activity. Examples of suitable non-catalytic non-porphyrin precursors include, but are not necessarily limited to low molecular weight precursors that form complexes with iron such as 4-aminoantipirine, phenylenediamine, hydroxysuccinimide, ethanolamine, and the like.

Abstract translation: 公开了一种使用牺牲支撑方法制备M-N-C催化剂的方法，并且公开了廉价和容易获得的聚合物前体作为氮和碳的来源。 示例性聚合物前体包括没有初始催化活性的非卟啉前体。 合适的非催化非卟啉前体的实例包括但不必限于与铁形成络合物的低分子量前体，例如4-氨基安替比林，苯二胺，羟基琥珀酰亚胺，乙醇胺等。

公开(公告)号：EP2254476A4

公开(公告)日：2013-10-30

申请号：EP09716644

申请日：2009-02-27

Applicant: STC UNM

Inventor： CHEN JINGKUANG

IPC: A61B8/00 ,  B06B1/02

CPC classification number: B06B1/0292

公开(公告)号：EP1618593A4

公开(公告)日：2007-12-05

申请号：EP04757871

申请日：2004-03-19

Applicant: STC UNM

Inventor： ENKE CHRISTIE

IPC: H01J49/40 ,  G01N20060101 ,  G01N27/64 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/40 ,  G01N27/622 ,  H01J49/0045

Abstract: A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A "distance-of-flight" (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

公开(公告)号：EP1007538A4

公开(公告)日：2005-08-24

申请号：EP97918677

申请日：1997-04-14

Applicant: STC UNM

Inventor： WHEELER COSETTE M ,  MANOS M MICHELE

IPC: C12Q1/70 ,  C07H21/04 ,  C07H21/00 ,  C12Q1/68

CPC classification number: C12Q1/708

Abstract: The present invention provides probes for the human papillomaviruses HPV-18, HPV-33, HPV-35, HPV-39, HPV-45, HPV-51, HPV-52, HPV-58, HPV-59, HPV-68 (ME180), MM4/W13B and MM9/PAP238A which hybridize with the homologous regions of these HPVs' DNA. The present invention also provides probes for these human papillomaviruses which are capable of hybridizing with newly discovered variant regions of these HPVs' DNA.