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公开(公告)号：KR1020070070300A
公开(公告)日：2007-07-04
申请号：KR1020050069505
申请日：2005-07-29
Applicant: (주)아모레퍼시픽
CPC classification number: C12N15/113 , A61K8/606 , A61K31/7105 , A61Q19/02 , C12N2310/141
Abstract: A method for inhibiting melanosome migration by using prohibitin siRNA(small interference RNA) is provided to inhibit expression of prohibitin in a melanin synthesis cell and uniformed distribution of melanosome in the melanin synthesis cell, so that the skin is whitened. The melanosome migration to the end of melanin synthesis cell is inhibited by administering prohibitin siRNA into the melanin synthesis cell, melan-a, thereby inhibiting binding of prohibitin to melanophilin as a melanosome vehicle and uniformed distribution of melanosome in the melanin synthesis cell.
Abstract translation: 提供了通过使用prohibitin siRNA（小干扰RNA）抑制黑素体迁移的方法，以抑制黑色素合成细胞中的禁忌蛋白的表达和黑色素合成细胞中黑素体的均匀分布，从而使皮肤变白。 黑色素细胞迁移到黑色素合成细胞末端受到抑制黑色素合成细胞，黑色素a的抑制蛋白siRNA，从而抑制黑素素作为黑素体载体和黑素体合成细胞中黑素体分布均匀的结合。
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公开(公告)号：KR100701269B1
公开(公告)日：2007-03-29
申请号：KR1020060129745
申请日：2006-12-19
Applicant: (주)아모레퍼시픽
CPC classification number: A23L33/11 , A23V2002/00 , A23V2200/332 , A23V2250/20
Abstract: A food composition for improving and preventing obesity is provided to promote a beta oxidation of fatty acids effectively, and prevent and reduce an accumulation of excessive fat. The food composition for improving and preventing obesity contains coumestrol, a coumesterol-containing natural materials or an extract thereof as an active component. The active component promotes expression of Carnitine Palmitoyl Transferase 1A gene to increase a beta oxidation of fatty acids. The food composition for improving and preventing obesity is formulated into drink, diet bar, chocolate, caramel, or confectionery. The coumestrol is contained in an amount of 0.02-10wt% based on the total composition.
Abstract translation: 提供用于改善和预防肥胖症的食物组合物，用于有效促进脂肪酸的β氧化，并防止和减少过量脂肪的积累。 用于改善和预防肥胖症的食物组合物含有作为活性成分的香豆素，含有壳聚糖的天然材料或其提取物。 活性成分促进肉碱棕榈酰转移酶1A基因的表达，增加脂肪酸的β氧化。 用于改善和预防肥胖症的食物组合物被配制成饮料，饮食酒吧，巧克力，焦糖或糖果。 基于总组合物，孕菊酯的含量为0.02-10重量％。
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123.发明公开
公开(公告)号：KR1020050095415A
公开(公告)日：2005-09-29
申请号：KR1020040020800
申请日：2004-03-26
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/63 , A61K8/046 , A61K8/347 , A61K2800/59 , A61Q17/04 , A61Q19/00 , A61Q19/08
Abstract: 본 발명은 진세노사이드 F1(20-O-β-D-글루코피라노실-20(S)-프로토파낙사트리올)과 EGCG((-)에피갈로카테킨-3-갈레이트)의 상승효과에 의한 용도에 관한 것으로, 더욱 상세하게는 상기 화합물들을 동시에 처리하는 것을 특징으로 하는, 자외선 조사로 유도되는 피부세포의 사멸을 방지하는 방법에 관한 것이다. 본 발명은 단독 처리시에는 효과가 없는 낮은 농도의 두 화합물을 혼합하여 처리함으로써 자외선 조사에 의해 유발되는 Bcl-2의 발현 감소를 효과적으로 억제하여 피부세포의 사멸을 방지하는 Bcl-2 발현 조절제로서의 용도를 제공한다. 또한, 암억제 유전자인 Rb 단백질의 탈인산화를 억제하여 안정화시킴으로써 자외선에 의한 피부세포의 손상을 방지하는 용도를 제공한다. 본 발명을 통해 단가가 높은 두 화합물을 낮은 농도(단독 사용시 각각 2.5배, 5배 농도 필요)로 사용함으로써 원료비를 낮추어 고기능성 제품을 보다 저렴한 가격에 공급할 수 있다.
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公开(公告)号：KR1020040059139A
公开(公告)日：2004-07-05
申请号：KR1020020085716
申请日：2002-12-28
Applicant: (주)아모레퍼시픽
IPC: A61K31/704
CPC classification number: A61K31/70
Abstract: PURPOSE: Provided is a controlling agent of Bcl-2 expression which characteristically contains ginsenoside F1(20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) represented by the formula(1), as an active ingredient. It prevents apoptosis caused by radiating low doses of ultraviolet rays, while promoting apoptosis when radiating high doses of ultraviolet rays, therefore it removes the risk of cancers. CONSTITUTION: A controlling agent of the expression of Bcl-2 is characterized by containing ginsenoside F1(20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol), which is represented by the formula(1), as an active ingredient. It inhibits the decrease of Bcl-2 expression caused by radiating ultraviolet rays. Therefore, it prevents apoptosis by the radiation of low doses of ultraviolet rays, but promotes apoptosis by the radiation of high doses of ultraviolet rays.
Abstract translation: 目的：提供一种Bcl-2表达的控制剂，其特征在于含有式（1）所示的人参皂甙F1（20-O-β-D-吡喃葡萄糖基-20（S） - 原人参三醇）作为活性成分。 防止辐射低剂量紫外线引起的细胞凋亡，同时在辐射高剂量的紫外线时促进细胞凋亡，从而消除癌症的风险。 构成：Bcl-2表达的控制剂的特征在于将由式（1）表示的人参皂甙F1（20-O-β-D-吡喃葡萄糖基-20（S） - 原人参三醇）作为活性物质 成分。 它抑制由辐射紫外线引起的Bcl-2表达的降低。 因此，通过低剂量的紫外线辐射可防止细胞凋亡，但通过高剂量紫外线的辐射促进细胞凋亡。
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公开(公告)号：KR102164345B1
公开(公告)日：2020-10-13
申请号：KR1020170128159
申请日：2017-09-29
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61K36/82 , A23L33/105 , A61Q19/00
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Patent Agency Ranking
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公开(公告)号：KR102090133B1
公开(公告)日：2020-03-17
申请号：KR1020170127667
申请日：2017-09-29
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61K36/185 , A23L33/105 , A61Q19/00
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公开(公告)号：KR102087189B1
公开(公告)日：2020-03-11
申请号：KR1020170127665
申请日：2017-09-29
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61K36/185 , A23L33/105 , A61Q17/00 , A61Q19/00
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公开(公告)号：KR102045879B1
公开(公告)日：2019-11-18
申请号：KR1020180042940
申请日：2018-04-12
Applicant: (주)아모레퍼시픽 , 경희대학교 산학협력단
IPC: G01N33/50 , G01N33/68 , A23L33/13 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P27/02
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