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    ＣＰＴ-１ 유전자의 발현을 특이적으로 전사 단계에서조절하는 화학물질의 스크리닝 방법 및 그 방법으로검색된 제니스테인을 유효 성분으로 포함하는 ＣＰＴ-１발현 촉진제
    1.
    发明公开
    ＣＰＴ-１ 유전자의 발현을 특이적으로 전사 단계에서조절하는 화학물질의 스크리닝 방법 및 그 방법으로검색된 제니스테인을 유효 성분으로 포함하는 ＣＰＴ-１발현 촉진제 有权
    特异性控制CPT-1基因转录表达的化合物的筛选方法和包含通过相同方法筛选的基因的CPT-1表达增强子

    公开(公告)号：KR1020040060749A

    公开(公告)日：2004-07-06

    申请号：KR1020030095226

    申请日：2003-12-23

    Applicant: (주)아모레퍼시픽

    Inventor： 김수정 ,  신의석 ,  이은희 ,  장희경 ,  조시영 ,  김선영 ,  이상준 ,  이태룡 ,  심영철

    IPC: C12N15/85

    CPC classification number: C12N15/85 ,  C12N5/0693 ,  C12N9/1025 ,  G01N33/5044

    Abstract: PURPOSE: A screening method of compounds specifically controlling transcriptional expression of CPT-1 gene, and a CPT-1 expression enhancer comprising genistein which is screened by the same method are provided, thereby easily screening natural compounds reducing fat of human. CONSTITUTION: The screening method of compounds specifically controlling transcriptional expression of CPT-1 gene comprises the steps of: constructing a recombinant plasmid pCPT-1P-luc containing CPT-1 promoter and luciferase; producing a transformant Huh7 cell line(KCLRF-BP-00090) transformed with the recombinant plasmid pCPT-1P-luc; contacting a compound with the transformant Huh7 cell line(KCLRF-BP-00090); quantification of the signal produced by the contact; and comparing the signal amount measured with that of a control.

    Abstract translation: 目的：提供特异性控制CPT-1基因转录表达的化合物的筛选方法，以及通过相同方法筛选含有染料木素的CPT-1表达增强子，从而容易地筛选天然化合物，减少人的脂肪。 构成：特异性控制CPT-1基因转录表达的化合物的筛选方法包括以下步骤：构建含有CPT-1启动子和荧光素酶的重组质粒pCPT-1P-luc; 产生用重组质粒pCPT-1P-luc转化的转化体Huh7细胞系（KCLRF-BP-00090）; 使化合物与转化体Huh7细胞系（KCLRF-BP-00090）接触; 量化由接触产生的信号; 并将测量的信号量与对照的信号量进行比较。

    진세노사이드 Ｆ1을 유효성분으로 하는 Ｂｃｌ-2 발현조절제
    3.
    发明公开
    진세노사이드 Ｆ1을 유효성분으로 하는 Ｂｃｌ-2 발현조절제 有权
    含有GINSENOSIDE F1作为活性成分的Bcl-2表达的控制剂

    公开(公告)号：KR1020040059139A

    公开(公告)日：2004-07-05

    申请号：KR1020020085716

    申请日：2002-12-28

    Applicant: (주)아모레퍼시픽

    Inventor： 조시영 ,  이은희 ,  김수정 ,  신의석 ,  장희경 ,  김덕희 ,  염명훈 ,  우광식 ,  이태룡 ,  심영철

    IPC: A61K31/704

    CPC classification number: A61K31/70

    Abstract: PURPOSE: Provided is a controlling agent of Bcl-2 expression which characteristically contains ginsenoside F1(20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) represented by the formula(1), as an active ingredient. It prevents apoptosis caused by radiating low doses of ultraviolet rays, while promoting apoptosis when radiating high doses of ultraviolet rays, therefore it removes the risk of cancers. CONSTITUTION: A controlling agent of the expression of Bcl-2 is characterized by containing ginsenoside F1(20-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol), which is represented by the formula(1), as an active ingredient. It inhibits the decrease of Bcl-2 expression caused by radiating ultraviolet rays. Therefore, it prevents apoptosis by the radiation of low doses of ultraviolet rays, but promotes apoptosis by the radiation of high doses of ultraviolet rays.

    Abstract translation: 目的：提供一种Bcl-2表达的控制剂，其特征在于含有式（1）所示的人参皂甙F1（20-O-β-D-吡喃葡萄糖基-20（S） - 原人参三醇）作为活性成分。 防止辐射低剂量紫外线引起的细胞凋亡，同时在辐射高剂量的紫外线时促进细胞凋亡，从而消除癌症的风险。 构成：Bcl-2表达的控制剂的特征在于将由式（1）表示的人参皂甙F1（20-O-β-D-吡喃葡萄糖基-20（S） - 原人参三醇）作为活性物质 成分。 它抑制由辐射紫外线引起的Bcl-2表达的降低。 因此，通过低剂量的紫外线辐射可防止细胞凋亡，但通过高剂量紫外线的辐射促进细胞凋亡。

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